JP3779613B2 - Automatic chemical analyzer and inter-reagent interference information providing device - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to an automatic chemical analysis apparatus for analyzing a target sample by reacting a test sample with a reagent and measuring a reaction solution thereof.
[0002]
[Prior art]
2. Description of the Related Art Conventionally, there has been known an automatic chemical analyzer that uses various body fluids of a human body as a sample, causes a chemical reaction by adding a desired reagent to the sample, and obtains the concentration and activity value of a specific component in the sample for diagnosis.
[0003]
In such an automatic chemical analyzer, multiple items are measured at the same time. At this time, interference between reagents may affect the analysis results. A test is performed.
[0004]
Similarly, the inter-reagent interference test is performed when a new item is added or when the reagent is changed.
[0005]
By the way, there are many items measured by such an automatic chemical analyzer, and many reagent manufacturers sell reagents for each item, so it is generally difficult to grasp inter-reagent interference across reagent manufacturers.
[0006]
In addition, preparation of a measurement request for inter-reagent interference test and determination of reagent interference from the test result are laborious operations.
[0007]
[Problems to be solved by the invention]
An object of the present invention is to effectively obtain and provide inter-reagent interference information.
[0008]
[Means for Solving the Problems]
A first aspect of the present invention is based on storage means for storing inter-reagent interference information, means for receiving reagent information from an automatic chemical analyzer, and the received reagent information and inter-reagent interference information stored in the storage means. Necessity determination means for determining whether or not an interference test is necessary, means for generating interference test order information including the necessity of the determined interference test, and the interference test order information from the automatic chemical analyzer or other And means for transmitting to an automatic chemical analyzer.
According to a second aspect of the present invention, in an automatic chemical analyzer that dispenses a measurement target sample and a reagent into a reaction container and measures the reaction liquid to analyze the target sample, the reagent information is input, or the reagent container Means for reading reagent information attached to the device, means for transmitting the reagent information to an external device, means for receiving interference test order information including the necessity of an interference test received from the external device, and the interference test order And a means for performing an interference test when the information includes information necessary for the interference test.
[0011]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, the present invention will be described by way of preferred embodiments with reference to the drawings.
FIG. 1 is a diagram illustrating an overall configuration of an inter-reagent interference information providing system according to the present embodiment. A plurality of automatic chemical analyzers 101 are connected to the server 105 via electronic communication lines 103 such as general public lines and dedicated lines. The server 105 is connected to a database 107 having an arbitrary recording medium such as magnetism, light, and magnetomagnetism in order to store the reagent interference information. The automatic chemical analyzer 101 is positioned as a client that receives various services such as inter-reagent interference information from the server 105.
[0012]
FIG. 2 shows a typical structure of the main body of the automatic chemical analyzer 101. The main body of the automatic chemical analyzer 101 includes reagent containers 2 and 3 in which a reagent rack 1 containing a plurality of reagent bottles 7 containing reagents that react with various components of the sample to be tested can be installed, and a plurality of parts on the circumference. It has a reaction disk 5 in which a reaction tube 4 is arranged, and a disk sampler 6 in which a test sample container in which a test sample is stored is set. The reagent containers 2 and 3, the reaction disk 5, and the disk sampler 6 are each rotated by a driving device. Reagents necessary for measurement are received from the reagent bottle 7 stored in the reagent rack 1 of the reagent store 2 or the reagent store 3 on the reaction disk 5 using the reagent probes 14 and 15 of the reagent dispensing arms 8 and 9, respectively. It is dispensed into the reaction tube 4.
[0013]
The test sample stored in the test sample container 17 arranged on the disk sampler 6 is dispensed into the reaction tube 4 on the reaction disk 5 using the sample arm 10. The reaction tube 4 into which the test sample and the reagent are dispensed moves to the stirring position by the rotation of the reaction disk 5, and the mixed solution of the test sample and the reagent is stirred by the stirring unit 11. Thereafter, the photometric unit 13 performs component analysis of the test sample by irradiating the reaction tube 4 moved to the photometric position with light and measuring the change in absorbance of the mixed solution. Then, the mixed liquid in the reaction tube 4 that has been analyzed is discarded, and then the reaction tube 4 is washed by the washing unit 12.
[0014]
FIG. 3 is a block diagram showing the main components of the automatic chemical analyzer 101 and the server 105. The automatic chemical analyzer 101 is a sequence controller as a dedicated controller for the analyzer main body 111 shown in FIG. 2 to control the operation of each part in accordance with the host controller 113 and the analysis procedure via the data / control bus 112. 114 is connected. A communication device 117 for communicating with the external server 105 is connected to the data / control bus 112 via the operation panel 115, the display 116, and the communication line 103.
[0015]
The server 105 is a database in charge of inputting / outputting information and updating information with respect to the communication device 151, the operation panel 153, and the inter-reagent interference information database 107 via the data / control bus 158 centering on the host controller 152. A controller 154 is connected. Further, an interference information generation unit 155, a test order generation unit 156, a test result analysis unit 157, and a recommended measurement order determination unit 159 are connected to the data / control bus 158.
[0016]
FIG. 4 shows an example of inter-reagent interference information stored in the inter-reagent interference information database 107. The inter-reagent interference information is typically constructed in a table format. In the table, an item that receives interference from an item to be given is displayed in the “item to be given (measurement item)” field that interferes with another measurement. ”Column is associated, and an“ interference reagent information ”column used between the corresponding measurement items and an“ avoidance method ”column are added. Furthermore, in the “Items to be given” and “Items to be received” columns, as the reagent information used in each item, the measurement item (item name), the reagent name as reagent specifying information, and the vendor (manufacturing or sales) of the reagent Manufacturer name) is listed. Also, in the interference information column, the normal sample concentration value when there is no interference, the interference rate indicating how many times (or what percentage) the normal value changes due to interference, and the change due to the interference increases the concentration Up / Down indicating whether it is (Up) or down (Down). Further, in the “avoidance method” column, as a method for avoiding interference between reagents, the type of cleaning agent, the number of times of cleaning, and the objects to be cleaned (reagent probe, stirring bar, reaction tube) are described.
[0017]
Next, the operation of this embodiment will be described with reference to FIG. First, a plurality of measurement items for which inter-reagent interference information is desired are input together with the measurement method and reagent information (reagent name, reagent manufacturer name) via the operation panel 115 of the automatic chemical analyzer 101 (S1). The input method is not limited to direct input by the operator via the operation panel 115, and may be a method of extracting from the analysis test information by the host computer 113, or automatic reading by a reagent barcode or the like.
[0018]
Next, under the control of the host computer 113 of the automatic chemical analyzer 101, a plurality of input measurement items together with reagent information and the like, as a request for examination of interference between reagents, is transmitted to a server 105 installed in a service center or the like. It is transmitted from 117 via the communication line 103 (S2).
[0019]
The host controller 152 of the server 105 that has received the inter-reagent interference review request in S3 searches the database 107 via the database controller 154 using the measurement item name and reagent name requested for review as keywords (S4; database query). If the interference information between the reagents is stored in the database 107 (NO in the test requiring S5), the interference information is reduced to the interference determined by the recommended measurement order determination unit 159 based on the interference information. Along with the recommended measurement order information, the communication device 151 returns the information to the automatic chemical analyzer 101 as the request source via the communication line 103 (S8).
[0020]
Upon receiving the inter-reagent interference information and the recommended measurement order information, the automatic chemical analyzer 101 displays the inter-reagent interference information and the recommended measurement order information on the display 116 under the control of the host controller 113 (S9). The operator can suitably set the actual measurement items together with the order of each sample with reference to the displayed inter-reagent interference information and recommended measurement order information.
[0021]
Here, when the inter-reagent interference information between the measurement items requested for examination and between the reagents is not stored in the database 107 (YES in the test required), the interference between the reagents for the interference test, The test order generation unit 156 generates test request information, and under the control of the host controller 152, the automatic chemical analysis installed exclusively for the request source or interference test from the communication device 151 via the communication line 103. It is transmitted to the apparatus 101 (S10). FIG. 6 shows an example of the test order information. The test order information includes the sample number, the position of the sampler, and measurement items that are required (or unnecessary) for the test. The order in FIG. 6 indicates that the measurement of all measurement items with a circle is required for each sampler position.
[0022]
In the automatic chemical analysis apparatus 101 that has received the test order information, which is the requester of the examination request, or another automatic chemical analysis apparatus 101 that is installed exclusively for testing, a sample prepared according to the test order information under the control of the host controller 113 And the reagent are used to repeat the inter-reagent interference test (S12).
[0023]
As a measurement result obtained by this interference test, for example, sample concentration information is transmitted from the communication device 117 to the server 105 via the communication line 103 under the control of the host controller 113 of the automatic chemical analyzer 101 (S13). Then, the test result analysis unit 157 of the server 105 performs an analysis on inter-reagent interference based on the sample concentration information (S14). Here, the analysis means that the sample concentration as a test result transmitted is the number of times or what percentage, and the numerical value or percentage is relative to a known value when there is no interference in a measurement item that is subject to interference. To get up or down. This analysis may be performed in the automatic chemical analyzer 101. That is, the automatic chemical analyzer 101 may be equipped with the test result analysis unit 157, and the analysis result acquired there may be transmitted to the server 105.
[0024]
The analysis result regarding the inter-reagent interference is reported to the operator of the server 105 site, and interference information generation unit 155 generates new interference information based on the analysis result, and the new interference information is sent to DB controller 154. Via, it is registered in the inter-reagent interference database 107 (S15). Thereafter, through the processes of S7, S8, and S10 described above, the operator refers to the displayed inter-reagent interference information and recommended measurement order information, and suitably sets actual measurement items together with the order of each sample. be able to.
[0025]
As described above, according to the present embodiment, the inter-reagent interference information database can be centrally managed, so that the inter-reagent interference information database can be expanded. It is possible to easily provide an information providing service regarding interference. In addition, in the inter-reagent interference test, it is possible to automate the complicated work of creating a measurement request and analyzing the measurement result, thereby contributing to the efficiency of the inspection work.
[0026]
In the above description, the overall configuration has been described in the database centralized server / client system. However, the present invention is not limited to this.
For example, FIG. 7A shows the overall configuration of a database distributed server-client method. In this configuration, a plurality of automatic chemical analyzers 201 form a group together with the server 305 via the communication line 103. Each of the plurality of automatic chemical analyzers 201 is equipped or attached with a local database 207. In the local database 207, inter-reagent interference information generated by the inter-reagent interference test performed by the corresponding automatic chemical analyzer 201 is mainly stored.
[0027]
Within the group, each automatic chemical analyzer 201 is mutually granted access rights to the local database 207 of the other automatic chemical analyzer 201, and between the reagents for the local database 207 of the other automatic chemical analyzer 201 It is possible to request provision of interference information.
[0028]
Addresses related to inter-reagent interference information and access method information stored in a plurality of local databases 207 in the group are centrally managed by the access point information database 307, and the server 305 When there is a request for provision of inter-reagent interference information from the automatic chemical analyzer 201, the access point information database 307 is searched with the reagent keyword, and the address and access of the local database 207 storing the inter-reagent interference information corresponding thereto. Information on the method is obtained and returned to the automatic chemical analyzer 201 of the request source.
[0029]
The requesting automatic chemical analyzer 201 can access the local database 207 according to the returned access method, and obtain desired inter-reagent interference information by the address via the communication line 103.
[0030]
Further, when there is a request to provide inter-reagent interference information from any of the automatic chemical analyzers 201 in the group, the server 305 searches the access point information database 307 with the reagent keyword, and inter-reagent interfering information corresponding thereto. Information about the address and access method of the local database 207 that stores the information, accesses the local database 207 according to the access method, and communicates the inter-reagent interference information of the address to the requesting automatic chemical analyzer 201 The storage destination local database 207 may be instructed to transmit the data via the line 103.
[0031]
By adopting the database-distributed server-client method as described above, there is an advantage that the burden on the scale of the database can be reduced as compared with the example of FIG. With the adoption of this method, each automatic analyzer 201 includes a database controller 154, an interference information generation unit 155, a test order generation unit 156, a test result analysis unit 157, which are included in the server 105 of FIG. The recommended measurement order determination unit 159 needs to be equipped.
[0032]
FIG. 7B shows the overall configuration of a database self-sustained distribution type. In this configuration, a plurality of automatic chemical analyzers 201 form a group via the communication line 103. Each of the plurality of automatic chemical analyzers 201 is equipped or attached with a local database 207. In the local database 207, inter-reagent interference information generated by the inter-reagent interference test performed by the corresponding automatic chemical analyzer 201 is mainly stored. Within the group, each automatic chemical analyzer 201 is mutually granted access rights to the local database 207 of the other automatic chemical analyzer 201, and between the reagents for the local database 207 of the other automatic chemical analyzer 201 It is possible to request provision of interference information.
[0033]
Each automatic chemical analysis apparatus 201 includes a database controller 154, an interference information generation unit 155, a test order generation unit 156, a test result analysis unit 157, and a recommended measurement order determination unit 159 provided in the server 105 of FIG. The controller 154 can access and search the database 207 of another automatic chemical analysis apparatus 201 to obtain desired inter-reagent interference information.
[0034]
In this database independent distribution type, it is not necessary to centrally manage information management within the group, so that the system can be easily constructed and the group expansion can be flexibly dealt with.
[0035]
(Modification)
The present invention is not limited to the above-described embodiments, and various modifications can be made without departing from the scope of the invention at the stage of implementation. Furthermore, the above embodiment includes various stages, and various inventions can be extracted by appropriately combining a plurality of disclosed constituent elements. For example, some constituent requirements may be deleted from all the constituent requirements shown in the embodiment.
[0036]
【The invention's effect】
According to the present invention, inter-reagent interference information can be obtained and provided effectively.
[Brief description of the drawings]
FIG. 1 is a diagram showing an overall configuration of an inter-reagent interference information providing system according to an embodiment of the present invention.
2 is a diagram showing a typical structure of the automatic chemical analyzer of FIG.
FIG. 3 is a block diagram showing a configuration of main parts of the automatic chemical analyzer and server of FIG. 1;
4 is a diagram showing an example of interference information stored in the inter-reagent interference database of FIG. 1. FIG.
FIG. 5 is a workflow showing the type and flow of information in this embodiment.
6 is a diagram illustrating an example of measurement request information for inter-reagent interference test generated by the test order generation unit in FIG. 3;
FIG. 7 is a diagram showing another configuration example of the inter-reagent interference information providing system in the present embodiment.
[Explanation of symbols]
101 ... Automatic chemical analyzer,
103 ... an electronic communication line,
105 ... server,
107: Inter-reagent interference database,
1 ... Reagent rack,
2 ... Reagent storage,
3 ... Reagent storage,
4 ... reaction tube,
5 ... Reaction disk,
6 ... Sampler,
7 ... Reagent bottle,
8 ... Reagent arm,
9: Reagent arm,
10 ... Sample arm,
11: Stirring unit,
12 ... Cleaning unit,
13 ... Metering unit,
14: Reagent probe,
15 ... Reagent probe,
16 ... Sample probe,
17: Test sample installation position,
111 ... analyzer main body,
112: Data / control bus,
113 ... Host controller,
114 ... Sequence controller,
115 ... operation panel,
116 ... display,
117: Communication device,
151. Communication device,
152 ... Host controller,
153: Operation panel,
154 ... Database controller,
155 ... interference information generation unit,
156 ... Test order generator,
157 ... Test result analysis section,
158 Data / control bus,
159... Recommended measurement order determination unit.

Claims (10)

A storage means for storing inter-reagent interference information;
Means for receiving reagent information from the automatic chemical analyzer;
Necessity determining means for determining the necessity of an interference test based on the received reagent information and inter-reagent interference information stored in the storage means;
Means for generating interference test order information including the necessity of the determined interference test;
Means for transmitting the interference test order information to the automatic chemical analyzer or other automatic chemical analyzer;
An inter-reagent interference information providing apparatus comprising: Means for analyzing interference test result information received from the automatic chemical analyzer or other automatic chemical analyzer and generating inter-reagent interference information;
2. The inter-reagent interference information providing apparatus according to claim 1, wherein the storage unit adds the generated inter-reagent interference information.   The inter-reagent interference information providing apparatus according to claim 2, wherein the inter-reagent interference information includes interference avoidance information.   4. The inter-reagent interference information providing apparatus according to claim 3, further comprising means for determining a recommended measurement order based on the inter-reagent interference information.   5. The inter-reagent interference information providing apparatus according to claim 4, wherein the transmitting unit transmits the recommended measurement order information together with the inter-reagent interference information.   6. The inter-reagent interference information providing apparatus according to claim 5, wherein the recommended measurement order is a measurement order in which the degree of interference between reagents is the smallest. In an automatic chemical analyzer that dispenses a sample to be measured and a reagent into a reaction container, measures the reaction solution and analyzes the sample
Means for inputting reagent information or reading reagent information attached to a reagent container;
Means for transmitting the reagent information to an external device;
Means for receiving interference test order information including necessity of interference test received from the external device;
A means for performing an interference test when the interference test order information includes information necessary for an interference test;
An automatic analyzer characterized by comprising:   8. The automatic analyzer according to claim 7, further comprising means for analyzing the result of the interference test to generate inter-reagent interference information.   9. The automatic chemical analyzer according to claim 8, further comprising storage means for storing the inter-reagent interference information.   9. The automatic chemical analyzer according to claim 8, further comprising means for transmitting the inter-reagent interference information to an external device.

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