JP3519767B2 - Cataplasm - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a poultice containing horse chestnut seed extract, which has a high adhesive strength and can be supplied in a stable physical property even when stored for a long period of time.

[0002]

2. Description of the Related Art Horse chestnut (Aesculus)
hippocastanum L. ) Seeds have been used in Germany since ancient times as a folk medicine for hemorrhoids, uterine bleeding, etc. The active ingredient is aesci, a triterpene saponin
n, kryptoaescin, various flavones, coumarins, etc. are known and are currently used in many dosage forms such as varicose veins, hemorrhoids, swelling at trauma, treatment for pain relief, oral medication, injections, ointments, etc. There is. Under such circumstances, recently, horse chestnut seed extract has been incorporated into poultices, and products expecting the effect have been introduced. However,
Since these poultices are low in tackiness, they have been peeled off or turned over during use, so that the effect of horse chestnut seed extract cannot be sufficiently exerted. In addition, it was not possible to design a formulation for improving the adhesive strength of a poultice containing a horse chestnut seed extract due to the influence of various active ingredients in the horse chestnut seed extract.

[0003]

DISCLOSURE OF THE INVENTION The present invention provides a poultice that has high adhesion even when horse chestnut seed extract is mixed in a poultice base, and has no back bleeding even when stored for a long period of time. It is provided.

[0004]

[Means for Solving the Problems] The inventors of the present invention prevent the decrease in the adhesive strength when blending horse chestnut seed extract into a poultice base containing sodium polyacrylate, polyacrylic acid, and a cellulose derivative, and As a result of keen search for prevention of back bleeding by storage, it was found that the above object can be achieved by adding ethylenediaminetetraacetic acid or a salt thereof, and the present invention has been completed. That is, the poultice of the present invention is a water-containing poultice containing one or more water-soluble polymers selected from polyacrylic acid, sodium polyacrylate, and cellulose derivatives. 20
.About.3.50% by weight and 0.01 to 1.2% by weight of ethylenediaminetetraacetic acid and / or a salt thereof.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION In the hydrous poultice containing horse chestnut seed extract of the present invention, ethylenediaminetetraacetic acid or a salt thereof is used.
~ 3K salt, etc., and 0.01 to 1.2 in the poultice base
By blending the composition in an amount of% by weight, it is possible to expect a sufficient effect of preventing a decrease in adhesive strength and preventing back blurring. It is preferable to add 0.02 to 0.7% by weight. If the blending amount is less than 0.01%, sufficient adhesive force cannot be obtained, and the blending amount is 1.5
If it exceeds%, back bleeding occurs during long-term storage.

The horse chestnut seed extract used in the present invention comprises horse chestnut seeds containing hydrous ethanol,
Alternatively, a soft extract that has been concentrated under reduced pressure after extraction with ethanol,
Alternatively, a powder extract can be used. The blended amount of horse chestnut seed extract is 0.20 to 3.5.
A sufficient effect can be exhibited by adjusting the content to be wt%. 0.20
If it is less than 3.5% by weight, a sufficient effect cannot be obtained, and if it exceeds 3.5% by weight, coloring of the base material becomes remarkable, which causes problems such as aesthetic appearance and adhesion to clothes.

Specific examples of sodium polyacrylate used in the present invention include Aronbis M, SS (manufactured by Nippon Pure Chemical Co., Ltd.), Viscomate P-460, P-480 (manufactured by Showa Denko) and the like. Specifically, Jurimer AC10H, AC10SH (manufactured by Nippon Pure Chemical Co., Ltd.) or the like can be used. Further, as the cellulose derivative, carboxymethyl cellulose, methyl cellulose,
Hydroxypropyl cellulose or the like is used, and specifically, CMC1250, CMC1100 (manufactured by Daicel Chemical), Metroze 60SH, 90SH (manufactured by Shin-Etsu Chemical) or the like can be used.

As the other components, conventionally used components such as mineral powder, water-soluble polymers other than the above, humectants, polyvalent metal salts and the like can be appropriately used. Examples of mineral powders include kaolin, talc, titanium oxide, zinc oxide, silicic acid anhydride, bentonite, and montmorillonite.

Examples of water-soluble polymers other than the above include polyvinyl alcohol, polyvinylpyrrolidone, pectin, sodium alginate, xanthan gum and the like. Examples of the moisturizer include glycerin, sorbitol, propylene glycol, maltitol, ethylene glycol and the like. Examples of the polyvalent metal compound include aluminum hydroxide, potassium aluminum sulfate, aluminum chloride, synthetic hydrotalcite, dihydroxyaluminum aminoacetate, magnesium aluminometasilicate and the like.

The water content of the plaster is preferably 30 to 60%, and if necessary, anti-inflammatory agents such as glycol salicylate, methyl salicylate, indomethacin, ketoprofen and flurbiprofen, menthol, camphor, A cooling agent such as thymol and eucalyptus, vitamin E, a vitamin E derivative, capsaicin, nonyl acid vanillyl amide, cinnamon oil and the like can be added as a blood flow promoter. The poultice of the present invention can be produced by applying a plaster on a support by a known method.

[0011]

EFFECTS OF THE INVENTION According to the present invention, it is possible to obtain a poultice containing horse chestnut seed extract, which has high adhesive strength and has no back bleeding even after long-term storage.

[0012]

【Example】

Example 1 A solution of 0.02 part by weight of disodium ethylenediaminetetraacetate dissolved in purified water and 0.25 part by weight of horse chestnut seed extract were mixed with various bases, active ingredients and the like using a Henschel mixer according to a conventional method. Knead with. Immediately after the production, a stretchable nonwoven fabric made of 100% polyester fiber was coated and cut so that the weight per sheet (140 × 100 mm) was 14 g to obtain a poultice of Example 1 having the composition shown in Table 1. The obtained poultice was stored in a thermostatic chamber at 40 ° C., and the adhesive strength was evaluated up to 6 months later (JIS Z0237).
Ball tack value measurement), back bleeding evaluation (sensory 4-step evaluation), and actual use evaluation (peeling agent was applied to elbows of 15 healthy males and peeling and swelling were observed after 6 hours).
From the adhesive strength evaluation result (Table 3), the back bleeding evaluation result (Table 5), and the actual use evaluation result (Table 7), the product of the present invention has the same high adhesive strength as the initial one even after 40 ° C. and 6 months have passed. Maintaining bleeding control, and from all panelists in actual use,
Excellent evaluation results with less peeling and turning over were obtained. In addition, since the adhesive surface is strong and the ability to follow the skin is good, the drug surface does not peel off from the affected area. Therefore, in the rat carrageenin paw edema test shown in Table 17, it was also confirmed that it has an excellent anti-inflammatory effect. Was done.

Example 2 A solution prepared by heating 0.35 parts by weight of disodium ethylenediaminetetraacetate in purified water and 0.5 parts by weight of horse chestnut seed extract were mixed with various bases using a Henschel mixer according to a conventional method. Knead with active ingredients. Immediately after the production, a stretchable non-woven fabric made of 100% polyester fiber was coated and cut so that the weight per sheet (140 × 100 mm) was 14 g to obtain a poultice of Example 2 having the composition shown in Table 1. The obtained poultice is stored in a constant temperature room at 40 ° C,
Adhesiveness evaluation up to 6 months (JIS Z0237 ball tack value measurement), back bleeding evaluation (four-level evaluation by sensory), actual use evaluation (peeling agent was applied to elbows of 15 healthy males and peeled off after 6 hours, Observe the curl). From the adhesive strength evaluation result (Table 3), the back bleeding evaluation result (Table 5), and the actual use evaluation result (Table 7), the product of the present invention has the same high adhesive strength as the initial one even after 40 ° C. and 6 months have passed. An excellent evaluation result was obtained in which bleeding suppression was maintained and peeling and curling were small in actual use from all panelists. In addition, since the adhesive surface is strong and the ability to follow the skin is good, the drug surface does not peel off from the affected area. Therefore, in the rat carrageenin paw edema test shown in Table 17, it was also confirmed that it has an excellent anti-inflammatory effect. Was done.

Example 3 A solution prepared by heating 1.00 parts by weight of disodium ethylenediaminetetraacetate in purified water and 1.5 parts by weight of horse chestnut seed extract were mixed with various bases by a conventional method using a Henschel mixer. Knead with active ingredients. Immediately after production, a stretchable nonwoven fabric made of 100% polyester fiber was coated and cut so that the weight per sheet (140 × 100 mm) was 14 g to obtain a poultice of Example 3 having the composition shown in Table 1. The obtained poultice is stored in a constant temperature room at 40 ° C,
Adhesiveness evaluation up to 6 months (JIS Z0237 ball tack value measurement), back bleeding evaluation (four-level evaluation by sensory), actual use evaluation (peeling agent was applied to elbows of 15 healthy males and peeled off after 6 hours, Observe the curl). From the adhesive strength evaluation result (Table 3), the back bleeding evaluation result (Table 5), and the actual use evaluation result (Table 7), the product of the present invention has the same high adhesive strength as the initial one even after 40 ° C. and 6 months have passed. An excellent evaluation result was obtained in which bleeding suppression was maintained and peeling and curling were small in actual use from all panelists. In addition, since the adhesive surface is strong and the ability to follow the skin is good, the drug surface does not peel off from the affected area. Therefore, in the rat carrageenin paw edema test shown in Table 17, it was also confirmed that it has an excellent anti-inflammatory effect. Was done.

Example 4 A solution prepared by heating 0.20 part by weight of tetrasodium ethylenediaminetetraacetate in purified water and 2.5 parts by weight of horse chestnut seed extract were mixed with various bases using a Henschel mixer according to a conventional method. Knead with active ingredients. Immediately after production, a stretchable non-woven fabric made of 100% polyester fiber was coated and cut so that the weight per sheet (140 × 100 mm) was 14 g to obtain a poultice of Example 4 having the composition shown in Table 2. The obtained poultice is stored in a constant temperature room at 40 ° C,
Adhesiveness evaluation up to 6 months (JIS Z0237 ball tack value measurement), back bleeding evaluation (four-level evaluation by sensory), actual use evaluation (peeling agent was applied to elbows of 15 healthy males and peeled off after 6 hours, Observe the curl). From the adhesive strength evaluation results (Table 4), the back bleeding evaluation results (Table 6), and the actual use evaluation results (Table 8), the product of the present invention has a high adhesive strength and a back surface equivalent to those at the initial stage even at 40 ° C. for 6 months. An excellent evaluation result was obtained in which bleeding suppression was maintained and peeling and curling were small in actual use from all panelists. In addition, since the adhesive surface is strong and the ability to follow the skin is good, the drug surface does not peel off from the affected area. Therefore, in the rat carrageenin paw edema test shown in Table 17, it was also confirmed that it has an excellent anti-inflammatory effect. Was done.

Example 5 A solution prepared by dissolving 0.50 part by weight of ethylenediaminetetraacetic acid in purified water with heating and 2.0 parts by weight of horse chestnut seed extract were mixed with various bases and active ingredients by a conventional method using a Henschel mixer. And so on. 1 piece (14
The elastic nonwoven fabric made of 100% polyester fiber was coated and cut to give 14 g per 0 × 100 mm).
A poultice of Example 5 having the composition shown in 1. was obtained. The obtained poultice is stored in a thermostatic chamber at 40 ° C., and the adhesive strength is evaluated up to 6 months later (JIS Z0237 ball tack value measurement), back bleeding evaluation (four-level evaluation by sensory), and actual use evaluation (popping agent It was attached to the elbows of 15 healthy males and peeled off after 6 hours and observed for turning up. From the adhesive strength evaluation results (Table 4), the back bleeding evaluation results (Table 6), and the actual use evaluation results (Table 8), the product of the present invention has a high adhesive strength and a back surface equivalent to those at the initial stage even at 40 ° C. for 6 months. An excellent evaluation result was obtained in which bleeding suppression was maintained and peeling and curling were small in actual use from all panelists. In addition, since the adhesive surface is strong and the ability to follow the skin is good, the drug surface does not peel off from the affected area. Therefore, in the rat carrageenin paw edema test shown in Table 17, it was also confirmed that it has an excellent anti-inflammatory effect. Was done.

Example 6 A solution prepared by heating 0.20 parts by weight of dipotassium ethylenediaminetetraacetate in purified water and 3.0 parts by weight of horse chestnut seed extract were mixed with various bases using a Henschel mixer according to a conventional method. Knead with active ingredients. Immediately after the production, a stretchable nonwoven fabric made of 100% polyester fiber was coated and cut so that the weight per sheet (140 × 100 mm) was 14 g to obtain a poultice of Example 6 having the composition shown in Table 2. The obtained poultice is stored in a thermostatic chamber at 40 ° C,
Adhesiveness evaluation up to months (JIS Z0237 ball tack value measurement), back bleeding evaluation (four-level evaluation by sensory), actual use evaluation (sticking the patch on the elbows of 15 healthy males, peeling off after 6 hours, and turning over Was observed). From the adhesive strength evaluation results (Table 4), the back bleeding evaluation results (Table 6), and the actual use evaluation results (Table 8), the product of the present invention has a high adhesive strength and a back surface equivalent to those at the initial stage even at 40 ° C. for 6 months. An excellent evaluation result was obtained in which bleeding suppression was maintained and peeling and curling were small in actual use from all panelists. In addition, since the adhesive surface is strong and the ability to follow the skin is good, the drug surface does not peel off from the affected area. Therefore, in the rat carrageenin paw edema test shown in Table 17, it was also confirmed that it has an excellent anti-inflammatory effect. Was done.

[0018]

TABLE 1 poultice Composition Table Ingredient Example 1 Example 2 Example 3 Sodium polyacrylate (Aronbisu S) 3.0 1.5 2.0 Polyacrylic acid (JURYMER AC-10H) * 18.0 14.5 12.0 Polyvinyl alcohol (Gohsenol NH-26) 2.5 3.0 1.8 Sodium carboxymethyl cellulose 3.0 4.2 3.3 (Daicel CMC-1250) Horse chestnut seed extract 0.25 0.5 1.5 Disodium ethylenediaminetetraacetate 0.02 0.35 1.0 Kaolin 3.0 4.2 5.5 Titanium oxide 1.5 0.5 0.5 Glycerin 18.0 22.0 15.7 70% Sorbitol Liquid 11.0 11.0 10.0 Synthetic hydrotalcite 0.11 0.11 0.12 Aluminum chloride 0.08 0.12 0.2 Glycolic salicylate 1.50 0.50 2.00 Tocopherol acetate 0.30 1.00 0.50 Indomethacin 0.50-l-menthol 1.2 1.5 1.2 Castor oil 1.0 1.0 1.0 Polysorbate 80 (Nikkor TO-10M) 1.5 1.0 1.8 seminal Water production balance (%) 100.00 100.00 100.00 *) 4% as solid content

[0019]

[Table 2]Table 2: Composition table of poultice Component   Example 4 Example 5 Example 6 Sodium polyacrylate (Aronbis S) 3.0 1.5 2.0 Polyacrylic acid (Jurimer AC-10H) * 18.0 14.5 12.0 Polyvinyl alcohol (Gohsenol NH-26) 2.5 3.0 1.8 Carboxymethyl cellulose sodium 3.0 4.2 3.3 (Daicel CMC-1250) Horse chestnut seed extract 2.5 2.0 3.0 Ethylenediaminetetraacetic acid tetrasodium 0.2 − − Ethylenediaminetetraacetic acid dipotassium − − 0.2 Ethylenediaminetetraacetic acid − 0.5 − Kaolin 3.0 4.2 5.5 Glycerin 18.0 22.0 15.7 70% sorbitol solution 11.0 11.0 10.0 Aluminum glycinate 0.11 0.11 0.12 Capsicum extract 0.02 − − Flurbiprofen − 0.5 − Glycol salicylate 0.5 1.5 1.0 Tocopherol acetate 0.5 1.0 0.3 l-menthol 1.2 1.5 1.2 Castor oil 1.0 1.0 1.0 Polysorbate 80 (Nikkor TO-10M) 1.5 1.0 1.8 Purified water balance Total (%) 100.00 100.00 100.00 *) 4% as solid content

[0020]

[Table 3] Table 3: Adhesive strength (ball tack value) measurement result (n = 5) * 1 Repeated ABCDE Example 1 Initial period 15 16 15 15 16 16 1 month later 16 15 14 15 15 15 3 months later 15 14 15 14 14 14 6 months later 14 15 15 14 15 15 Example 2 Initial stage 16 16 16 16 16 16 1 month later 16 15 15 16 16 3 3 months later 16 15 16 15 15 6 months later 14 15 14 14 14 Example 3 Initial period 15 15 16 16 16 15 1 month later 15 16 16 16 16 15 3 months later 15 15 15 14 14 15 6 months later 15 14 14 13 13 13 * 1: JIS Z0237 tack (ball rolling method)

[0021]

[Table 4] Table 4: Adhesive force (ball tack value) measurement result (n = 5) * 1 Repeated ABCDE Example 4 Initial period 16 16 15 15 15 15 1 month later 15 15 15 15 15 15 3 months later 14 14 15 15 14 6 6 months later 15 14 14 14 14 14 Example 5 Initial period 16 16 16 16 16 16 1 month later 15 15 16 15 16 3 months later 15 14 15 15 15 6 months later 14 15 15 14 14 Example 6 First term 16 15 15 15 15 16 1 month later 15 15 15 15 15 15 3 months later 14 15 15 15 15 15 6 months later 15 14 14 13 14 * 1: JIS Z0237 tack (ball rolling method)

[0022]

[Table 5] Table 5: Back bleeding evaluation result (n = 5) Repeat ABCDE Example 1 Early stage --- --- 1 month later --- --- 3 months later --- --- 6 months Post ------- Example 2 Initial stage --- ----- 1 month later --- --- 3 months later --- --- 6 months later --- --- --Example 3 early stage --- --- After 1 month − − − − − After 3 months − − − − − After 6 months − − − − − Back bleeding evaluation standard −: None ±: Slightly +: About half ++: Wide range

[0023]

[Table 6] Table 6: Repeated results of back bleeding evaluation (n = 5) ABCDE Example 4 Initial stage --- --- 1 month later --- --- 3 months later --- --- 6 months After ------- Example 5 Initial stage -------- One month later ------- Three months later ------ 6 months later ------- Example 6 early stage ------ After 1 month − − − − − After 3 months − − − − − After 6 months − − − − − Back bleeding evaluation standard −: None ±: Slightly +: About half ++: Wide range

[0024]

[Table 7] Table 7: Peeling and flipping evaluation results in actual use (n = 15) Repeat ABCDCEFHIJJKLMLNO Example 1 Initial stage --- --- --- − ± − − − − − ± 1 month later − ± − − − − − − − − − ± − − − 3 months later ± − − − − ± − − − − ± − − − − 6 months later − − ± − ± − − − − − − ± − − ± Example 2 Initial period − − − − ± − − − − ± − − − − − 1 month later − − ± − − − − − ± − − − ± − − Three months later − − − − ± − − − − − ± − − − − Six months later − − ± − − − − ± − − − − − ± − Example 3 Initial period − − ± − − − − − ± − − − − − − 1 month later − ± − − − − − − − − ± − − − − 3 months later − − − − ± − − − − ± − ± − − − 6 months later − − − ± − − ± ± - - - ± - - Evaluation Criteria -: None ±: there is a slight +: There are about half ++: The peeled

[0025]

[Table 8] Table 8: Peeling and flipping evaluation results in actual use (n = 15) Repeated ABCDCEFHIJJKLMMNO Example 4 Initial − − − − − ± − − − ± − − − − − − 1 month later − ± − − − − ± − − − − − − − − 3 months later − − − − ± ± − − − − − − ± − − 6 months later − ± ± − ± − − − − − ± ± − − − Example 5 Initial period − − ± − − − ± − − − ± − − − − 1 month later − − ± − − − − − ± − − − ± − − Three months later − − − − ± − − − − − ± − − − − Six months later − − ± ± − − − ± − − − − − − − Example 6 Initial period − ± − − − − − − ± − ± − − − − 1 month later ± − − − − − − ± − − − − − − − 3 months later − ± − − − − ± − − ± − − − − − 6 months later ± − − − ± − − ± ± − − ± − ± − Evaluation criteria −: None ±: Slightly present +: About half present ++: Peeled

Comparative Example 1 0.50 part by weight of horse chestnut seed extract is kneaded with various bases, active ingredients and the like using a Henschel mixer according to a conventional method. Immediately after production, 1 sheet (140 x 100 m
m) 100% polyester fiber to be 14g per
The elastic non-woven fabric was cut by coating to obtain a poultice of Comparative Example 1 having the composition shown in Table 9. The obtained poultice is stored in a thermostatic chamber at 40 ° C., and the adhesive strength is evaluated up to 6 months later (JIS Z0237 ball tack value measurement), back bleeding evaluation (four-level evaluation by sensory), and actual use evaluation (popping agent It was attached to the elbows of 15 healthy males and peeled off after 6 hours and observed for turning up. From the adhesive strength evaluation result (Table 11), the back bleeding evaluation result (Table 13), and the actual use evaluation result (Table 15), the product of the present invention retains the same high adhesive strength as that at the initial stage at 40 ° C. for 6 months. In addition, it was not possible to obtain excellent results against peeling and swelling from all panelists in actual use.

Comparative Example 2 1.0 part by weight of horse chestnut seed extract is kneaded with various bases, active ingredients and the like using a Henschel mixer according to a conventional method. Immediately after production, 1 sheet (140 x 100 mm)
A stretchable non-woven fabric made of 100% polyester fiber was coated and cut so as to have a weight of 14 g to obtain a poultice of Comparative Example 2 having the composition shown in Table 9. 4 of the obtained poultice
Store in a constant temperature room at 0 ° C and evaluate the adhesive strength up to 6 months later (J
IS Z0237 ball tack value measurement), back blurring evaluation (four-level sensory evaluation), and actual use evaluation (peeling agent was applied to the elbows of 15 healthy males and peeling and swelling were observed after 6 hours). From the adhesive strength evaluation result (Table 11), the back blur evaluation result (Table 13), and the actual use evaluation result (Table 15),
The product of the present invention had a low adhesive strength after 40 months at 40 ° C. as in the initial stage, and could not obtain excellent results against peeling and swelling from all panelists in actual use.

Comparative Example 3 A solution prepared by heating 1.5 parts by weight of disodium ethylenediaminetetraacetate in purified water and 0.50 parts by weight of horse chestnut seed extract were mixed with various bases using a Henschel mixer according to a conventional method. Knead with active ingredients. Immediately after the production, a stretchable non-woven fabric made of 100% polyester fiber was coated and cut so that the weight per sheet (140 × 100 mm) was 14 g to obtain a poultice of Comparative Example 3 having the composition shown in Table 9. The obtained poultice is stored in a constant temperature room at 40 ° C,
Adhesiveness evaluation up to 6 months (JIS Z0237 ball tack value measurement), back bleeding evaluation (four-level evaluation by sensory), actual use evaluation (peeling agent was applied to elbows of 15 healthy males and peeled off after 6 hours, Observe the curl). Adhesive strength evaluation results (Table 11), back bleeding evaluation results (Table 13),
From the actual use evaluation results (Table 15), the product of the present invention was 40 ° C., 3
After the lapse of months or more, the back bleeding could not be suppressed, and the back bleeding was remarkable, and the adhesive strength evaluation and the actual use evaluation could not be performed. Due to the occurrence of back bleeding, the commercial value as a poultice has disappeared.

Comparative Example 4 A solution prepared by heating 0.005 parts by weight of ethylenediaminetetraacetic acid in purified water, and horse chestnut seed extract 0.5.
Parts by weight are kneaded with various bases, active ingredients and the like using a Henschel mixer according to a conventional method. 1 piece (1
A stretchable non-woven fabric made of 100% polyester fiber was coated and cut to give 14 g per 40 × 100 mm) to obtain a poultice of Comparative Example 4 having the composition shown in Table 10.
The obtained poultice is stored in a thermostatic chamber at 40 ° C., and the adhesive strength is evaluated up to 6 months later (JIS Z0237 ball tack value measurement), back bleeding evaluation (four-level evaluation by sensory), and actual use evaluation (popping agent It was attached to the elbows of 15 healthy males and peeled off after 6 hours and observed for turning up. From the adhesive strength evaluation result (Table 12), the back bleeding evaluation result (Table 14), and the actual use evaluation result (Table 16), the adhesive strength of the product of the present invention was low at 40 ° C. for 6 months as in the initial stage, Moreover, it was not possible to obtain excellent results against peeling and swelling from all panelists in actual use.

Comparative Example 5 A solution prepared by dissolving 2.0 parts by weight of tetrasodium ethylenediaminetetraacetate in purified water with heating and 2.5 parts by weight of horse chestnut seed extract were mixed with various bases using a Henschel mixer according to a conventional method. Knead with active ingredients. Immediately after the production, a stretchable non-woven fabric made of 100% polyester fiber was coated and cut so that the weight per sheet (140 × 100 mm) was 14 g to obtain a poultice of Comparative Example 5 having the composition shown in Table 10. The obtained poultice is stored in a constant temperature room at 40 ° C,
Adhesiveness evaluation up to 6 months (JIS Z0237 ball tack value measurement), back bleeding evaluation (four-level evaluation by sensory), actual use evaluation (peeling agent was applied to elbows of 15 healthy males and peeled off after 6 hours, Observe the curl). Adhesive strength evaluation results (Table 12), back bleeding evaluation results (Table 14),
From the actual use evaluation result (Table 16), the product of the present invention was 40 ° C., 3
After the lapse of months or more, the back bleeding could not be suppressed, and the back bleeding was remarkable, and the adhesive strength evaluation and the actual use evaluation could not be performed. Due to the occurrence of back bleeding, the commercial value as a poultice has disappeared.

Comparative Example 6 A solution prepared by heating 2.0 parts by weight of dipotassium ethylenediaminetetraacetate in purified water and 0.5 parts by weight of horse chestnut seed extract were mixed with various bases using a Henschel mixer according to a conventional method. Knead with active ingredients. Immediately after production 1
A stretchable nonwoven fabric made of 100% polyester fiber was coated and cut so that the weight per sheet (140 × 100 mm) was 14 g to obtain a poultice of Comparative Example 6 having the composition shown in Table 10. The obtained poultice is stored in a thermostatic chamber at 40 ° C,
Adhesiveness evaluation up to months (JIS Z0237 ball tack value measurement), back bleeding evaluation (four-level evaluation by sensory), actual use evaluation (sticking the patch on the elbows of 15 healthy males, peeling off after 6 hours, and turning over Was observed). Adhesive strength evaluation results (Table 12), back bleeding evaluation results (Table 14),
From the actual use evaluation result (Table 16), the product of the present invention was 40 ° C., 3
After the lapse of months or more, the back bleeding could not be suppressed, and the back bleeding was remarkable, and the adhesive strength evaluation and the actual use evaluation could not be performed. Due to the occurrence of back bleeding, the commercial value as a poultice has disappeared. In summary, the blending amount of ethylenediaminetetraacetic acid and / or its salt is 0.0
In the case of 05% or less, Comparative Examples 1, 2, and 4 could not obtain sufficient adhesive strength. Further, in Comparative Example 3, Comparative Example 5, and Comparative Example 6 in which the content of ethylenediaminetetraacetic acid and / or its salt was 1.5% or more, the occurrence of back bleeding was remarkable due to long-term storage. The occurrence of back bleeding means that the commercial value of the poultice is lost.

[0032]

[Table 9]Table 9: Composition of poultice Component   Comparative Example 1 Comparative Example 2 Comparative Example 3 Sodium polyacrylate (Aronbis S) 3.0 1.5 2.0 Polyacrylic acid (Jurimer AC-10H) * 1 18.0 14.5 12.0 Polyvinyl alcohol (Gohsenol NH-26) 2.5 3.0 1.8 Carboxymethyl cellulose sodium 3.0 4.2 3.3 (Daicel CMC-1250) Horse chestnut seed extract 0.5 1.0 0.5 Ethylenediaminetetraacetic acid disodium − − 1.5 Kaolin 3.0 4.2 5.5 Titanium oxide 1.5 0.5 0.5 Glycerin 18.0 22.0 15.7 70% sorbitol solution 11.0 11.0 10.0 Aluminum glycinate 0.11 0.11 0.12 Aluminum chloride 0.08 0.12 0.2 Ketoprofen 0.5 − − Glycol salicylate 0.5 1.5 1.0 Tocopherol acetate 0.3 1.0 0.5 l-menthol 1.2 1.5 1.2 Castor oil 1.0 1.0 1.0 Polysorbate 80 (Nikkor TO-10M) 1.5 1.0 1.8 Purified water balance Total (%) 100.00 100.00 100.00 *) 4% as solid content

[0033]

[Table 10]Table 10: Composition of poultice Component   Comparative Example 4 Comparative Example 5 Comparative Example 6 Sodium polyacrylate (Aronbis S) 3.0 1.5 2.0 Polyacrylic acid (Jurimer AC-10H) * 1 18.0 14.5 12.0 Polyvinyl alcohol (Gohsenol NH-26) 2.5 3.0 1.8 Carboxymethyl cellulose sodium 3.0 4.2 3.3 (Daicel CMC-1250) Horse chestnut seed extract 0.5 2.5 0.5 Ethylenediaminetetraacetic acid 0.005 − − Ethylenediaminetetraacetic acid tetrasodium-2.0- Ethylenediaminetetraacetic acid dipotassium − − 2.0 Kaolin 3.0 4.2 5.5 Titanium oxide 1.5 0.5 0.5 Glycerin 18.0 22.0 15.7 70% sorbitol solution 11.0 11.0 10.0 Synthetic hydrotalcite 0.11 0.11 0.12 Aluminum chloride 0.08 0.12 0.2 Glycol salicylate 1.76 1.76 1.68 Tocopherol acetate 0.32 0.315 0.31 l-menthol 1.2 1.5 1.2 Castor oil 1.0 1.0 1.0 Polysorbate 80 (Nikkor TO-10M) 1.5 1.0 1.8 Purified water balance Total (%) 100.00 100.00 100.00 *) 4% as solid content

[0034]

[Table 11] Table 11: Adhesive force (ball tack value) measurement result (n = 5) repeated A B C D E Comparative Example 1 Initial period 7 9 7 7 6 1 month later 6 7 8 7 6 3 months later 5 7 6 6 6 6 months later 4 6 5 4 4 Comparative example 2 Initial period 8 8 8 7 7 1 month later 7 7 7 7 6 3 months later 7 7 7 6 6 6 months later 4 5 6 6 6 Comparative example 3 initial period 15 15 14 15 14 1 month after 12 13 12 14 13 after 3 months - - - - - 6 months after - - - - - * after 3 months of Comparative example 3, after six months not measurable by the back bleeding

[0035]

[Table 12] Table 12: Adhesive force (ball tack value) measurement result (n = 5) repeated A B C D E Comparative Example 4 Initial period 9 7 8 7 8 1 month later 7 8 8 7 8 3 months later 7 6 6 7 7 6 months later 6 7 6 6 7 Comparative Example 5 initial period 15 15 15 15 15 15 1 month later 13 13 14 12 12 3 months later − − − − − 6 months later − − − − − Comparative Example 6 initial stage 15 15 15 15 16 1 month after 14 12 13 13 12 3 months after - - - - - 6 months after - - - - - * after 3 months of Comparative examples 5 and 6, not determined by the back bleeding after 6 months JIS Z0237 Tuck (Rolling ball method)

[0036]

[Table 13] Table 13: Back bleeding evaluation result (n = 5) Repeat ABCDE Comparative Example 1 Early stage --- --- 1 month later --- --- 3 months later --- --- 6 months Later − ± − ± − Comparative Example 2 Initial − − − − − 1 month later − − − − − 3 months later − − − − − 6 months later ± − ± ± − Comparative Example 3 initial stage − − ± ± − After 1 month ± ＋ ± ± ＋ After 3 months ++ ++ ++ ++ ++ ++ After 6 months ++ ++ ++ ++ ++ ++ Back bleeding evaluation standard −: None ±: Slightly +: About half Yes ++: Wide range

[0037]

[Table 14] Table 14: Back bleeding evaluation result (n = 5) Repeat ABCDE Comparative Example 4 Initial stage --- --- 1 month later --- --- 3 months later --- --- 6 months After − − ± − ± Comparative Example 5 Initial − − ± − ± After 1 month ++ + ++ ± After 3 months ++ ++ ++ ++ ++ ++ After 6 months ++ ++ ++ ++ ++ Comparative Example 6 Initial − ±± − ± After 1 month ± ++ ++ ± After 3 months ++ ++ ++ ++ ++ ++ After 6 months ++ ++ ++ ++ ++ ++ Back bleeding evaluation standard −: None ±: Slightly +: About half ++: Wide range

[0038]

[Table 15] Table 15: Peeling and flipping evaluation results in actual use (n = 15) Repeated A B C D E F G H I J K L M N O Comparative Example 1 Initial + ++ + + + + + + ++ ++ ++ ± ++ +1 month later ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ 3 months later ++ ++ ++ ++ ++ ++ ++ + ++ ++ ++ ＋ 6 months later ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ Comparative Example 2 Initial ++ ++ ++ ++ ++ ++ ++ ++ ++ +1 month later ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ＋ 3 months later ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ + 6 After a month ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ Comparative Example 3 Initial period ± − ± − − − − − − ± − ± − − − 1 month later ± ± - - ± - ± - ± - - - - - - after three months / / / / / / / / / / / / / / / 6 months after the / / / / / / / / / / / / / / * After three months of Comparative Example 3, after 6 months, non-measurable criteria by bleeding in the back -: None ±: there is a slight +: There are about half ++: The peeled

Table 16: Evaluation results of peeling and turning over in actual use (n = 15) Repeated A B C D E F G H I J K L M N O Comparative Example 4 Initial stage ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ +1 month later ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ + 3 months later ++ ++ ++ ++ ++ + + ++ ++ ++ ++ ++ ++ ++ ++ 6 months later ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ ++ Comparative Example 5 Initial ± − ± − ± − − − − − − − − ± − After 1 month − − ± ± − − ± − ± − ± − − − − After 3 months / / / / / / / / / / / / / / / / 6 months After / / / / / / / / / / / / / / / Comparative Example 6 Initial ± − − − − − − − − − − − − ± ± ± 1 month later − ± ± − − ± ± ± ± − − ± ± - after ± 3 months / / / / / / / / / / / / / / / 6 months after the / / / / / / / / / / / / / / * After three months of Comparative Examples 4 and 5, after 6 months, back bleeding by non-measurable criteria -: None ±: there is a slight +: There are about half ++: The peeled

Experimental method: Carrageenin paw edema inhibitory effect upon topical application of a poultice containing horse chestnut seed extract 1 group of 10 male wistar rats 5 weeks old (4 weeks old at arrival: Charles River Japan) 1% An aqueous solution of carrageenin (stirred for 1 day and night. Pykunin A: Zushi Kagaku) was subcutaneously added to the foot pad at 0.1 ml / W. B. W. Administered and administered every 1 hour until 5 hours after volume differential
The paw edema volume was measured by a meter and the edema inhibition rate was calculated from the value before drug administration. The poultices of Examples 1 to 6 and the control (4 × 5 cm, immediately after production) were applied to the skin on the back of the rat. The poultice was applied from 2 hours before inflammation and was reapplied every 2 hours. Results From the results of edema ratio over time, it was confirmed from Table 17 that the poultices of Examples 1 to 6 have a high anti-inflammatory effect.

[0041]

[Table 17] Table 17: Rat carrageenin paw edema rate (%) 1 hour 2 hours 3 hours 4 hours 5 hours Example 1 18.6 16.5 15.0 15.8 16.4 Example 2 17.4 27 .5 25.2 27.1 24.9 Example 3 19.5 20.1 22.6 22.5 26.6 Example 4 20.1 18.3 19.0 20.1 18.4 Example 5 18.5 15.7 16.7 15.2 16.3 Example 6 17.3 18.5 18.3 20.9 18.1 Control 21.8 48.2 61.6 63.8 62.2

   ─────────────────────────────────────────────────── ─── Continued front page       (56) Reference JP-A-5-105628 (JP, A)                 JP-A-61-275212 (JP, A)                 JP-A-3-135049 (JP, A)

Claims (3)

(57) [Claims] 1. A water-soluble polymer selected from polyacrylic acid, sodium polyacrylate, and cellulose derivatives.
In a hydrous poultice containing two or more species,
Horse chestnut seed extract 0.20 to 3.50% by weight, ethylenediaminetetraacetic acid and / or its salt 0.0
1 to 1.2% by weight of a poultice, characterized by being blended. 2. The poultice according to claim 1, wherein the two or more water-soluble polymers are at least one selected from polyacrylic acid and sodium polyacrylate and a cellulose derivative. 3. The poultice according to claim 1, further comprising a polyvalent metal compound.