JP3524169B2 - Skin cosmetics for acne improvement - Google Patents
Skin cosmetics for acne improvementInfo
- Publication number
- JP3524169B2 JP3524169B2 JP25279994A JP25279994A JP3524169B2 JP 3524169 B2 JP3524169 B2 JP 3524169B2 JP 25279994 A JP25279994 A JP 25279994A JP 25279994 A JP25279994 A JP 25279994A JP 3524169 B2 JP3524169 B2 JP 3524169B2
- Authority
- JP
- Japan
- Prior art keywords
- skin
- acid
- acne
- examples
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Cosmetics (AREA)
Description
【発明の詳細な説明】
【０００１】
【発明の属する技術分野】本発明は、常在菌叢に影響を
与えずPropionibacterium acnes ( 以下、P.acnes と略
称する。) の生育を特異的に抑制するニキビ改善効果、
および安全性に優れたニキビ改善用皮膚化粧料に関す
る。
【０００２】
【従来の技術】従来、108 ／cm2 を越えるP.acnes が皮
膚に生育し、細菌のリパーゼにより皮脂が分解されて生
じた脂肪酸による炎症を含むニキビに悩む若年者用に、
殺菌力のある抗菌性物質等が応用されてきた。そのた
め、有害な細菌のみならず、皮膚表面に生育して、脂質
の分解や、アルカリ中和能等の皮膚生理作用において有
用な役割を持つ細菌Staphylococcus epidermidis等にた
いしても生育抑制をする欠点があった。
【０００３】またステアリン酸、ラウリン酸、ペンタデ
カン酸またはパルミトレイン酸を含む皮膚化粧料は従来
から知られているが、皮膚刺激、皮膚上細菌叢に及ぼす
影響の配慮に欠け、必ずしもニキビを改善する効果は得
られなかった。
【０００４】
【発明が解決しようとする課題】本発明の目的は、常在
菌叢に影響を与えずP.acnes の生育を特異的に抑制する
ニキビ改善効果、および安全性に優れた皮膚化粧料を提
供することにある。
【０００５】
【課題を解決するための手段】本発明者は、上記ニキビ
改善効果および安全性に優れた脂肪酸またはそのエステ
ル類について鋭意検討した結果、Ｓ．ｅｐｉｄｅｒｍｉ
ｄｉｓを中心とする常在菌叢に影響を与えず、ステアリ
ン酸、ラウリン酸またはそのグリセリルエステルもしく
はコレステリルエステルの少なくとも２種以上と、ペン
タデカン酸、パルミトレイン酸またはそのグリセリルエ
ステルもしくはコレステリルエステルの少なくとも２種
以上とを配合することによりＰ．ａｃｎｅｓが１０８／
ｃｍ２を越えて皮膚に生育していても抑制効果を示し、
かつ安全性に優れていることを見出し、本発明を完成し
た。
【０００６】本発明に用いられるステアリン酸、ラウリ
ン酸、そのグリセリルエステルもしくはコレステリルエ
ステル、ペンタデカン酸、パルミトレイン酸またはその
グリセリルエステルもしくはコレステリルエステルとし
ては、化学合成物または市販されている化合物などが挙
げられる。
【０００７】本発明に用いられるステアリン酸、ラウリ
ン酸またはそのグリセリルエステルもしくはコレステリ
ルエステルの配合量としては、化粧料総量を基準として
１〜５０重量％（以下、重量％を％として略称する。）
が好ましい。１％未満では本発明の目的とする効果は充
分得難く、また５０％を越えてもその増加分に見合った
効果の向上は認めがたい。
【０００８】また、本発明に用いられるペンタデカン
酸、パルミトレイン酸またはそのグリセリルエステルも
しくはコレステリルエステルの配合量としては、0.0001
〜１％が好ましい。該用量で、充分なS.epidermidis を
中心とするその他の菌叢を維持される。0.0001％未満で
は本発明の目的とする効果は充分得難く、また１％を越
えると逆のP.acnes 生育促進効果を生じ本発明の効果向
上は認めがたい。
【０００９】本発明で用いられるステアリン酸、ラウリ
ン酸またはそのグリセリルエステルもしくはコレステリ
ルエステルの内、２種以上とペンタデカン酸、パルミト
レイン酸またはそのグリセリルエステルもしくはコレス
テリルエステルの内、２種以上とを組み合わせて配合す
ることは、ニキビ改善効果を著明にさせる点で特に好ま
しい。
【００１０】本発明の皮膚化粧料の剤型としては、特に
限定されるものではないが、例えば、軟膏剤、ローショ
ン剤、パップ剤、ゲル剤、クリーム剤、液剤、スプレー
剤、入浴剤および貼付剤などが挙げられる。通常許容さ
れる医薬または化粧料などの原料から成る基剤に配合し
たもので良い。
【００１１】
【実施例】本発明の実施例を説明するに先立ち、皮膚刺
激試験およびニキビ治療効果試験について示す。
【００１２】（１）皮膚刺激試験
被験者２５名の前腕屈側部皮膚に、試料0.05ｇを直径1.
0 cmの円形ろ紙のついた貼付試験用判創膏を用いて24時
間の閉塞貼付を行った。次いで、下記表１の判定基準に
従って、判創膏除去１時間後、２４時間後の判定を実施
した。判定結果は、反応の強い方の評価を採用し、被験
者２５名のうち評価が（±）以上と判定された人の数で
示した。
【００１３】
【表１】
【００１４】（２）ニキビ治療効果試験
顔面がニキビ症状を有する被験者２５名の左部に対照品
（脂肪酸類無しの組成物）を右部には実施例あるいは比
較例の試験品を各々１日に朝夕２回ずつ１ヵ月間連続塗
布した。次いで、ニキビ疾患部の治療効果を下記表２の
判定基準に従って、半顔比較法により判定した。判定結
果は、評価点の平均値で示した。
【００１５】
【表２】
【００１６】以下、実施例および比較例によって本発明
を更に詳細に説明する
【００１７】実施例１〜５、比較例１〜４
【００１８】（１）ローション
ローション基剤に脂肪酸類をそれぞれ表３に記載の如く
配合した各試料を調製し、試験に使用した。
【００１９】
【表３】【００２０】（２）調製法
表３に示す脂肪酸混合物、エタノール、可溶化剤、プロ
ピレングリコールを精製水に溶解した。必要に応じて加
熱溶解後、組成総量が１００ｗｔ％となるように残量の
精製水を加えて均一に混合し、表４記載の実施例１〜
５、比較例１〜４のローションをそれぞれ調製した。
【００２１】（３）特性
実施例１〜５、比較例１〜４のにきび治療効果試験の結
果を表４に示す。表４に示す如く、実施例１〜５の脂肪
酸混合物を配合したローションは、明らかに高いニキビ
治療効果が認められた。また、ヒト皮膚貼付試験におけ
る皮膚刺激性は認められなかった。一方、比較例１〜４
の脂肪酸の一部を除去したローションは、ニキビ治療効
果が低く、一部ヒト皮膚貼付試験における皮膚刺激性が
高かった。
【００２２】
【表４】
【００２３】実施例６〜10、比較例５〜８
【００２４】
【表５】【００２５】（２）調製法
表５のＡ及びＢ成分を、各々８０℃に加熱溶解したもの
を混合した後、攪拌しつつ室温まで冷却して、表６記載
の実施例６〜１０、比較例５〜８のスキンクリームをそ
れぞれ調製した。
【００２６】（３）特性
実施例６〜１０、比較例５〜８のニキビ治療効果試験の
結果を表６に示す。表６に示す如く、実施例６〜１０の
脂肪酸コレステリルエステルを配合したスキンクリーム
は明らかに高いニキビ治療効果が認められた。また、ヒ
ト皮膚貼付試験における皮膚刺激性は認められなかっ
た。一方、比較例５〜８の脂肪酸コレステリルエステル
の一部を除去したスキンクリ−ムは、ニキビ治療効果が
低く、一部ヒト皮膚貼付試験における皮膚刺激性が高か
った。
【００２７】
【表６】【００２８】
【発明の効果】以上の記載から、本発明は、常在菌叢に
影響を与ないニキビ改善効果、および安全性に優れたニ
キビ改善用皮膚化粧料を提供できることは明らかであ
る。Description: TECHNICAL FIELD [0001] The present invention specifically inhibits the growth of Propionibacterium acnes (hereinafter abbreviated as P. acnes) without affecting the indigenous flora. Acne improvement effect,
And a skin cosmetic for acne improvement excellent in safety. 2. Description of the Related Art Conventionally, P. acnes exceeding 10 8 / cm 2 grows on the skin, and for young people suffering from acne including inflammation caused by fatty acids produced by the decomposition of sebum by bacterial lipase,
Bactericidal antibacterial substances and the like have been applied. Therefore, there is a defect that not only harmful bacteria, but also growth on the skin surface, growth of lipids, and bacteria, such as Staphylococcus epidermidis, which has a useful role in skin physiological actions such as alkali neutralization ability, have a defect of inhibiting growth. . [0003] Further, skin cosmetics containing stearic acid, lauric acid, pentadecanoic acid or palmitoleic acid have been known, but they do not take into account the effects on skin irritation and bacterial flora on the skin, and do not necessarily improve acne. Was not obtained. [0004] An object of the present invention is to provide an acne-improving effect that specifically suppresses the growth of P. acnes without affecting the indigenous flora, and a skin cosmetic that is excellent in safety. Is to provide a fee. The inventors of the present invention have conducted intensive studies on the above-mentioned fatty acids or esters thereof excellent in acne improvement effect and safety. epidermi
without affecting the normal flora around the dis, stearic acid, and at least two or more of lauric acid or glyceryl esters or cholesteryl ester, pentadecanoic acid, palmitoleic acid or at least two of the glyceryl esters or cholesteryl ester
By mixing the above with P.I. acnes is 10 8 /
Even if it grows on the skin beyond cm 2 , it shows an inhibitory effect,
The inventors have found that the present invention is excellent in safety and completed the present invention. Examples of stearic acid, lauric acid, glyceryl ester or cholesteryl ester thereof, pentadecanoic acid, palmitoleic acid or glyceryl ester or cholesteryl ester thereof used in the present invention include chemically synthesized compounds and commercially available compounds. The amount of stearic acid, lauric acid or glyceryl ester or cholesteryl ester thereof used in the present invention is 1 to 50% by weight (hereinafter, weight% is abbreviated as%) based on the total amount of the cosmetic.
Is preferred. If it is less than 1%, the desired effect of the present invention is not sufficiently obtained, and if it exceeds 50%, the effect corresponding to the increase cannot be recognized. The compounding amount of pentadecanoic acid, palmitoleic acid or glyceryl ester or cholesteryl ester thereof used in the present invention is 0.0001.
~ 1% is preferred. At this dose, sufficient other flora centered on S. epidermidis is maintained. If the amount is less than 0.0001%, the desired effect of the present invention is not sufficiently obtained. If the amount exceeds 1%, the opposite effect of promoting P. acnes growth is produced, and the improvement of the effect of the present invention is hardly recognized. [0009] Two or more of stearic acid, lauric acid or glyceryl ester or cholesteryl ester thereof and pentadecanoic acid, palmitoleic acid or two or more of glyceryl ester or cholesteryl ester thereof used in the present invention are combined. It is particularly preferable to make the acne improvement effect remarkable. [0010] The form of the skin cosmetic of the present invention is not particularly limited. For example, ointments, lotions, cataplasms, gels, creams, liquids, sprays, bath preparations and patches Agents and the like. It may be compounded with a base composed of raw materials such as generally accepted medicines or cosmetics. EXAMPLES Before describing the examples of the present invention, a skin irritation test and a test for treating acne are shown. (1) Skin irritation test 0.05 g of a sample having a diameter of 1.0 g was applied to the skin of the flexion side of the forearm of 25 subjects.
A 24-hour occlusive patch was performed using a patch for patch test with a 0 cm circular filter paper. Then, according to the criterion shown in Table 1 below, the judgment was made 1 hour and 24 hours after the bandage removal. The result of the determination was the evaluation of the person with the strongest response, and was represented by the number of persons judged to be (±) or higher among the 25 subjects. [Table 1] (2) Acne treatment effect test Control subjects (compositions containing no fatty acids) were placed on the left side of 25 subjects with acne symptoms on the right side, and test products of Examples or Comparative Examples were placed on the right side for one day. Was continuously applied twice a morning and evening for one month. Next, the therapeutic effect of the acne diseased part was determined by the half-face comparison method according to the criteria shown in Table 2 below. The judgment result was shown by the average value of the evaluation points. [Table 2] Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples. Examples 1 to 5 and Comparative Examples 1 to 4 (1) Fatty acids as a lotion lotion base are shown in Table 3. Each sample formulated as described in was prepared and used for the test. [Table 3] (2) Preparation method The fatty acid mixture, ethanol, solubilizing agent and propylene glycol shown in Table 3 were dissolved in purified water. After heating and dissolving as needed, the remaining amount of purified water was added and uniformly mixed so that the total composition became 100 wt%.
5, lotions of Comparative Examples 1 to 4 were prepared. (3) Characteristics Table 4 shows the results of the acne treatment effect tests of Examples 1 to 5 and Comparative Examples 1 to 4. As shown in Table 4, the lotion containing the fatty acid mixture of Examples 1 to 5 clearly showed a high acne treatment effect. Further, no skin irritation was observed in the human skin sticking test. On the other hand, Comparative Examples 1-4
The lotion from which a part of the fatty acid was removed had a low acne treatment effect and a high skin irritancy in a human skin patch test. [Table 4] Examples 6 to 10 and Comparative Examples 5 to 8 (2) Preparation method After mixing the components A and B in Table 5 by heating and dissolving each at 80 ° C., the mixture was cooled to room temperature with stirring. The skin creams of Examples 5 to 8 were respectively prepared. (3) Characteristics Table 6 shows the results of the acne treatment effect tests of Examples 6 to 10 and Comparative Examples 5 to 8. As shown in Table 6, the skin cream containing the fatty acid cholesteryl ester of Examples 6 to 10 clearly showed a high acne treatment effect. In addition, no skin irritation was observed in the human skin application test. On the other hand, the skin creams of Comparative Examples 5 to 8 from which a part of the cholesteryl fatty acid ester was removed had a low acne treatment effect and a high skin irritancy in a part of a human skin sticking test. [Table 6] From the above description, it can be seen that the present invention provides an acne-improving effect that does not affect the indigenous flora and an excellent safety .
It is clear that a skin cosmetic for improving millet can be provided.
フロントページの続き (56)参考文献 特開 昭59−134710（ＪＰ，Ａ) 特開 平５−221849（ＪＰ，Ａ) 特開 昭64−79114（ＪＰ，Ａ) 特開 平１−110610（ＪＰ，Ａ) 特表 平４−504562（ＪＰ，Ａ) 米国特許5231087（ＵＳ，Ａ) 国際公開94／18943（ＷＯ，Ａ１) (58)調査した分野(Int.Cl.7，ＤＢ名) A61K 7/00 - 7/50 ＣＡ（ＳＴＮ) ＲＥＧＩＳＴＲＹ（ＳＴＮ)Continuation of the front page (56) References JP-A-59-134710 (JP, A) JP-A-5-221849 (JP, A) JP-A 64-79114 (JP, A) JP-A-1-110610 (JP) JP-A-4-504562 (JP, A) U.S. Pat. No. 5,310,872 (US, A) WO 94/18943 (WO, A1) (58) Fields investigated (Int. Cl. 7 , DB name) A61K7 / 00-7/50 CA (STN) REGISTRY (STN)
Claims (1)
のステアリン酸、ラウリン酸またはそのグリセリルエス
テルもしくはコレステリルエステルの少なくとも２種以
上と、化粧料総量を基準として０．００１〜１重量％の
ペンタデカン酸、パルミトレイン酸またはそのグリセリ
ルエステルもしくはコレステリルエステルの少なくとも
２種以上とを配合することを特徴とするニキビ改善用皮
膚化粧料。(57) [Claims 1] 1 to 50% by weight based on the total amount of cosmetics
Stearic acid, lauric acid or glyceryl ester or cholesteryl ester thereof, and at least two kinds of pentadecanoic acid, palmitoleic acid or glyceryl ester or cholesteryl ester thereof in an amount of 0.001 to 1% by weight based on the total amount of the cosmetic. A skin cosmetic composition for improving acne, comprising:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25279994A JP3524169B2 (en) | 1994-09-20 | 1994-09-20 | Skin cosmetics for acne improvement |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25279994A JP3524169B2 (en) | 1994-09-20 | 1994-09-20 | Skin cosmetics for acne improvement |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0892058A JPH0892058A (en) | 1996-04-09 |
| JP3524169B2 true JP3524169B2 (en) | 2004-05-10 |
Family
ID=17242402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP25279994A Expired - Fee Related JP3524169B2 (en) | 1994-09-20 | 1994-09-20 | Skin cosmetics for acne improvement |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3524169B2 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5738856A (en) * | 1995-11-03 | 1998-04-14 | Ocular Research Of Boston, Inc. | Skin care preparation and method |
| DE102005019951A1 (en) * | 2005-04-27 | 2006-11-09 | Beiersdorf Ag | Cosmetic preparations containing pristanic acid |
| JP6650276B2 (en) * | 2016-01-21 | 2020-02-19 | 大東化成工業株式会社 | Antibacterial pigment and antibacterial composition |
| JP6815006B2 (en) * | 2016-11-01 | 2021-01-20 | 株式会社桃谷順天館 | Acne strain selective antibacterial agent |
| MX2019010822A (en) * | 2017-03-16 | 2019-10-30 | Unilever Nv | An antimicrobial composition comprising essential oil and antimicrobial lipid. |
-
1994
- 1994-09-20 JP JP25279994A patent/JP3524169B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0892058A (en) | 1996-04-09 |
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