JP4058215B2 - Sugar-coated seamless capsules containing water-soluble substances - Google Patents
Sugar-coated seamless capsules containing water-soluble substances Download PDFInfo
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- JP4058215B2 JP4058215B2 JP2000053615A JP2000053615A JP4058215B2 JP 4058215 B2 JP4058215 B2 JP 4058215B2 JP 2000053615 A JP2000053615 A JP 2000053615A JP 2000053615 A JP2000053615 A JP 2000053615A JP 4058215 B2 JP4058215 B2 JP 4058215B2
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- Prior art keywords
- sugar
- water
- capsule
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- soluble substance
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- Medicinal Preparation (AREA)
Description
【０００１】
【産業上の利用分野】
本発明は経時安定性と呈味性及び食感に優れた水溶性物質を内容物とする糖衣シームレスカプセルに関するものである。
【０００２】
【従来の技術】
ゼラチンなどを皮膜とするカプセルを糖衣層で被覆したものは、特開昭５９−７１６７３号公報などに開示されている。通常、これらの糖衣カプセルは、カプセル内容物が油溶性物質に限定されている。なぜならば、ゼラチン皮膜のカプセルは、水溶性物質を内容物とすると、カプセル皮膜が溶解して、カプセルとしての形態を保持できないからである。
【０００３】
医薬品においては水溶性薬剤成分を水溶液状態で投与することでの即効性と糖衣剤の形での優れた携帯性及び服用性を兼ね備えた製剤が望まれており、また食品においても口中で素早く呈味成分が広がる水溶液状成分と食べ易さと食感に優れた糖衣剤とを組み合わせた製剤が望まれていた。
【０００４】
【発明が解決しようとする課題】
本発明は、経時安定性に優れた水溶性物質を内容物として包含する糖衣シームレスカプセルを提供することを目的とする。
【０００５】
【課題を解決するための手段】
本発明は、（１）水溶性物質を内容物とするシームレスカプセル、および（２）該シームレスカプセル上に形成された糖衣層を含有する、粒径１．０ｍｍ以上の水溶性物質を内容物とする糖衣シームレスカプセルを提供する。
【０００６】
本発明に用いられるシームレスカプセルの内容物は水溶性物質を含むが、水溶性物質単独ではカプセルの形態を保持するのが難しいので、アルコール基剤との混合物の形で内容物とする。アルコール基剤は、グリセリンまたはソルビトール液等の糖アルコール液及びこれらの混合物があげられ、基剤中の水溶性物質の含有水分は５０％以下、好ましくは３０％以下である。該アルコール基剤に医薬品や食品の水溶性物質を適宜溶解することで所望のシームレスカプセルの内容物を得ることができる。
【０００７】
医薬品の水溶性主薬としては葛根湯エキス、小柴胡湯エキス等の薬用エキス類、苦味チンキ，モッコウチンキ等のチンキ類、アセトアミノフェン、塩酸メキシレチン、アカルボース、クロモグリク酸ナトリウム、プラバスタチンナトリウム等の水溶性医薬品成分が例示できるが、水溶性であれば特にこれらに限定されるものではなく、所望により矯味剤（例えば、甘味剤、酸味剤、苦味抑制剤等）、ｐＨ調整剤、増粘剤、防腐剤、色素等を添加してもよい。
【０００８】
食品の水溶性主剤としては梅肉エキス、羅漢果エキス、ザクロエキス、ブルーベリーエキス、シジミエキス等の動植物エキス類および酵母エキス等の微生物エキス類、微生物産生物質、レモン果汁、リンゴ果汁、グレープ果汁、ピーチ果汁等の果汁類、ムコ多糖等の機能性多糖類、クロレラ、ペプチド、ポリフェノール等が例示できるが水溶性であれば特にこれらに限定されるものではなく、更に所望により甘味剤、酸味剤、香料、ｐＨ調整剤、増粘剤、防腐剤、色素等を添加してもよい。
【０００９】
水溶性内容物とカプセル皮膜の間には疎水性保護層を介在させる必要がある。疎水性保護層として用いられる物質は、一般的に硬化油脂であり、植物性硬化油脂または動物性硬化油脂およびこれらの水添物であって良い。好ましくはパーム硬化油脂もしくはパーム核硬化油脂であり、融点が３５℃〜５５℃、好ましくは４０℃〜５０℃のものが最適である。疎水性保護層には、更に必要に応じて柔軟剤として天然物のレシチンまたは化学合成品のグリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、プロピレングリコール脂肪酸エステル、ショ糖脂肪酸エステル、もしくはこれらの混合物の乳化剤を硬化油脂重量に対して０．１〜１０重量％、好ましくは０．５〜５重量％を適宜添加してもよい。
【００１０】
シームレスカプセルの皮膜物質としてはゼラチン、寒天、ペクチンまたはこれらの混合物が挙げられ、所望により可塑剤（例えば、ソルビト−ル、グリセリン等の水溶性多価アルコ−ル等）、甘味剤、酸味剤、香料、防腐剤、色素等を添加してもよい。
【００１１】
糖衣層を形成する糖衣剤としては砂糖とシロップを主成分とする公知の処方であり、所望により酸味剤、香料、色素等を添加してもよい。また、シュガーレスで低カロリー処方とする場合は還元麦芽糖水飴、ソルビトール、エリスリトール等の糖アルコールや還元パラチノースおよびこれらの混合物を基剤とし、所望により酸味剤、香料、色素等を添加してもよい。
【００１２】
糖衣層はカプセル重量に対して１００％〜３００％が好ましいが、必ずしもこれらに限定されるものではない。
【００１３】
糖衣後の製品は、経時安定性の面から水分活性を０．３〜０．７、好ましくは０．５〜０．６になるまで温風乾燥もしくは真空乾燥することが望ましい。
【００１４】
本発明の糖衣シームレスカプセルは図１に示す如き、断面を有する。図１において、１は糖衣層、２はシームレスカプセル皮膜、３は疎水性保護層を示し、４は水溶液状内容物である。
【００１５】
【実施例】
本発明を以下の実施例によりさらに詳細に説明する。但し、本発明はこれらの実施例に限定されるものではない。
【実施例１】
ソルビトール液（固形分濃度７０％）と食用濃グリセリンを重量比３：１で混合したアルコール基剤８０重量％に梅肉エキス（３０％含水物）２０重量％を加えて４０℃で加熱溶解して糖衣のセンターカプセルの内容物である水溶液状物を調製し、該水溶液状物を融点５０℃のパーム硬化油脂の保護層膜とゼラチンを基剤とした外皮膜との二層膜で被覆してシ−ムレスカプセルを製造した。
【００１６】
シームレスカプセルの製造方法は同芯三重ノズルを用いて内側ノズルから内容物液、中間ノズルから硬化油脂、外側ノズルからは皮膜剤液の順に三層ジェットとし、１０℃に冷却した植物油中に同時に射出することより、粒径５ｍｍの三層構造シ−ムレスカプセルを得た。
【００１７】
更に該シ−ムレスカプセルを通気乾燥により乾燥し、表面に還元麦芽糖水飴の糖蜜と粉末を用いて公知の方法で厚さ１ｍｍのコーティングを施し、水分活性が０．６になるまで４０℃の温風で乾燥して本発明の製品を得た。
【００１８】
本品を室温４ケ月間での噛み心地と４０℃、２０％ＲＨ、８週間での重量残存率を測定して経時的な保存安定性を評価した。その結果を表１および表２に示す。
【００１９】
【比較例１】
梅肉エキス（３０％含水物）２０重量％に精製水８０重量％を加えて水溶液状内容物を調製し、保護層に融点５０℃のパーム硬化油脂を用いて実施例１と同様の方法で水溶液状物を内包する糖衣シームレスカプセルを製造した。
【００２０】
本品を室温４ケ月間での噛み心地と４０℃、２０％ＲＨ、８週間での重量残存率を測定して経時的な保存安定性を評価した。その結果を表１および表２に示す。
【００２１】
【表１】
水溶液状物を内包した糖衣シームレスカプセルの噛み心地測定結果（室温、４ケ月間）
【００２２】
【表２】
水溶性物質を内包した糖衣シームレスカプセルの経時的重量残存率測定結果（４０℃、２０％ＲＨ、８週間）
【００２３】
【発明の効果】
本発明によれば、水溶性物質を内包した長期間保存安定性に優れた糖衣シームレスカプセルを提供することができる
【図面の簡単な説明】
【図１】 本発明の水溶性物質を内包した糖衣シームレスカプセル（四層構造）の模式的な断面図を示す。
【符号の説明】
１…糖衣層、２…カプセル皮膜、３…疎水性保護層、４…水溶液状内容物[0001]
[Industrial application fields]
The present invention relates to a sugar-coated seamless capsule containing a water-soluble substance excellent in stability over time, taste and texture.
[0002]
[Prior art]
A capsule in which a capsule made of gelatin or the like is coated with a sugar coating layer is disclosed in Japanese Patent Application Laid-Open No. 59-71673. Usually, these sugar-coated capsules are limited to oil-soluble substances in the capsule contents. This is because gelatin-coated capsules cannot retain their capsule shape when the water-soluble substance is used as the content.
[0003]
For pharmaceuticals, preparations that combine the immediate effect of administering a water-soluble drug component in the form of an aqueous solution with excellent portability in the form of a sugar coating and ingestion are desired. There has been a demand for a preparation comprising a combination of an aqueous component in which a taste component spreads and a sugar coating excellent in ease of eating and texture.
[0004]
[Problems to be solved by the invention]
An object of the present invention is to provide a sugar-coated seamless capsule containing a water-soluble substance having excellent temporal stability as a content.
[0005]
[Means for Solving the Problems]
The present invention includes (1) a seamless capsule containing a water-soluble substance as a content, and (2) a water-soluble substance having a particle diameter of 1.0 mm or more, which contains a sugar coating layer formed on the seamless capsule. To provide sugar-coated seamless capsules.
[0006]
The contents of the seamless capsule used in the present invention contain a water-soluble substance, but it is difficult to maintain the capsule form with the water-soluble substance alone, so the contents are made in the form of a mixture with an alcohol base. Examples of the alcohol base include sugar alcohol liquids such as glycerin or sorbitol liquid and mixtures thereof, and the water content of the water-soluble substance in the base is 50% or less, preferably 30% or less. Desired seamless capsule contents can be obtained by appropriately dissolving water-soluble substances of pharmaceuticals and foods in the alcohol base.
[0007]
Water-soluble main ingredients of pharmaceuticals include medicinal extracts such as Kakkonto extract and Sho-saiko-to extract, tinctures such as bitter tincture and mokko tincture, water-soluble pharmaceuticals such as acetaminophen, mexiletine hydrochloride, acarbose, sodium cromoglycate, and pravastatin sodium Ingredients can be exemplified, but are not particularly limited as long as they are water-soluble. If desired, they are taste-masking agents (for example, sweeteners, sour agents, bitterness inhibitors, etc.), pH adjusters, thickeners, preservatives. , Pigments and the like may be added.
[0008]
Water-soluble main ingredients of food include plum extract, rakan fruit extract, pomegranate extract, blueberry extract, swordfish extract and other microbial extracts such as yeast extract, microbial product, lemon juice, apple juice, grape juice, peach Examples include fruit juices such as fruit juices, functional polysaccharides such as mucopolysaccharides, chlorella, peptides, polyphenols and the like, but are not particularly limited as long as they are water soluble. Further, if desired, sweeteners, sour agents, flavorings , PH adjusters, thickeners, preservatives, pigments and the like may be added.
[0009]
It is necessary to interpose a hydrophobic protective layer between the water-soluble content and the capsule film. Substances used as the hydrophobic protective layer are generally hardened oils and fats, and may be vegetable hardened oils or animal hardened oils and fats and hydrogenated products thereof. Preferably, it is palm hardened oil or fat or palm kernel hardened oil and fat, and those having a melting point of 35 ° C to 55 ° C, preferably 40 ° C to 50 ° C are optimal. For the hydrophobic protective layer, if necessary, a natural product lecithin or a chemically synthesized glycerin fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, sucrose fatty acid ester, or a mixture thereof can be hardened. You may add suitably 0.1-10 weight% with respect to fats and oils, Preferably 0.5-5 weight%.
[0010]
Examples of the film material of the seamless capsule include gelatin, agar, pectin, or a mixture thereof. If desired, a plasticizer (for example, a water-soluble polyhydric alcohol such as sorbitol and glycerin), a sweetener, a sour agent, A fragrance, a preservative, a pigment, and the like may be added.
[0011]
The sugar-coating agent for forming the sugar-coating layer is a known formulation mainly composed of sugar and syrup. If desired, a sour agent, a fragrance, a pigment, and the like may be added. In addition, in the case of a sugarless, low-calorie formulation, sugar alcohols such as reduced maltose starch syrup, sorbitol, erythritol, reduced palatinose, and mixtures thereof may be used as a base, and if desired, sour agents, fragrances, pigments, etc. may be added. .
[0012]
The sugar coating layer is preferably 100% to 300% with respect to the capsule weight, but is not necessarily limited thereto.
[0013]
The product after sugar coating is desirably dried with warm air or vacuum until the water activity becomes 0.3 to 0.7, preferably 0.5 to 0.6, in terms of stability over time.
[0014]
The sugar-coated seamless capsule of the present invention has a cross section as shown in FIG. In FIG. 1, 1 is a sugar coating layer, 2 is a seamless capsule film, 3 is a hydrophobic protective layer, and 4 is an aqueous solution.
[0015]
【Example】
The invention is illustrated in more detail by the following examples. However, the present invention is not limited to these examples.
[Example 1]
Add 20% by weight of plum extract (30% water-containing product) to 80% by weight of alcohol base prepared by mixing sorbitol solution (solid content 70%) and concentrated edible glycerin at a weight ratio of 3: 1 and dissolve by heating at 40 ° C. An aqueous solution that is the contents of the sugar-coated center capsule is prepared, and the aqueous solution is coated with a two-layer film of a hardened palm oil protective layer film having a melting point of 50 ° C. and an outer film based on gelatin. Thus, a seamless capsule was manufactured.
[0016]
A seamless capsule is manufactured by using a concentric triple nozzle and a three-layer jet of the contents liquid from the inner nozzle, the hardened fat from the intermediate nozzle, and the film agent liquid from the outer nozzle, which are simultaneously injected into vegetable oil cooled to 10 ° C. Thus, a three-layered seamless capsule having a particle size of 5 mm was obtained.
[0017]
Further, the seamless capsule was dried by aeration drying, and the surface was coated with a 1 mm thick coating using molasses and powder of reduced maltose syrup and heated at a temperature of 40 ° C. until the water activity reached 0.6. The product of the present invention was obtained by drying with wind.
[0018]
The storage stability over time was evaluated by measuring the biting comfort at room temperature for 4 months and the weight residual ratio at 40 ° C., 20% RH, 8 weeks. The results are shown in Tables 1 and 2.
[0019]
[Comparative Example 1]
An aqueous solution content is prepared by adding 80% by weight of purified water to 20% by weight of plum extract (30% water-containing product), and using a hardened palm oil with a melting point of 50 ° C. in the protective layer in the same manner as in Example 1. Sugar-coated seamless capsules containing an aqueous solution were produced.
[0020]
The storage stability over time was evaluated by measuring the biting comfort at room temperature for 4 months and the weight residual ratio at 40 ° C., 20% RH, 8 weeks. The results are shown in Tables 1 and 2.
[0021]
[Table 1]
Results of chewing comfort measurement of sugar-coated seamless capsules containing aqueous solution (room temperature, 4 months)
[0022]
[Table 2]
Results of measurement of weight retention over time of sugar-coated seamless capsules containing water-soluble substances (40 ° C, 20% RH, 8 weeks)
[0023]
【The invention's effect】
According to the present invention, a sugar-coated seamless capsule excellent in long-term storage stability containing a water-soluble substance can be provided.
FIG. 1 is a schematic cross-sectional view of a sugar-coated seamless capsule (four-layer structure) encapsulating a water-soluble substance of the present invention.
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 ... Sugar coating layer, 2 ... Capsule film, 3 ... Hydrophobic protective layer, 4 ... Contents in aqueous solution
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000053615A JP4058215B2 (en) | 2000-02-29 | 2000-02-29 | Sugar-coated seamless capsules containing water-soluble substances |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000053615A JP4058215B2 (en) | 2000-02-29 | 2000-02-29 | Sugar-coated seamless capsules containing water-soluble substances |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001238611A JP2001238611A (en) | 2001-09-04 |
| JP4058215B2 true JP4058215B2 (en) | 2008-03-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000053615A Expired - Lifetime JP4058215B2 (en) | 2000-02-29 | 2000-02-29 | Sugar-coated seamless capsules containing water-soluble substances |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4058215B2 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2005102291A1 (en) * | 2004-04-21 | 2007-08-16 | 協和醗酵工業株式会社 | Seamless capsules containing water-soluble active ingredients |
| DK2436383T3 (en) * | 2009-05-29 | 2017-10-23 | Morishita Jintan Co | ORAL MEDICAL COMPOSITION AND ORAL MEDICAL Capsule WITH THE COMPOSITION CONCERNED |
| PL216320B1 (en) * | 2010-05-28 | 2014-03-31 | Inst Chemii Fizycznej Polskiej Akademii Nauk | Capsules with hydrophilic core and polymer coating and process for the preparation thereof |
| US9056208B2 (en) | 2013-02-07 | 2015-06-16 | Conopco Inc. | Personal care compositions that include enrobed sugar |
| WO2019111398A1 (en) * | 2017-12-08 | 2019-06-13 | 森下仁丹株式会社 | Trilayer-structure capsule comprising non-hydrogenated fat and oil, and manufacturing method therefor |
-
2000
- 2000-02-29 JP JP2000053615A patent/JP4058215B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001238611A (en) | 2001-09-04 |
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