JP3965521B2 - External agent for improving hair - Google Patents

Description

The present invention relates to a hair improving external preparation which has an effect of dyeing only white hair in gold without damaging hair and causing dermatitis.

  Hair is a change of epidermal cells, and is composed of keratin, which is the main component of the stratum corneum of the skin. There are various colors of black, brown, gold and red depending on race. Gray hair is a phenomenon that occurs because the production of melanin stops in melanocytes, and it seems to be a kind of aging phenomenon. The structure of the hair shaft is composed of three layers of hair cuticle, fur, and medulla from the outer side to the center, and further, the hair cuticle is formed of three layers. There are cell membrane complexes not only between adjacent cuticles, but also in the fur structure. The cell membrane complex contributes to the adhesion between the hair coat and between the cuticles and between the cells in the fur. Furthermore, the moisture and proteins in the fur are eluted, and the moisture from the outside, as well as the permanent and hair. It seems that a chemical solution such as a color agent becomes a way for penetrating and acting on the fur inside the hair. The fur is inside the hair dermis and is a group of cells in which cortical cells are regularly arranged along the length of the hair, and it contains a melanin pigment that is surrounded by a cell membrane complex and determines the color of the hair. It is also an important part that affects the properties of hair such as suppleness and strength. The medulla is located in the center of the hair, and the honeycomb cells in the form of cavities are aligned in the axial direction and contain melanin pigment.

White hair appears to be an aging phenomenon in which melanin production stops in melanocytes. Conventionally, it is colored by hair dyeing. Hair is damaged by hair dyeing. The hair dyeing treatment is mainly performed by oxidative polymerization of a low molecular weight dye precursor such as paraphenylenediamine in the hair to develop a color. This treatment is an oxidation reaction using an oxidizing agent mainly composed of hydrogen peroxide. In order to efficiently perform this oxidation reaction in the hair, the treatment is performed in a region where the pH is high using an alkali agent, and therefore, damage is caused by the oxidant and the alkali agent. These chemical solutions pass through the cell membrane union between the hair skin and the hair skin and affect the inside of the hair through the cell membrane complex in the fur, causing the cell membrane complex itself to elute and the protein inside the hair to elute. The fur has a role of retaining moisture in hair, but its moisture retention function is impaired by elution of cell membrane complexes and internal proteins. For this reason, it is easily affected by changes in the temperature of the environment, and there are phenomena such as dryness, grouping of hairstyles, poor texture, and generation of split ends and cut hairs. Furthermore, the outermost surface of the hair cuticle covering the hair surface has a lipid layer called F layer. The branched fatty acid contained in the F layer has a function related to the smooth feel of the hair surface. When this fatty acid is treated with an alkaline solution, it is hydrolyzed and the bound fatty acid is liberated, so that the hydrophobic film and F layer present on the hair surface disappear, and the hair feels tinged. [Non-Patent Document 1 Latest hair science Takashi Matsuzaki _other p229~236]

  People who are sensitive to hair dyeing agents develop dermatitis due to hair dyeing, and the symptoms worsen with each hair dyeing. There is a need for an external preparation that does not cause dermatitis with a hair dye, does not damage the hair by hair dyeing, and further dyes the white hair of female envy.

  Gray hair is thought to be an aging phenomenon of hair. The inventor discovered that the hair of the present inventor was applied to the white hair by applying the external preparation of the inventor to the white hair, and had no adverse effects on the aging and weakened white hair. An object of the present invention is to provide an external preparation that does not cause dermatitis and dyes white hair into a female envy blonde.

The present invention is an external preparation for improving hair containing coenzyme Q10, cysteine, vitamins A, C, E, vaccinia virus-inoculated rabbit inflammation skin extract .

Coenzyme Q10 (0.03 to 1.2 parts by weight) L cysteine (0.48 to 2.4 parts by weight), vitamin A (0.06 to 0.36 parts by weight) with respect to 500 parts by weight of the hydrophilic ointment, Vitamin C (2.0 to 8.0 parts by weight), Vitamin E (0.4 to 1.6 parts by weight), vaccinia virus-inoculated rabbit inflammation skin extract effective for antiallergic action and pruritus 3.6 to An external preparation containing 14.4 units, 3 ml to 12 ml (0.6 to 2.4 parts by weight) and fluid paraffin (4.4 to 13.2 parts by weight) is prepared. Vitamin C, coenzyme Q10 other than rabbit skin inoculated vaccinia virus, L-cysteine, vitamin A, vitamins for chemical stability between each drug and for stable absorption of drugs on the hair and skin E is an external preparation for improving hair and skin using a preparation containing additives. Moreover, although the external preparation of this invention was created as a cream, it can be set as the form of external preparation compositions, such as ointment and lotion.

The present inventor has an effect of dyeing only white hair into blond hair by applying it to the hair for 3 to 4 months without damaging the white hair weakened by the inventor's external preparation. Conventional hair dyes are treated with strong acids and strong alkalis, causing damage to the cell membrane complex in the fur, elution, and elution of internal proteins, reducing the moisture retention function of the hair and receiving changes in the temperature of the environment. It becomes easier, and the hair gets dry, the hair style is lumpy, the stickiness, split ends, and the hair ends. Furthermore, the fur layer of F disappears and the hair feels tingling. The external preparation of the present inventor does not use a strong acid or a strong alkali agent, does not give the hair damage as described above, rather becomes glossy, regains its natural beauty, and dermatitis due to a hair dye during hair dyeing. There is no onset of. Also, by applying to the hair and skin once a day, the skin is moisturized, tanned, stained, freckled, whitening of senile pigment spots, moisturizing, smooth and glossy skin. In addition to the effect of improving the color of the skin, especially the cheeks of the face, there has been no external preparation that has the effect of coloring newly found white hair into blond hair.
(Test Example 1)
The test for dyeing gray hair into blond hair was carried out by 3 men and 6 women. Once applied to hair once a day, it began to lightly fade into blonde hair in about 30 days. There was no damage to the hair due to the dyeing, but rather the luster appeared and the natural beauty was restored. There is no occurrence of dermatitis due to the external preparation of the present inventor.

  Coenzyme Q10 used in the present invention has biological activity as a coenzyme, is a component of the mitochondrial electron transport system, and has a function of generating energy as a component for activating ATP biosynthesis. Coenzyme Q10 is a ubiquinone peculiar to humans whose isoprene unit in the side chain of ubiquinones (2.3-dimethoxy-5-methyl-6polyprenyl-1,4benzoquinone) is 10, and is also called ubidecalenone or coenzyme UQ10. It is a yellow to orange-yellow crystalline powder having a molecular weight of 863.36 and a melting point of about 48 degrees, and has no smell or taste. Easily soluble in ether, decomposes by light and becomes more colored. The amount of coenzyme Q10 added is not particularly limited, but is preferably 0.001 to 4.0 parts by weight, more preferably 0.03 to 1.2 parts by weight. If the concentration is higher than this, it cannot be expected that the positive effect on the skin is improved, and if the concentration is lower than this, the positive effect on the hair and skin is not expected.

  Cysteine used in the present invention plays a role as an SH donor in the in vivo metabolic system and acts as an activator of SH enzyme. Has normal skin metabolism, anti-allergy and detoxification. Cysteine or its derivative is not particularly limited, but examples of L-cysteine derivatives include N-acetyl-L-cysteine, L-homocysteine, L-cysteic acid, L-homocysteic acid, L-cysteine sulfin. Examples thereof include acids, S-sulfinol L-cysteine, S-sulfo L-cysteine, and cystine. Examples of salts of L-cysteine and derivatives thereof include mineral salts such as hydrochloride, nitrate and sulfate, alkali metal salts such as sodium salt, potassium salt, calcium salt and magnesium salt, and alkaline earth metal salts. I can do it. In the present invention, L-cysteine is preferred as L-cysteine, a derivative thereof or a salt thereof.

  Vitamin A used in the present invention has an action of increasing dark adaptation of the retina, an abnormal dryness and keratinization of the skin and mucous membranes, and an action of increasing resistance to diseases. Vitamin A is not particularly limited, and specific examples thereof include retinol, dehydroretinol, retinol acetate, retinol palmitate, or derivatives thereof. Retinoids that are analogs of retinol include retinal, Derivatives such as retinal ester and retinoic acid are listed. In the present invention, retinol and its derivative are preferably retinol palmitate.

  Ascorbic acid or a salt thereof used in the present invention was originally considered to have an anti-scurvy effect, but is further necessary for maintaining the formation of intercellular matrix and collagen in vivo, and ascorbic acid is administered by administration. Increase in collagen is seen. It is also involved in melanin pigment production and suppresses the production process from tyrosin to melanin. In addition, it has the effect of changing oxidized dark melanin to reduced light melanin, preventing abnormal pigmentation. Furthermore, it is an important substance involved in protein metabolism and endocrine function. Although it does not specifically limit as vitamin Cs, As the specific example, L-ascorbic acid and its derivative (s) or those salts are mineral salts, such as hydrochloride, nitrate, a sulfate, sodium salt, potassium Examples thereof include alkali metal salts such as salts, calcium salts and magnesium salts, and alkaline earth metal salts. Examples of L-ascorbic acid and its derivatives or salts thereof include L-ascorbic acid salts such as L-ascorbic acid, sodium L-ascorbate, potassium L-ascorbate, calcium L-ascorbate, and magnesium L-ascorbate. L-ascorbic acid monostearate, L-ascorbic acid monopalmitate, ascorbic acid monoalkyl or monoalkenyl esters such as L-ascorbic acid monooleate; L-ascorbic acid distearate, L-ascorbic acid dipalmitate, L-ascorbic acid L-ascorbic acid dialkyl or dialkenyl esters such as dioleate; L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, etc. L-ascorbic acid sulfates such as L-ascorbyl sulfate, sodium L-ascorbyl sulfate, potassium L-ascorbyl sulfate, magnesium L-ascorbyl sulfate, calcium L-ascorbyl sulfate; L-ascorbyl sulfate; L-ascorbic acid phosphates such as ascorbyl phosphate, sodium L-ascorbyl phosphate, potassium L-ascorbyl phosphate, magnesium L-ascorbyl phosphate, calcium L-ascorbyl phosphate, etc .; ascorbic acid such as L-ascorbic acid glycoside Examples include glycosides. In the present invention, L-ascorbic acid, its derivative or a salt thereof is preferably L-ascorbic acid.

  Vitamin E is related to pregnancy and childbirth, and is said to be a longevity drug. It works to dilate peripheral blood vessels and improve blood circulation. Vitamin E and coenzyme Q10 coordinate the movement of electrons through the cooperation of both components. It is known as a very closely related component, such as suppressing the oxidation reaction in the body. Vitamin E is not particularly limited, and specific examples thereof include tocopherol succinate, tocopherol acetate, tocopherol nicotinate or derivatives thereof. In the present invention, vitamin E and its derivative are preferably tocopherol nicotinate.

  Vaccinia virus-inoculated rabbit inflammation skin extract is an effective drug for itching, cooling and abnormal perception of skin, as well as low back pain, neuralgia, and other anti-allergic effects.

  The present invention will be described below with reference to examples, but the present invention is not limited to the following examples.

[0028]
【Example】
In the external preparation of the present invention, hydrophilic ointment and fluid paraffin used as a cream base are used. Furthermore, it is an external preparation to which coenzyme Q10, L-cysteine, vitamins A, C, E, vaccinia virus-inoculated rabbit inflammatory skin extract effective for antiallergic action and pruritus are added as ingredients.

Example 1
The external preparation for hair and skin improvement had the following composition, and the external preparation was produced by a conventional method.
NE soft capsule (tocopherol nicotinate 200 mg) 20 tablets (excluding soft capsules)
Chocola A (retinol palmitate) 30ml
Adeliel Tablets (Coenzyme Q10, Ubidecarenone) 10mg 300 tablets (after grinding)
Hythiol powder 32% (L cysteine) 15g
Ascorbic acid (Japanese Pharmacy Law) 20g
Nabutopine (Vaccinia virus inoculated rabbit inflammation skin extract 7.2 units 6 ml
Flowing paraffin (Japanese Pharmacy Law) 50ml
Hydrophilic ointment (Japanese Pharmacy Law) 500g

Claims (7)

An external preparation for improving hair used for dyeing only gray hair containing coenzyme Q10, cysteine, vitamins and vaccinia virus-inoculated rabbit inflammation skin extract. The hair improvement external preparation according to claim 1, wherein the vitamin is vitamin A, C, E, or a derivative thereof . Cysteine, the hair improving external preparation according to any one of claims 1 to 2 is L-cysteine or a derivative thereof. Vitamin A, the hair improving external preparation according to any one of claims 1 to 3 is a retinyl palmitate or derivatives thereof. Vitamin C, the hair improving external preparation according to any one of claims 1 to 4 is ascorbic acid or a derivative thereof. Vitamin E, hair improving external preparation according to any one of claims 1 to 5 is a tocopherol or a derivative thereof. The hair improvement external preparation according to any one of claims 1 to 6 , wherein 500 parts by weight of the hydrophilic ointment is coenzyme Q10 (0.03-1.2 parts by weight), L cysteine (0.48-2.4 parts by weight). ), Vitamin A (0.06-0.36 parts by weight), vitamin C (2.0-8.0 parts by weight), vitamin E (0.4-1.6 parts by weight), antiallergic action and pruritus Effective vaccinia virus inoculated rabbit inflammation skin extract 3.6-14.4 units, 3-12 ml, (0.6-2.4 parts by weight), fluid paraffin (4.4-13.2 parts by weight) An external preparation for improving hair, comprising