JP3934179B2 - Method and granulated product for granulating powder made of substance ingested into animal body - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a method for granulating a powder of a substance ingested into the body of an animal and a granulated product.
[0002]
[Prior art]
In order to improve the handleability of powder and to combine a plurality of powders, it is widely practiced to granulate the powder in the presence of a binder.
In such a granulation method of powder, when the powder is made of a substance that is ingested into the animal body including humans such as foods and pharmaceuticals, the binding agent is highly safe for animals. Is required. In addition, for the binder in this case, the high binding property and low cost are also important factors.
On the other hand, a granulated product obtained by granulation of powder is required to have a sharp particle size distribution as much as possible from the viewpoint of its use characteristics.
Conventionally, a wide variety of methods for granulating powder, including the type of binder, are known, but when granulating powdered foods, pharmaceuticals, etc., from the viewpoint of safety Therefore, there is no method that can be satisfied because there are major restrictions in the selection of the binder, and development of an industrially advantageous granulation method that can efficiently obtain a granulated product with a sharp particle size distribution. Is desired.
[0003]
[Problems to be solved by the invention]
An object of the present invention is to provide an industrial granulation method that can be advantageously applied to a powder of a substance ingested into an animal body.
[0004]
[Means for Solving the Problems]
As a result of intensive studies to solve the above problems, the present inventors have completed the present invention.
That is, according to the present invention, in a method of granulating a powder of a substance ingested into an animal body into a granular material having an average particle diameter of 100 to 1500 μm, at least a part of the powder is passed through a gas dispersion plate. A spray liquid composed of a hemicellulose aqueous solution is sprayed as fine droplet particles through a spray nozzle on a powder fluidized bed formed by fluidizing with a rising airflow, and a plurality of liquid droplets in the presence of the fine droplet particles of the spray liquid are sprayed. Including a granulation step of adhering and bonding powder particles to each other to form a granulated product, wherein the spray liquid viscosity is in the range of 3 to 100 mpa · s, and the fineness of the spray liquid formed by spraying from the spray nozzle The particle size of the droplets is in the range of 10 to 200 μm, and further in the range of 0.7M to 1.3M (where M is the average particle size of the granulated product) in the resulting granulated product. Content is 75% by weight There is provided the above method characterized by the above.
[0005]
DETAILED DESCRIPTION OF THE INVENTION
The material to be treated used in the present invention is a powder of a substance ingested into the animal body, and such powder includes edible substances, physiologically active substances, additives to these substances, and the like. Edible substances include those based on carbohydrates, proteins and fats. Specific examples of edible substances include starch, sucrose, maltose, dextrin, wheat flour, protein, peptide, amino acid, agar, plant fiber, coffee, tea, cocoa, health food, seasoning, spice, feed, etc. . Examples of the physiologically active substance include pharmaceuticals, vitamins, calcium salts, chlorella, bihizu bacteria, and ginkgo biloba extract. Examples of additives include colorants, preservatives, extenders and the like. Powders are roughly classified into self-binding powders and non-self-binding powders that adhere and terminate with water or organic solvents. The granulation method of the present invention can be applied to any of these powders. It can also be applied to.
The average particle diameter of the powder is usually 200 μm or less, preferably 10 to 100 μm.
[0006]
The granulating binder used in the present invention is water-soluble hemicellulose, which is a conventionally known substance. This water-soluble hemicellulose is obtained by hydrolyzing water-insoluble plant fibers consisting of polysaccharides that are bound to cellulose in the plant body under weak acidity and separating the water-soluble product. Can do.
Examples of water-insoluble plant fibers include water-insoluble plant fibers of oil seeds such as soybeans and palm palms, and water-insoluble plant fibers of cereals such as rice, wheat and corn. Okara obtained after removing most can be used advantageously.
The hydrolysis reaction of the water-insoluble plant fiber needs to be performed under pH conditions near the isoelectric point of the protein contained in the water-insoluble plant fiber. The hydrolysis reaction when the raw material is okara is performed at pH 3-7, preferably 4-7, because the isoelectric point of soybean protein is around pH 4.5.
As described above, the hydrolysis is performed near the isoelectric point of the protein under a pH condition that is considerably lower than the isoelectric point of the protein, for example, okara containing soybean protein as described above under strong acidity of pH 2 or less. When hydrolyzed, the plant fiber is decomposed too much and the protein is also decomposed and eluted together with the plant fiber, while the water-insoluble plant fiber containing the protein has a pH considerably higher than the isoelectric point of the protein. This is because the protein is solubilized and eluted together with the plant fiber when hydrolysis is carried out in neutral or alkaline.
Details of this reaction are described in JP-A-4-325058 and JP-A-3-236759.
[0007]
The hydrolysis reaction product is filtered or centrifuged to separate and remove solids such as cellulose that have not been decomposed from the aqueous solution containing the water-soluble hemicellulose, thereby obtaining a water-soluble hemicellulose aqueous solution.
[0008]
This hemicellulose aqueous solution contains a polysaccharide composed of galactose, arabinose, galacturonic acid, xylose, fucose, glucose, rhamnose, etc., and the main components therein are polysaccharides composed of galactose, arabinose, galacturonic acid and the like. The details of the component analysis results of the water-soluble hemicellulose obtained by hydrolysis are described in JP-A-4-325058. A solid water-soluble hemicellulose can be obtained by concentrating and drying the aqueous hemicellulose solution.
[0009]
In the powder granulation method of the present invention, an aqueous solution of hemicellulose is sprayed as fine droplet particles onto a powder fluidized bed formed by fluidizing at least a part of the powder by an ascending gas flow passing through a gas dispersion plate. And a granulation step in which a plurality of powder particles are adhered to each other in the presence of the fine droplet particles to form a granulated product.
[0010]
FIG. 1 shows a schematic diagram of an example of a fluidized bed granulator used in the present invention.
In FIG. 1, 1 is a fluidized bed granulator, 2 is a gas dispersion plate, 3 is a gas introduction tube, 4 is a gas discharge tube, 5 is a spray solution introduction tube made of a hemicellulose aqueous solution, 6 is a spray solution spray nozzle, and 7 is a spray solution spray nozzle. Filter, 8 is a heat exchanger, 9 is a bag filter, and F is a powder fluidized bed.
In order to perform the powder granulation according to the present invention using the apparatus shown in FIG. 1, after the powder is filled in the apparatus 1, a fluidizing gas is introduced through the gas introduction pipe 3, and the filter 7 and the heat exchanger 8 are introduced. After the gas is circulated, the gas is blown up as an updraft through the gas dispersion plate 2, the powder on the gas dispersion plate is fluidized, and the powder fluidized bed F is formed. The gas passing through the powder fluidized bed F is circulated through the bag filter 9 and then discharged through the gas discharge pipe 4. As the fluidizing gas, air is usually used, but other gases may be used. The temperature of the fluidizing gas supplied to the powder fluidized bed F is 40 to 100 ° C, preferably 50 to 90 ° C. The fluidizing gas temperature is controlled by the heat exchanger 8.
The powder fluidized bed F formed as described above is sprayed with the spray liquid supplied through the pipe 5 via the spray nozzle 6. As a result, the fluidized powder is gradually granulated, and a plurality of fluidized powder particles are formed into a granulated product adhered and bonded together by the binding action of hemicellulose. In such a granulation method, the particle size of the granulated product gradually increases with the passage of time, but the flow rate of the fluidizing gas is increased accordingly, and the entire granulated product is fluidized. Hold on. After a predetermined time has elapsed, the spraying of the fluidized spray liquid is stopped, and the granulated product is dried by continuing the blowing of the fluidizing gas. After drying, the blowing of the fluidizing gas is stopped, and the granular material is taken out to make a product granulated product. In this case, the granulated product can be dried by taking out the granulated product to the outside.
[0011]
The gas dispersion plate has many fine through holes on the plate surface. The hole diameter (diameter) of the through hole is 10 to 300 μm, preferably 20 to 200 μm.
The diameter (diameter) of the liquid ejection hole in the spray nozzle is 0.5 to 3 μm, preferably 1.2 to 1.8 μm.
[0012]
The molecular weight of the water-soluble hemicellulose used in the present invention is a molecular weight that gives a viscosity of 10 to 500 mPa · s, preferably 15 to 100 mPa · s, using the viscosity at 25 ° C. as a 10% by weight aqueous solution as an index. It is. The concentration of the aqueous hemicellulose solution used in the present invention is 3 to 15% by weight, preferably 4 to 12% by weight.
If necessary, the hemicellulose aqueous solution may be added with an appropriate amount of other binders that are harmless to the human body, for example, water-soluble polymers such as gum arabic, pullulan, starch, hydroxypropylcellulose, carboxymethylcellulose and the like. it can. Moreover, surfactant, a coloring agent, a flavoring agent, a fragrance | flavor, an antiseptic | preservative, saccharides, etc. can be added to the said hemicellulose aqueous solution suitably.
In the spray liquid composed of the hemicellulose aqueous solution used in the present invention, the viscosity of the spray liquid is 3 to 100 mpa · s, preferably 5 to 80 mpa · s. In this case, the viscosity of the spray liquid can be adjusted by temperature and hemicellulose concentration. When the viscosity of the spray liquid deviates from the above range, the sprayability from the spray nozzle deteriorates, and it becomes difficult to form fine droplet particles of the spray liquid with good granulation properties. In this case, the particle size distribution of the resulting granulated product is also broad.
[0013]
In the present invention, the flow rate of the gas blown upward through the gas dispersion plate is 0.3 to 3 m / second, preferably 0.5 to 2 m / second, in terms of gas linear velocity. When the gas linear velocity increases, the particle size of the granular material decreases, and is appropriately selected according to the intended granulated particle size.
The usage-amount of the spray liquid used by this invention is 0.1-10 weight part per 100 weight part of powders in dry hemicellulose conversion amount, Preferably it is 0.2-5 weight part. When the amount used is increased, the particle size of the granulated product becomes large, and it is appropriately selected according to the intended granule particle size.
Further, the supply rate of the spray liquid is 0.03 to 1 part by weight, preferably 0.05 to 0.5 part by weight, as the supply rate of dry hemicellulose per 100 parts by weight of the powder per minute. When the supply rate of the spray liquid exceeds the above range, the particle size distribution of the resulting granulated product becomes a floating one. On the other hand, when the spray rate decreases, the granulation of the powder takes time.
[0014]
In the apparatus shown in FIG. 1, it is preferable to use a plurality of spray nozzles, and the spray nozzles can be disposed at a plurality of locations such as an upper portion, an intermediate portion, and a lower portion in the powder fluidized bed. As the spray nozzle, a conventional liquid spray nozzle is used. In the present invention, it is preferable to use a spray nozzle having a two-fluid nozzle structure.
The average particle diameter (diameter) of the fine droplet particles of the spray liquid ejected from the spray nozzle is 5 to 200 μm, preferably 10 to 100 μm. When the average particle size exceeds the above range, the resulting granule has a broad particle size distribution. On the other hand, when the average particle size is smaller than the above range, the ratio of scattering upward from the powder fluidized bed with the fluidizing gas is high. Increases and granulation efficiency decreases.
[0015]
Further, in the apparatus of FIG. 1, the gas dispersion plate 2 may be a rotatable one, for example, a rotary disk. When such a rotatable gas dispersion plate is used, the flow rate of the fluidizing gas is adjusted so that a part of the granulated material exists on the dispersion plate, and the plate surface is rotated by rotating it. The above granulated product can be rolled to obtain a granulated product having a spherical shape or a shape close to a spherical shape. The rotation speed in this case is such that 30 to 500 m / min, preferably 50 to 300 m / min is obtained.
[0016]
In the granulated product obtained by the present invention, its average particle size is 100 to 1500 μm, preferably about 150 to 600 μm, its particle size distribution is sharp, and it is excellent in handleability, meterability and the like. In the granulated product of the present invention, when the average particle size is M, the content of the granular material having a particle size range of 0.7M to 1.3M is 75% by weight or more, preferably 80% by weight or more. .
[0017]
Since the method of the present invention uses water-soluble hemicellulose derived from natural products as a binder for granulation, the resulting granulated product is highly safe and can be harmful even if ingested into the human body. There is nothing.
In the present invention, the powder fluidized bed formed by fluidizing the powder is sprayed with a spray liquid composed of an aqueous hemicellulose solution to granulate the powder, and the viscosity of the spray liquid is adjusted to 3 to 3. Granulation with good particle size uniformity with a sharp particle size distribution because the spray liquid is smoothly sprayed from the spray nozzle into fine droplet particles with good particle size uniformity and adhesion. You can get things. Moreover, the granulated product of the present invention is excellent in mechanical strength.
[0018]
【Example】
Next, the embodiment of the present invention will be described in more detail.
In addition, the viscosity of the spray liquid shown below is measured with a B-type clay meter.
[0019]
Example 1
Lactose 7: 3 kg of mixed powder of corn starch 3 (weight ratio) is charged into a fluidized bed granulator (flow coater FLO-5, manufactured by Freund Sangyo Co., Ltd.), and air is supplied at an air supply temperature of 30 ° C. A fluidized bed was formed, and a 7 wt% aqueous solution of water-soluble hemicellulose (Fuji Oil Co., Ltd., hemirose) (10 wt% aqueous solution having a viscosity of 134 mPa · s at 20 ° C) was formed on the powder fluidized bed. Viscosity at 30 ° C .: 40.5 mpa · s) was used as a spray liquid, and this was sprayed at a rate of 80 ml / min under a temperature condition of 30 ° C. and granulated for 37 minutes. The amount of hemicellulose added was 3.0 wt% with respect to the mixed powder. The obtained granulated product has an average particle size (diameter) of about 150 μm, fine powder of less than 100 μm is 17.1 wt%, coarse particles of 500 μm or more is 0.5 wt%, mechanical strength (compressive strength) and The fluidity was also good. In this granulated product, the content of the granular material in the range of 0.7 M (M is an average particle size) to 1.3 M (105 to 195 μm) was 90 wt% or more.
[0020]
Comparative Example 1
A mixture obtained by adding 3.0 wt% of the same hemicellulose powder to 5 kg of the same mixed powder as in Example 1 was charged into a high-speed mixer FS / GS / 25J type (manufactured by Fukae Kogyo Co., Ltd., stirring granulator), water 850 g was added dropwise little by little, and granulated with stirring for 15 minutes. The average particle size of the obtained granulated product is about 130 μm, the fine powder of 100 μm or less is 25.0 wt%, the coarse particle of 500 μm or more is 6.3 wt%, and the particle size distribution is larger than that of fluidized bed granulation. Wide, coarse and fine.
[0021]
Example 2
7 wt% aqueous solution (viscosity at 30 ° C: 17.2 mPa · s) of hemicellulose (Fuji Oil Co., Ltd., Soya Five · S) (10 wt% aqueous solution with a viscosity at 20 ° C of 48.2 mPa · s) The average particle size of the obtained granulated product was about 150 μm, the fine powder of 100 μm or less was 15.3 wt%, and the coarse particle of 500 μm or more was 0.2 wt%. In this granulated product, the content of the granulated product having a particle size in the range of 0.7 M to 1.3 M was 90 wt% or more.
[0022]
Comparative Example 2
The experiment was performed in the same manner as in Comparative Example 1 except that the hemicellulose shown in Example 2 was used. The average particle diameter of the obtained granulated product was about 150 μm, which was about the same as Example 2. However, fine particles of 100 μm or less were 39.2 wt%, and coarse particles of 500 μm or more were 12.2 wt%. there were.
[0023]
Example 3
The experiment was performed in the same manner as in Example 1 except that 3 kg of lactose was used. The average particle size of the obtained granulated product was about 250 μm, fine powder of 100 μm or less was 3.2 wt%, and coarse particles of 500 μm or more was 3.8 wt%. In this granulated product, the content of the granular material having a particle size range of 0.7 M to 1.3 M was 90 wt% or more.
[0024]
Comparative Example 3
The experiment was performed in the same manner as in Comparative Example 1 except that 5 kg of lactose was used. The obtained granulated product had an average particle diameter of about 250 μm, which was almost the same as Example 3. However, the fine powder of 100 μm or less was 9.3 wt%, and the coarse particle of 500 μm was 12.7 wt%. It was.
[0025]
Example 4
The experiment was performed in the same manner as in Example 2 except that 3 kg of lactose was used. The average particle diameter of the obtained granulated product was about 360 μm, the fine powder of 100 μm or less was 2.0 wt%, and the coarse particle of 500 μm or more was 2.3 wt%. Moreover, in this granulated material, the content of the granular material having a particle size in the range of 0.7M to 1.3M was 90 wt% or more.
[0026]
Comparative Example 4
An experiment was conducted in the same manner as in Comparative Example 2 except that 5 kg of lactose was used. The obtained granulated product had an average particle diameter of about 350 μm, fine powders of 100 μm or less were 10.3 wt%, and coarse grains of 500 μm or more were 11.1 wt%.
[0027]
Example 5
In addition to 3 kg of mixed powder consisting of 70 wt% lactose and 30 wt% microcrystalline cellulose (Avicel FD-101), the amount of hemicellulose added was 3.5 wt%, the spray rate was 120 ml / min, and the granulation time was 15 min. The experiment was performed in the same manner as in Example 1. The average particle size of the obtained granulated product was about 250 μm, fine powder of 100 μm or less was 1.0 wt%, and coarse particle of 500 μm or more was 5.9 wt%. Further, in this granulated product, the content of the granulated product having a particle size in the range of 0.7M to 1.3M was 90 wt% or more.
[0028]
Comparative Example 5
In Example 5, an experiment was conducted in the same manner except that a 7 wt% aqueous solution of gum arabic was used instead of the aqueous solution of hemicellulose. However, the spray rate in this case was 80 ml / min, and the granulation time was 30 minutes. The obtained granulated product had an average particle size of about 120 μm, fine powders of less than 100 μm were 27.2 wt%, and coarse particles of 500 μm or more were 3.7 wt%. That is, in this case, the granulation effect is poor and it is not preferable in handling such as powdering.
[0029]
【The invention's effect】
According to the present invention, since a specific combination of a granulating binder and a granulating method is used and a specific granulating condition is adopted, a powder taken into the body of an animal including a human is efficiently used. Granulates well and with high safety. In addition, the granulated product obtained by the present invention has a sharp particle size distribution, good mechanical strength, and excellent handleability and meterability.
[Brief description of the drawings]
FIG. 1 shows a schematic view of a granulating apparatus used for carrying out the method of the present invention.
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 Fluidized bed granulator 2 Gas dispersion plate 3 Gas introduction pipe 4 Gas discharge pipe 5 Spray liquid introduction pipe 6 Spray liquid spray nozzle 7 Filter 8 Heat exchanger 9 Bag filter F Powder fluidized bed

Claims (4)

In a method of granulating a powder of a substance ingested into an animal body into a granular material having an average particle diameter of 100 to 1500 μm, at least a part of the powder is fluidized by an ascending current through a gas dispersion plate. A spray liquid consisting of an aqueous solution of hemicellulose is sprayed as fine droplet particles through the spray nozzle to the formed powder fluidized bed, and a plurality of powder particles are adhered and bonded in the presence of the fine droplet particles of the spray liquid. Including a granulation step to form a granulated product, the spray liquid viscosity is in the range of 3 to 100 mpa · s, and the fine droplet particle diameter of the spray liquid formed by spraying from the spray nozzle is 10 to 200 μm. Furthermore, the content of the granular material in the particle size range of 0.7M to 1.3M (where M is the average particle size of the granulated product) in the obtained granulated material is 75% by weight or more. It is characterized by being Said method. 2. The method according to claim 1, wherein a rotating plate is used as the dispersing plate, and the dispersing plate is rotated so as to obtain a peripheral speed of 30 to 500 m / min, and the granulated material on the dispersing plate is rolled. The method according to claim 1 or 2, wherein the hemicellulose is soybean-derived hemicellulose. A granulated product obtained by the method according to claim 1.

Images