JP3929701B2 - 網膜補綴物 - Google Patents
網膜補綴物 Download PDFInfo
- Publication number
- JP3929701B2 JP3929701B2 JP2000535412A JP2000535412A JP3929701B2 JP 3929701 B2 JP3929701 B2 JP 3929701B2 JP 2000535412 A JP2000535412 A JP 2000535412A JP 2000535412 A JP2000535412 A JP 2000535412A JP 3929701 B2 JP3929701 B2 JP 3929701B2
- Authority
- JP
- Japan
- Prior art keywords
- pulse
- retinal
- duration
- signal
- stimulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002207 retinal effect Effects 0.000 title claims abstract description 79
- 230000000638 stimulation Effects 0.000 claims abstract description 90
- 210000004027 cell Anatomy 0.000 claims abstract description 78
- 210000003050 axon Anatomy 0.000 claims abstract description 26
- 230000002051 biphasic effect Effects 0.000 claims abstract description 23
- 230000004936 stimulating effect Effects 0.000 claims abstract description 20
- 210000003994 retinal ganglion cell Anatomy 0.000 claims abstract description 17
- 210000001525 retina Anatomy 0.000 claims description 23
- 230000003278 mimic effect Effects 0.000 claims description 4
- 230000000737 periodic effect Effects 0.000 claims 1
- 208000003098 Ganglion Cysts Diseases 0.000 abstract description 28
- 208000005400 Synovial Cyst Diseases 0.000 abstract description 28
- 238000000034 method Methods 0.000 abstract description 25
- 230000001413 cellular effect Effects 0.000 abstract description 3
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 1
- 206010034962 Photopsia Diseases 0.000 abstract 1
- 230000007717 exclusion Effects 0.000 abstract 1
- 229910000065 phosphene Inorganic materials 0.000 abstract 1
- 208000007014 Retinitis pigmentosa Diseases 0.000 description 8
- 210000005056 cell body Anatomy 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- 108091008695 photoreceptors Proteins 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 210000002569 neuron Anatomy 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 238000010276 construction Methods 0.000 description 4
- 230000001537 neural effect Effects 0.000 description 4
- 230000000007 visual effect Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 210000001328 optic nerve Anatomy 0.000 description 3
- 201000004569 Blindness Diseases 0.000 description 2
- 206010047571 Visual impairment Diseases 0.000 description 2
- 230000036982 action potential Effects 0.000 description 2
- 230000005786 degenerative changes Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 210000000608 photoreceptor cell Anatomy 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 208000029257 vision disease Diseases 0.000 description 2
- 230000004393 visual impairment Effects 0.000 description 2
- 208000002177 Cataract Diseases 0.000 description 1
- 208000027534 Emotional disease Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 210000000411 amacrine cell Anatomy 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000002469 basement membrane Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000003487 electrochemical reaction Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000004424 eye movement Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 210000002287 horizontal cell Anatomy 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000004126 nerve fiber Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 210000004279 orbit Anatomy 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000000225 synapse Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36046—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the eye
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Electrotherapy Devices (AREA)
- Prostheses (AREA)
- Small-Scale Networks (AREA)
- Maintenance And Management Of Digital Transmission (AREA)
- Communication Control (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/041,932 | 1998-03-13 | ||
| US09/041,932 US5944747A (en) | 1998-03-13 | 1998-03-13 | Method for preferential outer retinal stimulation |
| PCT/US1999/005259 WO1999046001A1 (en) | 1998-03-13 | 1999-03-11 | Method for preferential outer retinal stimulation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002505929A JP2002505929A (ja) | 2002-02-26 |
| JP2002505929A5 JP2002505929A5 (enExample) | 2007-03-08 |
| JP3929701B2 true JP3929701B2 (ja) | 2007-06-13 |
Family
ID=21919111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000535412A Expired - Lifetime JP3929701B2 (ja) | 1998-03-13 | 1999-03-11 | 網膜補綴物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5944747A (enExample) |
| EP (1) | EP1061996B1 (enExample) |
| JP (1) | JP3929701B2 (enExample) |
| AT (1) | ATE287277T1 (enExample) |
| AU (1) | AU739523B2 (enExample) |
| CA (1) | CA2323551C (enExample) |
| DE (1) | DE69923296T2 (enExample) |
| ES (1) | ES2235468T3 (enExample) |
| WO (1) | WO1999046001A1 (enExample) |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6324429B1 (en) * | 1998-05-08 | 2001-11-27 | Massachusetts Eye And Ear Infirmary | Chronically implantable retinal prosthesis |
| EP1864690A3 (en) * | 1999-03-24 | 2008-01-02 | Second Sight Medical Products, Inc. | Logarithmic light intensifier for use with photoreceptorbased implanted retinal prosthetics and those prosthetics |
| US6507758B1 (en) | 1999-03-24 | 2003-01-14 | Second Sight, Llc | Logarithmic light intensifier for use with photoreceptor-based implanted retinal prosthetics and those prosthetics |
| US6389317B1 (en) * | 2000-03-31 | 2002-05-14 | Optobionics Corporation | Multi-phasic microphotodetector retinal implant with variable voltage and current capability |
| US20040039401A1 (en) * | 2000-03-31 | 2004-02-26 | Chow Alan Y. | Implant instrument |
| US6427087B1 (en) | 2000-05-04 | 2002-07-30 | Optobionics Corporation | Artificial retina device with stimulating and ground return electrodes disposed on opposite sides of the neuroretina and method of attachment |
| US7043129B2 (en) * | 2000-06-16 | 2006-05-09 | Wayne State University | Wide bandgap semiconductor waveguide structures |
| US6848295B2 (en) * | 2002-04-17 | 2005-02-01 | Wayne State University | Acoustic wave sensor apparatus, method and system using wide bandgap materials |
| US6970745B2 (en) * | 2000-08-09 | 2005-11-29 | The United States Of America As Represented By The Secretary Of The Navy | Microelectronic stimulator array for stimulating nerve tissue |
| US6647297B2 (en) * | 2000-08-09 | 2003-11-11 | The United States Of America As Represented By The Secretary Of The Navy | Permanent retinal implant device |
| US6560490B2 (en) | 2000-09-26 | 2003-05-06 | Case Western Reserve University | Waveforms for selective stimulation of central nervous system neurons |
| US7103416B2 (en) * | 2001-01-16 | 2006-09-05 | Second Sight Medical Products, Inc. | Visual prosthesis including enhanced receiving and stimulating portion |
| US7149586B2 (en) * | 2002-03-28 | 2006-12-12 | Second Sight Medical Products, Inc. | Variable pitch electrode array |
| US7037943B2 (en) | 2001-04-10 | 2006-05-02 | Optobionics Corporation | Retinal treatment method |
| US20030022374A1 (en) * | 2001-06-22 | 2003-01-30 | Elias Greenbaum | Modulating photoreactivity in a cell |
| US20050004625A1 (en) * | 2001-06-29 | 2005-01-06 | Chow Alan Y. | Treatment of degenerative retinal disease via electrical stimulation of surface structures |
| US7031776B2 (en) * | 2001-06-29 | 2006-04-18 | Optobionics | Methods for improving damaged retinal cell function |
| US20050033202A1 (en) * | 2001-06-29 | 2005-02-10 | Chow Alan Y. | Mechanically activated objects for treatment of degenerative retinal disease |
| DE10151650A1 (de) * | 2001-10-17 | 2003-05-08 | Univ Eberhard Karls | Elektrodenanordnung zur elektrischen Stimulation von biologischem Material sowie Multielektrodenarray zur Verwendung in einer solchen |
| WO2003061537A1 (en) * | 2002-01-17 | 2003-07-31 | Masachusetts Eye And Ear Infirmary | Minimally invasive retinal prosthesis |
| US20040144927A1 (en) * | 2003-01-28 | 2004-07-29 | Auner Gregory W. | Microsystems arrays for digital radiation imaging and signal processing and method for making microsystem arrays |
| US6853075B2 (en) * | 2003-01-28 | 2005-02-08 | Wayne State University | Self-assembled nanobump array stuctures and a method to fabricate such structures |
| US20030204222A1 (en) * | 2002-04-26 | 2003-10-30 | Medtronic, Inc. | Recharge delay for an implantable medical device |
| US7483748B2 (en) * | 2002-04-26 | 2009-01-27 | Medtronic, Inc. | Programmable waveform pulses for an implantable medical device |
| RU2216363C1 (ru) * | 2002-05-21 | 2003-11-20 | Михаил Иванович Хворостенко | Способ изменения функциональной активности клеток тканевой структуры патологического очага живого организма (варианты) |
| WO2004009022A2 (en) | 2002-07-18 | 2004-01-29 | The General Hospital Corp. | Method for augmenting vision in persons suffering from photoreceptor cell degeneration |
| US7565202B2 (en) * | 2002-07-30 | 2009-07-21 | Second Sight Medical Products, Inc. | Field focusing and mapping in an electrode array |
| US7574263B2 (en) * | 2003-01-31 | 2009-08-11 | Second Sight Medical Products, Inc. | Pixel re-mapping for visual prosthesis |
| US20060265057A1 (en) * | 2003-01-31 | 2006-11-23 | Greenberg Robert J | Field focusing and mapping in an electrode array |
| US8014878B2 (en) | 2005-04-28 | 2011-09-06 | Second Sight Medical Products, Inc. | Flexible circuit electrode array |
| US8131375B2 (en) * | 2003-03-21 | 2012-03-06 | Second Sight Medical Products, Inc. | Trans-retinal flexible circuit electrode array |
| US8260428B2 (en) * | 2003-05-01 | 2012-09-04 | California Institute Of Technology | Method and system for training a visual prosthesis |
| US7321796B2 (en) * | 2003-05-01 | 2008-01-22 | California Institute Of Technology | Method and system for training a visual prosthesis |
| US7251528B2 (en) * | 2004-02-06 | 2007-07-31 | Scyfix, Llc | Treatment of vision disorders using electrical, light, and/or sound energy |
| US8103352B2 (en) | 2004-12-03 | 2012-01-24 | Second Sight Medical Products, Inc. | Mimicking neural coding in retinal ganglion cells with short pulse electrical stimulation |
| US7571004B2 (en) | 2005-01-26 | 2009-08-04 | Second Sight Medical Products, Inc. | Neural stimulation for increased persistence |
| EP1858586B1 (en) * | 2005-02-16 | 2016-05-11 | Second Sight Medical Products, Inc. | Fitting of brightness in a visual prosthesis |
| EP2932998B1 (en) | 2005-04-28 | 2019-12-25 | Second Sight Medical Products, Inc. | Flexible circuit electrode array |
| JP4873897B2 (ja) * | 2005-07-29 | 2012-02-08 | 株式会社ニデック | 視覚再生補助装置 |
| WO2007035617A1 (en) * | 2005-09-16 | 2007-03-29 | Second Sight Medical Products, Inc. | Neural stimulation for increased contrast |
| US9913985B2 (en) * | 2006-04-28 | 2018-03-13 | Second Sight Medical Products, Inc. | Method and apparatus to provide safety checks for neural stimulation |
| US7877866B1 (en) * | 2005-10-26 | 2011-02-01 | Second Sight Medical Products, Inc. | Flexible circuit electrode array and method of manufacturing the same |
| US7610098B2 (en) * | 2005-12-20 | 2009-10-27 | Imi Intelligent Medical Implants Ag | Charge-integrating retinal prosthesis and method |
| US7914842B1 (en) | 2006-02-10 | 2011-03-29 | Second Sight Medical Products, Inc | Method of manufacturing a flexible circuit electrode array |
| JP4969882B2 (ja) * | 2006-03-24 | 2012-07-04 | 株式会社ニデック | 視覚再生補助装置 |
| WO2007127444A2 (en) * | 2006-04-28 | 2007-11-08 | Second Sight Medical Products, Inc. | Visual prosthesis fitting |
| US8457754B2 (en) * | 2006-06-16 | 2013-06-04 | Second Sight Medical Products, Inc. | Apparatus and method for electrical stimulation of human neurons |
| US8311634B2 (en) * | 2006-06-16 | 2012-11-13 | Second Sight Medical Products Inc. | Apparatus and method for electrical stimulation of human retina |
| EP2046442B1 (en) * | 2006-06-21 | 2017-01-25 | Second Sight Medical Products, Inc. | Flexible circuit electrode array with at least one tack opening |
| WO2008011096A2 (en) | 2006-07-20 | 2008-01-24 | Second Sight Medical Products, Inc. | Apparatus and method for visual stimulation indication |
| WO2008013937A2 (en) * | 2006-07-28 | 2008-01-31 | Second Sight Medical Products, Inc. | Visual prosthesis |
| US7831309B1 (en) | 2006-12-06 | 2010-11-09 | University Of Southern California | Implants based on bipolar metal oxide semiconductor (MOS) electronics |
| EP2101865B1 (en) * | 2006-12-22 | 2016-03-09 | EBS Technologies GmbH | Apparatus for stimulating a brain of a person |
| WO2008079171A1 (en) * | 2006-12-22 | 2008-07-03 | Second Sight Medical Products, Inc. | Visual prosthetic apparatus for retinal stimulation |
| DE202006021009U1 (de) | 2006-12-22 | 2012-01-05 | Ebs Technologies Gmbh | Vorrichtung zum Stimulieren des Gehirns einer Person |
| US20080183242A1 (en) * | 2007-01-29 | 2008-07-31 | Nidek Co., Ltd. | Electrical stimulation method for vision improvement |
| JP4959377B2 (ja) * | 2007-02-28 | 2012-06-20 | 株式会社ニデック | 視覚再生補助装置 |
| US8798756B2 (en) | 2007-11-07 | 2014-08-05 | Second Sight Medical Products, Inc. | Video processing unit for a visual prosthetic apparatus |
| US8195302B2 (en) * | 2007-11-07 | 2012-06-05 | Second Sight Medical Products, Inc. | Video processing unit for a visual prosthetic apparatus |
| US8195303B2 (en) * | 2007-11-07 | 2012-06-05 | Second Sight Medical Products, Inc. | Video processing unit for a visual prosthetic apparatus |
| HUE028406T2 (en) | 2008-01-07 | 2016-12-28 | Salutaris Medical Devices Inc | Means for minimally invasive extraocular delivery of radiation to the posterior part of the eye |
| US9873001B2 (en) | 2008-01-07 | 2018-01-23 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
| US9056201B1 (en) | 2008-01-07 | 2015-06-16 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
| US8602959B1 (en) | 2010-05-21 | 2013-12-10 | Robert Park | Methods and devices for delivery of radiation to the posterior portion of the eye |
| US8608632B1 (en) | 2009-07-03 | 2013-12-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive extraocular delivery of radiation and/or pharmaceutics to the posterior portion of the eye |
| US10022558B1 (en) | 2008-01-07 | 2018-07-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
| US8340756B2 (en) * | 2008-08-05 | 2012-12-25 | Tony Picciano | Electronic stimulation device |
| USD691270S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to an eye |
| USD691269S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to an eye |
| USD691267S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to eye |
| USD691268S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to eye |
| US8428740B2 (en) | 2010-08-06 | 2013-04-23 | Nano-Retina, Inc. | Retinal prosthesis techniques |
| US8706243B2 (en) | 2009-02-09 | 2014-04-22 | Rainbow Medical Ltd. | Retinal prosthesis techniques |
| US8442641B2 (en) | 2010-08-06 | 2013-05-14 | Nano-Retina, Inc. | Retinal prosthesis techniques |
| US8150526B2 (en) * | 2009-02-09 | 2012-04-03 | Nano-Retina, Inc. | Retinal prosthesis |
| US8718784B2 (en) | 2010-01-14 | 2014-05-06 | Nano-Retina, Inc. | Penetrating electrodes for retinal stimulation |
| US8571669B2 (en) | 2011-02-24 | 2013-10-29 | Nano-Retina, Inc. | Retinal prosthesis with efficient processing circuits |
| EP2686062A4 (en) * | 2011-03-18 | 2014-09-10 | Salk Inst For Biological Studi | METHOD FOR IDENTIFYING NETWORK CELL TYPES USING INTRINSIC PROPERTIES |
| US9370417B2 (en) | 2013-03-14 | 2016-06-21 | Nano-Retina, Inc. | Foveated retinal prosthesis |
| US9990861B2 (en) | 2013-05-28 | 2018-06-05 | Pixium Vision | Smart prosthesis for facilitating artificial vision using scene abstraction |
| US9474902B2 (en) | 2013-12-31 | 2016-10-25 | Nano Retina Ltd. | Wearable apparatus for delivery of power to a retinal prosthesis |
| US9331791B2 (en) | 2014-01-21 | 2016-05-03 | Nano Retina Ltd. | Transfer of power and data |
| US9808625B2 (en) | 2015-05-01 | 2017-11-07 | Second Sight Medical Products, Inc. | Spatial fitting by percept location tracking |
| US9861820B2 (en) | 2015-05-13 | 2018-01-09 | Second Sight Medical Products, Inc. | Cortical visual prosthesis |
| USD814637S1 (en) | 2016-05-11 | 2018-04-03 | Salutaris Medical Devices, Inc. | Brachytherapy device |
| USD815285S1 (en) | 2016-05-11 | 2018-04-10 | Salutaris Medical Devices, Inc. | Brachytherapy device |
| USD814638S1 (en) | 2016-05-11 | 2018-04-03 | Salutaris Medical Devices, Inc. | Brachytherapy device |
| JP6804078B2 (ja) * | 2016-08-26 | 2020-12-23 | 国立大学法人大阪大学 | 眼内閃光発生装置 |
| USD808529S1 (en) | 2016-08-31 | 2018-01-23 | Salutaris Medical Devices, Inc. | Holder for a brachytherapy device |
| USD808528S1 (en) | 2016-08-31 | 2018-01-23 | Salutaris Medical Devices, Inc. | Holder for a brachytherapy device |
| US11338139B2 (en) | 2018-10-01 | 2022-05-24 | Biovisics Medical, Inc. | System and methods for controlled electrical modulation for vision therapy |
| US11305118B2 (en) | 2018-11-30 | 2022-04-19 | Biovisics Medical, Inc. | Head worn apparatuses for vision therapy |
| EP3952979A1 (en) | 2019-04-10 | 2022-02-16 | Biovisics Medical, Inc. | Systems and interfaces for ocular therapy |
| WO2020252278A1 (en) | 2019-06-14 | 2020-12-17 | Biovisics Medical, Inc. | Wearable medical device |
| WO2021011255A1 (en) | 2019-07-12 | 2021-01-21 | Biovisics Medical, Inc. | Ocular therapy modes and systems |
| US20230355973A1 (en) * | 2020-09-24 | 2023-11-09 | University Of Southern California | System and method for restoring color perception to the blind |
| WO2025166287A1 (en) * | 2024-02-01 | 2025-08-07 | I-Lumen Scientific, Inc. | Systems and methods for ocular microstimulation therapy |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4979508A (en) * | 1984-10-09 | 1990-12-25 | Beck Stephen C | Apparatus for generating phosphenes |
| US4664117A (en) * | 1984-10-09 | 1987-05-12 | Beck Stephen C | Apparatus and method for generating phosphenes |
| US4628933A (en) * | 1985-07-23 | 1986-12-16 | Michelson Robin P | Method and apparatus for visual prosthesis |
| US5117826A (en) * | 1987-02-02 | 1992-06-02 | Staodyn, Inc. | Combined nerve fiber and body tissue stimulation apparatus and method |
| US4918745A (en) * | 1987-10-09 | 1990-04-17 | Storz Instrument Company | Multi-channel cochlear implant system |
| EP0325201A3 (de) * | 1988-01-20 | 1990-01-31 | Etama Ag | Stimulationsgerät zur Verbesserung des Sehvermögens des Sehbehinderten |
| US5159927A (en) * | 1989-07-26 | 1992-11-03 | Ferdinand Schmid | Visual prosthesis apparatus and method |
| US5016633A (en) * | 1989-08-08 | 1991-05-21 | Chow Alan Y | Artificial retina device |
| US5024223A (en) * | 1989-08-08 | 1991-06-18 | Chow Alan Y | Artificial retina device |
| RU1799577C (ru) * | 1989-08-17 | 1993-03-07 | Межотраслевой научно-технический комплекс "Микрохирургия глаза" | Способ улучшени зрительных функций при заболевани х зрительного нерва и сетчатки и устройство дл его осуществлени |
| US5109844A (en) * | 1990-10-11 | 1992-05-05 | Duke University | Retinal microstimulation |
| US5476494A (en) * | 1992-09-11 | 1995-12-19 | Massachusetts Institute Of Technology | Low pressure neural contact structure |
| US5556423A (en) * | 1993-05-03 | 1996-09-17 | Alan Y. Chow | Independent photoelectric artificial retina device and method of using same |
| US5397350A (en) * | 1993-05-03 | 1995-03-14 | Chow; Alan Y. | Independent photoelectric artificial retina device and method of using same |
| US5411540A (en) * | 1993-06-03 | 1995-05-02 | Massachusetts Institute Of Technology | Method and apparatus for preferential neuron stimulation |
| US5597381A (en) * | 1993-06-03 | 1997-01-28 | Massachusetts Eye And Ear Infirmary | Methods for epi-retinal implantation |
| US5804566A (en) * | 1993-08-26 | 1998-09-08 | The Regents Of The University Of California | Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides |
| CN1121039A (zh) * | 1994-09-16 | 1996-04-24 | P·J·汤姆生 | 电梯探测器 |
| US5522864A (en) * | 1994-10-25 | 1996-06-04 | Wallace; Larry B. | Apparatus and method for ocular treatment |
| JPH08297465A (ja) * | 1995-04-26 | 1996-11-12 | Hiroshi Yamamoto | 視神経映像出力装置とその方法 |
| AU709207B2 (en) * | 1995-06-06 | 1999-08-26 | Optobionics Corporation | Multi-phasic microphotodiode retinal implant and adaptive imaging retinal stimulation system |
| US5554187A (en) * | 1995-08-18 | 1996-09-10 | Rizzo, Iii; Joseph | Medication dispensing intra-ocular lens system |
-
1998
- 1998-03-13 US US09/041,932 patent/US5944747A/en not_active Expired - Lifetime
-
1999
- 1999-03-11 DE DE69923296T patent/DE69923296T2/de not_active Expired - Lifetime
- 1999-03-11 EP EP99911299A patent/EP1061996B1/en not_active Revoked
- 1999-03-11 JP JP2000535412A patent/JP3929701B2/ja not_active Expired - Lifetime
- 1999-03-11 AU AU29976/99A patent/AU739523B2/en not_active Expired
- 1999-03-11 AT AT99911299T patent/ATE287277T1/de active
- 1999-03-11 WO PCT/US1999/005259 patent/WO1999046001A1/en not_active Ceased
- 1999-03-11 CA CA002323551A patent/CA2323551C/en not_active Expired - Lifetime
- 1999-03-11 ES ES99911299T patent/ES2235468T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1061996A1 (en) | 2000-12-27 |
| US5944747A (en) | 1999-08-31 |
| DE69923296T2 (de) | 2005-06-09 |
| AU2997699A (en) | 1999-09-27 |
| ES2235468T3 (es) | 2005-07-01 |
| JP2002505929A (ja) | 2002-02-26 |
| ATE287277T1 (de) | 2005-02-15 |
| CA2323551C (en) | 2008-07-29 |
| DE69923296D1 (de) | 2005-02-24 |
| CA2323551A1 (en) | 1999-09-16 |
| EP1061996B1 (en) | 2005-01-19 |
| AU739523B2 (en) | 2001-10-18 |
| WO1999046001A1 (en) | 1999-09-16 |
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