JP3503149B2 - Laser treatment cover film - Google Patents

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a cover film for laser treatment using a film having flexibility and flame retardancy. Particularly, it is used in the field of laser treatment to prevent infection from a patient to a medical staff such as a doctor or a nurse.

[0002]

2. Description of the Related Art A cover film is sometimes used for the purpose of preventing wound infection during surgery, but a satisfactory one has not been developed so far. In particular, with regard to the cover film for laser treatment, not only the bacterial barrier property of preventing the infection of medical personnel such as doctors and nurses from patients,
Flexibility to expand and contract following the movement of the skin and flame resistance to laser light heat are required.

[0003]

When the conventionally used wound infection preventing cover film is used as a laser treatment cover film, none of the properties required as the above laser treatment cover film are satisfied. It was That is, there is a problem that flexibility and flame retardancy are insufficient even if the bacterial barrier property is satisfied, and flame retardancy is poor even when the bacterial barrier property and flexibility are satisfied.

The present invention focuses on the above-mentioned problems in the conventional cover film, has a bacterial barrier property useful for preventing wound infection, and is flexible to expand and contract following the movement of the skin of a medical staff. Further, it is an object of the present invention to provide a cover film for laser treatment, which has no problem of burning due to laser light heat.

[0005]

The cover film for laser treatment of the present invention which is suitable for this purpose has a tensile elastic modulus of 1 kg / mm ² or more and 200 kg / mm ² or less, a LOI of 26 or more, and a heating loss at 100 ° C. The rate is less than 1% ,
A laser treatment cover film characterized it to contain copolymerized polyester film.

[0006] The film can be used as a laser therapy cover film of the present invention include such as a film of a film or a polymer alloy of copolymerized polyester full <br/> I le-time and blends thereof.

There are no particular restrictions on the raw materials for the copolyester film. For example, as the acid component, terephthalic acid, isophthalic acid, sodium sulfoisophthalic acid,
Azelaic acid, sebacic acid, eicosanoic acid, dodecanedioic acid, dimer acid, naphthalene dicarboxylic acid, p- hydroxybenzoic acid, .epsilon. Kapurora click tons are preferred. As the alcohol component, ethylene glycol, propylene glycol, 1,4-butanediol, 1,6-hexanediol, 1,8-octanediol, neopentyl glycol, cyclohexanedimethanol, polyethylene glycol, polypropylene glycol, polytetramethylene, etc. Glycol is preferred. A block copolymerized polyester and a random copolymerized polyester synthesized from three or more kinds of raw materials in total from the acid component and the alcohol component are preferable.

[0008]

[0009]

The cover film for laser treatment of the present invention has a tensile elastic modulus of 1 kg / mm ² or more and 200 k
g / mm ² or less, preferably 1
It is about 10 kg / mm ² . Tensile elastic modulus is 200kg
If it exceeds / mm ² , the flexibility of the film is insufficient, and there is a problem in that the film does not follow the movement of the skin during use and does not expand or contract. If it is less than 1 kg / mm ² , the strength is insufficient,
Not practical.

Also, the LOI (Limited Oxygen Index) of the film
Is required to be 26 or more, preferably 30 or more. When the LOI is less than 26, there is a problem in combustibility during laser treatment. The film having an LOI of 26 or more includes a film having a LOI of 26 or more and a film having a LOI of less than 26 and a flame retardant imparted by a flame retardant. Examples of the method of imparting flame retardancy with a flame retardant include a method of coating the film with a flame retardant and a method of laminating the film with a flame retardant film.

As the flame retardant, tetrabromobisphenol A (TBA), TBA epoxy oligomer or polymer, decabromodiphenyl oxide (DBDP)
O), hexabromocyclododecane, polydibromodiphenylene oxide, ethylene bistetrabromophthalimide, pentabromobenzyl polyacrylate, and other brominated flame retardants, and aluminum hydroxide and other inorganic flame retardants are preferred.

The heating weight loss rate of the film at 100 ° C. is
Ru der less than 1%. If the heating weight loss rate exceeds 1%, the film will be deformed remarkably by the heat at the time of laser treatment and cannot be put into practical use. There may be a problem with the safety and hygiene of the film.

In the cover film for laser treatment of the present invention, it is preferable to form a pressure-sensitive adhesive layer on one surface of the film having both flexibility and flame retardancy. The pressure sensitive adhesive layer is formed, for example, by coating with a pressure sensitive adhesive. The pressure-sensitive adhesive is preferably based on, for example, an acrylic acid ester-based or methacrylic acid ester-based copolymer and a silicone-based polymer.

The pressure-sensitive adhesive layer preferably has antibacterial properties. Examples of the antibacterial agent used include compound antibacterial agents such as benzalkonium chloride, hexamethylene bigamido hydrochloride, polyhexamethylene bigamido hydrochloride, organic silicon quaternary ammonium salts, pyridonecarboxylic acid derivatives, and silver. Ceramic-based antibacterial agents in which copper, zinc and the like are introduced into zeolite by ion exchange, metal ion-based antibacterial agents such as silver, copper and zinc, and mineral zeolite antibacterial agents are preferable.

Examples of the sterilant, benzethonium chloride, gluconate Kuroruhekishiji emissions (Hibitane), disinfectants iodine are preferred.

[0017] As a method for granting the antimicrobial to pressure sensitive adhesive layer, coating the antibacterial agent to the pressure-sensitive adhesive layer, or is formed by kneading the antibacterial agent.

Next, the method of measuring and evaluating the film characteristics obtained in the examples and comparative examples will be described.

(1) Tensile elastic modulus (kg / mm ² ) According to ASTM D-882.

(2) LOI (Limited Oxygen Index) This is the minimum volume fraction of oxygen required for the substance to continue combustion in an atmosphere of a mixed gas of oxygen and nitrogen, and nO ₂ /
It is calculated by (nO ₂ + nN ₂ ) × 100. n = number of moles

(3) Heat loss rate (%) Using a thermobalance (TG-8111) manufactured by RIGAKU, 20 mg of a sample was heated at 20 ° C./min in a nitrogen stream and measured.

(4) Adhesive strength A film having a width of 15 mm is attached to a plywood, and the film is placed at 40 ° C. for 9 minutes.
It was evaluated from the result of the peeling force after 2 weeks in the atmosphere of 0% RH. X: Not easily peeled off by hand. ◯: It is easily peeled off by hand.

(5) Evaluation was made based on the state of combustion and smoke emission when irradiated with flame-retardant CO ₂ laser light. ◯: The film burns up and smoke is hardly generated from the film. X: The film burns up or smoke is generated from the film.

(6) An elastic sample of 10 cm ² was attached to an arm and evaluated by the degree of ease of movement of the arm. ◯: Almost no resistance is felt when bending or stretching the arm. ×: There is resistance when the arm is bent and stretched, and it is difficult to move.

(7) Dimensional stability Evaluation was made by the dimensional change and the degree of deformation of the sample when it was left in an atmosphere of 100 ° C. for 5 minutes. ◯: Almost no dimensional change or deformation. Δ: Very slight dimensional change and / or slight deformation is observed. X: The dimensions are changed significantly and / or large deformation is observed.

[0026]

EXAMPLES The present invention will be described in more detail with reference to examples below, but the present invention is not limited to these examples.

Example 1 A copolyester was synthesized using dimethyl terephthalate as an acid component, 70 mol% of 1,4-butanediol and 30 mol% of polytetramethylene glycol as an alcohol component. After vacuum drying the obtained polymer,
It was melted, extruded using a T-die, and then cooled to form a sheet. The obtained copolyester-based sheet material was stretched in the MD direction, and then a flame-retardant coating agent based on pentabromobenzyl polyacrylate was applied on one surface (surface). Then TD
Thickness of 25 μm
To obtain a transparent biaxially stretched copolyester film.
A cover film for laser treatment was obtained by coating one surface (back surface) of the obtained film with a pressure-sensitive adhesive layer containing an antibacterial agent based on a pyridonecarboxylic acid derivative. Table 1 shows the results of measurement and evaluation of the characteristics of the thus obtained cover film for laser treatment.
This film was excellent in flexibility, expanded and contracted following the movement of the skin, and had a flame retardancy against a laser beam.

Example 2 A copolyester was synthesized by using 70 mol% of terephthalic acid and 30 mol% of sebacic acid as an acid component and ethylene glycol as an alcohol component. A sheet-like material was molded from the obtained polymer in the same manner as in Example 1, and the flame-retardant coating agent (P
Fluorine-containing coating agent such as TFE) and a pressure-sensitive adhesive containing chlorhexidine gluconate as an antibacterial agent is coated on one surface (back surface) of the sheet-like unstretched copolyester film Got Table 1 shows the results of measuring and evaluating the characteristics of the obtained film. Good results were obtained in substantially the same manner as in Example 1.

Comparative Example 1 A polyester was synthesized using terephthalic acid as an acid component and ethylene glycol as an alcohol component. A sheet-like material was formed from the obtained polymer in the same manner as in Example 1, and then biaxially stretched in the MD and TD directions to obtain a biaxially stretched polyester film having a thickness of 25 μm.
Further, this film-like material was coated with a pressure-sensitive adhesive containing chlorhexidine gluconate as a sterilizing agent to prepare a cover film for laser treatment based on a stretched polyester film. The results of measurement and evaluation of the characteristics are shown in Table 1. The obtained film has a high tensile elastic modulus of 350 kg / mm ^2, and therefore hardly follows the movement of the skin and hardly expands or contracts. Further, in terms of flammability with respect to laser light heat, the LOI value is as low as 21, and there is a problem that combustion is easily caused by laser light heat. Further, the adhesive strength is poor, and there is a possibility that problems such as peeling may occur during use.

Comparative Example 2 Polyvinyl chloride resin (average degree of polymerization P: 1300) 100
Relative to the weight part dioctyl phthalate (D O P) 30 parts by weight, and epoxidized soybean oil 3 parts by weight of calcium stearate 0.5 parts by weight was added a film molding resin as a stabilizer blended as a plasticizer did. Then, the compounded resin was kneaded and extruded to obtain a soft polyvinyl chloride film. A cover film for laser treatment was obtained by coating one surface (back surface) of the obtained film with a pressure-sensitive adhesive. The results of measurement and evaluation of the characteristics are shown in Table 1. The obtained film had problems such as dimensional change due to laser light heat, plasticizer bleeding out, and reduction in adhesive strength of the pressure-sensitive adhesive. Furthermore, since no antibacterial agent is added, there is a problem that the effect of preventing wound infection during surgery is not sufficient.

[0031]

[Table 1]

[0032]

As described in detail above, the cover film for laser treatment of the present invention is flexible, so that it expands and contracts in accordance with the movement of the skin during use, is also flame retardant, and is dimensioned by laser light heat. Little change. Furthermore, when an antibacterial agent or a sterilizing agent is used, the wound infection prevention effect is also excellent.

─────────────────────────────────────────────────── ─── Continuation of the front page (56) References JP-A-1-110137 (JP, A) JP-A-62-82967 (JP, A) JP-A-63-145307 (JP, A) Jitsukaihei 3- 85053 (JP, U) (58) Fields surveyed (Int.Cl. ⁷ , DB name) A61L 15/00 B29D 7/01 A61B 18/20 A61N 5/06

Claims (3)

(57) [Claims] 1. A resin containing a copolymerized polyester film.
A Za therapeutic cover film, the film is a <br/> tensile modulus 1 kg / mm ² or more 200 kg / mm ² or less, LOI is Ri der 26 above, heating at 100 ° C.
A cover film for laser treatment , which has a weight loss rate of 1% or less . 2. The cover film according to claim 1, wherein a pressure-sensitive adhesive layer is formed on one surface of the film. 3. The cover film according to claim 2, wherein the pressure-sensitive adhesive layer contains an antibacterial agent and / or a sterilizing agent.