JP2004275634A - Oral cavity drug administration appliance - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an oral cavity drug administration appliance scarcely causing peeled fall-out occurring in a drug sheet adhesion or leaked runoff of drug and eliminated from giving a patient discomfort such as pain due to the leakage or unnecessary numbness when administering the drug such as anesthetic to the mucosa in the oral cavity. <P>SOLUTION: This oral cavity drug administration appliance is provided with a U-shaped clip 1 straddled across either of a tooth or the gingiva, inside and outside the lip, the cheek and the oral cavity inner wall, or top/bottom of the tongue and energizing a spring to reduce its opening end sense by its elastic restoration force, and a drug carrier attached or fixed to, at least, one of the opened ends of the U-shaped clip. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to an intraoral drug administration device which is applied in the oral cavity and can administer a drug such as an anesthetic to a desired site with high efficiency via a mucous membrane in the oral cavity.
[0002]
[Prior art]
Conventionally, as a means for administering a drug such as an anesthetic via the oral mucosa, a method of administering a liquid, an ointment, a jelly, a spray, a troche, a buccal, a sublingual tablet, or the like has been adopted. Have been. In recent years, as disclosed in, for example, Japanese Patent Application Laid-Open No. 9-235220, a sheet-like patch having good adhesion even at a wet site has been developed.
[0003]
On the other hand, as a case of performing local anesthesia in the oral cavity, there is surface anesthesia in dental treatment. Application of dental surface anesthetics: Anesthesia of the mucosa of the needle insertion site during infiltration anesthesia or transmission anesthesia, Anesthesia of the calcified area of gingival abscess in a small superficial area, Anesthesia of the inner wall of the pocket when removing tartar or scraping the gingival pocket, etc. There is.
[0004]
At that time, since a large amount of saliva is present in the oral cavity, it has been difficult to avoid leakage of the applied anesthetic into saliva or transfer to an unnecessary site. Therefore, there is a problem that the patient feels uncomfortable due to bitterness, unnecessarily numbness, and the like, and a sufficient drug effect cannot be obtained due to a decrease in the drug utilization rate.
[0005]
In order to solve this problem, drying of the gingival part by applying compressed air or wiping with absorbent cotton etc. is performed in advance, but sufficient effects can be obtained even in children with a large amount of saliva, especially in children. Did not. In addition, even if the site to be anesthetized is guarded with absorbent cotton or the like, the absorbent cotton itself absorbs the anesthetic and there is a problem that a sufficient amount of the drug such as anesthetic is not retained at the site to which the anesthetic is administered. In addition, the absorbent cotton absorbs a large amount of saliva, dilutes the anesthetic and promotes the outflow, and in consideration of this, it is necessary to use a large amount of the anesthetic.
[0006]
On the other hand, in the oral patch preparation, when the water-soluble or water-swellable polymer of the adhesive layer is swollen or dissolved by saliva, it may be peeled off or the drug may leak out. In addition, when the adhesive layer is largely deformed due to swelling of the water-swellable polymer, a significant foreign-body sensation occurs in the oral cavity. Furthermore, when the problem of peeling-off or the like does not occur, there is a risk of pain or damage to the oral mucous membrane if the peeling is performed within a short time because the adhesive is generally adhered with a strong adhesive force.
[0007]
[Problems to be solved by the invention]
An object of the present invention is to solve the above-mentioned problems in the prior art, and to provide an intraoral drug administration device which does not easily cause detachment and shedding and leakage of a drug and does not cause discomfort to a patient due to leakage. .
[0008]
[Means for Solving the Problems]
The invention according to claim 1 for solving the above-mentioned problem is characterized in that it straddles the teeth or gums, the inside and outside of the lips, the cheeks and the inner wall of the mouth, and the upper and lower sides of the tongue, and the open end thereof is elastically restored. An intraoral medicine dispensing device having a U-shaped clip which is urged by an elastic device to reduce the interval, and a drug carrier attached or fixed to at least one of the open ends of the U-shaped clip. According to the present invention, in particular, when the U-shaped clip is straddled over the teeth or gums, the position of the drug carrier can be accurately fixed by the occlusion of the arc-shaped top of the U-shaped clip, so that the desired position of the oral mucosa can be easily fixed. Can be administered with high efficiency.
[0009]
According to a second aspect of the present invention, in the oral cavity according to the first aspect, the U-shaped clip has one open end branched into a plurality of portions, and the branch open end is provided with a pressing arc surface projection. It is a drug administration device. According to the present invention, in an embodiment in which a U-shaped clip is straddled above and below the inside and outside of the lips, the cheek and the inner wall of the mouth, and the tongue, the U-shaped clip is attached to one of the open ends of the U-shaped clip or integrally with the clip. The medicine is administered from the formed medicine carrier through the intraoral mucosa, and the medicine administration position can be accurately held by the plurality of pressing arc surface projections at the other end.
[0010]
The invention according to claim 3 is the intraoral drug administration device according to claim 1, wherein the drug carrier has a flexible dish-shaped portion in which a cavity for storing a drug is formed. According to the present invention, the periphery of the flexible dish-shaped portion in which the cavity is formed so that the drug carrying device closely follows the surface shape of the drug administration site is formed so as to be thinner and gradually thicker toward the center of the plane. Therefore, invasion of saliva from the outside and leakage and leakage of the drug in the cavity can be effectively prevented.
[0011]
The invention according to claim 4 is the intraoral drug administration device according to claim 1, wherein the drug carrier has a granular drug or a tablet adhered to a surface in contact with the oral mucosa.
[0012]
The invention according to claim 5 is the intraoral drug administration device according to claim 1, wherein the drug carrier has a gel or a drug impregnated pad fitted in a concave portion on the side in contact with the oral mucosa. .
[0013]
The invention according to claim 6 is the intraoral drug administration device according to claim 1, wherein the drug carrier has a capsule having a drug exuding opening. According to the present invention, for example, the drug can be continuously administered from the sublingual mucosa for a desired time.
[0014]
BEST MODE FOR CARRYING OUT THE INVENTION
Hereinafter, the present invention will be described based on preferred embodiments. The present invention relates to a U-shaped clip for applying a force in the direction of reducing the interval between the open ends by an elastic restoring force, and a drug carrier attached or fixed to at least one of the open ends of the U-shaped clip. It is an intraoral drug administration device having the same. With this intraoral drug administration device, a drug such as an anesthetic is leaked through an intraoral mucosa into a desired site without being diluted by saliva or the like, and the drug is leaked out of the desired site. It can be administered without fuss.
[0015]
【Example】
Example 1
FIG. 1 shows a state in which an intraoral drug administration device according to one embodiment of the present invention is applied to upper and lower gingiva. Fig. 1 (a) shows an embodiment in which the intraoral drug administration device of the present invention is applied to the gingival portion of the upper front teeth, and Fig. 1 (b) shows the embodiment in which the intraoral drug administration device of the present invention is applied to the gingival portion of the lower front teeth. FIG. 1 (c) shows an embodiment in which the intraoral drug administration device of the present invention is applied to the gingival part of the upper back teeth, and FIG. 1 (d) shows an embodiment in which the intraoral drug administration device of the present invention is applied. The embodiment applied to the gingival part of the lower back tooth is shown, respectively. In FIG. 1, 1 is a clip, 2 is a drug carrier, 3 is upper front teeth, 4 is lower front teeth, 5 is upper back teeth, and 6 is lower back teeth.
[0016]
In this embodiment, the clip 1 has a thickness of 0.4 mm to 1.0 mm, a width of 5 mm to 7 mm, and is placed on one of the teeth or gums, the inside and outside of the lips, the cheek and the inner wall of the mouth, and the top and bottom of the tongue. It is a U-shaped elastic body that can be straddled. When the clip 1 is in a free state, as shown in FIG. 2, the open end interval is reduced and bent. Thus, in the mounted state of the intra-oral drug administration device shown in FIG. 1, the clip 1 is urged by an elastic machine so as to press the agent carrier 2 against the oral mucosa such as the gingiva by elastic restoring force. This biasing force can be changed by changing at least one of the thickness, the width and the length of the clip 1.
[0017]
The material of the clip 1 may be any material that is harmless when applied to the oral cavity and has elastic deformability capable of exerting a pressing force on the mucous membrane in the oral cavity such as the gingiva. In this embodiment, the clip 1 is a U-shaped body as shown in FIG. 2 by heating and plastically deforming a polycarbonate plate. This material is the same material as the syringe and the like, is harmless to the human body and hard to break, and does not cause accidents such as accidental swallowing by the patient. In the unlikely event that such a patient is at risk, a thread may be tied to the clip 1 and led out and fixed outside the oral cavity.
[0018]
As shown in a development view in FIG. 3, the clip 1 can take dimensions in which thickness: C, width: B, and length L are variously combined. That is, differences in tooth and gingival shapes due to age differences, individual differences, differences in upper and lower positions of the gums, differences in the inside and outside of the gums, differences in the positions and shapes of front teeth, back teeth, etc., presence of teeth The various differences described above can be easily dealt with by selecting a size and a shape corresponding to the difference due to the presence or absence of the above. The types are not mischievous, and various differences can be dealt with by three to five types.
[0019]
When the doctor stores the medicine in the cavity of the medicine carrier 2, the clip 1 can easily increase the interval between the open ends. Further, the clip 1 is mounted, for example, by straddling the teeth, and the position of the medicine carrier 2 attached or fixed to the open end thereof can be accurately held by the occlusion of the bend portion by the teeth, and the oral cavity Even when a plurality of internal medicine administration devices are worn in the oral cavity, the patient does not feel uncomfortable or uncomfortable. Further, as shown in FIG. 13, the width of the clip 1 is made equal to or slightly smaller than the width of the medicine carrier 2 so that the clips 1 can be mounted side by side in a plurality of oral cavity without gaps.
[0020]
FIG. 3 shows a planar shape of the plate 1 before the clip 1 is heated and plastically processed into a U-shape as shown in FIG. A process for mounting the medicine carrier 2 is applied to both ends of the plate. As shown in FIG. 3A, both ends of the clip 1 are arc-shaped, and a round hole 11 is formed. In the case of the embodiment shown in FIG. 3A, the top of the stem 21 of the drug carrier 2 shown in FIG. It is slightly larger than. A groove 22 is provided in the axial direction of the stem 21 so as to extend in the circumferential direction. When the sphere-shaped crown of the stem 21 is pushed into the round hole 11 of the clip 1, the groove 22 and the round hole 11 are engaged with each other, and the medicine carrier 2 is tightly fixed to the clip 1. By this mounting, the medicine carrier 2 does not come off the clip 1 unexpectedly, and does not wobble. Further, the attachment / detachment of the medicine carrier 2 to / from the clip 1 can be easily performed.
[0021]
Here, the medicine carrier 2 will be described. In this embodiment, the medicine carrier 2 is made of silicone resin harmless to the human body. 4 (a), a flexible dish 23 is integrally formed below the stem 21, and a cavity c is formed on the side of the flexible dish 23 which contacts the oral mucosa. . 4 (a) and 4 (b), so that the flexible dish 23 in the drug carrier 2 can follow the surface shape of the mucous membrane such as the gingiva or the difference in the shape of the front teeth and the back teeth without any gap. As shown in FIG. 5, FIG. 5 and FIG. 6, the peripheral portion is made thin and supple, and is made gradually thicker toward the center of the plane. To prevent leakage from the cavity c.
[0022]
The medicine stored in the cavity c of the flexible dish 23 is, for example, a gel in the case of an anesthetic, and can be stored in the cavity c as it is when the medicine carrier 2 is brought into contact with the oral mucosa. When the drug is in a liquid state, a drug carrying means for impregnating the sponge-like material and storing it in the sponge-like cavity c can be employed.
[0023]
Example 2
As shown in FIG. 3B, both ends of the clip 1 are arc-shaped, and a circular hole is formed as a cutout circular hole 12. In the case of this embodiment, the attachment of the medicine carrier 2 to the clip 1 is performed by displacing the medicine carrier 2 in parallel to the plate surface of the clip 1 so that the groove 22 shown in FIG. Can be combined. In the case of this embodiment, the top of the stem 21 of the medicine carrier 2 may be flat, and the dimension of the top of the stem 21 in the axial direction can be reduced, so that the foreign body sensation given to the patient can be further reduced.
[0024]
Example 3
FIG. 3C shows an end shape in which constrictions 13 are formed at both ends of the clip 1. In the case of this embodiment, a medicine carrier 200 shown in FIG. 5 is used. In this medicine carrier 200, a clip insertion hole 201 into which the end of the clip 1 is inserted is formed in the axial center of the stem. Also in the case of this embodiment, the top of the stem 21 in the medicine carrier 2 may be flat, and the axial dimension of the top can be reduced, so that the foreign-body sensation given to the patient can be further reduced.
[0025]
Example 5
FIG. 4B shows the medicine carrier 20 having an elliptical planar shape. In the case of this medicine carrier 20, both the flexible dish 23 and the stem 21 have a planar elliptical shape.
[0026]
Example 6
FIG. 6 shows an embodiment in which the clip 1 and the medicine carrier 2 are integrally formed. In this embodiment, the clip 1 and the drug carrying device 2 integrated type intraoral drug administration device is made of silicone resin.
[0027]
In addition, instead of the flexible dish 23, the drug carrier 2 may be a capsule having a row of microholes or slits for storing and exuding the drug.
[0028]
Example 7
7 to 10 show an embodiment of the present invention when there is a tooth extraction portion on either the upper or lower side. FIG. 7 shows an embodiment in which the upper front tooth has a tooth extraction portion. In this embodiment, the medicine carrier 2 is pressed against the gingival part 7 of the lower front tooth from both inside and outside by interposing a padding 8 such as absorbent cotton between the upper gingiva 7 and the lower front tooth to locally administer the anesthetic. . FIG. 8 shows an embodiment in which the medicine carrier 2 is pressed against the gingival part 7 of the lower back tooth from both inside and outside to locally administer the anesthetic, and FIG. 9 shows the upper back tooth extraction. An embodiment in which the medicine carrier 2 is pressed against the inner and outer surfaces of the gingiva 7 at the portion to locally administer the anesthetic, and FIG. 10 shows the inner and outer surfaces of the gingiva 7 at the lower and upper back tooth extraction portion. This is an embodiment in which the drug carrier 2 is pressed and contacted to locally administer the anesthetic.
[0029]
Example 8
FIG. 11 and FIG. 12 show an embodiment in which the medicine is carried out by pressing the medicine carrier 2 over the boundary region between the teeth and the gingiva. FIG. 11 shows an embodiment in which the medicine carrier 2 is pressed and abutted from the inner and outer surfaces over the lower front teeth 4 and the gingival boundary region to administer the medicine, and FIG. 12 shows the lower back teeth 6 and the gingival boundary. This is an embodiment in which the medicine carrier 2 is pressed and abutted from the inner and outer surfaces over the region to administer the medicine.
[0030]
Example 9
FIG. 13 shows an embodiment in which four oral medicine administration devices of the present invention are arranged, and the medicine carrier 2 is pressed against and brought into contact with one or both of the inside and the outside of the gum to administer the medicine. In this embodiment, the width of the medicine carrier 2 is formed to be slightly smaller than the width of the clip 1 so that the intraoral medicine administration devices are arranged without gaps.
[0031]
Example 10
FIG. 14 shows that the medicine carrier having the elliptical planar shape shown in FIG. 4 (b) is brought into pressure contact with one or both of the inside and the outside over the tooth-gingival boundary region. This is an example in which is administered.
[0032]
Example 11
FIG. 15 shows an embodiment in which the intraoral drug administration device of the present invention is applied so that the drug carrier 2 is pressed against the lower tongue and the lower lip.
[0033]
Example 12
FIG. 16 shows an embodiment in which the clip 1 is bifurcated from the U-shaped bend (arc top), the pressing spherical projection 14 is fixed to the end of the branch, and the drug carrier 2 is attached to the other open end. . FIG. 16A is a front view, and FIG. 16B is a side view. FIG. 17 shows an embodiment in which the intraoral drug administration device shown in FIG. 16 is applied to a side surface of the face where the upper and lower lips abut. In this embodiment, the clip 1 straddles the abutting portion of the upper and lower lips, two pressing spherical projections 14 are pressed against the cheek, and one drug carrier 2 is It is pressed against the intraoral mucosa at the abutment site of the lips.
[0034]
Example 13
FIG. 18 shows an example in which the medicine carrier 2 carries a medicine 241 in the form of a medicine via an adhesive.
[0035]
Example 14
FIG. 19 shows an embodiment in which the medicine holding device 2 holds a medicine as a tablet 242 via an adhesive. FIG. 20 shows an embodiment in which three tablets are dispersed and supported.
[0036]
Example 15
FIG. 21 shows an embodiment in which the medicine carrier 2 has a flat circular recess, and a gel medicine or a sponge pad impregnated with the medicine is fitted and carried.
[0037]
【The invention's effect】
ADVANTAGE OF THE INVENTION According to this invention, a clip is bite | engaged with a simple and extremely small intraoral medicine administration device through a pad between upper and lower teeth or between teeth and gingiva, and the medicine holding device is pressed against the oral mucosa in a fixed state. Because it can be held, the drug can be administered to the desired site in the oral cavity without leaking and flowing into the oral cavity and without inflow of saliva, without causing discomfort and unnecessary numbness etc. to the patient This has the effect of enabling highly efficient drug administration.
[0038]
According to the invention described in claim 6, the desired drug can be continuously administered to the sublingual site or the like for a long time.
[Brief description of the drawings]
FIG. 1 is a longitudinal sectional view showing an embodiment of the present invention when a drug such as an anesthetic is administered to a desired site of a gingiva. FIG. 2 is a side view showing clips of various sizes according to an embodiment of the present invention. FIG. 3 is an exploded plan view showing a shape of an open end of a clip for mounting the drug carrier according to the embodiment of the present invention. FIG. 4 is a side view showing an embodiment of the drug carrier in the intraoral drug administration device of the present invention. FIG. 5 is a side view showing another embodiment of the drug carrier in the intraoral drug dispenser of the present invention. FIG. 6 is an embodiment of a clip / drug carrier integrated type intraoral drug dispenser of the present invention. FIG. 7 is a longitudinal sectional view showing an embodiment in which the intraoral drug administration device of the present invention is applied to a gingival part of a lower front tooth by occlusal engagement between an upper tooth extraction part and a lower front tooth. Intraoral drug administration of the present invention to the gingival part of the lower posterior teeth due to the occlusion between the upper extraction part and the lower posterior teeth FIG. 9 is a longitudinal sectional view showing an application example of the intraoral drug administration device of the present invention to an upper posterior tooth extraction part due to occlusion between a lower posterior upper extraction part and a lower posterior tooth. FIG. 11 is a longitudinal sectional view showing an embodiment of application of the intraoral drug administration device of the present invention to a lower posterior tooth extraction portion by occlusion between a lower posterior lower extraction portion and an upper posterior tooth. FIG. 12 is a longitudinal sectional view showing an embodiment of the present invention in which pressure is applied. FIG. 12 is a longitudinal sectional view showing an embodiment of the present invention in which a medicine carrier is applied over a back tooth and a gingival part. FIG. 14 is a front view showing an embodiment when the intraoral drug administration device of the present invention is applied at four places at the same time. FIG. 14 is a diagram of the present invention in which the drug carrying device of the present invention shown in FIG. FIG. 15 is a front view showing an embodiment. FIG. 16 is a longitudinal sectional view showing an embodiment applied to a lateral mucous membrane. FIG. 16 is a front view showing an intraoral drug administration device according to an embodiment of the present invention, which has a branched branch in which a U-shaped clip is branched from a bend portion. FIG. 17 is a perspective view showing an embodiment in which the intraoral medicine administration device shown in FIG. 16 administers the medicine through the intraoral mucosa at the site where the upper and lower lips meet. FIG. 18 relates to an embodiment of the present invention. FIG. 19 is a side view showing a drug carrier according to one embodiment of the present invention. FIG. 20 is a side view showing a drug carrier according to one embodiment of the present invention. FIG. 2 is a side view showing a medicine carrier according to one embodiment of the present invention.
DESCRIPTION OF SYMBOLS 1 Clip 2 Drug carrier 3 Upper front tooth 4 Lower front tooth 5 Upper back tooth 6 Lower back tooth 7 Gum part 8 Filling 11 Round hole 12 Notch round hole 13 Constriction part 14 Pressing spherical projection 20 Drug carrier 21 Stem 22 Groove 23 Flexibility Dish 200 Drug carrier 201 Clip insertion hole 241 Granular drug 242 Tablet 243 Dispersed tablet 244 Sponge-like pad c Cavity

Claims (6)

A U-shaped clip that straddles the teeth or gums, inside and outside the lips, the cheeks and the inner wall of the mouth, and the top and bottom of the tongue and reduces the open end interval by elastic restoring force; A drug carrier attached to or fixed to at least one of the open ends of the U-shaped clip. The intraoral drug administration device according to claim 1, wherein the U-shaped clip has one open end branched into a plurality of parts, and the branch open end is provided with a pressing arc surface projection. The oral medicine administration device according to claim 1, wherein the medicine carrier has a flexible dish-shaped portion in which a cavity for storing the medicine is formed. The oral drug administration device according to claim 1, wherein the drug carrier is a device in which a granular drug or a tablet is attached to a surface in contact with the oral mucosa. The intraoral drug administration device according to claim 1, wherein the drug carrier has a gel or a drug-impregnated pad fitted in a concave portion on the side in contact with the oral mucosa. The intraoral drug administration device according to claim 1, wherein the drug carrier has a capsule having a drug exuding opening.

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