JP3947784B2 - Oral drug administration device - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to an intraoral drug administration device that can be applied to the oral cavity and can administer a drug such as an anesthetic agent to a desired site with high efficiency through a mucous membrane in the oral cavity.
[0002]
[Prior art]
Conventionally, as a means of administering a drug such as an anesthetic via the oral mucosa, a method of administering it in a dosage form such as a liquid, an ointment, a jelly, a spray, a troche, a buccal, or a sublingual tablet has been adopted. I came. In recent years, for example, as disclosed in JP-A-9-235220, a sheet-like patch having good adhesion even at a wet site has been developed.
[0003]
On the other hand, as a case where local anesthesia is performed in the oral cavity, there is surface anesthesia in dental treatment. Dental surface anesthetic application means as infiltration anesthesia and transduction anesthesia during injection Haritoge join the club position anesthesia mucosa, superficial small range of anesthesia gingival abscess incision site pocket inner wall during scaling or gingival pockets curettage anesthetic such There is.
[0004]
At that time, since a large amount of saliva is present in the oral cavity, it has been difficult to avoid leakage of the applied anesthetic into the saliva and transfer to an unnecessary site. For this reason, there are problems that the patient feels uncomfortable due to bitterness or numbness more than necessary, or that the utilization rate of the drug is reduced and sufficient drug efficacy cannot be obtained.
[0005]
In order to solve this problem, the gingiva part is dried in advance by applying compressed air or wiping with absorbent cotton, etc., but even in patients with a large amount of saliva, sufficient effects can be obtained in children. There wasn't. In addition, even if the part to be anesthetized is guarded with absorbent cotton or the like, there is a problem that the absorbent cotton itself absorbs the anesthetic agent and sufficient anesthetic agent or the like is not retained at the part to be administered with the anesthetic agent. Absorbent cotton absorbs a large amount of saliva and dilutes the anesthetic or promotes outflow, which necessitates the use of a large amount of anesthetic.
[0006]
On the other hand, in the oral patch preparation, the water-soluble or water-swellable polymer in the adhesive layer may swell or dissolve due to saliva, and the drug may leak and flow away. In addition, when the deformation of the adhesive layer due to swelling of the water-swellable polymer is large, a noticeable foreign body sensation is produced in the oral cavity. Furthermore, when problems such as peeling off do not occur, since the adhesive is generally strong, there is a risk of causing pain and damaging the oral mucosa if peeling is attempted within a short time.
[0007]
[Problems to be solved by the invention]
An object of the present invention is to solve the above-mentioned problems in the prior art, and to provide an intraoral drug administration device that does not easily cause peeling-off or drug leakage and does not cause patient discomfort due to leakage. .
[0008]
[Means for Solving the Problems]
In order to solve the above-mentioned problems, the invention according to claim 1 lies on the teeth or gingiva, the inside and outside of the lips, the cheek and the inner wall of the oral cavity, and the upper and lower sides of the tongue, and the open end thereof by the elastic restoring force. The urging force is applied to reduce the interval, and the U-shaped clip (1) having a round hole (11) at the open end and the open end of the U-shaped clip are detachably mounted. A stem (21) having a crest-shaped top part having a diameter slightly larger than the diameter A of the round hole (11) and a groove (22), and the axial direction of the stem (21) The groove (22) and the round hole (11) are brought into a fitted state by pushing the top of the blastomer shape into the round hole (11), and the cavity c is located on the side in contact with the oral mucosa. The peripheral edge is thin and flexible, and gradually increases toward the center of the plane. A drug-carrying tool (2) having a flexible dish-like body (23) and configured to suppress saliva from entering the cavity c from the outside and to suppress the leakage of the drug from the cavity c. An intraoral drug administration device. According to the present invention, in particular, when a U-shaped clip is straddled on a tooth or gingiva, the position of the drug carrier can be accurately fixed by occlusion of the arc-shaped top of the U-shaped clip, so that it can be easily placed on a desired portion of the oral mucosa. In addition, drugs such as anesthetics can be administered with high efficiency.
[ 0009 ]
According to the second aspect of the present invention, there is provided an ambulance that straddles either the teeth or gums, the inside and outside of the lips, the cheek and the inner wall of the mouth, or the upper and lower sides of the tongue, and reduces the distance between the open ends by elastic restoring force. with biasing, the U-shaped clip having a cutout round hole in the open end (12) and (1) is detachably mounted to at least one of the open ends of the U-shaped clip, A stem (21) having a groove (22) is press-fitted into the notch round hole (12) in a direction perpendicular to the axis thereof to bring the groove (22) and the notch round hole (12) into a fitted state. At the same time, the peripheral part of the cavity c is in contact with the mucous membrane in the oral cavity, and the peripheral part thereof is thin and flexible and gradually increases in thickness toward the center of the plane. Suppresses saliva entry and prevents leakage of drug from cavity c A buccal drug administration device comprising a obtained as configured drug carrying device (2).
[ 0010 ]
According to a third aspect of the present invention, there is provided an ammunition device for straddling any one of teeth or gums, inside and outside of lips, cheek and inner wall of the mouth, and above and below the tongue, and reducing the open end interval by elastic restoring force. A U-shaped clip (1) having a constricted portion (13) formed at an open end thereof and a stem that is detachably attached to at least one of the open ends of the U-shaped clip. A clip insertion hole (201) into which the end of the U-shaped clip (1) is press-fitted is formed at the axial center, and the clip insertion hole (201 is formed by pressing-in the open end of the U-shaped clip. ) And the constricted part (13) of the open end, and the peripheral part of the cavity c is thin and flexible on the side contacting the oral mucosa, and gradually becomes thicker toward the center of the plane. Cavity from the outside with a plate-shaped body (23) A buccal drug administration device comprising a drug carrying member configured to be suppressed leaking flow of the drug from the cavity c (2) suppresses the saliva from entering the chromatography c.
[ 0011 ]
The invention according to claim 4, U-shaped clip, one open end is branched into a plurality of any claims 1 to 3 in which is mounted a pressing arc surface protruding to the branch open end a buccal drug administration device crab according. According to the present invention, in the embodiment in which the U-shaped clip is straddled on the inside and outside of the lips, the cheek and the inner wall of the mouth, and the upper and lower sides of the tongue, the U-shaped clip is attached to one of the open ends or integrated with the clip While the drug is administered from the formed drug carrier through the intraoral mucosa, the drug administration position can be accurately held by pressing with the plurality of pressing arcuate protrusions at the other end.
[ 0012 ]
The invention according to claim 5 is the intraoral drug administration device according to any one of claims 1 to 3 , wherein the drug carrier has a gel-like or drug-impregnated pad fitted in the cavity c. is there.
[ 0013 ]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, the present invention will be described according to preferred embodiments thereof. The present invention includes a clip a U-shaped exerting a force on the elastic restoring force depending on a direction to reduce the open end interval, and a drug loading device that is attached or fixed to at least one of the open ends of the clip of this U-shaped It is an intraoral drug administration device. This intraoral drug administration device allows drugs such as anesthetics to enter the desired site via the oral mucosa without being diluted by saliva etc., and the drug leaks out of the desired site. It can be administered without coughing.
[ 0014 ]
【Example】
Example 1
FIG. 1 shows a state when an oral drug administration device according to one embodiment of the present invention is applied to the upper gingiva and the lower gingiva. FIG. 1 (a) shows an embodiment in which the intraoral drug administration device of the present invention is applied to the gingival part of the upper front tooth, and FIG. 1 (b) shows the oral drug administration device of the present invention on the gingival part of the lower front tooth. Fig. 1 (c) shows the applied embodiment, Fig. 1 (c) shows the embodiment in which the intraoral drug administration device of the present invention is applied to the gingival part of the upper and rear teeth, and Fig. 1 (d) shows the oral drug administration device of the present invention. The embodiment applied to the gingival part of the lower back tooth is shown, respectively. In FIG. 1, 1 is a clip, 2 is a drug carrier, 3 is an upper front tooth, 4 is a lower front tooth, 5 is an upper back tooth, and 6 is a lower back tooth.
[ 0015 ]
In this embodiment, the clip 1 has a thickness of 0.4 mm to 1.0 mm and a width of 5 mm to 7 mm, and is placed on any of teeth or gums, inside and outside of the lips, cheek and inner wall of the mouth, and above and below the tongue. It is a U-shaped elastic body that can be straddled. When the clip 1 is in a free state, as shown in FIG. 2, the gap between the open ends is reduced and bent. Thus, in the mounted state of the intraoral drug administration device shown in FIG. 1, the clip 1 is elastically urged so as to press the drug carrier 2 against the oral mucosa such as gums by elastic restoring force. This ammunition biasing force can be changed by changing at least one of the thickness, width and length of the clip 1.
[ 0016 ]
The material of the clip 1 may be any material with elastic deformability which is applied to the oral cavity a harmless drug loading device 2 may caused to act a pressing force to the buccal mucosa for example gums. In this embodiment, the clip 1 is a U-shaped body as shown in FIG. 2 obtained by heating and plastically deforming a polycarbonate plate. This material is the same material as a syringe and the like, which is harmless to the human body and difficult to break, so that accidents that would be accidentally swallowed by the patient do not occur. In the unlikely event that there is such a risk, a thread can be tied to the clip 1 and led out of the oral cavity and fixed.
[ 0017 ]
As shown in a development view in FIG. 3, the clip 1 can take dimensions with various combinations of thickness: C, width: B, and length L. In other words, age differences, individual differences in teeth, differences in gingival shapes, differences in positions above and below the gingiva, differences due to the inside and outside of the gingiva, positions of front teeth, back teeth, etc., differences in shape, presence of teeth By selecting the size and shape corresponding to the difference depending on the presence or absence of the above, it is possible to easily cope with the above various differences. Also, the types are not mischievous, and various differences can be dealt with about 3 to 5 types.
[ 0018 ]
The clip 1 can easily increase the open end interval when the doctor stores the medicine in the cavity of the medicine carrier 2. Further, the clip 1 can be mounted straddling the teeth, for example, and the position of the drug carrier 2 mounted or fixed to the open end can be accurately held by the occlusion of the bend portion by the teeth, and the oral cavity Even when a plurality of internal drug administration devices are installed in the oral cavity, the patient does not feel uncomfortable or uncomfortable. Furthermore, as shown in FIG. 13, the width of the clip 1 is made equal to or slightly smaller than the width of the drug carrier 2 so that the clip 1 can be mounted side by side in the plurality of oral cavity without gaps.
[ 0019 ]
FIG. 3 shows a planar shape when the clip 1 is a plate-like body before being heated and plastically processed into a U shape as shown in FIG. Processing for mounting the drug carrier 2 is performed on both ends of the plate-like body. As shown in FIG. 3 (a), both ends of the clip 1 are arcuate, and round holes 11 are formed. In the case of the embodiment shown in FIG. 3 (a), the top of the stem 21 of the drug carrier 2 shown in FIG. 4 (a) has a blast ball shape, and its diameter D is the diameter A of the round hole 11 of the clip 1. It is slightly larger than. A groove 22 is engraved in the middle of the stem 21 in the axial direction so as to extend in the circumferential direction. Thus, when the blast ball-shaped top of the stem 21 is pushed into the round hole 11 of the clip 1, the groove 22 and the round hole 11 are brought into a fitted state, and the drug carrier 2 is tightly fixed to the clip 1. By this attachment, the medicine carrier 2 is not unexpectedly detached from the clip 1 and does not wobble. Furthermore, the medicine carrier 2 can be easily attached to and detached from the clip 1.
[ 0020 ]
Here, the drug carrier 2 will be described. In this embodiment, the drug carrier 2 is made of a silicone resin that is harmless to the human body. As shown in FIG. 4A, a flexible dish-like body 23 is integrally formed below the stem 21, and a cavity c is formed on the side of the flexible dish-like body 23 in contact with the oral mucosa. . The flexible dish-like body 23 in the drug carrier 2 can follow the surface shape of the mucous membrane such as the gingiva or the difference in the shape of the front tooth portion and the back tooth portion without any gaps, as shown in FIGS. As shown in FIGS. 5 and 6, the peripheral portion is made thin and supple and gradually thicker toward the center of the plane, and suppresses the invasion of saliva from the outside and a drug such as an anesthetic. It is configured to prevent leakage and leakage from the cavity c.
[ 0021 ]
The medicine stored in the cavity c of the flexible dish-like body 23 is, for example, in the case of an anesthetic, a gel, and can be stored in the cavity c as it is when the medicine carrier 2 is brought into contact with the oral mucosa. When the drug is in a liquid state, it is possible to adopt a drug carrying means for impregnating the sponge-like material and storing the sponge-like material in the cavity c.
[ 0022 ]
Example 2
As shown in FIG. 3B, both ends of the clip 1 are arc-shaped, and a round hole is formed as a notched round hole 12. In the case of this embodiment, the drug carrier 2 is attached to the clip 1 by displacing the drug carrier 2 parallel to the plate surface of the clip 1 and fitting the groove 22 in FIG. Can be combined. In the case of this embodiment, the top of the head of the stem 21 in the drug carrier 2 may be flat, and the axial dimension of the top of the head can be reduced, further reducing the feeling of foreign matter given to the patient.
[ 0023 ]
Example 3
FIG. 3C shows an end shape in which the constricted portions 13 are formed at both ends of the clip 1. In the case of this embodiment, a medicine carrier 200 shown in FIG. 5 is used. The drug carrier 200 is provided with a clip insertion hole 201 through which the end of the clip 1 is inserted in the axial center portion of the stem. In this embodiment as well, the top of the stem 21 of the drug carrier 2 may be flat, and the axial dimension of the top of the head can be reduced, further reducing the feeling of foreign matter given to the patient.
[ 0024 ]
Example 4
FIG. 4B shows a drug carrier 20 having an elliptical plane shape. In the case of this medicine carrier 20, both the flexible dish-like body 23 and the stem 21 have a planar elliptical shape.
[ 0025 ]
Example 5
FIG. 6 shows an embodiment in which the clip 1 and the drug carrier 2 are integrally formed. In this embodiment, the clip 1 and the drug carrier 2 integrated oral drug delivery device are made of silicone resin.
[ 0026 ]
In addition to this, the drug carrier 2 may be a capsule having a micro-hole array or slits for storing a drug and leaching the drug instead of the flexible dish 23.
[ 0027 ]
Example 6
7 to 10 show an embodiment of the present invention when there is a tooth extraction part on either the upper or lower side. FIG. 7 shows an embodiment when the upper front tooth has a tooth extraction portion. In this embodiment, a filling 8 such as absorbent cotton is interposed between the upper gingiva 7 and the lower front tooth, and the anesthetic is locally administered by pressing the drug carrier 2 against the gingival portion 7 of the lower front tooth from both inside and outside. . FIG. 8 shows an embodiment in which the anesthetic is locally administered by pressing and contacting the drug carrier 2 from both the inside and outside of the gingiva portion 7 of the lower back tooth, and FIG. 9 shows the upper back tooth extraction tooth. FIG. 10 shows an embodiment in which the anesthetic is locally administered by pressing and contacting the drug carrier 2 on both the inner and outer surfaces of the gingiva 7, and FIG. 10 shows both the inner and outer surfaces of the gingiva 7 of the lower upper back tooth extraction portion. In this embodiment, the anesthetic is locally administered by pressing and contacting the drug carrier 2.
[ 0028 ]
Example 7
FIG. 11 and FIG. 12 show an embodiment in which a drug is administered by pressing the drug carrier 2 across the boundary region between teeth and gums. FIG. 11 shows an embodiment in which the drug carrier 2 is pressed and abutted from the inner and outer surfaces across the lower front tooth 4 and the gingival boundary region, and FIG. 12 shows the lower back tooth 6 and the gingival boundary. This is an embodiment in which a medicine is administered by pressing and contacting the medicine carrier 2 from inside and outside over a region.
[ 0029 ]
Example 8
FIG. 13 shows an embodiment in which four intraoral drug administration devices of the present invention are arranged side by side and the drug carrier 2 is pressed and brought into contact with either or both of the inside and outside of the gingiva to administer the drug. In this embodiment, the width of the drug carrier 2 is formed slightly smaller than the width of the clip 1 so that the intraoral drug administration devices are arranged without gaps.
[ 0030 ]
Example 9
FIG. 14 shows that the medicine carrying tool having the elliptical planar shape shown in FIG. 4B is pressed and brought into contact with either or both of the inside and outside of the tooth and the gingival boundary region. It is an Example which administers.
[ 0031 ]
Example 10
FIG. 15 shows an embodiment in which the intraoral drug administration device of the present invention is applied so that the drug carrier 2 is pressed and brought into contact with the lower tongue and the lower lip.
[ 0032 ]
Example 11
FIG. 16 shows an embodiment in which the clip 1 is bifurcated from a U-shaped bend (arc top), the pressing spherical protrusion 14 is fixed to the branch branch end, and the drug carrier 2 is attached to the other open end. . FIG. 16A is a front view, and FIG. 16B is a side view. FIG. 17 shows an embodiment in which the intraoral drug administration device shown in FIG. 16 is applied to a face side portion where upper and lower lips meet. In this embodiment, the clip 1 straddles the abutting portion of the upper and lower lips, the two pressing spherical protrusions 14 are pressed against the cheek, and the one medicine carrier 2 is moved up and down. It is pressed against the mucous membrane in the oral cavity at the lip collision site.
[ 0033 ]
Reference example 1
FIG. 18 shows an example in which the medicine carrier 2 carries a medicine 241 in the form of granules through an adhesive.
[ 0034 ]
Reference example 2
FIG. 19 shows an example in which the drug carrier 2 is a tablet 242 that carries a drug via an adhesive. FIG. 20 shows a mode in which three tablets are dispersed and supported.
[ 0035 ]
Example 12
FIG. 21 shows an embodiment in which the drug carrier 2 has a flat circular recess, and a gel drug or a sponge pad impregnated with a drug is fitted and supported.
[ 0036 ]
【The invention's effect】
According to the present invention, a simple and extremely small intraoral drug administration device is used to bite a clip through a filling between upper and lower teeth or between teeth and gums, and press the drug carrier to the oral mucosa with the position fixed. Because it can be held, the drug can be administered to the desired site in the oral cavity without leakage and discharge into the oral cavity, and without inflow of saliva, without causing patient discomfort, unnecessary numbness, etc. In addition, there is an effect that enables highly efficient drug administration.
In addition, a desired drug can be continuously administered to the sublingual site or the like for a long time.
[ 0037 ]
[Brief description of the drawings]
FIG. 1 is a longitudinal sectional view showing an embodiment of the present invention when a drug such as an anesthetic is administered to a desired site of a gingiva. FIG. 2 is a side view showing clips of various sizes according to an embodiment of the present invention. FIG. 3 is a developed plan view showing a clip open end shape for mounting a drug carrier according to an embodiment of the present invention. FIG. 4 is a side view showing an embodiment of the drug carrier in the intraoral drug administration device of the present invention. FIG. 5 is a side view showing another embodiment of the drug carrier in the oral drug administration device of the present invention. FIG. 6 is an embodiment of the clip / drug carrier integrated oral drug administration device of the present invention. FIG. 7 is a longitudinal sectional view showing an application example of the intraoral drug administration device of the present invention to the gingival part of the lower anterior tooth by occlusion of the upper tooth extraction part and the lower anterior tooth. The oral medicine of the present invention to the gingival part of the lower back tooth by occlusion of the upper back tooth extraction part and the lower back tooth FIG. 9 is a longitudinal cross-sectional view showing an application example of the intraoral drug administration device of the present invention to the upper and lower teeth extracted by occlusion of the upper teeth and the lower teeth. FIG. 10 is a longitudinal sectional view showing an embodiment in which the intraoral drug administration device of the present invention is applied to the lower back tooth extraction part by occlusion of the back lower tooth extraction part and the upper back tooth. FIG. 11 shows the medicine over the front tooth and its gingival part. FIG. 12 is a longitudinal sectional view showing an embodiment of the present invention in which the carrier is pressed and applied. FIG. 12 is a longitudinal sectional view showing an embodiment of the present invention in which the medicine carrier is pressed over the back teeth and the gingival portion. FIG. 14 is a front view showing an embodiment of the present invention when four oral drug administration devices of the present invention are applied simultaneously. FIG. 14 shows a book in which the drug carrying device of the present invention shown in FIG. FIG. 15 is a front view showing an embodiment of the invention. FIG. FIG. 16 is a longitudinal sectional view showing an embodiment applied to the inner lining of the lower lip and FIG. 16 shows an oral drug administration device having a branch branch in which a U-shaped clip is branched from a bend according to an embodiment of the present invention. FIG. 17 is a perspective view showing an embodiment in which the drug is administered through the oral mucosa at the site where the upper and lower lips meet with the oral drug administration device shown in FIG. 16. FIG. FIG. 19 is a side view showing a medicine carrier according to an embodiment of the present invention. FIG. 20 is a side view showing a medicine carrier according to an embodiment of the invention. 21 is a side view showing a drug loading device according to an embodiment of the present invention [0038]
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 Clip 2 Drug carrying | support tool 3 Upper front tooth 4 Lower front tooth 5 Upper back tooth 6 Lower back tooth 7 Gingival part 8 Stuffing 11 Round hole 12 Notch round hole 13 Constriction part 14 Pressing spherical protrusion 20 Drug holding tool 21 Stem 22 Groove 23 Flexible Dish-shaped body 200 Drug carrier 201 Clip insertion hole 241 Granular drug 242 Tablet 243 Dispersed tablet 244 Sponge pad c Cavity

Claims (5)

Stretching the teeth or gums, inside and outside of the lips, cheeks and the inner wall of the oral cavity, and above and below the tongue , and urging the elastic device to reduce the interval between the open ends by elastic restoring force, and the open end And a U-shaped clip (1) having a round hole (11) on the open end of the U-shaped clip. The diameter of the U-shaped clip is larger than the diameter A of the round hole (11). Has a stem (21) having a slightly larger blast ball-shaped top and a groove (22), and the kerf-shaped head is formed in the round hole (11) in the axial direction of the stem (21). By pushing, the groove (22) and the round hole (11) are brought into a fitted state, and the peripheral portion is thin and supple and gradually becomes thicker toward the center of the plane on the side where the cavity c comes into contact with the oral mucosa. Cavity c from outside with flexible dish (23) Buccal drug administration device comprising a drug carrying member configured to be suppressed leaking flow of the drug from the cavity c (2) suppresses the saliva from entering the. Stretch the teeth or gums, inside and outside the lips, cheeks and inner wall of the mouth, and above and below the tongue, and urging the elastic to reduce the distance between the open ends, and the open ends And a stem (21) having a groove (22) removably attached to at least one of the open ends of the U-shaped clip (1). The groove (22) and the cutout circular hole (12) are fitted into the cutout circular hole (12) in a direction perpendicular to the axial center thereof, and the cavity c is brought into contact with the oral mucosa. It has a flexible dish-like body (23) that is thin, supple and gradually thicker toward the center of the plane, and prevents saliva from entering the cavity c from the outside and from the cavity c. Configured to be able to prevent leakage and leakage of drugs Buccal drug administration device comprising a tool (2). Stretch the teeth or gums, inside and outside the lips, cheeks and inner wall of the mouth, and above and below the tongue, and urging the elastic to reduce the distance between the open ends, and the open ends The U-shaped clip (1) formed with a constricted portion (13) and the U-shaped clip at the axially central portion of the stem, which is detachably attached to at least one of the open ends of the U-shaped clip. A clip insertion hole (201) into which the end of the clip (1) is press-fitted is formed, and the clip insertion hole (201) and a constricted portion of the open end (by a press-fitting of the open end of the U-shaped clip ( 13) is in a fitted state, and has a flexible dish-like body (23) in which the peripheral portion of the cavity c is thin and flexible and gradually increases toward the center of the plane on the side where the cavity c comes into contact with the oral mucosa. Intrusion of saliva into cavity c from the outside Buccal drug administration device comprising a drug carrying device (2) configured to be suppressed leaking flow of the drug from the cavity c together obtain. The intraoral drug administration device according to any one of claims 1 to 3 , wherein the U-shaped clip has one open end branched into a plurality of ends, and a pressing arc surface protrusion is attached to the branch open end. . The intraoral drug administration device according to any one of claims 1 to 3 , wherein the drug carrier is a gel or a drug-impregnated pad fitted in the cavity c .

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