JP4160276B2 - Food and drink with uric acid level lowering agent and uric acid level lowering effect - Google Patents

Description

[0001]
[Industrial application fields]
The present invention relates to a uric acid level-lowering agent that can effectively reduce the uric acid level in the body, and foods and drinks having such a pharmacological effect.
[0002]
[Prior art and problems to be solved by the invention]
In the body, purine bodies taken from food are broken down by the liver, producing a certain amount of uric acid every day. This uric acid is dissolved and circulated in body fluids such as blood, and almost the same amount as the production amount is mainly filtered from the kidneys into the urine and excreted. However, if the balance between uric acid production and excretion is lost due to some cause (for example, eating habits, alcohol consumption, stress, decreased kidney function, effects of drugs, genetic factors, etc.), the amount of uric acid in the body increases too much. May cause uricemia. By the way, the uric acid concentration in blood (serum uric acid level) is generally controlled within the range of 3.8 to 7.0 mg / dL for men and 2.4 to 5.8 mg / dL for women. If the value exceeds 7.0 mg / dL, the possibility of developing hyperuricemia is considered high.
[0003]
Hyperuricemia itself has no symptoms, but leaving it alone can cause various diseases including gout. That is, when the concentration of uric acid in the blood rises and exceeds the saturation concentration, uric acid that has become insoluble forms a salt with sodium to form crystals. If the concentration of uric acid continues to be high, these urate crystals will be deposited in various parts of the body.For example, if urate is deposited in the joints to cause gout, or crystallizes in the kidney, the urinary tract It can cause stones and kidney damage. Hyperuricemia is also said to cause ischemic heart diseases such as myocardial infarction.
[0004]
Currently, drugs that lower uric acid levels include drugs that promote excretion of uric acid, such as benzbromarone, and drugs that inhibit uric acid synthesis, such as allopurinol, and are prescribed according to the type of hyperuricemia in patients. Yes. These drugs currently prescribed are extremely excellent as a control agent for uric acid level, and the serum uric acid level can be returned to normal by taking the drug. However, since hyperuricemia itself is a very difficult disease to cure, if you stop taking the medicine, it will return to the state of hyperuricemia again. For this reason, in order to fundamentally treat hyperuricemia, it is necessary to continue taking the medicine patiently for a long time.
In view of the above, a therapeutic agent for hyperuricemia has been desired that can be taken safely and comfortably for a long period of time, for example, a product derived from a natural product that has been ingested daily since ancient times.
[0005]
However, very few have been disclosed as therapeutic agents for hyperuricemia derived from natural products or agents for lowering uric acid levels. For example, JP-A-6-31868 discloses that an edible liquid mainly composed of birch sap has an effect on gout and the like, and JP-A-6-247868 discloses a uric acid level reducing agent containing chlorella as an active ingredient. Was disclosed.
[0006]
Therefore, the present invention does not provide a uric acid level-lowering agent comprising a natural product-derived ingredient that has been ingested on a daily basis for a long time and can be safely consumed by anyone, and a food or drink with a uric acid level-lowering effect. It is what.
[0007]
[Means for Solving the Problems]
This invention provides the food and drink provided with the uric acid value lowering agent which contains the tea polyphenol derived from the tea which is ingested routinely for a long time as an active ingredient, and the uric acid value lowering effect.
[0008]
By ingesting the uric acid level-lowering agent and food and drink of the present invention, the uric acid level in the state of hyperuricemia can be effectively reduced and returned to normal. Moreover, since it is an ingredient that is derived from tea that has been enjoyed and enjoyed everyday by anyone and can be safely consumed by anyone, it can be taken with confidence for a long period of time and radically treats hyperuricemia Therefore, it is extremely useful as a therapeutic agent. In addition, since it can be taken daily without difficulty, it is extremely useful as a preventive agent for hyperuricemia. Furthermore, it is also useful as a therapeutic or preventive agent for various diseases caused by gout and hyperuricemia, and foods and drinks having these pharmacological effects.
[0009]
DETAILED DESCRIPTION OF THE INVENTION
As described above, the uric acid level-lowering agent of the present invention is a uric acid level-lowering agent containing polyphenol obtained by extracting tea, that is, tea polyphenol as an active ingredient, and a food and drink having a uric acid level-lowering effect.
[0010]
Here, the tea polyphenol in the present invention is the following tea catechins having the basic structure of flavan-3-ol, namely (-)-epicatechin, (-)-epigallocatechin, (-)- Epicatechin gallate, (-)-epigallocatechin gallate, (±) -catechin, (-)-gallocatechin, (-)-catechin gallate, (-)-gallocatechin gallate, or free theaflavin, theaflavin monogallate A , Theaflavin monogallate B, theaflavin digallate, any polymer thereof, and any one or a mixture of two or more selected from the group consisting of two or more of these copolymers, especially tea catechins, Of these, those containing 50% or more of (−)-epicatechin gallate and (−)-epigallocatechin gallate are particularly preferred as the active ingredient of the present invention.
In addition, when the mixture containing said tea catechins is retort-sterilized, it is known that the polymer and copolymer of these tea catechins will arise.
[0011]
These tea polyphenols can be extracted from tea obtained from leaves, stems, xylem, roots and fruits obtained from Camellia sinensis belonging to the camellia family, or a mixture of two or more of these. As the tea, either fresh tea leaves, fermented teas such as black tea and puer tea, semi-fermented teas such as oolong tea and bun tea, green tea, kettle roasted green tea, non-fermented tea such as hoji tea, or these 2 It may be a mixture of more than one kind, and a mixture obtained by extracting from each tea (single) or a mixture extracted from each tea can be used. As an extraction method, extraction and purification may be performed by any currently known method, and a commercially available tea polyphenol can also be used.
[0012]
Of course, the active ingredient of the present invention can be composed only of tea polyphenol, but a tea extract containing tea polyphenol at a high concentration can also be used as the active ingredient of the present invention. In addition, an ingredient already known to have a uric acid value lowering effect can be added to make it an active ingredient.
As the tea extract containing the above-mentioned tea polyphenol at a high concentration, for example, the above tea is extracted with water, hot water or hot water, preferably 90 to 100 ° C. in hot water of 40 ° C. to 100 ° C. In order to increase the tea catechin content by purification means such as resin adsorption, ultrafiltration / reverse osmosis filtration, or partition extraction using ethyl acetate, etc. The tea extract obtained by refining can be used, or the tea extract obtained by concentrating or drying these tea extracts. In this case, the concentration of tea polyphenol is 25 to 97%, preferably 30 to 90%. As a specific example of this tea extract, green tea is subjected to hot water extraction treatment, and the extract is dried to make tea catechin. Green tea extract (trade name: Teaflan 30A, manufactured by ITO EN) with a concentration of about 30% or green tea is extracted with hot water, and this extract is processed by the column method and dried to exclude components other than tea catechins. An example is a green tea extract (trade name: Tea Franc 90S manufactured by ITO EN) with a tea polyphenol concentration of about 85 to 95%.
[0013]
The uric acid level-lowering agent of the present invention can be used for various uses such as pharmaceuticals, quasi drugs, health foods and health drinks, food additives, feeds, feed additives, etc. It can be dried by freeze-drying or spray-drying, etc., and can be provided as a dry powder, or it can be prepared as a liquid, tablet, powder, granule, dragee, capsule, suspension, emulsion, ampoule, injection, or any other form Can also be provided.
When provided as a pharmaceutical product, for example, the active ingredient can be prepared by dissolving it in purified water or physiological saline as it is.
As a quasi-drug, it can be prepared by adding components that are usually blended into a quasi-drug, and this can be provided as a drinking form such as a bottled drink or a form such as a tablet, capsule or granule.
Examples of the food and drink include the active ingredients of the present invention, food ingredients (including fruits and jelly), milk ingredients, carbonic acid, excipients (including granulating agents), diluents, or further sweeteners, flavors, Sports drinks and fruit drinks by adding one or more selected from various proteins such as wheat flour, starch, sugar, fats and oils, carbohydrate raw materials, vitamins, minerals, other physiologically active ingredients, hormones, nutritional ingredients, etc. , Tea beverages, vegetable juices, milk beverages, alcoholic beverages, jelly beverages, carbonated beverages and other beverages, jelly, chewing gum, chocolate, ice cream, candy, biscuits and other sweets, snacks, bread, cakes and other starches Processed foods, fish paste products, livestock meat products, protein-based processed foods such as tofu and cheese, miso, soy sauce, dressings and other seasonings Other supplements, feed, can be provided as a variety of forms, such as pet food.
[0014]
The content of the active ingredient in the present invention varies depending on the use, but in the case of a pharmaceutical, it is preferably 0.001 to 1% by weight, particularly 0.01 to 0.5% by weight in terms of catechin dry weight. If it is a food or drink, it is preferably added in an amount of 0.001 to 1% by weight, particularly 0.01 to 0.5% by weight in terms of dry weight of catechin.
The amount of intake is 10 to 5000 mg per day in terms of dry weight of catechin, preferably about 100 to 1500 mg.
[0015]
(test)
A test beverage containing 230 mg of theafuran 90S (trade name, manufactured by ITO EN) per 190 mL of can, and adding a small amount of cyclodextrin, vitamin C and flavor to improve the taste was prepared. Theafuran 90S had a tea polyphenol content of 92% and a tea catechin content of 63% (of which EGCg was 50% and ECg was 13%). Moreover, since the test beverage is sterilized by retort, it is a mixed beverage containing a polymer or isomer of tea catechins.
[0016]
Seven males 20 years or older (hyperuricemia group) with serum uric acid level concentrations exceeding 7.0 mg / dL, which is the upper limit of serum uric acid levels, and serum uric acid levels are less than 6.5 mg / dL Nine males aged 20 years or older (normal uric acid level group) were subjects, and each subject took the test sample with meals three times a day for 8 weeks. Serum uric acid levels were measured at each time point after 4 weeks, 6 weeks and 8 weeks. FIG. 1 is a graph showing the average serum uric acid level (mg / dL) in the hyperuricemia group over time, and FIG. 2 shows the average serum uric acid level (mg / dL) in the normal uric acid level group over time. It is the graph shown in.
[0017]
As a result, the blood uric acid level significantly decreased in the hyperuricemia group in which the blood uric acid level exceeded 7.0 mg / dL. On the other hand, no significant change was observed in the normal uric acid level group with a blood uric acid level of less than 6.5 mg / dL. In any group, no side effects were observed in the subjects during the intake period, and there was no resistance during intake.
From this, it became clear that this test drink can be ingested safely and without difficulty, and can effectively lower the uric acid level particularly for those who have high serum uric acid levels.
[0018]
(Example 1)
The tablet as a uric acid level lowering agent was created with the following prescription.
[0019]
Tea extract (teafuran 90S or teafuran 30A) ... 120mg
Vitamin C ... 50mg
Emulsified oligosaccharide ... 90mg
Granulating agent 60mg
Crystalline cellulose ... 80mg
Reduced maltose starch syrup ... 90mg
Sucrose ... 100mg
Perfume ... appropriate amount [0020]
(Example 2)
A beverage as a food and drink having the effect of lowering the uric acid value with the following formulation was prepared.
[0021]
Tea extract (teafuran 90S or teafuran 30A) ... 150mg
Vitamin C ... 50mg
Fructose grape sugar: 10g
Water-soluble dietary fiber: 500mg
Fragrance ... Appropriate amount of ion-exchanged water ... Adjust to 100 mL [Brief description of the drawings]
FIG. 1 is a graph showing the mean serum uric acid level (mg / dL) of 7 patients with hyperuricemia over time.
FIG. 2 is a graph showing the mean serum uric acid level (mg / dL) of 9 normal uric acid level groups over time.

Claims (3)

Reduces uric acid levels for those with high plasma uric acid levels and decreases uric acid levels with tea catechins as active ingredients for those with normal plasma uric acid levels. Agent. The tea catechins include the following tea catechins having the basic structure of flavan-3-ol: (−)-epicatechin, (−)-epigallocatechin, (−)-epicatechin gallate, (−)-epi Gallocatechin gallate, (±) -catechin, (-)-gallocatechin, (-)-catechin gallate, (-)-gallocatechin gallate, any of these polymers, and two or more types of these copolymers The uric acid level-lowering agent according to claim 1, which is any one selected from the group consisting of or a mixture of two or more. The uric acid according to claim 1 or 2, comprising 0.001 to 1% by weight of a tea extract containing both EGCg and ECg as the tea catechins, which are 50% or more of the total catechin amount. Value reducing agent.

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