JP4279361B2 - Hydrogel base for skin application - Google Patents

Description

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[0001]
[Industrial application fields]
The present invention relates to a hydrogel base.
[0002]
[Prior art]
Conventionally, natural gels such as agar gel, carrageenan, sodium alginate, and gelatin are known. However, focusing on their high water content, we tried to use it for the purpose of keeping the object moist and cold (for example, in the application of a compress). . However, these natural product gels are very brittle and have a problem of poor shape retention.
[0003]
On the other hand, similarly, glucomannan, which is a natural product gel, is stable and retains its shape when it is maintained in a strong alkaline region. However, since it is preferable that the human skin is in a weakly acidic region, there is a problem in that it is defective for use as a poultice.
[0004]
[Problems to be solved by the invention]
Accordingly, the present invention is intended to provide a stable water-containing gel base shapeless also hardly occurs in the weakly acidic region.
[0005]
[Means for Solving the Problems]
As a result of diligent investigation to solve the above problems, by adding a polymer such as locust bean gum or carrageenan to glucomannan, and forming a hydrous gel base, it is stable and hardly loses its shape even in weakly acidic regions. As a result, the present invention has been completed.
[0006]
Hydrogel base of the invention of claim 1, wherein the containing as an active ingredient and glucomannan and locust bean gum, but with locust bean gum functions as inhibitor syneresis, the shapeless glucomannan even in the weakly acidic region It is hard to occur and can be maintained stably. In addition, when the content of locust bean gum is less than about 0.1% by weight, it may be difficult to maintain the shape retention, and when it exceeds about 5.0% by weight, it becomes too hard and becomes a gel. There may be a problem that it is difficult.
[0007]
Further, if the content of glucomannan is less than about 0.1% by weight, there may be a problem that the shape retention is insufficient, and if it exceeds about 5.0% by weight, there is a problem that the transparency and elasticity are poor. There is a case.
[0008]
【The invention's effect】
The present invention is configured as described above and has the following effects.
[0009]
It is possible to provide a stable water-containing gel base that does not easily lose its shape even in a weakly acidic region.
[0010]
【Example】
The configuration of the present invention will be described below with reference to examples.
[0011]
Hydrogel base in this example, contains glucomannan and locust bean gum as an active ingredient. The glucomannan is a neutral complex polysaccharide composed of about 7: 3 glucose and mannose, and is the original substance of konjac.
[0012]
Tables 1 and 2 show the proportions of the blending amounts in each Example. As shown in Table, Glucomannan about 0.1 to 5.0 wt%, locust bean gum are blended about 0.1 to 5.0 wt%, the range of the amount of the extent water A gel base is preferable because it is easy to stabilize. In addition, Table 5 shows the ratio of the amount of the comparative example that does not use glucomannan.
[0013]
Concentrated glycerin, carboxymethylcellulose (CMC), gelatin, calcium alginate and the like can be blended in an amount of about 5 to 20% by weight as a water retention substance. This functions as a moisturizing agent for preventing water separation and can provide gel strength.
[0014]
Further, a small amount of paraben or the like, for example, about 0.1% by weight or less can be blended as a preservative. As a tackifier, PEG, PVA, etc. can be blended, for example, at about 5.0% by weight or less. For example, about 5.0% by weight or less of l-menthol can be blended as a fragrance. In addition, a small amount of camphor, for example, about 5.0% by weight or less can be blended as a refreshing agent. And most of the remaining amount is water.
[0015]
Next, the manufacturing method of this hydrogel base is demonstrated . First, the whole amount of glucomannan, locust bean gum and carrageenan is gradually added while heating concentrated glycerin to about 60 ° C. Next, distilled water is gradually added to the extent that about 50% of the total amount is added to such an extent that no lumps (gel-like lumps) are formed. Then, other components to be blended are added sequentially, and finally distilled water is added until a predetermined blending amount is reached. During these procedures, always stir. Make sure there are no lumps, after which the solidified promptly cooled slowly poured into a mold, the water-containing gel base was completed and removed from the mold is obtained.
[0016]
Glucomannan functions as a shape-retaining agent, and this water-containing gel base has the advantage of being excellent in shape retention, flexibility, elasticity, adhesion, water retention, moisture release, transparency and the like. Moreover, the gel strength is stable over time even in a weakly acidic region.
[0017]
When this hydrogel base is affixed to the skin, its pH is in a weakly acidic region, so that there is less irritation to the skin, which is preferable. Moreover, it was able to cool for a long time in a comfortable state with good adhesion to the skin.
[0018]
The water-containing gel base of this example was evaluated by a sensory test. Evaluation was based on the following items and methods.
[0019]
The production of shape retention hydrous gel base, depending on whether its shape during demolding is held, flexibility depending on whether hydrogel bases may fit to the skin without stiff, resilient hydrogel depending on whether coming restored by pressing base, depending on whether adhesion is liable to adhere to the skin and body, water retention by whether hydrogel base is not syneresis are 24 hours water retention, transparency Judgment was made based on whether there was turbidity. The results of each example are shown in Tables 3 and 4, and the results of each comparative example are shown in Table 5.
[0020]
For each of these evaluation items, “◎” in the table indicates evaluation results of “good”, “◯” indicates “good”, Δ indicates “bad”, and × indicates “very bad”.
[0021]
As shown in the table, each of the examples is superior in shape retention as compared with each of the comparative examples, and is not easily deformed and is stable.
[0022]
[Table 1]

[0023]
[Table 2]

[0024]
[Table 3]

[0025]
[Table 4]

[0026]
[Table 5]

Claims (3)

A hydrogel base for skin application (excluding edible bases), characterized by containing glucomannan and locust bean gum as active ingredients. Water-containing gel base according to claim 1 containing locust bean gum about 0.1 to 5.0 wt%. Water-containing gel base according to claim 1 or 2, wherein contains glucomannan about 0.1 to 5.0 wt%.