JP2007153863A - Hair improving external preparation - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a hair and skin improving external preparation effective in improving skin surface, particularly color of cheeks without causing dermatitis or damage on hair, and dyeing hair in envious gold covering up gray hair of women and improvement of atopic dermatitis. <P>SOLUTION: The hair and skin improving external preparation contains coenzyme Q10, L-cysteine, vitamins A, C and E, and a skin extract of domestic rabbit inoculated with a vaccinia virus. In addition, ingredients other than the vitamin C and the inflammatory skin extract of domestic rabbit inoculated with a vaccinia virus are used with additives for preparation of the external preparation. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

The present invention improves the skin's epidermal stratum corneum by application once a day, making it smooth and glossy skin, improving the color of the face, moisturizing effect, sunburn, dark black, blotches Skin whitening effect such as freckles, freckles, and senile pigment spots, and skin removing effects such as wrinkle removal, and also has the effect of preventing dark spots, spots, freckles, senile pigment spots and wrinkles.
It also has the effect of dyeing only white hair golden without damaging hair and causing dermatitis.
Further, the present invention relates to an external preparation for improving hair and skin used for improving or healing atopic dermatitis.

  The epidermis is divided from the deep into the basal layer, spiny layer, granule layer, and stratum corneum. Most of the cellular components are called keratinocytes (keratinocytes), and are cells that ultimately make up the stratum corneum that make up the stratum corneum. In the stratum corneum, various organelles such as the nucleus disappear, and most of the cells are filled with a fibrous protein called keratin. In addition, the cell membrane also becomes a tough keratinous thickened membrane by binding the backing protein from the inside of the cell with a strong cross-linked structure. In this way, in the epidermis, the divided basal cells are pushed up one after another, changing the morphology, and continuously creating a stratum corneum that is physically and chemically resistant through a complex process of synthesis and degradation. This stratum corneum prevents the entry of viruses, bacteria, molds and mites, prevents the entry of antigens, and prevents allergic reactions.

  UV B hits the epidermis and becomes tanned, and if it hits too much, it will not return to the dark skin, blotches, freckles, senile pigment spots, UV A will return to the dermis even if the elastin that binds the collagen is unwound, the collagen will disappear, Become a trap. Drying, overwashing and aging of the skin will cause the skin's stratum corneum to lose moisture, resulting in rough skin and wrinkles. When the state of the stratum corneum on the skin surface deteriorates, virus, bacteria, mold, mite infection and allergic reaction are likely to occur.

Skin pigmentation such as dark skin, spots, freckles, and senile pigment spots is a result of excessive enhancement of melanin synthesis caused by ultraviolet rays and other acupuncture, and is a serious cosmetic problem. In order to prevent dark skin, stains, freckles, and senile pigment spots, whitening ingredients such as L-ascorbic acid, kojic acid, cysteine, arbutin, and glutathione are used as external preparations. It is common to do. At the same time, these whitening cosmetic agents are not necessarily effective enough.
On the other hand, coenzyme Q10 is effective for removing skin, and it is known that coenzyme Q10 is used in combination with a conventional whitening component to increase the whitening effect (see, for example, Patent Document 1). There is a need for external preparations that have not only sunburn, dark black, stains, freckles, whitening effects of senile pigment spots, and skin wiping effects, but also skin beautifying effects.

  Hair is a change of epidermal cells, and is composed of keratin, which is the main component of the stratum corneum of the skin. There are various colors of black, brown, gold and red depending on race. Gray hair is a phenomenon that occurs because the production of melanin stops in melanocytes, and it seems to be a kind of aging phenomenon. The structure of the hair shaft is composed of three layers of hair cuticle, fur, and medulla from the outer side to the center, and further, the hair cuticle is formed of three layers. There are cell membrane complexes not only between adjacent cuticles, but also in the fur structure. The cell membrane complex contributes to the adhesion between the hair coat and between the cuticles and between the cells in the fur. Furthermore, the moisture and proteins in the fur are eluted, and the moisture from the outside, as well as the permanent and hair. It seems that a chemical solution such as a color agent becomes a way for penetrating and acting on the fur inside the hair. The fur is inside the hair dermis and is a group of cells in which cortical cells are regularly arranged along the length of the hair, and it contains a melanin pigment that is surrounded by a cell membrane complex and determines the color of the hair. It is also an important part that affects the properties of hair such as suppleness and strength. The medulla is located in the center of the hair, and the honeycomb cells in the form of cavities are aligned in the axial direction and contain melanin pigment.

  White hair appears to be an aging phenomenon in which melanin production stops in melanocytes. Conventionally, it is colored by hair dyeing. Hair is damaged by hair dyeing. The hair dyeing treatment is mainly performed by oxidative polymerization of a low molecular weight dye precursor such as paraphenylenediamine in the hair to develop a color. This treatment is an oxidation reaction using an oxidizing agent mainly composed of hydrogen peroxide. In order to efficiently perform this oxidation reaction in the hair, the treatment is performed in a region where the pH is high using an alkali agent, and therefore, damage is caused by the oxidant and the alkali agent. These chemical solutions pass through the cell membrane union between the hair skin and the hair skin and affect the inside of the hair through the cell membrane complex in the fur, causing the cell membrane complex itself to elute and the protein inside the hair to elute. The fur has a role of retaining moisture in hair, but its moisture retention function is impaired by elution of cell membrane complexes and internal proteins. For this reason, it is easily affected by changes in the temperature of the environment, and there are phenomena such as dryness, grouping of hairstyles, poor texture, and generation of split ends and cut hairs. Furthermore, the outermost surface of the hair cuticle covering the hair surface has a lipid layer called F layer. The branched fatty acid contained in the F layer has a function related to the smooth feel of the hair surface. When this fatty acid is treated with an alkaline solution, it is hydrolyzed and the bound fatty acid is liberated, so that the hydrophobic film and F layer present on the hair surface disappear, and the hair feels tinged.

  People who are sensitive to hair dyeing agents develop dermatitis due to hair dyeing, and the symptoms worsen with each hair dyeing. There is a need for an external preparation that does not cause dermatitis with a hair dye, does not damage the hair by hair dyeing, and further dyes the white hair of female envy.

  In recent years, an increasing number of people complain of various allergic symptoms and need treatment. Allergy is the first time that a living body that has not caused any special symptoms when it comes into contact with the substance repeatedly reacts with the same substance. Say excessive preventive reaction.

  Examples of antigens that cause allergic symptoms include plant pollen, animal hair and epithelium, mites, fungi, various foods, indoor dust, exhaust gas components, volatile chemicals emitted from synthetic interior materials, etc. Has been confirmed.

  Allergies include immediate allergic reactions involving antibodies and delayed allergic reactions mediated by sensitized lymphocytes without involving antibodies. Of these, antigens that cause immediate allergic reactions are called allergens. Normally, normal people do not elicit an immune response that is hypersensitive to this allergen, but there are occasions where immediate hypersensitivity is shown to this allergen, and atopy belongs to this.

A cure for atopic dermatitis is not well established today. In particular, for severe atopic dermatitis, symptomatic treatment is performed by relying on folk remedies or temporarily using steroid hormone drugs with strong side effects. In some cases, steroid hormone topical preparations may be used for a long time, resulting in steroid hormone dermatitis and becoming refractory. Tacrolimus has been discovered from the metabolites of actinomycetes and has been used as an immunosuppressant, but has been shown to be highly effective in atopic dermatitis, particularly intractable flushing lesions on the face (see Non-Patent Document 1, for example). . In addition, the initial irritation is strong, and the occurrence of lymphoma and the risk of carcinogenicity have been pointed out, and it is necessary to use under the guidance of a specialist. There is a need for an external preparation effective for atopic dermatitis that has no side effects and can be used for a long time.
JP 2004-107262 A “External preparation for skin and its application and usage” Noriyuki Harada, pages 131-132

  By applying to the skin once a day, it has the effect of preventing dark skin, spots, freckles, senile pigment spots, wrinkles, and moisturizing skin, tanning skin, dark skin, spots, freckles, elderly Not only the whitening effect of sexual pigment spots and the skin wiping action, but also the destruction of the epidermal stratum corneum caused by scratching and scratching, etc., and the improvement effect of the epidermal stratum corneum, etc., to smooth and glossy skin An object of the present invention is to provide an external preparation that has the effect of beautifying and has a skin-beautifying effect such as improving the color of the face. In addition, the whole body application of this external preparation makes the epidermal stratum corneum healthy and prevents the invasion of viruses, bacteria, mold, mites, etc., and allergic reactions are less likely to occur. Because it works quickly, the use of UV cut cream during the daytime and the topical preparation of the discoverer during the night can reduce the effects of ultraviolet rays on the skin. The occurrence of wrinkles is also reduced, beautiful skin with smooth and smooth gloss can be maintained for a long time, and the occurrence of skin cancer due to ultraviolet rays is expected to be reduced.

  Gray hair is thought to be an aging phenomenon of hair. The inventor discovered that the hair of the present inventor was applied to the white hair by applying the external preparation of the inventor to the white hair, and had no various adverse effects on the aging and weakened white hair. An object of the present invention is to provide an external preparation that does not cause dermatitis and dyes white hair into a female envy blonde.

In many cases, atopic dermatitis has dry skin without feeling moist. This dry skin is further aggravated when a topical agent containing a steroid hormone used for treatment is used for a long period of time. In the early stages of use of steroid hormone topical preparations, it is apt to be used for atopic dermatitis for a long time because it has a strong pruritic sensation in atopic dermatitis, an improvement in eczema state, and a good therapeutic effect. When a steroid external preparation is used for a long period of time, the skin of the application part gradually darkens, becomes keratinized, and changes to dry hard skin. Although there are individual differences in keratinized skin in this way, the skin tissue is destroyed, and mites, molds, bacteria, and viruses are more easily attached, and atopic dermatitis is more difficult to cure and sometimes worsens.
Therefore, the present inventor is able to use patients with atopic dermatitis with peace of mind, darkening, keratinizing and drying, softening the skin of atopic dermatitis that has become hard, holding itching, and destroying the epidermal stratum corneum by scratching The purpose of the present invention was to provide an external preparation that promotes the regeneration of the epidermal stratum corneum, prevents the infection of viruses, bacteria, fungi, and ticks, and prevents the occurrence of allergic reactions.

  The present invention relates to an external preparation for improving hair and skin, comprising coenzyme Q10, cysteine, vitamins A, C, E, rabbit skin inoculated with vaccinia virus, antihistamine, antiallergic agent and the like.

  Coenzyme Q10 (0.03 to 1.2 parts by weight) L cysteine (0.48 to 2.4 parts by weight), vitamin A (0.06 to 0.36 parts by weight) with respect to 500 parts by weight of the hydrophilic ointment, Vitamin C (2.0 to 8.0 parts by weight), Vitamin E (0.4 to 1.6 parts by weight), vaccinia virus-inoculated rabbit inflammation skin extract effective for antiallergic action and pruritus 3.6 to 14.4 units, 3 ml to 12 ml (0.6 to 2.4 parts by weight), external preparation having fluid paraffin (4.4 to 13.2 parts by weight), sodium hyaluronate (0 0.01 to 0.1 parts by weight) are prepared. The external preparation for allergic dermatitis does not contain sodium hyaluronate. The antiallergic action of loratadine (0.01 to 0.12 parts by weight) and antihistamine is effective for antiallergic action and pruritus. It is an external preparation characterized by adding clemastine (0.001 to 0.012 parts by weight) effective for pruritus and is chemically stable between each drug, and also on the hair and skin surface Co-enzyme Q10 other than vitamin C, L-cysteine, vitamin A, vitamin E, vaccinia virus-inoculated rabbit inflammation skin extract, loratadine, clemastine for hair and skin improvement topical preparations with additives . Moreover, although the external preparation of this invention was created as a cream, it can be set as the form of external preparation compositions, such as ointment and a lotion.

The inventor's external preparation is applied not only to the skin moisturizing effect, skin tanning, dark skin, blotches, freckles, whitening effect of senile pigment spots, skin removing effect, Vaccinia virus inoculated rabbit inflammatory skin extract contained in the external preparation of the present inventor reduces scratching by the effect of suppressing skin itching, and the skin epidermal stratum corneum is less damaged. This is thought to contribute to the improvement of the epidermal stratum corneum. Although details are unknown, the external preparation of the present inventor has the effect of improving the epidermal stratum corneum and the like, and has an effect of smoothening the rough skin to make it smooth and glossy. In addition, whitening of the skin, such as sunburn, dark skin, spots, freckles, and senile pigment spots, whitens the skin, whitening skin, and the expansion of peripheral blood vessels of vitamin E to improve blood circulation, etc. Therefore, it is an external preparation effective for improving the color of the face. The skin color of the face is improved when the external preparation of the present inventor is applied to the whole body after bathing, and the applied surface starts to feel the heat of others about 5 minutes after the application, and the heat feeling lasts for about 30 minutes. . The details are unknown, and it is thought that there are various factors, but one of the causes of this heat sensation is thought to be the result of effects such as expanding peripheral blood vessels such as vitamin E to improve blood circulation, and the skin surface, especially the face This is considered to be one of the factors that improve the blood color. In this way, the external preparation of the present inventor has a skin moisturizing effect, sunburn, dark black, blotches, freckles, whitening effect that makes senile pigment spots thinner or disappeared, an effect that makes wrinkles shallower or disappears, and swells the skin It is an external preparation for skin that has an effect of making the skin smooth and glossy. So far, once in a day, it can be moisturized, tanned, dark black, blotches, freckles, whitening effect of senile pigment spots, and smooth and glossy and dark skinned skin. There is no topical medicine that can be expected to have a skin-beautifying effect that has a wrinkle-removing effect, as well as spots, freckles, senile pigment spots and wrinkle-preventing effects. Although details are unknown, it is considered that the external preparation of the present inventor has a positive effect on the epidermal stratum corneum, melanocytes, dermis and the like of the skin. Also, the soundness of the epidermal stratum corneum by applying this inventor's external preparation to the whole body prevents the invasion of viruses, bacteria, molds, mites, etc., makes allergic reactions less likely, and excessive ultraviolet rays, dryness This will prevent the skin from aging, and it is expected to extend its lifespan. In addition, since it has the effect of removing the effects of ultraviolet rays quickly, using UV cut cream during the daytime and the inventor's external preparation at night will reduce the effects of ultraviolet rays on the skin. Occurrence of sexual pigment spots and wrinkles is also reduced, it is possible to maintain smooth, smooth, glossy, ruddy, beautiful skin for a long time, and to reduce the occurrence of skin cancer due to ultraviolet rays. In addition, since ultraviolet rays have damaged the skin since childhood, to prevent skin changes such as darkness, blotches, freckles, senile pigment spots, wrinkles, etc., ultraviolet rays, stains, freckles, freckles, senile pigment spots, It is desirable to take measures against ultraviolet rays by using the inventor's external preparation at night and in the daytime by using a UV cut cream at an early stage before the occurrence of skin changes such as wrinkles.
(Test Example 1)
The skin beautifying effect was examined for 4 men and 20 women. Although there are some differences depending on the usage method of each person, by applying once a day before going to bed, the skin surface becomes smooth when used for about 10 days, and when applied for about 3 months or more, it becomes smooth when smooth. It gives glossy skin, improves the color of the face, and has a moisturizing effect. In addition, the skin whitening effect of sunburn, spots, freckles, dark black, senile pigment spots, the wrinkle removal effect that makes the wrinkles shallower or disappears, and the skin beautifying effect that makes the skin more beautiful than before using the external preparation of the present inventor. Admitted.

The present inventor has found that the external preparation of the inventor dyes only white hair into blond hair without damaging the white hair that has weakened due to aging. Conventional hair dyes are treated with strong acids and strong alkalis, causing damage to the cell membrane complex in the fur, elution, and elution of internal proteins, reducing the moisture retention function of the hair and receiving changes in the temperature of the environment. It becomes easier, and the hair gets dry, the hair style is lumpy, the stickiness, split ends, and the hair ends. Furthermore, the fur layer of F disappears and the hair feels tingling. The external preparation of the present inventor does not use a strong acid or a strong alkali agent, does not give the hair damage as described above, rather becomes glossy, regains its natural beauty, and dermatitis due to a hair dye during hair dyeing. There is no onset of. In addition, by applying it to hair and skin once a day, the hair is dyed into blonde hair, and the skin is further moisturized, tanned, stained, freckled, whitening of senile pigment spots, moisturizing action, There are no external preparations that have a smooth and glossy skin and a beautiful skin that improves the color of the skin. Although details are unknown, there is a possibility that coenzyme Q10 having a yellow to orange-yellow color passes through the cell membrane complex of hair and enters the hair to be colored.
(Test Example 2)
The test for dyeing gray hair into blond hair was carried out by 3 men and 6 women. Once applied to hair once a day, it started to lightly fade into blonde hair in about 30 days, and all of them were able to dye hair in about 90 to 120 days. There was no damage to the hair due to the dyeing, but rather the luster appeared and the natural beauty was restored. There is no occurrence of dermatitis due to the external preparation of the present inventor.

Atopic dermatitis begins in childhood and begins with a strong sensation of flushing and small papules or serous papules. The initial use of steroid hormone topical agents is effective and tends to be used continuously because of its therapeutic effects such as pruritus and improvement of eczema. When a topical steroid is used for a long time, the skin at the site of application gradually darkens and becomes keratinized and hardened. Although the keratinized skin varies among individuals, the epidermal stratum corneum is destroyed by scratching and the like, and bacteria, mold, mites, etc. are likely to be attached, and atopic dermatitis may be further aggravated. If a topical steroid is used for a long period of time, dermatitis due to steroid hormone is caused, and it becomes further intractable. On the other hand, the tacrosum-containing ointment effective for atopic dermatitis is carcinogenic and needs to be used under the guidance of a specialist. Then, this inventor provides the external preparation without the side effect which the patient with atopic dermatitis can use safely. A test example is presented.
(Test Example 3)
The healing effect of atopic dermatitis was examined in 2 males and 2 females.
(1) 3-year-old male Atopic dermatitis with bronchial asthma, and at the start of treatment, steroid hormone ointment and the external preparation of the inventor of the above composition were used in combination, and the symptoms improved. After that, the rash appeared sporadically about 3 times, but the steroid ointment was not used, and the inventor's topical medicine was applied to the lesion twice a day. .
(2) 22-year-old female Atopic dermatitis develops in the back, chest, and upper limbs every winter. In the same year, the skin became keratinized in March, dry skin without moist feeling, and itching and scratching marks were recognized. Without using a steroid hormone ointment, the rash disappeared, itching was recovered, and dry skin was also normalized by applying the topical medicine of the present inventor. After that, by continuing to apply the inventor's external medicine, there is no recurrence after 7 months.
(3) 28-year-old female Atopic dermatitis, long-term use of steroid hormone ointment, developed dermatitis due to intractable steroid hormone ointment, dark skin, dryness, keratinization, no moist feeling, itchy feeling, strong scratching Look at the marks. Candida bacteria were attached, and Candida dermatitis also occurred. Using the topical medicine of the present inventor and an antifungal ointment, the skin surface became smooth and moistened, and the skin was darkened, dried, keratinized, and itchy.
(4) 9-year-old male Atopic dermatitis, steroid hormone ointment has been used so far when symptoms worsen. The skin surface is dark skin peculiar to atopic dermatitis, keratinized and dry skin with no moist feeling, strong pruritus, and scratch marks. Discontinue application of steroid hormone ointment and apply the inventor's topical medicine once a day for about 30 days. The dark, keratinized dry skin regains its moist feeling, the skin surface becomes smooth and itchy. The skin surface is becoming normal.
(1) The mild cases of (2) have improved to the extent that there are no subjective symptoms or objective symptoms.
(3) In the case of (4), the use of a topical steroid hormone preparation has been darkening, keratinized, and dry skin with scratch marks has become wet, smooth and free of scratch marks, and is becoming normal.
In mild cases, the onset of atopic dermatitis can be suppressed only by applying the inventor's external preparation. In the long-term use of steroid hormone topical drugs, complete cure has not yet been achieved, but the darkened skin, keratinized and hardened dry skin becomes darkened, moistened, pruritus is reduced or eliminated, and scratches disappear. However, it is being improved to normal skin. The details are unknown and may be due to various factors, but the effect of the inventor's topical medicine on inflammatory skin extract and loratadine inoculated with vaccinia virus reduces skin scratching and destroys the epidermal stratum corneum This is considered to be one of the reasons for the improvement of the epidermal stratum corneum. In addition, since the external preparation of the present inventor is effective, it can shorten the period of use of the external preparation of steroid hormone, which is often used for a long time, and can reduce the side effects of the steroid hormone. The external preparation of the present inventor has almost no side effects due to its composition and can be used for a long period of time with confidence.

  Coenzyme Q10 used in the present invention has biological activity as a coenzyme, is a component of the mitochondrial electron transport system, and has a function of generating energy as a component for activating ATP biosynthesis. Coenzyme Q10 is a ubiquinone peculiar to humans whose isoprene unit in the side chain of ubiquinones (2.3-dimethoxy-5-methyl-6polyprenyl-1,4benzoquinone) is 10, and is also called ubidecalenone or coenzyme UQ10. It is a yellow to orange-yellow crystalline powder having a molecular weight of 863.36 and a melting point of about 48 degrees, and has no smell or taste. Easily soluble in ether, decomposes by light and becomes more colored. The amount of coenzyme Q10 added is not particularly limited, but is preferably 0.001 to 4.0 parts by weight, more preferably 0.03 to 1.2 parts by weight. If the concentration is higher than this, it cannot be expected that the positive effect on the skin is improved, and if the concentration is lower than this, the positive effect on the hair and skin is not expected.

  Cysteine used in the present invention plays a role as an SH donor in the in vivo metabolic system and acts as an activator of SH enzyme. Has normal skin metabolism, anti-allergy and detoxification. Cysteine or its derivative is not particularly limited, but examples of L-cysteine derivatives include N-acetyl-L-cysteine, L-homocysteine, L-cysteic acid, L-homocysteic acid, L-cysteine sulfin. Examples thereof include acids, S-sulfinol L-cysteine, S-sulfo L-cysteine, and cystine. Examples of salts of L-cysteine and derivatives thereof include mineral salts such as hydrochloride, nitrate and sulfate, alkali metal salts such as sodium salt, potassium salt, calcium salt and magnesium salt, and alkaline earth metal salts. I can do it. In the present invention, L-cysteine is preferred as L-cysteine, a derivative thereof or a salt thereof.

  Vitamin A used in the present invention has an action of increasing dark adaptation of the retina, an abnormal dryness and keratinization of the skin and mucous membranes, and an action of increasing resistance to diseases. Vitamin A is not particularly limited, and specific examples thereof include retinol, dehydroretinol, retinol acetate, retinol palmitate, or derivatives thereof. Retinoids that are analogs of retinol include retinal, Derivatives such as retinal ester and retinoic acid are listed. In the present invention, retinol and its derivative are preferably retinol palmitate.

  Ascorbic acid or a salt thereof used in the present invention was originally considered to have an anti-scurvy effect, but is further necessary for maintaining the formation of intercellular matrix and collagen in vivo, and ascorbic acid is administered by administration. Increase in collagen is seen. It is also involved in melanin pigment production and suppresses the production process from tyrosin to melanin. In addition, it has the effect of changing oxidized dark melanin to reduced light melanin, preventing abnormal pigmentation. Furthermore, it is an important substance involved in protein metabolism and endocrine function. Although it does not specifically limit as vitamin Cs, As the specific example, L-ascorbic acid and its derivative (s) or those salts are mineral salts, such as hydrochloride, nitrate, a sulfate, sodium salt, potassium Examples thereof include alkali metal salts such as salts, calcium salts and magnesium salts, and alkaline earth metal salts. Examples of L-ascorbic acid and its derivatives or salts thereof include L-ascorbic acid salts such as L-ascorbic acid, sodium L-ascorbate, potassium L-ascorbate, calcium L-ascorbate, and magnesium L-ascorbate. L-ascorbic acid monostearate, L-ascorbic acid monopalmitate, ascorbic acid monoalkyl or monoalkenyl esters such as L-ascorbic acid monooleate; L-ascorbic acid distearate, L-ascorbic acid dipalmitate, L-ascorbic acid L-ascorbic acid dialkyl or dialkenyl esters such as dioleate; L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, etc. L-ascorbic acid sulfates such as L-ascorbyl sulfate, sodium L-ascorbyl sulfate, potassium L-ascorbyl sulfate, magnesium L-ascorbyl sulfate, calcium L-ascorbyl sulfate; L-ascorbyl sulfate; L-ascorbic acid phosphates such as ascorbyl phosphate, sodium L-ascorbyl phosphate, potassium L-ascorbyl phosphate, magnesium L-ascorbyl phosphate, calcium L-ascorbyl phosphate, etc .; ascorbic acid such as L-ascorbic acid glycoside Examples include glycosides. In the present invention, L-ascorbic acid, its derivative or a salt thereof is preferably L-ascorbic acid.

  Vitamin E is related to pregnancy and childbirth, and is said to be a longevity drug. It works to dilate peripheral blood vessels and improve blood circulation. Vitamin E and coenzyme Q10 coordinate the movement of electrons through the cooperation of both components. It is known as a very closely related component, such as suppressing the oxidation reaction in the body. Vitamin E is not particularly limited, and specific examples thereof include tocopherol succinate, tocopherol acetate, tocopherol nicotinate or derivatives thereof. In the present invention, vitamin E and its derivative are preferably tocopherol nicotinate.

  Vaccinia virus-inoculated rabbit inflammation skin extract is an effective drug for itching, cooling and abnormal perception of skin, as well as low back pain, neuralgia, and other anti-allergic effects.

  Antihistamines include diphenhydramine, tripelenamine, phenothiazine, diphenylpyraline, diproheptadine hydrochloride, homochlorcyclidine hydrochloride, clemastine fumarate, chlorpheniramine maleate, and antiallergic agents include azelastine hydrochloride, epinastine hydrochloride, ozagrel hydrochloride, olobatadine hydrochloride, hydrochloric acid Examples include cetirizine, fexofenadine hydrochloride, and loratadine. Loratadine is an antiallergic agent that has histamine H1 receptor antagonistic action and antigen-induced reaction inhibitory action, is effective in pruritus of skin diseases, and also has antiallergic action. In the present invention, loratadine is preferred.

  The present invention will be described below with reference to examples, but the present invention is not limited to the following examples.

  In the external preparation of the present invention, hydrophilic ointment and fluid paraffin used as a cream base are used. Furthermore, as an essential component, a topical preparation containing coenzyme Q10, L-cysteine, vitamins A, C, E, vaccinia virus-inoculated rabbit inflammation skin extract effective for antiallergic action and pruritus, and atopic dermatitis In addition to these external preparations, loratadine and clemastine, which are effective for antiallergic action and pruritus, are added to the above external preparations. In order to further increase the moisturizing effect, an external preparation containing sodium hyaluronate is prepared. The drugs used are chemically stable between each drug, and for stable absorption of drugs on the hair and skin, coenzyme Q10 other than vitamin C, L cysteine, vitamin A, vitamin E, vaccinia virus For the inoculated rabbit inflammation skin extract, loratadine and clemastine, preparations containing additives were used.

Example 1
The external preparation for hair and skin improvement had the following composition, and the external preparation was produced by a conventional method.
NE soft capsule (tocopherol nicotinate 200 mg) 20 tablets (excluding soft capsules)
Chocola A (retinol palmitate) 30ml
Adeliel Tablets (Coenzyme Q10, Ubidecarenone) 10mg 300 tablets (after grinding)
Hythiol powder 32% (L cysteine) 15g
Ascorbic acid (Japanese Pharmacy Law) 20g
Nabutopine (Vaccinia virus inoculated rabbit inflammation skin extract 7.2 units 6 ml
Flowing paraffin (Japanese Pharmacy Law) 50ml
Hydrophilic ointment (Japanese Pharmacy Law) 500g

(Example 2)
In order to increase the moisturizing effect of the external preparation for skin improvement, an external preparation was produced by a conventional method with the following composition.
NE soft capsule (tocopherol nicotinate 200mg) 20 tablets (remove soft capsule)
Chocola A (retinol palmitate) 30ml
Adeliel Tablets (Coenzyme Q10, Ubidecarenone) 10mg 300 tablets (after grinding)
Hythiol powder 32% (L cysteine) 15g
Ascorbic acid (Japanese Pharmacy Law) 20g
Nabutopin (Vaccinia virus inoculated rabbit inflammation skin extract) 7.2 units 6ml
Flowing paraffin (Japanese Pharmacy Law) 50ml
Hydrophilic ointment (Japanese Pharmacy Law) 500g
Hyaltowa (sodium hyaluronate) 10ml, 100mg

(Example 3)
For external preparations for atopic dermatitis, external preparations were produced by the usual method with the following composition.
NE soft capsule (tocopherol nicotinate 200mg) 20 tablets (remove soft capsule)
Chocola A (retinol palmitate) 30ml
Adeliel Tablets (Coenzyme Q10, Ubidecarenone) 10mg 300 tablets (after grinding)
Hythiol powder 32% (L cysteine) 15g
Ascorbic acid (Japanese Pharmacy Law) 20g
Nabutopin (Vaccinia virus inoculated rabbit inflammation skin extract) 7.2 units 6ml
Flowing paraffin (Japanese Pharmacy Law) 50ml
Hydrophilic ointment (Japanese Pharmacy Law) 500g
Claritin tablets 10mg (loratadine) 20 tablets (after grinding)

Example 4
For external preparations for atopic dermatitis, external preparations were produced by the usual method with the following composition.
NE soft capsule (tocopherol nicotinate 200mg) 20 tablets (remove soft capsule)
Chocola A (retinol palmitate) 30ml
Adeliel Tablets (Coenzyme Q10, Ubidecarenone) 10mg 300 tablets (after grinding)
Hythiol powder 32% (L cysteine) 15g
Ascorbic acid (Japanese Pharmacy Law) 20g
Nabutopin (Vaccinia virus inoculated rabbit inflammation skin extract) 7.2 units 6ml
Flowing paraffin (Japanese Pharmacy Law) 50ml
Hydrophilic ointment (Japanese Pharmacy Law) 500g
Lacretin dry syrup (clemastine fumarate 1.34mg) 20g

[0001]
The present invention is effective in improving the color of the skin, particularly the color of the cheeks of the face.
It also has the effect of dyeing only white hair in gold without damaging the hair and causing dermatitis.
Furthermore, it is related with the hair and skin improvement external preparation which have the effect of improving atopic dermatitis.
DISCLOSURE OF THE INVENTION
[Problems to be solved by the invention]

[0012]
By applying to the skin once a day, it has the effect of preventing dark skin, spots, freckles, senile pigment spots, wrinkles, and moisturizing skin, tanning skin, dark skin, spots, freckles, elderly Not only the whitening effect of sexual pigment spots and the skin wiping action, but also the destruction of the epidermal stratum corneum caused by scratching and scratching, etc., and the improvement effect of the epidermal stratum corneum, etc., to smooth and glossy skin Therefore, it was an object to provide an external preparation having a conventionally known effect, a new and unknown effect, and an effect of improving the color of the face, especially the cheek. In addition, the whole body application of this external preparation makes the epidermal stratum corneum healthy and prevents the invasion of viruses, bacteria, mold, mites, etc., and allergic reactions are less likely to occur. Because it works quickly, the use of UV cut cream during the daytime and the topical preparation of the discoverer during the night can reduce the effects of ultraviolet rays on the skin. The occurrence of wrinkles is also reduced, beautiful skin with smooth and smooth gloss can be maintained for a long time, and the occurrence of skin cancer due to ultraviolet rays is expected to be reduced.
[Means for Solving the Problems]

The present invention is an external preparation for improving hair and skin containing coenzyme Q10, cysteine, vitamins A, C, E, vaccinia virus-inoculated rabbit inflammation skin extract.

[0016]
Coenzyme Q10 (0.03 to 1.2 parts by weight) L cysteine (0.48 to 2.4 parts by weight), vitamin A (0.06 to 0.36 parts by weight) with respect to 500 parts by weight of the hydrophilic ointment, Vitamin C (2.0 to 8.0 parts by weight), Vitamin E (0.4 to 1.6 parts by weight), vaccinia virus-inoculated rabbit inflammation skin extract effective for antiallergic action and pruritus 3.6 to An external preparation containing 14.4 units, 3 ml to 12 ml (0.6 to 2.4 parts by weight) and fluid paraffin (4.4 to 13.2 parts by weight) is prepared. Vitamin C, coenzyme Q10 other than rabbit skin inoculated vaccinia virus, L-cysteine, vitamin A, vitamins for chemical stability between each drug and for stable absorption of drugs on the hair and skin E is an external preparation for improving hair and skin using a preparation containing additives. Moreover, although the external preparation of this invention was created as a cream, it can be set as the form of external preparation compositions, such as ointment and lotion.
【The invention's effect】

The external preparation of the present inventor is a skin moisturizing effect conventionally known by application to the skin once a day, tanning of the skin, dark skin, spots, freckles, whitening effect of senile pigment spots, skin removing action In addition, the effect of suppressing the skin itch of the rabbit skin-inoculated vaccinia virus inoculated vaccinia virus contained in the external preparation of the present inventor reduces the scratching and the destruction of the epidermal stratum corneum of the skin. This is thought to contribute to the improvement of the epidermal stratum corneum. Although details are unknown, the external preparation of the present inventor has the effect of improving the epidermal stratum corneum and the like, and has an effect of smoothening the rough skin to make it smooth and glossy. In addition, whitening of the skin, such as sunburn, dark skin, spots, freckles, and senile pigment spots, whitens the skin, whitening skin, and the expansion of peripheral blood vessels of vitamin E to improve blood circulation, etc. Therefore, it is a topical preparation that improves the color of the face, especially the cheeks, and this effect is more pronounced for people with poor blood. If you have a light makeup, you don't need blusher. Look at the color of the face through people's interaction, the face is nice and looks fine. If it was bad again, how did you get sick? The more you say, the more important it is to your life. As described above, the external preparation of the present inventor has conventionally known skin moisturizing effect, sunburn, dark black, blotch, freckles, whitening effect that makes senile pigment spots thin but disappears, effect that wrinkles become shallow or disappear Furthermore, in addition to the effect of making the skin smooth and smooth, the present inventor's skin improvement external preparation makes the skin surface, particularly the cheeks of the face, a ruddy skin, which has not been known so far It is an external preparation for skin that has a new effect. In this way, once a day, it is moisturizing, tanned, dark black, blots, freckles, whitening effect of senile pigment spots, and the effect of making the skin smooth and shiny skin There is no topical medicine that can be expected to have a good skin effect, a beautifying skin effect, a stain, freckles, senile pigment spots, and wrinkle-preventing effects. Although details are unknown, it is considered that the external preparation of the present inventor has a positive effect on the epidermal stratum corneum, melanocytes, dermis and the like of the skin. Also, the soundness of the epidermal stratum corneum by applying this inventor's external preparation to the whole body prevents the invasion of viruses, bacteria, molds, mites, etc., makes allergic reactions less likely, and excessive ultraviolet rays, dryness This will prevent the skin from aging, and it is expected to extend its lifespan. In addition, since it has the effect of removing the effects of ultraviolet rays quickly, using UV cut cream during the daytime and the inventor's external preparation at night will reduce the effects of ultraviolet rays on the skin. Occurrence of sexual pigment spots and wrinkles is also reduced, it is possible to maintain smooth, smooth, glossy, ruddy, beautiful skin for a long time, and to reduce the occurrence of skin cancer due to ultraviolet rays. In addition, since ultraviolet rays have damaged the skin since childhood, to prevent skin changes such as darkness, blotches, freckles, senile pigment spots, wrinkles, etc., ultraviolet rays, stains, freckles, freckles, senile pigment spots, It is desirable to take measures against ultraviolet rays by using the inventor's external preparation at night and in the daytime by using a UV cut cream at an early stage before the occurrence of skin changes such as wrinkles.
(Test Example 1)
The skin beautifying effect was examined for 4 men and 20 women. Although there are some differences depending on the usage method of each person, by applying once a day before going to bed, the skin surface becomes smooth when used for about 10 days, and when applied for about 3 months or more, it becomes smooth when smooth. It gives glossy skin, improves the color of the face, especially the cheeks, and has a moisturizing effect. In addition, the skin whitening effect of sunburn, spots, freckles, dark black, senile pigment spots, the wrinkle removal effect that makes the wrinkles shallower or disappears, and the skin beautifying effect that makes the skin more beautiful than before using the external preparation of the present inventor. Admitted.

[0018]
The present inventor has the effect of dyeing only white hair into blond hair by applying it to the hair for 3 to 4 months without damaging the white hair weakened by the inventor's external preparation. Conventional hair dyes are treated with strong acids and strong alkalis, causing damage to the cell membrane complex in the fur, elution, and elution of internal proteins, reducing the moisture retention function of the hair and receiving changes in the temperature of the environment. It becomes easier, and the hair gets dry, the hair style is lumpy, the stickiness, split ends, and the hair ends. Furthermore, the fur layer of F disappears and the hair feels tingling. The external preparation of the present inventor does not use a strong acid or a strong alkali agent, does not give the hair damage as described above, rather becomes glossy, regains its natural beauty, and dermatitis due to a hair dye during hair dyeing. There is no onset of. In addition, once a day, once on a day's hair and skin, the skin is moisturized, tanned, stained, freckled, whitening of senile pigment spots, moisturizing, smooth and glossy skin. In addition to the conventional effects, there are no external preparations that have the effect of improving the color of the skin surface, particularly the cheeks of the face, in addition to dyeing newly discovered gray hair into blonde hair.
(Test Example 2)
The test for dyeing gray hair into blond hair was carried out by 3 men and 6 women. Applied to the one-time hair a day, beginning dyed in thin blonde in about 30 days, it could be dyed in all blonde in about three to four months. There was no damage to the hair due to the dyeing, but rather the luster appeared and the natural beauty was restored. There is no occurrence of dermatitis due to the external preparation of the present inventor.
【Example】
[0028]
In the external preparation of the present invention, hydrophilic ointment and fluid paraffin used as a cream base are used. Furthermore, it is an external preparation to which coenzyme Q10, L-cysteine, vitamins A, C, E, vaccinia virus-inoculated rabbit inflammatory skin extract effective for antiallergic action and pruritus are added as ingredients. The effect increases when loratadine and clemastine are added to the topical preparation for atopic dermatitis. To increase the moisturizing effect, sodium hyaluronate is added. The chemicals used were coenzyme Q10, L-cysteine other than vitamin C and vaccinia virus-inoculated rabbit inflammation skin extract for chemical stability between each drug and for stable absorption of the drug on the hair and skin surface. Vitamin A, vitamin E, loratadine, clemastine, and sodium hyaluronate used preparations containing additives.
Formulation additives
Lolatadine claritin tablets contain lactose, corn starch, and stearsanmagnesium.
Klemastine lacretin dry syrup contains D mannitol and sucrose.
Sodium hyaluronate hyaltowa injection is sodium chloride, sodium hydrogen phosphate, sodium dihydrogen phosphate.

(Example 3)
In order to increase the effect of the external preparation for atopic dermatitis, the external preparation was produced by the usual method with the following composition.
NE soft capsule (tocopherol nicotinate 200mg) 20 tablets (remove soft capsule)
Chocola A (retinol palmitate) 30ml
Adeliel Tablets (Coenzyme Q10, Ubidecarenone) 10mg 300 tablets (after grinding)
Hythiol powder 32% (L cysteine) 15g
Ascorbic acid (Japanese Pharmacy Law) 20g
Nabutopin (Vaccinia virus inoculated rabbit inflammation skin extract) 7.2 units 6ml
Flowing paraffin (Japanese Pharmacy Law) 50ml
Hydrophilic ointment (Japanese Pharmacy Law) 500g
Claritin tablets 10mg (loratadine) 20 tablets (after grinding)

Example 4
In order to increase the effect of the external preparation for atopic dermatitis, the external preparation was produced by the usual method with the following composition.
NE soft capsule (tocopherol nicotinate 200mg) 20 tablets (remove soft capsule)
Chocola A (retinol palmitate) 30ml
Adeliel Tablets (Coenzyme Q10, Ubidecarenone) 10mg 300 tablets (after grinding)
Hythiol powder 32% (L cysteine) 15g
Ascorbic acid (Japanese Pharmacy Law) 20g
Nabutopin (Vaccinia virus inoculated rabbit inflammation skin extract) 7.2 units 6ml
Flowing paraffin (Japanese Pharmacy Law) 50ml
Hydrophilic ointment (Japanese Pharmacy Law) 500g
Lacretin dry syrup (clemastine fumarate 1.34mg) 20g

The present invention relates to a hair improving external preparation which has an effect of dyeing only white hair in gold without damaging hair and causing dermatitis.

White hair appears to be an aging phenomenon in which melanin production stops in melanocytes. Conventionally, it is colored by hair dyeing. Hair is damaged by hair dyeing. The hair dyeing treatment is mainly performed by oxidative polymerization of a low molecular weight dye precursor such as paraphenylenediamine in the hair to develop a color. This treatment is an oxidation reaction using an oxidizing agent mainly composed of hydrogen peroxide. In order to efficiently perform this oxidation reaction in the hair, the treatment is performed in a region where the pH is high using an alkali agent, and therefore, damage is caused by the oxidant and the alkali agent. These chemical solutions pass through the cell membrane union between the hair skin and the hair skin and affect the inside of the hair through the cell membrane complex in the fur, causing the cell membrane complex itself to elute and the protein inside the hair to elute. The fur has a role of retaining moisture in hair, but its moisture retention function is impaired by elution of cell membrane complexes and internal proteins. For this reason, it is easily affected by changes in the temperature of the environment, and there are phenomena such as dryness, grouping of hairstyles, poor texture, and generation of split ends and cut hairs. Furthermore, the outermost surface of the hair cuticle covering the hair surface has a lipid layer called F layer. The branched fatty acid contained in the F layer has a function related to the smooth feel of the hair surface. When this fatty acid is treated with an alkaline solution, it is hydrolyzed and the bound fatty acid is liberated, so that the hydrophobic film and F layer present on the hair surface disappear, and the hair feels tinged. [Non-Patent Document 1 Latest hair science Takashi Matsuzaki _other p229~236]

The present invention is an external preparation for improving hair containing coenzyme Q10, cysteine, vitamins A, C, E, vaccinia virus-inoculated rabbit inflammation skin extract .

The present inventor has an effect of dyeing only white hair into blond hair by applying it to the hair for 3 to 4 months without damaging the white hair weakened by the inventor's external preparation. Conventional hair dyes are treated with strong acids and strong alkalis, causing damage to the cell membrane complex in the fur, elution, and elution of internal proteins, reducing the moisture retention function of the hair and receiving changes in the temperature of the environment. It becomes easier, and the hair gets dry, the hair style is lumpy, the stickiness, split ends, and the hair ends. Furthermore, the fur layer of F disappears and the hair feels tingling. The external preparation of the present inventor does not use a strong acid or a strong alkali agent, does not give the hair damage as described above, rather becomes glossy, regains its natural beauty, and dermatitis due to a hair dye during hair dyeing. There is no onset of. Also, by applying to the hair and skin once a day, the skin is moisturized, tanned, stained, freckled, whitening of senile pigment spots, moisturizing, smooth and glossy skin. In addition to the effect of improving the color of the skin, especially the cheeks of the face, there has been no external preparation that has the effect of coloring newly found white hair into blond hair.
(Test Example 1)
The test for dyeing gray hair into blond hair was carried out by 3 men and 6 women. Once applied to hair once a day, it began to lightly fade into blonde hair in about 30 days. There was no damage to the hair due to the dyeing, but rather the luster appeared and the natural beauty was restored. There is no occurrence of dermatitis due to the external preparation of the present inventor.

[0028]
【Example】
In the external preparation of the present invention, hydrophilic ointment and fluid paraffin used as a cream base are used. Furthermore, it is an external preparation to which coenzyme Q10, L-cysteine, vitamins A, C, E, vaccinia virus-inoculated rabbit inflammatory skin extract effective for antiallergic action and pruritus are added as ingredients.

Claims (11)

  An external preparation for improving hair and skin comprising coenzyme Q10, cysteine, vitamins, rabbit skin inoculated vaccinia virus inoculated inflammatory skin extract and the like.   The external preparation for improving hair and skin according to claim 1, wherein the vitamins of claim 1 are vitamins A, C, E or derivatives thereof.   Applying once a day to the skin improves the epidermal stratum corneum, etc., and smoothes it to make the skin glossy, and the skin color by expanding peripheral blood vessels and improving blood circulation. The skin improvement external preparation according to claim 1 or 2, wherein the skin improvement external preparation further has a skin beautifying effect such as a moisturizing effect, a whitening effect, and a wrinkle removing effect.   4. The external preparation for improving hair according to claim 1, wherein it is found that only white hair is dyed golden by applying it to the hair, the hair is not damaged, and the hair dye does not cause dermatitis.   A skin improvement external preparation characterized by adding an antihistamine or an antiallergic agent to the external preparation according to claim 1 to 4 for use in improving or healing atopic dermatitis.   6. The external preparation for improving hair and skin according to claim 1, wherein the cysteine is L cysteine or a derivative thereof.   The external preparation for improving hair and skin according to claim 1, wherein the vitamin A is retinol palmitate or a derivative thereof.   8. The external preparation for improving hair and skin according to claim 1, wherein the vitamin C is ascorbic acid or a derivative thereof.   The hair and skin improvement external preparation according to claim 1 to 8, wherein the vitamin E is tocopherol or a derivative thereof.   The hair and skin improvement external preparation according to any one of claims 1 to 9, wherein the coenzyme Q10 (0.03 to 1.2 parts by weight) and L cysteine (0.48 to 2.4) are added to 500 parts by weight of the hydrophilic ointment. Parts by weight), vitamin A (0.06-0.36 parts by weight), vitamin C (2.0-8.0 parts by weight), vitamin E (0.4-1.6 parts by weight), antiallergic action Vaccinia virus-inoculated rabbit inflammation skin extract effective for pruritus 3.6 to 14.4 units, 3 to 12 ml, (0.6 to 2.4 parts by weight), fluid paraffin (4.4 to 13.2% by weight) Part) is prepared. In order to further increase the moisturizing effect, two external preparations to which sodium hyaluronate (0.01 to 0.1 parts by weight) is added are prepared. Further, the topical preparation for atopic dermatitis does not contain sodium hyaluronate, and the loratadine (0.01 to 0.12 parts by weight) and antihistamine which are effective for the antiallergic action and pruritus of the antiallergic agent An external preparation for improving hair and skin, characterized by adding clemastine (0.001 to 0.012 parts by weight) effective for anti-allergic action and pruritus.   The medicines used in the hair and skin improvement external preparations according to claim 1 to claim 10 other than vitamin C for chemical stabilization between each medicine and for stable absorption of the medicine on the hair and skin. Coenzyme Q10, L cysteine, vitamin A, vitamin E, vaccinia virus inoculated rabbit inflammation skin extract, loratadine and clemastine are external preparations for hair and skin using preparations containing additives.