JP3618336B2 - Coenzyme Q10-containing composition - Google Patents
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- JP3618336B2 JP3618336B2 JP2003084904A JP2003084904A JP3618336B2 JP 3618336 B2 JP3618336 B2 JP 3618336B2 JP 2003084904 A JP2003084904 A JP 2003084904A JP 2003084904 A JP2003084904 A JP 2003084904A JP 3618336 B2 JP3618336 B2 JP 3618336B2
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Description
【０００１】
【発明の属する技術分野】
本発明は、ビタミン類が存在するにもかかわらず、コエンザイムＱ１０が極めて安定なコエンザイムＱ１０含有組成物に関するものであり、本発明のコエンザイムＱ１０含有組成物は、添加物としてビタミン類が通常配合されている食品、飲料、医薬品および飼料の原料などとして有用なものである。
【０００２】
【従来の技術】
コエンザイムＱ１０は、補酵素として生物活性をもつだけでなく、酵素利用効率を改善させる作用を有するビタミン様作用物質として知られている。
コエンザイムＱ１０は、食品などに配合すると、他の添加物の影響により、非常に不安定である。これは、塩基性物質の影響または添加物との配合禁忌によるものと推察される。また、コエンザイムＱ１０は、他の添加物の影響により、酸化体が還元体に異性化し、分解が促進されるものと推察される。また、コエンザイムＱ１０は光に対しても不安定である。
また、コエンザイムＱ１０は、ビタミン類と併用すると、非常に不安定となることも知られている。ビタミン類は、食品、飲料、医薬品および飼料に通常配合されている添加物であるため、これらの用途へのコエンザイムＱ１０の利用が制限されている。
【０００３】
本出願人は、このようなコエンザイムＱ１０の安定性を改善する方法を研究する中で、ユビデカレノン（コエンザイムＱ１０）と水溶性ビタミン類とを組み合わせて製剤化する場合に、製剤中にゼラチンが存在すると、ユビデカレノンが分解することを見いだし、そして、このユビデカレノンの分解を阻止する方法として、有機酸を製剤中に添加することを提案した（特許文献１を参照）。また、本出願人は、有機酸の存在下、ユビデカレノンなどのユビキノンを水溶性物質の水溶液中に分散・乳化して、保護コロイドを形成させることにより、水性溶液に対する分散安定性及びバイオアベラビリティーを向上させたユビキノン含有製剤を提案した（特許文献２を参照）。
しかし、ビタミン類が通常配合されている食品などに、コエンザイムＱ１０を添加する場合に、該コエンザイムＱ１０の不安定化を阻止することについては言及されていない。
【０００４】
【特許文献１】
特開２００１−３５４５５３号公報
【特許文献２】
特開２００３−５５２０３号公報
【０００５】
【発明が解決しようとする課題】
従って、本発明の目的は、ビタミン類が存在するにもかかわらず、コエンザイムＱ１０が極めて安定であり、添加物としてビタミン類が通常配合されている食品、飲料、医薬品および飼料の原料などとして有用なコエンザイムＱ１０含有組成物を提供することにある。
【０００６】
【課題を解決するための手段】
本発明者らは、上記目的を達成すべく鋭意研究を重ねた結果、無機金属塩を添加することにより、好ましくは無機金属塩および有機酸を添加することにより、ビタミン類存在下におけるコエンザイムＱ10の安定性が極めて高くなることを知見した。
本発明は、上記知見に基づいてなされたもので、コエンザイムＱ10、ビタミン類および鉄塩を含有することを特徴とするコエンザイムＱ10含有組成物を提供するものである。
【０００７】
【発明の実施の形態】
以下、本発明のコエンザイムＱ１０含有組成物の好ましい実施形態について詳細に説明する。
【０００８】
本発明において使用されるコエンザイムＱ１０は、補酵素であるコエンザイム（Ｃｏｅｎｚｙｍｅ）Ｑ類（以下、ＣｏＱと略称する）の一種である。コエンザイムＱ１０の構造は、２，３−ジメチル−５−メチル−６−デカプレニル−１，４−ベンゾキノンであり、人をはじめとする多くの高等動植物のミトコンドリア内膜に存在する呼吸鎖の必須構成成分である。
【０００９】
本発明において使用される鉄塩としては、塩化第二鉄、クエン酸鉄、ピロリン酸第二鉄、乳酸鉄などが好ましい。これらの鉄塩は、２種以上適宜組み合わせて使用することもできる。
上記鉄塩の含有量は、鉄塩の種類などによっても異なるが、通常、コエンザイムＱ10１００質量部に対して、好ましくは１〜５００質量部、より好ましくは５〜４００質量部、最も好ましくは１０〜４００質量部である。上記鉄塩の含有量が１質量部未満では、効果が充分ではなく、上記鉄塩の含有量が多すぎると、効果が更に向上するものでもなく、味などの風味に悪影響を及ぼす。
【００１０】
また、本発明において使用されるビタミン類としては、制限されるものではなく、例えば、ビタミンＢ１ およびその誘導体、ビタミンＢ２ 、ビタミンＢ１２、ビタミンＣ、ビオチン、パントテン酸、ビタミンＡ、ビタミンＥ、β−カロチンおよびその塩類、またはこれらの混合物などが挙げられるが、コエンザイムＱ１０の安定性に悪影響を与えるビタミン類を用いることが、本発明の効果が最大限に発揮されるので好ましい。
上記ビタミン類の含有量は、特に制限はなく、本発明のコエンザイムＱ１０含有組成物が配合される食品、飲料、医薬品および飼料などに応じて適宜決定すればよい。
【００１１】
本発明のコエンザイムＱ10含有組成物には、さらに有機酸を含有させてもよい。
上記有機酸としては、クエン酸、フマル酸、マレイン酸、リンゴ酸、酒石酸、コハク酸、アスパラギン酸、またはこれらの混合物などが挙げられ、その含有量は、有機酸の種類などによっても異なるが、通常、コエンザイムＱ10１００質量部に対して、好ましくは１〜２００質量部、より好ましくは３〜１５０質量部、最も好ましくは３〜１００質量部である。上記有機酸の含有量が少なすぎると、鉄塩との併用効果が充分に発揮されず、上記有機酸の含有量が多すぎても、効果は同程度である。
【００１２】
本発明のコエンザイムＱ１０含有組成物は、一般の食品や飲料、健康食品、カプセル剤、錠剤、顆粒剤、ゼリー飲料、粉剤などのあらゆる食品および医薬品や、飼料などの形態に利用できる。
また、本発明のコエンザイムＱ１０含有組成物を上記の食品、飲料、医薬品または飼料などの形態に利用する場合、これらの食品、飲料、医薬品または飼料に配合する添加物を選定することにより、機能性を変化させることが可能である。例えば、シロップ剤や水易溶性機能を付加させた速溶性粉末の調製、塑性変形能を有した直接打錠可能な粉末とし、チュアブル錠、さらにはこれら機能を複合させた用時溶解型の錠剤、発泡錠の調製用原料としての利用も自由であり、この他、ジュース、スープなどの飲料またはゼリー、プリンなどの嚥下障害者用食品などに添加し、既存の製剤形に限定されない幅広い製剤設計が可能である。
本発明の含有組成物によれば、これらのあらゆる利用形態にコエンザイムＱ１０を安定的に配合、投与、摂取可能である。
【００１３】
【実施例】
以下、実施例をもって本発明を更に詳細に説明するが、本発明は、以下の実施例によって何ら制限を受けるものではない。
【００１４】
実施例１
コエンザイムＱ１０を水に分散させるために、次のようにしてコエンザイムＱ１０の乳化液を調製した。
コエンザイムＱ１０（日清ファルマ（株）製）１００ｇを、グリセリン脂肪酸エステル（日光ケミカルズ（株）製）３００ｇ、グリセリン（日本油脂（株）製）１００ｇおよび精製水５００ｇを用いて、加熱溶解し、乳化機（三和機械（株）製、Ｈ−１１型）により約３００ｋｇ／ｃｍ２ で乳化処理を行い、コエンザイムＱ１０濃度が１０％のコエンザイムＱ１０乳化液を調製した。
上記コエンザイムＱ１０乳化液３ｇ（ＣｏＱ１０として３００ｍｇ）、精製水８００ｇ、クエン酸（田辺製薬（株）製）１．０ｇおよびブドウ糖液（日本食品加工工業（株）製）２００ｇを、室温で攪拌溶解させ、微細なコエンザイムＱ１０が均一に分散したｐＨ３．０〜３．５の黄色のコエンザイムＱ１０含有液を得た。この液に、下記表１に示す量のビタミン類および無機金属塩を添加し、コエンザイムＱ１０含有組成物（検体１〜９および対照１〜４）をそれぞれ得た。これらのコエンザイムＱ１０含有組成物について、以下の保存条件で保存し、ＨＰＬＣを用いて以下の測定条件で、コエンザイムＱ１０の安定性（コエンザイムＱ１０の保存開始時に対しての残存率）を測定した。その結果を下記表２に示す。
【００１５】
コエンザイムＱ１０の安定性の測定条件
検出器；紫外吸光光度計（測定波長：２７５ｎｍ）
カラム；ＨｙｐｅｒｓｉｌＯＤＳ−５ ４．６ｍｍ×１５０ｍｍ
移動相；メタノール／無水エタノール（体積比１３：７）
コエンザイムＱ１０の保存条件
保存温度；５０℃
保存容器；ガラス瓶気密容器
保存期間；４週間
【００１６】
【表１】
【表２】
実施例２
コエンザイムＱ１０（日清ファルマ（株）製）９０ｇ、ビタミンＥ２０ｇ、グリセリン脂肪酸エステル（理研ビタミン（株）製）３５ｇおよび小麦胚芽油（日清ファルマ（株）製）４６０ｇを、アジホモミクサー（特殊機化工業（株）製）を用いて約６０℃で加温溶解し、溶解確認後、３０℃まで冷却し、ビタミンＣ３０ｇ、ビタミンＢ１ ５ｇ、パントテン酸Ｃａ１０ｇおよびクエン酸鉄２５０ｇを添加し、攪拌分散し、冷却し、ソフトカプセル充填液（本発明のコエンザイムＱ１０含有組成物）を得た。このソフトカプセル充填液を用いて通常の方法により１カプセル当たり約３００ｍｇ（ＣｏＱ１０が３０ｍｇ／ｃａｐ）になるように充填を行った。
【００１９】
比較例１
コエンザイムＱ１０（日清ファルマ（株）製）９０ｇ、ビタミンＥ２０ｇ、グリセリン脂肪酸エステル（理研ビタミン（株）製）３５ｇおよび小麦胚芽油（日清ファルマ（株）製）７１０ｇを、アジホモミクサー（特殊機化工業（株）製）を用いて約６０℃で加温溶解し、溶解確認後、３０℃まで冷却し、ビタミンＣ３０ｇ、ビタミンＢ１ ５ｇおよびパントテン酸Ｃａ１０ｇを添加し、攪拌分散し、冷却し、ソフトカプセル充填液を得た。このソフトカプセル充填液を用いて通常の方法により１カプセル当たり約３００ｍｇ（ＣｏＱ１０が３０ｍｇ／ｃａｐ）になるように充填を行った。
【００２０】
上記の実施例２および比較例１で得られたカプセルについて、実施例１と同じ保存条件および測定条件で、コエンザイムＱ１０の安定性（コエンザイムＱ１０の保存開始時に対しての残存率）を測定した。その結果を下記表３に示す。
【００２１】
【表３】
実施例３
コエンザイムＱ１０（日清ファルマ（株）製）９０ｇ、ビタミンＥ２０ｇ、グリセリン脂肪酸エステル（理研ビタミン（株）製）３５ｇおよび小麦胚芽油（日清ファルマ（株）製）５６０ｇを、アジホモミクサー（特殊機化工業（株）製）を用いて約６０℃で加温溶解し、溶解確認後、３０℃まで冷却し、ビタミンＣ３０ｇ、ビタミンＢ１ ５ｇ、パントテン酸Ｃａ１０ｇおよびピロリン酸第二鉄１５０ｇを添加し、攪拌分散し、冷却し、ソフトカプセル充填液（本発明のコエンザイムＱ１０含有組成物）を得た。このソフトカプセル充填液を用いて通常の方法により１カプセル当たり約３００ｍｇ（ＣｏＱ１０が３０ｍｇ／ｃａｐ）になるように充填を行った。
【００２３】
【発明の効果】
本発明のコエンザイムＱ１０含有組成物は、ビタミン類が存在するにもかかわらず、コエンザイムＱ１０が極めて安定であり、添加物としてビタミン類が通常配合されている食品、飲料、医薬品および飼料の原料などとして有用なものである。[0001]
BACKGROUND OF THE INVENTION
The present invention, despite the presence of vitamins, relates Coenzyme Q 10 is very stable coenzyme Q 10 containing composition, Coenzyme Q 10-containing composition of the present invention, vitamins as additives normally It is useful as a raw material for blended foods, beverages, pharmaceuticals and feeds.
[0002]
[Prior art]
Coenzyme Q 10 not only has a biological activity as a coenzyme, known as vitamin-like substance having an action of improving the enzyme efficiency.
Coenzyme Q 10, when compounded like food, due to the influence of other additives, is very unstable. This is presumably due to the influence of basic substances or incompatibility with additives. Moreover, Coenzyme Q 10 is due to the influence of other additives, oxidant is isomerized to reductant, decomposition is presumed to be promoted. In addition, coenzyme Q 10 is unstable against light.
In addition, coenzyme Q 10, when used in combination with vitamins, it is also known to be very unstable. Vitamins, food, beverages, because the pharmaceuticals and feed is additive being typically used, use of coenzyme Q 10 to these applications is limited.
[0003]
The applicant has, in studying a method of improving the stability of such coenzyme Q 10, when formulated in combination with a water soluble vitamins ubidecarenone (Coenzyme Q 10), the gelatin formulation When present, it was found that ubidecarenone was decomposed, and as a method for preventing the decomposition of ubidecarenone, it was proposed to add an organic acid to the preparation (see Patent Document 1). In addition, the present applicant can disperse and emulsify ubiquinone such as ubidecalenone in an aqueous solution of a water-soluble substance in the presence of an organic acid to form a protective colloid, thereby forming dispersion stability and bioavailability in an aqueous solution. A ubiquinone-containing preparation with improved resistance was proposed (see Patent Document 2).
However, such a food vitamins are usually blended in the case of adding coenzyme Q 10, it does not refer to preventing the destabilization of the coenzyme Q 10.
[0004]
[Patent Document 1]
JP 2001-354553 A [Patent Document 2]
Japanese Patent Laid-Open No. 2003-55203
[Problems to be solved by the invention]
Accordingly, an object of the present invention is, despite the presence of vitamins are very stable coenzyme Q 10, food vitamins as additives are typically blended beverages, useful as pharmaceuticals and feed ingredients and to provide a such coenzyme Q 10 containing composition.
[0006]
[Means for Solving the Problems]
As a result of intensive studies to achieve the above-mentioned object, the present inventors have added co-enzyme Q 10 in the presence of vitamins by adding an inorganic metal salt, preferably by adding an inorganic metal salt and an organic acid. It has been found that the stability of is extremely high.
The present invention has been made based on the above findings, and provides a coenzyme Q 10, coenzyme Q 10 containing composition characterized in that it contains vitamins and iron salts.
[0007]
DETAILED DESCRIPTION OF THE INVENTION
It will be described in detail preferred embodiments of the coenzyme Q 10 containing compositions of the present invention.
[0008]
Coenzyme Q 10 used in the present invention is a coenzyme coenzyme (COENZYME) Q acids (hereinafter, abbreviated as CoQ) is a kind of. Structure of coenzyme Q 10 is 2,3-dimethyl-5-methyl-6-decaprenyl-1,4-benzoquinone, essential constituent of the respiratory chain present in the mitochondrial inner membrane of many higher plants and animals, including humans It is an ingredient.
[0009]
The iron salt used in the present invention, ferric chloride, iron citrate, ferric pyrophosphate, etc. iron lactate are preferred. These iron salts can also be used in appropriate combination of two or more.
The content of the iron salt varies depending on the type of iron salt, usually, with respect to coenzyme Q 10 100 parts by weight, preferably 1 to 500 parts by weight, more preferably 5 to 400 parts by weight, and most preferably 10 to 400 parts by mass. Is less than the content of the iron salt is 1 part by weight, the effect is not sufficient, the content of the iron salt is too large, without also intended to further improve the effect, adversely affect the flavor, such as taste.
[0010]
In addition, the vitamins used in the present invention are not limited. For example, vitamin B 1 and its derivatives, vitamin B 2 , vitamin B 12 , vitamin C, biotin, pantothenic acid, vitamin A, vitamin E , beta-carotene and its salts, or mixtures thereof, and the like, the use of vitamins adversely affect the stability of the coenzyme Q 10, preferred because the effect of the present invention is maximized.
The content of the vitamins are not particularly limited, food Coenzyme Q 10-containing composition of the present invention is formulated, the beverage may be suitably determined in accordance with such pharmaceuticals and feed.
[0011]
Coenzyme Q 10-containing composition of the invention may further contain an organic acid.
Examples of the organic acid include citric acid, fumaric acid, maleic acid, malic acid, tartaric acid, succinic acid, aspartic acid, or a mixture thereof, and the content varies depending on the type of organic acid, Usually, it is preferably 1 to 200 parts by mass, more preferably 3 to 150 parts by mass, and most preferably 3 to 100 parts by mass with respect to 100 parts by mass of Coenzyme Q 10 . When the content of the organic acid is too small, the combined effect of the iron salt is not sufficiently exhibited, even too much content of the organic acid, the effect is comparable.
[0012]
Coenzyme Q 10-containing composition of the present invention are generally food and beverages, health foods, capsules, tablets, granules, jelly drink, and all food and pharmaceuticals, such as powders, can be used to form such feed.
Moreover, coenzyme Q 10 containing compositions the food of the present invention, a beverage, when utilized in the form of such pharmaceutical or feed, these foods, beverages, by selecting an additive to be incorporated into pharmaceutical or feed, functional It is possible to change gender. For example, preparation of fast-dissolving powders with syrup and easily water-soluble functions, direct-tabletable powders with plastic deformability, chewable tablets, and tablets that dissolve in use that combine these functions In addition, it can be used as a raw material for preparing effervescent tablets. In addition, it can be added to beverages such as juices and soups or foods for dysphagia such as jelly and pudding. Is possible.
According to containing composition of the present invention, blending a coenzyme Q 10 in these all use form stable, administration, can be ingested.
[0013]
【Example】
EXAMPLES Hereinafter, although an Example demonstrates this invention further in detail, this invention is not restrict | limited at all by the following examples.
[0014]
Example 1
Coenzyme Q 10 in order to disperse in water to prepare an emulsion of coenzyme Q 10 in the following manner.
100 g of coenzyme Q 10 (manufactured by Nisshin Pharma Co., Ltd.) was dissolved by heating using 300 g of glycerin fatty acid ester (manufactured by Nikko Chemicals Co., Ltd.), 100 g of glycerin (manufactured by NOF Corporation) and 500 g of purified water, emulsifier (Sanwa machine Co., Ltd., H-11 type) performs emulsification in the about 300 kg / cm 2, coenzyme Q 10 concentration was prepared with 10% of coenzyme Q 10 emulsion.
3 g of the above coenzyme Q 10 emulsion (300 mg as CoQ 10 ), 800 g of purified water, 1.0 g of citric acid (manufactured by Tanabe Seiyaku Co., Ltd.) and 200 g of glucose liquid (manufactured by Nippon Food Processing Co., Ltd.) are stirred at room temperature. lysed, to obtain a yellow coenzyme Q 10 containing liquid pH3.0~3.5 fine coenzyme Q 10 are uniformly dispersed. To this solution was added vitamins and inorganic metal salt in an amount shown in Table 1 to obtain coenzyme Q 10 containing composition (sample 1-9 and control 1-4), respectively. These coenzyme Q 10 containing composition, and stored under the following storage conditions, the following measurement conditions using HPLC, measuring the stability of the coenzyme Q 10 (residual ratio relative to the time of initiation of storage of coenzyme Q 10) did. The results are shown in Table 2 below.
[0015]
Coenzyme Q 10 stability measurement condition detector; ultraviolet absorption photometer (measurement wavelength: 275 nm)
Column; Hypersil ODS-5 4.6 mm x 150 mm
Mobile phase: methanol / absolute ethanol (volume ratio 13: 7)
Storage conditions for Coenzyme Q 10 Storage temperature; 50 ° C
Storage container; Glass bottle airtight container Storage period: 4 weeks
[Table 1]
[Table 2]
Example 2
Coenzyme Q 10 (Nisshin Pharma Co., Ltd.) 90g, Vitamin E 20g, Glycerin Fatty Acid Ester (Riken Vitamin Co., Ltd.) 35g and Wheat Germ Oil (Nisshin Pharma Co., Ltd.) 460g And dissolved at about 60 ° C., and after confirmation of dissolution, cooled to 30 ° C., added vitamin C 30 g, vitamin B 1 5 g, pantothenic acid Ca 10 g and iron citrate 250 g, It was stirred and dispersed, and cooled to obtain a soft capsule filled solution (coenzyme Q 10-containing composition of the present invention). Using this soft capsule filling solution, filling was carried out by an ordinary method so that each capsule was about 300 mg (CoQ 10 was 30 mg / cap).
[0019]
Comparative Example 1
Coenzyme Q 10 (Nisshin Pharma Co., Ltd.) 90g, Vitamin E 20g, Glycerin Fatty Acid Ester (Riken Vitamin Co., Ltd.) 35g and Wheat Germ Oil (Nisshin Pharma Co., Ltd.) 710g Melted by heating at about 60 ° C. using Kika Kogyo Co., Ltd., and after confirmation of dissolution, cooled to 30 ° C., added 30 g of vitamin C, 5 g of vitamin B 1 and 10 g of pantothenic acid, stirred and dispersed, cooled Thus, a soft capsule filling liquid was obtained. Using this soft capsule filling solution, filling was carried out by an ordinary method so that each capsule was about 300 mg (CoQ 10 was 30 mg / cap).
[0020]
The resulting capsule in the above Example 2 and Comparative Example 1, under the same storage conditions and measurement conditions as in Example 1, measuring the stability of the coenzyme Q 10 (residual ratio relative to the time of initiation of storage of coenzyme Q 10) did. The results are shown in Table 3 below.
[0021]
[Table 3]
Example 3
90 g of Coenzyme Q 10 (Nisshin Pharma Co., Ltd.), 20 g of vitamin E, 35 g of glycerin fatty acid ester (Riken Vitamin Co., Ltd.) and 560 g of wheat germ oil (Nisshin Pharma Co., Ltd.) Melted by heating at about 60 ° C. using Kika Kogyo Co., Ltd., and after confirmation of dissolution, cooled to 30 ° C., added vitamin C 30 g, vitamin B 1 5 g, pantothenic acid Ca 10 g and ferric pyrophosphate 150 g and it was stirred and dispersed, and cooled to obtain a soft capsule filled solution (coenzyme Q 10-containing composition of the present invention). Using this soft capsule filling solution, filling was carried out by an ordinary method so that each capsule was about 300 mg (CoQ 10 was 30 mg / cap).
[0023]
【The invention's effect】
Coenzyme Q 10-containing composition of the invention, despite the presence of vitamins are very stable coenzyme Q 10, food vitamins as additives are typically blended beverages, pharmaceuticals and feed ingredients It is useful as such.
Claims (5)
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| JP2006217807A (en) * | 2005-02-08 | 2006-08-24 | Yakult Honsha Co Ltd | Food and drink |
| JP5283359B2 (en) * | 2007-08-30 | 2013-09-04 | 株式会社カネカ | Composition containing reduced coenzyme Q |
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