JP4197147B2 - Oral moisturizer supply device and oral moisturizer - Google Patents

Description

  The present invention relates to a supply device capable of supplying an oral moisturizer hygienically and effectively into the oral cavity, and an oral moisturizer used therefor.

  Normally, the mouth is kept wet by saliva, but if saliva decreases for some reason, the mouth becomes dry and the mouth becomes dry. If the dry state persists for a long period of time, various symptoms and functional disorders called so-called xerostomia occur.

  Causes of xerostomia include various diseases that cause organic changes in salivary lines, diseases of salivary lines associated with systemic diseases, destruction of salivary cells by radiation therapy, HIV infection, and secretory function due to moxibustion It is known that this symptom is also caused by a decrease, an influence by taking various drugs, and mental fatigue and anomalies with complicated social life conditions.

  In the elderly, dry mouth is a daily sign, which is thought to be caused by a degenerative change in salivary lines due to the addition of saliva.

  By the way, when xerostomia occurs, not only does it feel dry, but also burning in the mouth, pain, tongue pain, abnormal taste, inflammation of the oral mucosa, ulceration, cracks in the tongue and mouth corners, other chewing, swallowing, Since it will cause a great deal of pain in daily life, such as difficulty in conversation, an appropriate response to these is strongly desired.

  In order to relieve xerostomia, it is only necessary to keep the oral cavity constantly moist. One possible method is to apply an ointment or the like to the finger and then apply the ointment or the like to the oral cavity.

  However, the oral cavity of people with xerostomia usually suffers from inflammation of the oral mucosa, tumor formation, wounds such as cracks in the tongue and mouth corners, etc. Is not hygienic. On the other hand, if the wetting agent can be directly injected into the oral cavity from the container containing the wetting agent, the hygiene problem is surely solved.

  In addition, as another method of imparting wettability to the oral cavity, it is conceivable to supply a beverage into the oral cavity. However, all of the currently disclosed beverages only impart temporary wettability. In essence, it does not lead to alleviation of xerostomia. Therefore, there is a strong demand for a humectant that continuously maintains the wettability in the oral cavity.

  This invention is made | formed in view of said various circumstances, Comprising: It aims at providing the oral moisturizer supply device which can inject a moistening agent directly in the oral cavity, and a durable oral moisturizer.

In order to solve the above-described problems, the present invention communicates with a chemical solution container that stores a chemical solution, a cylinder that stores the chemical solution sucked from the chemical solution container, a movable cylinder that moves up and down in the cylinder, and the movable cylinder. It is configured to have a discharge port, wherein the chemical solution, carboxymethyl cellulose and / or sodium carboxymethylcellulose 1-7% by weight, glycerin 5-20% by weight, of water, an oral wetting agent containing, When the movable cylinder is pushed in response to the pressurizing operation, a predetermined amount of the chemical stored in the cylinder is discharged from the discharge port. After that, when the pressurizing operation is released, the movable cylinder returns to the initial state. Thus, the mouth wetting agent supply device has a configuration in which a new chemical is sucked into the cylinder .

The present invention is preferably mounted on the upper part of the chemical liquid container, and is composed of an ejection part having the ejection port, a cap part covering the ejection part, and the chemical liquid container, and is portable with one hand as a whole. It is formed in size . More preferably, the jet unit comprises: a suction pipe for sucking the drug solution, and the cylinder that is provided continuously to the suction pipe, and said movable cylinder which moves up and down by sliding the inner peripheral surface of said cylinder, said cylinder screwed cap is fitted on the top, and an operation unit that is connected to the movable cylinder, a drug container for containing the mouth wetting agent is constituted by integrally, it is mounted on top of the drug container And a discharge portion.

Moreover, the oral wetting agent according to the present invention is an oral wetting agent accommodated in any of the above-mentioned supply devices. The present invention, carboxymethylcellulose and / or sodium carboxymethyl cellulose, glycerol, as well as an oral wetting agent containing water, carboxymethyl cellulose and / or carboxymethylcellulose sodium 1-7 wt%, glycerin 5 to 20 wt% An oral moisturizer. The wetting agent according to the present invention has carboxymethylcellulose and / or carboxymethylcellulose sodium, glycerin, and water in the composition.

  In the wetting agent, carboxymethyl cellulose and / or sodium carboxymethyl cellulose should be 7% by weight or less. Preferably, it is 1-5 weight% or less, More preferably, it is 1-3 weight%. If the concentration exceeds 7% by weight, the viscosity that can be injected and injected into the oral cavity cannot be maintained, and even if it can be injected into the oral cavity, the wetting agent does not diffuse in the oral cavity and immediately. Cannot get wet feeling. Moreover, it is preferable that the density | concentration of glycerol is 5 to 20 weight%. Water becomes the main solvent of the wetting agent.

  In order to prevent or alleviate bad breath and suppress the activity of acid causing caries, one or more of sodium chloride, potassium chloride, calcium chloride, calcium chloride and potassium dihydrogen phosphate are contained in the wetting agent. Good to do.

  When sodium chloride, potassium chloride, calcium chloride, magnesium chloride or dipotassium phosphate is included, it is possible to dissolve the carboxymethyl cellulose, sodium carboxymethyl cellulose and glycerin in water before preparing the wetting agent. It is simple. At this time, when 100-100 aqueous solution contains sodium chloride 60-100 mg, potassium chloride 100-140 mg, calcium chloride 11-16 mg, magnesium chloride 4-7 mg, dipotassium phosphate 30-40 mg good.

  The wetting agent may contain a preservative such as methyl paraoxybenzoate.

  The humectant can be prepared by preparing a predetermined amount of humectant composition and dissolving with heating and stirring. The heating temperature is desirably 100 ° C. or lower. If the heating temperature is 100 ° C. or higher, water in the preparation composition tends to evaporate and the viscosity of the wetting agent tends to increase. In addition, thickening of the wetting agent begins, and it becomes difficult to make the hue of each wetting agent to be the same hue.

  According to the oral humectant supply device described above, the humectant can be directly injected into the oral cavity, which is not only hygienic, but can supply the oral humectant at any time and anywhere. Dryness can be permanently relieved.

  Hereinafter, the present invention will be specifically described based on examples, but the present invention is not limited thereto.

[Examples 1-2, Comparative Examples 1-2]
Each component shown in Table 1 was heated, stirred and mixed to dissolve transparently, and then cooled to prepare a wetting agent. The blending amount was wt%, and the total composition was 100 wt%. In addition, what was adjusted with the following composition was used for aqueous solutions, such as sodium chloride, in Table 1 in a compounding composition.
(Aqueous solution such as sodium chloride)
Sodium chloride: 84.4 mg, Potassium chloride: 120.0 mg, Calcium chloride: 14.6 mg, Magnesium chloride: 5.2 mg, Dipotassium phosphate: 34.2 mg, Purified water: Remaining amount (amount to be 100 g in total)
The said heating was performed by immersing a preparation container in a warm water bath, and heating to the temperature of 100 degrees C or less.

Ten panelists with dry mouth symptoms evaluated the use of the wetting agents of Examples 1 and 2 and Comparative Examples 1 and 2 based on the following evaluation criteria. In this use evaluation, about 1 g of wetting agent was injected into the oral cavity.
[Injection characteristics]
○: Injection injection was easy.
X: Injection injection was impossible.
[Moisture in the mouth]
○: A wet feeling was obtained directly after the wetting agent was injected into the oral cavity.
-: The wetting agent cannot be injected into the oral cavity and is not subject to evaluation.
[Durability of wetness]
(Double-circle): The wet feeling continued for a long time.
○: Wet feeling persisted for several hours.
X: Immediate loss of wet feeling.
-: The wetting agent cannot be injected into the oral cavity and is not subject to evaluation.
[Diffusion into the oral cavity]
○: After injection, the wetting agent diffused into the oral cavity.
-: The wetting agent cannot be injected into the oral cavity and is not subject to evaluation.

  The above results are shown in Table 1.

  From the results in Table 1, it was confirmed that the use of the wetting agent supply device described below enabled the oral wettability to be continuously imparted to a paneler having a dry mouth symptom. In Table 1, since the wetting agent of Comparative Example 1 was a gum, it could not be injected and injected into the oral cavity.

  Moreover, when the use of the humectant of Examples 1 and 2 was continued, it was also confirmed that oral moist symptoms were alleviated and bad breath was prevented.

  Subsequently, preferred examples of the wetting agent supply device of the present invention will be described in detail. FIG. 1 illustrates the overall configuration of a supply device 1 that can directly supply oral lubricant into the oral cavity. The supply device 1 is composed of a chemical liquid container 2 that contains an oral lubricant, a jet part 3 that is screwed onto the upper part of the chemical liquid container 2, and a cap part 4 that covers the jet part 3, and is carried with one hand as a whole. It is formed in a possible size. The lower end opening 5a of the ejection part 3 is bent at the bottom of the drug solution container 2 so that the medicine can be inhaled to the end.

  FIG. 2 illustrates a cross-sectional structure of the ejection portion 3 in a free state, and shows a state in which the ejection portion 3 protrudes to the maximum. As shown in the figure, the ejection part 3 includes a suction pipe 5 for sucking a medicine, a cylinder 6 connected to the suction pipe 5, a movable cylinder 7 that slides up and down on the inner peripheral surface of the cylinder 6, and an upper part of the cylinder 6. The screwing cap 8 that is externally fitted to the movable cylinder 7 and the operation unit 9 that is coupled to the movable cylinder 7 are integrated. The operation part 9 is formed so as to be operable with an index finger. When the operation part 9 is pushed down, the movable cylinder 7 descends against a spring 10 built in the cylinder 6.

  A first seal body 11 and a packing 12 are mounted on the top of the cylinder 6, and the screw cap 8 is integrated with the transparent cylinder 13. When the screwing cap 8 is screwed into the upper opening of the chemical liquid container 2, the entire ejection portion 3 including the screwing cap 8 is attached to the chemical liquid container 2.

  As shown in FIG. 2, the cylinder 6 is provided with a communication hole 6a at an upper position thereof. The cylinder 6 is disposed at a connection portion with the suction pipe 5 and allows a suction valve 14 that allows only upward liquid flow, a guide member 15 disposed at the center in the radial direction, and concentrically disposed outside the guide member 15. The spring 10 is built in. The tip of the movable cylinder 7 including the second seal body 16 is inserted into the upper portion of the cylinder 6, and the spring 10 is disposed between the second seal body 16 and the lower flange 15 a of the guide member 15. Thus, the movable cylinder 7 is urged upward.

  The guide member 15 is formed with a large-diameter head portion 15b. When the large-diameter head portion 15b engages with the base end surface 16a of the second seal body 16, the movable cylinder 7 is prevented from falling off, A liquid-tight seal between the cylinder 6 and the movable cylinder 7 is realized. Further, on the outer periphery of the guide member 15, a passage groove 15 c is formed in the axial direction in the vicinity of the large-diameter head 15 b, and when the operation unit 9 is pushed down from the state of FIG. The inside of the cylinder 6 communicates. The guide member 15 has a passage opening 15 d at a position close to the suction valve 14.

  The movable cylinder 7 is provided with a discharge valve 17 in the upper part thereof, and allows only upward liquid flow. The movable cylinder 7 is divided into a large diameter part 7A, a medium diameter part 7B, and a small diameter part 7C in detail. In the illustrated free state, the open end 11a of the first seal body 11 is in close contact with the outer periphery of the large-diameter portion 7A, so that entry of dust and dirt can be prevented and the inside of the container can be prevented. Hygiene is ensured. On the other hand, when the operation part 9 is pushed down from the state of FIG. 2, a gap is formed between the open end 11a of the first seal body 11 and the medium diameter part 7B or the small diameter part 7C. In this state, as shown in FIG. 3, since the second seal body 16 that has previously covered the communication hole 6a moves downward, the inside of the container is opened to atmospheric pressure.

  The operation unit 9 includes an operation head 9a including a discharge port (discharge nozzle) 18 and an operation cap 9b that covers the operation head 9a. As shown in the drawing, the discharge port 18 communicates with the movable cylinder 7 and protrudes from the operation cap 9b.

  Then, operation | movement of the supply instrument 1 provided with the above structure is demonstrated, referring FIG.2 and FIG.3. FIG. 3 shows a state where the operation unit 9 is pushed to the limit position.

  For example, when a patient with xerostomia wants to supply a mouth wetting agent to the mouth, the operation unit 9 is pushed down with an index finger or the like. Then, the suction valve 14 is closed while the discharge valve 17 is opened, and the movable cylinder 7 and the cylinder 6 communicate with each other. Therefore, the oral wetting agent that has been stored in the cylinder 6 until then is pushed into the movable cylinder 7. Correspondingly, the oral wetting agent that has been stored in the movable cylinder 7 until then is stored in the guide member 15. It is discharged from the discharge port 18 with assistance of the approach. Then, the released oral moistening agent is supplied to a proper place in the oral cavity.

  Thereafter, when the pressing of the operation unit 9 is released, the state of FIG. 3 is automatically returned to the state of FIG. 2 by the urging force of the spring 10. In this returning operation, the suction valve 14 is opened while the discharge valve 17 is closed, so that the movable cylinder 7 and the cylinder 6 are replenished with a new oral wetting agent. Therefore, when the operation unit is pushed down again, the oral moistening agent is supplied into the oral cavity according to the same operation as described above.

  Although the oral wetting agent supply device has been specifically described above, the specific description is not intended to limit the present invention. That is, if it is a supply device which can supply a chemical | medical agent directly in an oral cavity by one-hand pressing operation, the structure will be changed suitably. For example, although the discharge nozzle 18 is formed short in the illustrated example, the medicine can be reliably supplied to the target site by forming the discharge nozzle 18 longer or by attaching an auxiliary nozzle.

It is drawing which shows the whole structure of the supply instrument which concerns on an Example. It is a fragmentary sectional view which shows the free state of the supply instrument of FIG. It is a fragmentary sectional view which shows the state which pressed the supply instrument of FIG.

Explanation of symbols

2 Drug container 3 Discharge part 5 Suction pipe 6 Cylinder 7 Movable cylinder 8 Cap 9 Operation part

Claims (4)

A chemical container containing chemical liquid, a cylinder that stores chemical liquid sucked from the chemical liquid container, a movable cylinder that moves up and down in the cylinder, and a discharge port that communicates with the movable cylinder.
The medicinal solution is an oral wetting agent containing carboxymethylcellulose and / or carboxymethylcellulose sodium 1 to 7 wt%, glycerin 5 to 20 wt%, and water ,
When the movable cylinder is pushed in response to the pressurizing operation, a predetermined amount of the chemical stored in the cylinder is discharged from the discharge port. After that, when the pressurizing operation is released, the movable cylinder returns to the initial state. Thus, an oral wetting agent supply device having a configuration in which a new chemical is sucked into the cylinder . Claims mounted on an upper part of the chemical liquid container, and composed of an ejection part having the discharge port, a cap part covering the ejection part, and the chemical liquid container, and is formed in a size that can be carried with one hand as a whole. Item 2. The supply device according to Item 1. The ejection part includes a suction pipe for sucking the drug solution, and the cylinder that is provided continuously to the suction pipe, and said movable cylinder which moves up and down by sliding the inner peripheral surface of the cylinder, fitted on top of the cylinder supply instrument and screwing the cap, an operation portion which is connected to the movable cylinder, according to claim 2 which is constructed by integrally being. An oral wetting agent housed in the supply device according to claim 1.

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