JP4116054B2 - シャペロン融合タンパク質としての風疹ｅ１エンベロープタンパク質変異体の組換え発現、可溶性で天然様かつ免疫反応性の抗原コンホメーションへのそのリフォールディングならびに抗風疹抗体の検出におけるその用途 - Google Patents

シャペロン融合タンパク質としての風疹ｅ１エンベロープタンパク質変異体の組換え発現、可溶性で天然様かつ免疫反応性の抗原コンホメーションへのそのリフォールディングならびに抗風疹抗体の検出におけるその用途 Download PDF

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JP4116054B2
JP4116054B2 JP2006290414A JP2006290414A JP4116054B2 JP 4116054 B2 JP4116054 B2 JP 4116054B2 JP 2006290414 A JP2006290414 A JP 2006290414A JP 2006290414 A JP2006290414 A JP 2006290414A JP 4116054 B2 JP4116054 B2 JP 4116054B2
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rubella
antigen
soluble
protein
region
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Japanese (ja)
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JP2007117090A5 (https=
JP2007117090A (ja
Inventor
ボルハゲン ラルフ
エンゲル アルフレッド
ファッツ エルケ
シャーツミッド ペーター
ショルツ クリスティアン
アプマイアー バルバラ
ツァルント トラルフ
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36211—Rubivirus, e.g. rubella virus
    • C12N2770/36222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2006290414A 2005-10-26 2006-10-25 シャペロン融合タンパク質としての風疹ｅ１エンベロープタンパク質変異体の組換え発現、可溶性で天然様かつ免疫反応性の抗原コンホメーションへのそのリフォールディングならびに抗風疹抗体の検出におけるその用途 Active JP4116054B2 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05109993 2005-10-26

Publications (3)

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JP2007117090A JP2007117090A (ja) 2007-05-17
JP2007117090A5 JP2007117090A5 (https=) 2008-04-24
JP4116054B2 true JP4116054B2 (ja) 2008-07-09

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ID=37965193

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JP2006290414A Active JP4116054B2 (ja) 2005-10-26 2006-10-25 シャペロン融合タンパク質としての風疹ｅ１エンベロープタンパク質変異体の組換え発現、可溶性で天然様かつ免疫反応性の抗原コンホメーションへのそのリフォールディングならびに抗風疹抗体の検出におけるその用途

Country Status (6)

Country Link
US (1) US7604935B2 (https=)
JP (1) JP4116054B2 (https=)
AT (1) ATE491030T1 (https=)
CA (1) CA2562738C (https=)
DE (1) DE602006018694D1 (https=)
ES (1) ES2356383T3 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007077008A1 (en) * 2006-01-03 2007-07-12 Roche Diagnostics Gmbh Chimaeric fusion protein with superior chaperone and folding activities
RU2010107199A (ru) * 2007-07-31 2011-09-10 Дзе Джонс Хопкинс Юниверсити (Us) Конъюгат полипептид-нуклеиновая кислота для иммунопрофилактики или иммунотерапии для неопластических или инфекционных нарушений
ES2450998T3 (es) * 2007-12-13 2014-03-26 F. Hoffmann-La Roche Ag Nuevas variantes de proteína de cubierta E1 de rubéola y su utilización en la detección de anticuerpos anti-rubéola
AR086250A1 (es) * 2011-05-05 2013-11-27 Hoffmann La Roche Polipeptido de fusion presentador de una secuencia de aminoacidos y utilizacion del mismo

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2095818B (en) 1981-03-27 1985-10-02 Exxon Research Engineering Co Staged adsorption/resorption heat pump
GB2206587A (en) 1987-07-08 1989-01-11 London Biotechnology Ltd Rubella e1 glycoprotein antigens
JP2001501093A (ja) 1996-09-26 2001-01-30 メディカル リサーチ カウンシル シャペロン断片
DE19649390A1 (de) 1996-11-29 1998-06-04 Boehringer Mannheim Gmbh Antigenspezifischer IgG-Nachweis
MXPA03011455A (es) 2001-06-22 2004-04-05 Hoffmann La Roche Complejo soluble que comprende glucoproteina de superficie retroviral.

Also Published As

Publication number Publication date
CA2562738A1 (en) 2007-04-26
US20070154883A1 (en) 2007-07-05
DE602006018694D1 (de) 2011-01-20
US7604935B2 (en) 2009-10-20
JP2007117090A (ja) 2007-05-17
ES2356383T3 (es) 2011-04-07
ATE491030T1 (de) 2010-12-15
CA2562738C (en) 2011-07-12

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