JP4215827B2 - 閉鎖帯毒素レセプター - Google Patents

閉鎖帯毒素レセプター Download PDF

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Publication number
JP4215827B2
JP4215827B2 JP53667698A JP53667698A JP4215827B2 JP 4215827 B2 JP4215827 B2 JP 4215827B2 JP 53667698 A JP53667698 A JP 53667698A JP 53667698 A JP53667698 A JP 53667698A JP 4215827 B2 JP4215827 B2 JP 4215827B2
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JP
Japan
Prior art keywords
zot
cells
seq
sequence
actin
Prior art date
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Expired - Fee Related
Application number
JP53667698A
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English (en)
Japanese (ja)
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JP2001518077A (ja
JP2001518077A5 (https=
Inventor
ファサノ,アレシオ
Original Assignee
ユニバーシティ オブ メリーランド,ボルチモア
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Priority claimed from US08/803,364 external-priority patent/US5864014A/en
Application filed by ユニバーシティ オブ メリーランド,ボルチモア filed Critical ユニバーシティ オブ メリーランド,ボルチモア
Publication of JP2001518077A publication Critical patent/JP2001518077A/ja
Publication of JP2001518077A5 publication Critical patent/JP2001518077A5/ja
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Publication of JP4215827B2 publication Critical patent/JP4215827B2/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/822Microorganisms using bacteria or actinomycetales
    • Y10S435/909Vibrio
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82Proteins from microorganisms
    • Y10S530/825Bacteria

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP53667698A 1997-02-20 1998-02-18 閉鎖帯毒素レセプター Expired - Fee Related JP4215827B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/803,364 1997-02-20
US08/803,364 US5864014A (en) 1997-02-20 1997-02-20 Zonula occludens toxin receptor
US09/024,198 1998-02-17
US09/024,198 US5912323A (en) 1997-02-20 1998-02-17 Zonula occludens toxin receptors
PCT/US1998/002257 WO1998037096A1 (en) 1997-02-20 1998-02-18 Zonula occludens toxin receptors

Publications (3)

Publication Number Publication Date
JP2001518077A JP2001518077A (ja) 2001-10-09
JP2001518077A5 JP2001518077A5 (https=) 2005-10-06
JP4215827B2 true JP4215827B2 (ja) 2009-01-28

Family

ID=26698164

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53667698A Expired - Fee Related JP4215827B2 (ja) 1997-02-20 1998-02-18 閉鎖帯毒素レセプター

Country Status (9)

Country Link
US (2) US5912323A (https=)
EP (1) EP1007553B1 (https=)
JP (1) JP4215827B2 (https=)
AT (1) ATE359294T1 (https=)
AU (1) AU6270298A (https=)
CA (1) CA2281617A1 (https=)
DE (1) DE69837546T2 (https=)
ES (1) ES2285762T3 (https=)
WO (1) WO1998037096A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458925B1 (en) * 1998-08-03 2002-10-01 University Of Maryland, Baltimore Peptide antagonists of zonulin and methods for use of the same
EP1249244A1 (en) * 2001-04-13 2002-10-16 Universiteit Gent Therapeutic compositions for the treatment of a disease modulated by the G-actin / F-actin equilibrium, especially a respiratory tract disease
AU2003244690A1 (en) 2002-03-15 2003-09-29 Rytek Compositions for treating digestive functional pathologies
FR2844201A1 (fr) * 2002-09-06 2004-03-12 Rytek Compositions pour le traitement de pathologies fonctionnelles digestives
AU2003268489B2 (en) 2002-09-06 2008-01-24 Promega Corporation Method for detecting transferase enzymatic activity
JP4485470B2 (ja) 2002-12-23 2010-06-23 プロメガ コーポレイション ルシフェラーゼ酵素活性を保護するための方法及びキット
KR20080056318A (ko) * 2003-07-15 2008-06-20 유니버시티 오브 메릴랜드, 볼티모어 Zot 및 조눌린에 대한 수용체의 작용제 폴리펩티드
US20080038843A1 (en) * 2006-08-11 2008-02-14 University Of Maryland - Baltimore Method of diagnosing celiac disease
EP1768687A2 (en) 2004-06-29 2007-04-04 Massachusetts Institute Of Technology Methods and compositions related to the modulation of intercellular junctions
FR2879100B1 (fr) 2004-12-09 2007-07-06 Lionel Bueno Compositions pour le traitement des pathologies oculaires de surface et de la retine
TW200637573A (en) * 2005-01-14 2006-11-01 Univ Maryland Peptide for delivery of mucosal vaccines
AR057058A1 (es) * 2005-06-09 2007-11-14 Alba Therapeutics Corp Metodo para usar antagonistas de zonulina para prevenir la perdida o para regenerar celulas pancreaticas
MX2008010221A (es) 2006-02-09 2009-03-05 Alba Therapeutics Corp Formulaciones para un efector de union ajustada.
WO2008043107A2 (en) * 2006-10-06 2008-04-10 Alba Therapeutics Corporation Use of tight junction antagonists to treat inflammatory bowel disease
US8034776B2 (en) * 2006-10-26 2011-10-11 Alba Therapeutics Corporation Materials and methods for the treatment of celiac disease
US20100144646A1 (en) * 2006-11-03 2010-06-10 Blake Paterson Method of diagnosing and treating asthma
WO2009023311A2 (en) * 2007-05-07 2009-02-19 Alba Therapeutics Corporation Transcutaneous delivery of therapeutic agents
US20110201543A1 (en) * 2007-06-29 2011-08-18 Blake Paterson Use of tight junction antagonists in the treatment of acute lung injury and acute respiratory distress
US8198233B2 (en) 2007-07-26 2012-06-12 Alba Therapeutics Corporation Synthetic peptides that enhance tight junction permeability

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5216126A (en) * 1991-06-19 1993-06-01 Genentech, Inc. Receptor polypeptides and their production and uses
US5665389A (en) * 1995-05-24 1997-09-09 University Of Maryland At Baltimore Oral dosage composition for intestinal delivery and method of treating diabetes

Also Published As

Publication number Publication date
DE69837546T2 (de) 2007-12-27
JP2001518077A (ja) 2001-10-09
DE69837546D1 (de) 2007-05-24
ES2285762T3 (es) 2007-11-16
US5948629A (en) 1999-09-07
AU6270298A (en) 1998-09-09
US5912323A (en) 1999-06-15
EP1007553B1 (en) 2007-04-11
EP1007553A1 (en) 2000-06-14
ATE359294T1 (de) 2007-05-15
EP1007553A4 (en) 2004-09-22
CA2281617A1 (en) 1998-08-27
WO1998037096A1 (en) 1998-08-27

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AU702385B2 (en) Oral dosage composition for intestinal delivery and method of use of the same
US5827534A (en) Oral dosage composition comprising zonnula occludens toxin and a therapeutic agent for intestinal delivery
Fasano et al. Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro.
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