JP4110618B2 - Antibacterial and smokeproofing agent - Google Patents

Description

で示される２−メトキシカルボニル−４−クロロトリフルオロメタンスルホンアニリドを燻煙剤の有効成分として使用することにより、汚染空間全域に亘り、カビ、細菌等の微生物を防除できると共に、哺乳動物に対する安全性の点でも優れることを見出し本発明に至った。
【０００４】
【課題を解決するための手段】
すなわち、本発明は一般式化２で示される２−メトキシカルボニル−４−クロロトリフルオロメタンスルホンアニリド（以下、本化合物と記す。）を有効成分として含有することを特徴とする防菌防黴燻煙剤を提供するものである。
【０００５】
【発明の実施の形態】
本発明の防菌防黴燻煙剤は、本化合物と有機発泡剤とを混合することにより調製され、本化合物の有効揮散率の向上を図るうえで、両者を均一に混合し、粒径１〜４ｍｍ、好ましくは粒径１．５〜３ｍｍ程度の大きさの顆粒状に成形される。
【０００６】
本発明において用いられる有機発泡剤としては、熱分解してガスを発生し得るものであれば特に限定されないが、通常、３００℃以下の発泡温度を有し、熱分解して窒素を発生し得る化合物であるアゾジカルボンアミド、ｐ−トルエンスルホニルヒドラジド、ベンゼンスルホニルヒドラジド、p,p'−オキシビス（ベンゼンスルホニルヒドラジド）、アゾビスイソブチロニトリル、2,2'−アゾビスイソブチロアミド、２−（カルバモイルアゾ）イソブチロニトリル、メチル−2,2'−アゾビスイソブチレート、2,4−ビス（アゾスルホニルトルエン）、1,1'−アゾビスシクロヘキサンカルボニトリル、ジニトロソペンタメチレンテトラミン等が用いられる。これらの有機発泡剤は、通常50〜200メッシュ程度の粉状物が用いられる。
【０００７】
また本化合物は、特開平８−３１９２０２号公報においてツメダニ類防除剤の活性成分として知られており、該公報の記載に従って製造することができる。
【０００８】
本発明の防菌防黴燻煙剤は、前述の屋内空間を汚染するカビ、細菌等の防除に卓効を発揮し、またカーペットや毛皮等への効果的な防除処理にも応用できる。
【０００９】
本発明の防菌防黴燻煙剤の施用量は本化合物量として、適用空間１ｍ³当たり通常１〜１０００ｍｇ、または、処理すべき面積１ｍ²当たり通常１０〜１０００ｍｇであるが、製剤形態、施用時期、施用場所、被害程度等により変わり得る。
【００１０】
本発明の防菌防黴燻煙剤は、さらに、必要により、他の殺虫剤、殺ダニ剤、抗菌剤等やピペロニルブトキシド、サイネピリン２２２、サイネピリン５００、オクタクロロジプロピルエーテル等の共力剤や香料、消臭剤などを含有してもよい。
【００１１】
また、酸化亜鉛、炭酸亜鉛、尿素、クロムイエロー、カーボンブラック、ステアリン酸亜鉛、ステアリン酸カルシウム等の発泡温度調節剤、澱粉、天然高分子、合成高分子等の結合剤などを含有してもよい。該天然高分子の具体例としては、トラガントガム、アラビアガム、グアーガム、ガンビル抽出粉末、カゼイン等及びこれらの混合物が、該合成高分子の具体例としては、ポリビニルアルコール、ポリアクリルアミド、ポリアクリル酸ナトリウム、ポリエチレンオキシド、ポリビニルピロリドン、メチルセルロース、エチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、カルボキシメチルセルロース塩、カルボキシメチル澱粉塩、ジアルデヒド澱粉、カチオン澱粉等及びこれらの混合物が挙げられる。
【００１２】
本発明の防菌防黴燻煙剤は、通常、金属等の熱伝導性の良好な容器内に入れ、該容器を周囲から加熱して有機発泡剤を分解、発泡させることにより、有効成分としての本化合物が気中に蒸散される。
【００１３】
より具体的には、図１に示されるような装置、即ち、本発明の防菌防黴燻煙剤１を入れた容器２の周囲に、該容器内の壁面４を隔てて、酸化カルシウム３を配した容器４を用意し、該酸化カルシウム相に注水口５から適量の水を加えることにより生じる化学反応熱を利用して本化合物を気中に蒸散させて防菌防黴処理を行うのが好都合である。
【００１４】
本発明の防菌防黴燻煙剤は、例えばAspergillus niger等のAspergillus属、Chaetomium globosum等のChaetomium属、Cladosporium cladosporioides等のCladosporium属、Gliocladium virens等のGliocladium属、Aureobasidium pullulans等のAureobasidium属、Penicillium funiculosum等のPenicillium属、Rhizopus oryzae等のRhizopus属、Fusarium属、Alternaria属、Tyromyces属、Coriolus属、Myrothecium属、Mucor属、Epicoccum属、Trychoderma属、Phoma属、Geotrichum属、Monilia属などの糸状菌、Saccharomyces属、Candida属などの酵母、MRSAを含むStaphylococcus属、Batillus属、Escherichia属、Pseudomonas属、Klebsiella属、Enterococcus属、Micrococcus属、Enterobacter属、Flavobacterium属、Desulphovibrio属、Achromobacter属、Cellulomonas属、Paracolabactrum属、Sphaerotilus属、Sporocytophaga属、Gallionella属、Leptothrix属、Beggiatoa属、Aerobacter属などの細菌に対して防除効力を有し、殊に近年問題となっている黄色ブドウ球菌（Staphylococcus aureus）の防除に好適である。
【００１５】
【実施例】
次に、試験例で本発明をより詳細に説明するが、本発明はこれらに限定されるものではない。
試験例１
酸化亜鉛0.5重量部、α−澱粉2.0重量部及びアゾジカルボンアミドを加えて全体を100重量部とし、水を加えて混練、押出機で粒径３〜４ｍｍ、１ｃｍの長さに成形、乾燥したものに、本化合物10.0重量部をアセトンに希釈した溶液を含浸させ、乾燥して本発明の防菌防黴燻煙剤を得た。
【００１６】
上記で得られた本発明の防菌防黴燻煙剤1.1ｇを図１に示される容器２に入れ、該容器内を1〜20メッシュの酸化カルシウム100gを入れた容器４の中央部に埋め込むように配し、燻煙装置を用意した。
一方、ガラスチャンバー（0.343m³）内の天井、壁面、床面に9cm径シャーレ寒天培地を設置し、チャンバー床中央に該燻煙装置を置いた。なお、上記培地としてはカビ類の試験にはポテトデキストロースアガー培地（ニッスイ）を、また細菌類の試験にはニュートリエントアガー（Ｄｉｆｃｏ）を用いた。次いで、該燻煙装置内の酸化カルシウムに水を加え発熱させた。６時間放置後、各シャーレ培地を取り出し、後述の菌液を滴下した後、カビ類は28℃で１週間、細菌類は34℃で２日間培養し、抗菌効果の評価を行った。
【００１７】
尚、比較燻煙剤として、本化合物を添加しない以外は、上記と同様にして得た燻煙剤を用い、同様の評価を行った。
用いたカビ類はAspergillus niger、細菌類はStaphylococcus aureus（黄色ブドウ球菌）であった。結果を表１に示す。
評価基準は次の通り。
「○」：全く菌の生育を認めない。
「△」：若干の菌の生育を認める。
「×」：明確な菌生育を認める。
【００１８】
【表１】

【００１９】
【発明の効果】
本発明の防菌防黴燻煙剤により、屋内空間等における微生物汚染を効果的に、また、安全且つ簡便に防除し得る。
【００２０】
【図面の簡単な説明】
【図１】図１は、本発明の防菌防黴燻煙剤の使用形態の一例を示す燻煙装置図である。
【符号の説明】
１・・防菌防黴燻煙剤
２・・防菌防黴燻煙剤を収容するための容器
３・・酸化カルシウム
４・・酸化カルシウムの収容容器
５・・注水口[0001]
BACKGROUND OF THE INVENTION
The present invention relates to an antibacterial and antifungal agent.
[0002]
[Prior art]
In recent years, the airtightness of houses has been promoted, and as a result, microorganisms such as mold and bacteria contaminated the interior of houses, hospitals, warehouses, and other indoor spaces, resulting in damage to the exterior of buildings and infectious diseases. It is an important hygiene issue. In particular, infections caused by MRSA (methicillin-resistant Staphylococcus aureus) are a problem in hospitals.
Conventionally, sprays and aerosols using an alcohol such as ethanol and an aqueous solution such as sodium hypochlorite have been used as a countermeasure for these problems. However, the control treatment with these spray type chemicals is not enough because it is difficult to treat uniformly in the contaminated space, and it is inevitable that it adheres to the user due to scattering during treatment, and it is safe for the human body. There is also a problem in terms of sex.
[0003]
[Problems to be solved by the invention]
Under such circumstances, we have the formula:

By using 2-methoxycarbonyl-4-chlorotrifluoromethanesulfonanilide represented by the above as an active ingredient of a smoke agent, microorganisms such as mold and bacteria can be controlled over the entire contaminated space, and safety to mammals In view of the above, the present invention was found to be excellent.
[0004]
[Means for Solving the Problems]
That is, the present invention contains 2-methoxycarbonyl-4-chlorotrifluoromethanesulfonanilide (hereinafter referred to as the present compound) represented by the general formula 2 as an active ingredient, and is used for antibacterial and smokeproofing. An agent is provided.
[0005]
DETAILED DESCRIPTION OF THE INVENTION
The antibacterial and smoke-proofing agent of the present invention is prepared by mixing the present compound and an organic foaming agent, and in order to improve the effective volatilization rate of the present compound, both are uniformly mixed to obtain a particle size of 1 It is formed into a granule having a size of about 4 mm, preferably about 1.5 to 3 mm.
[0006]
The organic foaming agent used in the present invention is not particularly limited as long as it can be thermally decomposed to generate gas, but usually has a foaming temperature of 300 ° C. or lower and can be thermally decomposed to generate nitrogen. Compounds such as azodicarbonamide, p-toluenesulfonyl hydrazide, benzenesulfonyl hydrazide, p, p'-oxybis (benzenesulfonyl hydrazide), azobisisobutyronitrile, 2,2'-azobisisobutyramide, 2- (Carbamoylazo) isobutyronitrile, methyl-2,2′-azobisisobutyrate, 2,4-bis (azosulfonyltoluene), 1,1′-azobiscyclohexanecarbonitrile, dinitrosopentamethylenetetramine, etc. Is used. As these organic foaming agents, powders of about 50 to 200 mesh are usually used.
[0007]
Moreover, this compound is known as an active ingredient of the tick mite control agent in JP-A-8-319202, and can be produced according to the description of the publication.
[0008]
The antibacterial and smoke-proofing agent of the present invention exhibits an excellent effect in controlling mold and bacteria that contaminate the indoor space described above, and can also be applied to an effective control treatment for carpets and furs.
[0009]
The application amount of the antibacterial and smoke-proofing agent of the present invention is usually 1 to 1000 mg per 1 m ^{3 of} application space or 10 to 1000 mg per 1 m ^{2 of} area to be treated as the amount of this compound. It may vary depending on the time, application location, damage level, etc.
[0010]
The antibacterial and smoke-proofing agent of the present invention may further include other insecticides, acaricides, antibacterial agents, etc., and synergists and perfumes such as piperonyl butoxide, sinepirin 222, sinepirin 500, and octachlorodipropyl ether. Further, it may contain a deodorant and the like.
[0011]
Moreover, you may contain binders, such as foaming temperature regulators, such as a zinc oxide, zinc carbonate, urea, chromium yellow, carbon black, zinc stearate, calcium stearate, starch, a natural polymer, a synthetic polymer. Specific examples of the natural polymer include tragacanth gum, gum arabic, guar gum, gambil extract powder, casein and the like, and specific examples of the synthetic polymer include polyvinyl alcohol, polyacrylamide, sodium polyacrylate, Examples include polyethylene oxide, polyvinyl pyrrolidone, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose salt, carboxymethyl starch salt, dialdehyde starch, cationic starch and the like, and mixtures thereof.
[0012]
The antibacterial and smoke-proofing agent of the present invention is usually placed in a container having good thermal conductivity such as metal, and the container is heated from the surroundings to decompose and foam the organic foaming agent, thereby making it an active ingredient. Of this compound is evaporated in the air.
[0013]
More specifically, an apparatus as shown in FIG. 1, that is, a calcium oxide 3 around a container 2 in which the antibacterial and smokeproof agent 1 of the present invention is placed, with a wall surface 4 in the container being separated. Is prepared, and the compound is evaporated in the air using the heat of chemical reaction generated by adding an appropriate amount of water from the water injection port 5 to the calcium oxide phase to carry out antibacterial and antifungal treatment. Is convenient.
[0014]
The antibacterial and smoke-proofing agent of the present invention includes, for example, Aspergillus genus such as Aspergillus niger, Chaetomium genus such as Chaetomium globosum, Cladosporium genus such as Cladosporium cladosporioides, Gliocladium genus such as Gliocladium virens, Aenicilsidiumic genus such as Aureobasidiumicum such as Aureobasidium pullulans, Penicillium genus, Rhizopus genus Rhizopus oryzae, etc. Genus, yeast such as Candida, Staphylococcus sp Has a controlling effect against bacteria such as Sphaerotilus, Sporocytophaga, Gallionella, Leptothrix, Beggiatoa, Aerobacter, etc. It is suitable for controlling Staphylococcus aureus.
[0015]
【Example】
Next, the present invention will be described in more detail with test examples, but the present invention is not limited thereto.
Test example 1
Zinc oxide 0.5 parts by weight, α-starch 2.0 parts by weight and azodicarbonamide were added to make 100 parts by weight, water was added to knead, molded into a particle size of 3-4 mm and 1 cm in length by an extruder, and dried. The product was impregnated with a solution obtained by diluting 10.0 parts by weight of the present compound in acetone, and dried to obtain the antibacterial and smokeproof agent of the present invention.
[0016]
1. 1.1 g of the antibacterial and smoke-proofing agent of the present invention obtained above is put in the container 2 shown in FIG. 1, and the inside of the container is embedded in the center of the container 4 containing 1 to 20 mesh calcium oxide 100 g. A smoke device was prepared.
On the other hand, a 9 cm diameter petri dish agar medium was installed on the ceiling, wall surface, and floor surface of the glass chamber (0.343 m ³ ), and the smoke device was placed in the center of the chamber floor. As the above-mentioned medium, potato dextrose agar medium (Nissui) was used for the mold test, and nutritent agar (Difco) was used for the bacteria test. Next, water was added to the calcium oxide in the smoke device to generate heat. After leaving for 6 hours, each petri dish medium was taken out and a bacterial solution described later was dropped. Then, the molds were cultured at 28 ° C. for 1 week and the bacteria were cultured at 34 ° C. for 2 days to evaluate the antibacterial effect.
[0017]
In addition, the same evaluation was performed using the smoke agent obtained like the above except not adding this compound as a comparative smoke agent.
The fungi used were Aspergillus niger and the bacteria were Staphylococcus aureus (Staphylococcus aureus). The results are shown in Table 1.
The evaluation criteria are as follows.
“O”: No growth of bacteria was observed.
“Δ”: Some growth of bacteria was observed.
“×”: A clear growth of bacteria is observed.
[0018]
[Table 1]

[0019]
【The invention's effect】
The antibacterial and smoke-proofing agent of the present invention can effectively and safely control microbial contamination in indoor spaces and the like.
[0020]
[Brief description of the drawings]
BRIEF DESCRIPTION OF DRAWINGS FIG. 1 is a smoke device diagram showing an example of how to use the antibacterial and smoke control agent of the present invention.
[Explanation of symbols]
1 .. Antibacterial and smoke-proofing agent. 2. Container 3 for containing anti-bacterial and anti-smoke agent. .. Calcium oxide 4..

Claims (1)

formula

An antibacterial and antifungal agent comprising 2-methoxycarbonyl-4-chlorotrifluoromethanesulfonanilide represented by the formula:

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