JP3469642B2 - Hair growth agent containing polyvinylpyrrolidone - Google Patents

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a hair growth agent.

[0002]

2. Description of the Related Art Conventionally, many hair restorers and hair nourishing agents have been provided, but most of them are compositions, and only a few ingredients have shown a hair restorer effect or a hair restorer effect. Have provided few hair regrowth agents that have demonstrated a hair growth effect, defined as the break-in effect of the hair cycle. The polyvinylpyrrolidone used in the present invention is, for example, a hair treatment preparation (JP-A-63-25880).
4), hair nourishing composition and method of using the same (JP-A-3-14510), hair treatment agent and method of using the same (JP-A-3-14310).
148211), it has been known that polyvinylpyrrolidone itself has a hair growth effect. Further, some of the sugars used in the present invention include, for example, skin moisturizing compositions (JP-A-61-100512), hair cosmetics (JP-A-62-267218), and hair treatment drugs ( JP-A-2-28
2314), solid cosmetic composition (JP-A-3-68507), hair-growth agent (JP-A-3-148210), hair treatment agent (JP-A-3-48211), and hair. It is known that it can be used as a component of a hair-growth and hair-restoration cosmetic (Japanese Patent Laid-Open No. 4-295412), but there is no known example of finding an action to enhance the hair growth effect derived from polyvinylpyrrolidone. Furthermore, the licorice extract used in the present invention is a hair tonic composition (JP-A-60-222409).
And hair oil (JP-A-63-211214), and horse oil and fat and assembly extract can be used as components in a hair-growth agent (JP-A-3-148210), respectively. However, there is no known example in which an effect of enhancing the hair growth effect derived from polyvinylpyrrolidone is found. That is, it is known that the components that can be used in the present invention can be used as components of hair restorers, hair nourishing agents, cosmetics for hair, etc., but there has been no example examined from the viewpoint of a hair growth agent so far. Therefore, there was no knowledge about the proper combination and amount.

[0003]

SUMMARY OF THE INVENTION An object of the present invention is to provide a hair growth agent containing polyvinylpyrrolidone (hereinafter referred to as PVP).

[0004]

[Means for Solving the Problems] In order to achieve the above-mentioned object, the present inventors screened a hair growth test using a shaved back of a C3H strain mouse (male 8 weeks old) in a resting period. As a result of repeated test studies with the system, the fact that PVP alone has a hair growth effect (breaking effect during the rest period) was discovered. The present invention has been completed in this way.

The present invention will be described in detail below. The following two effects can be observed in the test on the shaved back skin of C3H mice (male 8 weeks old) in which the hair cycle is in the resting state. Hair-growth promoting effect: This is a test method using skin in which the hair cycle is in a growing state. This is a method utilizing the fact that the resting period is converted to the growing stage by treating the cut portion with a depilatory cream. Since hair growth is observed in the drug-uncoated area, water, and alcohol-coated area, the hair-growth promoting effect can be determined by the difference in hair-growth area ratio and hair-growth rate from the drug-application area. Hair growth promoting effect: This is a test method using skin in which the resting state of the hair cycle continues. Without hair removal cream treatment, the rest period continues until about 14 weeks of age.
In the skin within this period, no hair growth is observed in the drug-uncoated area, the water- or alcohol-containing area. The presence and degree of the hair-growth promoting effect (breaking effect during the rest period) can be determined by the hair-growth area ratio of the drug-coated area. The test systems for detecting the hair growth promoting action and the hair growth promoting action are two test systems which have different cycles of hair growth mechanism, and are essentially completely different test systems. For example, Senburi extract and capsicum tincture, which are added as the main active ingredients of commercially available hair restorers and hair nourishing agents,
The effect can be detected by the above-mentioned test system for detecting the hair growth promoting action, but the effect cannot be detected by the test system for detecting the hair growth promoting action. This fact indicates that the assembly extract and capsicum tincture have a hair-growth promoting action but no hair-growth promoting action, and at the same time, the hair-growth promoting action and the hair-growth promoting action are completely different actions. Shows. The present inventors have screened a substance showing a hair growth promoting effect using the latter test method (hair growth promoting effect) described above.
It was discovered that PVP has a strong effect.

The PVP used in the present invention is N-vinyl-
It can be synthesized by radical polymerization of 2-pyrrolidone. In the present invention, by using a method synthesized from N-vinyl-2-pyrrolidone by a method described in the literature or a known method,
Commercially available PVP may be used. In order to show the hair growth effect by PVP alone, it is necessary to use an aqueous solution having a concentration exceeding 0.5%. The upper limit concentration is the saturation solubility. However, in order to show the effect more clearly, it is preferable to use an aqueous solution having a concentration of 1% or more, and since a high-concentration aqueous solution has a bad feeling in use, it is preferable to use it at 5% or less. More preferably, the concentration of PVP is 1 to 3%.

The hair growth effect of PVP is enhanced by sugars. The sugar is not particularly limited as long as it is a monosaccharide, disaccharide, or oligo having a sugar chain length of 20 or less, but, for example, glucose, xylose, fructose, galactose, arabinose,
Mannose, sucrose, lactose, palatinose, maltose,
Examples thereof include cellobiose, raffinose, fructooligosaccharides, isomaltooligosaccharides, xylooligosaccharides, dextrins, α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, or trehalose. These saccharides may be used alone or in combination of two or more. When these have isomers, they can be used either alone or as a mixture. Any of these saccharides can be prepared by the method described in the literature or a known method and used, or a commercially available product can be used.

When a hair growth agent is prepared by mixing saccharides with PVP, the hair growth enhancing effect of the saccharides is observed even when added in a small amount, but 0.2% or more of the hair growth agent aqueous solution is used. Preferably. It is more preferable to add 1% or more. Hair growth is promoted in proportion to the concentration of saccharides, but when the amount of saccharides is 20% or more of the weight of the aqueous solution of hair builder, the hair maker becomes extremely sticky and the feeling of use deteriorates. In order to obtain a good feeling during use, it is preferable that the amount of sugar is 10% or less. By adding sugar, the hair growth effect can be obtained even if the amount of PVP is reduced. For example, a hair-growing agent containing 10% saccharide with respect to the weight of the hair-growing agent solution can be used as a hair-growing agent by using 0.1% of PVP with respect to the weight of the hair-growing agent solution. . That is, P
With a hair-growing agent containing VP alone as an active ingredient, it is necessary to prepare a solution having a PVP concentration of more than 0.5%.
Hair growth agents containing PVP and saccharides as active ingredients include PV
Use of 0.1% or more of P can provide a useful hair growth agent.

As a substance that enhances the hair growth effect of PVP,
Besides saccharides, licorice extract, horse oil and fat, and assembly extract can be exemplified. These substances may be mixed alone in the PVP solution, two or more kinds thereof may be mixed, or may be mixed with the saccharide, but mixing with the saccharide is particularly preferable. The content of licorice extract is preferably 0.2 to 5
%, More preferably 0.5-3%, the content of horse fat is
Preferably 0.2-10%, more preferably 0.5-5
%, The content of assembly extract is preferably 0.2 to 2
%, More preferably 0.5 to 1%. The composition of the present invention is usually an aqueous solution, an aqueous suspension, an emulsion, a cream, a gel,
It can be used in the form of an aerosol or the like, but it is possible to add the constituent components necessary for holding those dosage forms. Further, if necessary, an antioxidant, a preservative, a colorant, a stabilizer, a solubilizing agent, a viscosity modifier, a cooling agent, a fragrance, etc. can be added. Further, an active ingredient which can be usually added to the hair restorer / hair nourishing agent may be added, and a composition having such a structure is also within the technical scope of the present invention.

The present invention will be described below with reference to examples.
The present invention is not limited to these. In the examples, commercially available products were used for all the components. PVP: PVP (K-90) manufactured by Wako Pure Chemical Industries, Ltd. α, α-trehalose: Glucose manufactured by SIGMA: Xylose manufactured by Wako Pure Chemical Industries, Ltd .: Fructose manufactured by Wako Pure Chemical Industries, Ltd. : Kanto Chemical Co., Ltd. Sugar: Kanto Chemical Co., Ltd. Lactose Monohydrate: Kanto Chemical Co., Palatinose Monohydrate: Wako Pure Chemical Industries Maltose Monohydrate: (Co) Wako Pure Chemical Industries, Ltd. D (+)-cellobiose: Seikagaku Corporation, Raffinose: Wako Pure Chemical Industries, Ltd. Fructo-oligosaccharides: Wako Pure Chemical Industries, Isomalto-oligosaccharides: Wako Pure Medicine Industrial xylooligosaccharide: Wako Pure Chemical Industries, Ltd. α-Cyclodextrin: Wako Pure Chemical Industries, Ltd. β-Cyclodextrin: Wako Pure Chemical Industries, Ltd. γ-Cyclodextrin: Wako Pure Chemical Industries, Ltd. Industrial dextrin: Wako Pure Chemical Industries licorice Scan :( stock) Alps Pharmaceutical Industry Co., Ma fats and oils: Japan Kampo Tongren of Pegasus (TM) assembly extract: assembly extraction liquid, Co., Maruzen Pharmaceuticals, Ltd.

[0011]

【Example】

Test example Hair growth effect test 10 backs of C3H / NeH mice (male, 8 weeks old) per each test section were clipped with electric clippers, and the left half was applied with each composition of Table 1 in Table 1 on the next day. Started from. The coating amount is
0.1 ml was used per animal once a day. On the 42nd day after the start of application (42 times of application), the area of the hair-growth part was measured, and the hair-growth area ratio was calculated to determine the effect. The results are shown in Table 1.

[0012]

[Table 1]

¹⁾ : The columns of the test agent contents of test numbers ^{1 to} 62 are
Examples and Comparative Examples, and the proportions of each component are shown using the following description methods. Test agent used in the test 100
g contains each component in the order listed. The balance is water. "Content of PVP g"-"Content of sugar is indicated by abbreviation and its content g"-"Content of licorice extract g"-"Content of horse oil / fat g"-"Content of ginger extract g" , Example-2 of Test Example 36 (1.5-F4-0-0-0),
It contains 1.5 g of PVP and 4 g of fructose, and does not contain licorice extract, horse oil and fat, and assembly extract. Also, test number 50
Example 16 (1.5-T2-1-4-1) shows that it contains PVP 1.5 g, trehalose 2 g, licorice extract 1 g, horse oil and fat 4 g, and assembly extract 1 g.

Abbreviations of sugar types used in Table 1 are shown in Table 2 of Table 2.

[Table 2]

[0015]

EFFECT OF THE INVENTION PVP can be used as a hair growth agent. This effect is enhanced by adding at least one sugar. Moreover, it increases when at least one kind selected from licorice extract, horse oil and fat, and assembly extract is added. It is further enhanced by adding at least one selected from licorice extract, horse oil and fat, and assembly extract in addition to the addition of sugar.

─────────────────────────────────────────────────── ─── Continuation of the front page (56) References JP-A-5-139936 (JP, A) JP-A-4-108722 (JP, A) JP-A 64-9912 (JP, A) JP-A-3- 14510 (JP, A) JP 3-148210 (JP, A) JP 6-145030 (JP, A) JP 2-4706 (JP, A) JP 60-56915 (JP, A) JP-A-56-63912 (JP, A) JP-A-62-36394 (JP, A) JP-A-5-229920 (JP, A) JP-A-5-227982 (JP, A) JP-A-4-295412 (JP, A) JP-A-7-304634 (JP, A) Special Table: 3-502447 (JP, A) (58) Fields investigated (Int.Cl. ⁷ , DB name) A61K 7/00-7 / 50 A61K 31/70 A61K 31/79

Claims (2)

(57) [Claims] 1. Polyvinylpyrrolidone having a K value of 90: 1.5 to 5%, glucose, xylose, fructose, galactose, arabinose, mannose, sucrose, lactose, palatinose, maltose, cellobiose, raffinose, fructooligosaccharides, isomaltooligosaccharide. 1 to 10 of at least one member selected from the group consisting of saccharides, xylooligosaccharides, dextrins, α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, and trehalose.
%, A hair growth agent. 2. 1.5 to 5% of polyvinylpyrrolidone having a K value of 90 and glucose, xylose, fructose, galactose, arabinose, mannose, sucrose, lactose, palatinose, maltose, cellobiose, raffinose, fructooligosaccharides, isomaltooligosaccharide. 1 to 10 of at least one member selected from the group consisting of saccharides, xylooligosaccharides, dextrins, α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, and trehalose.
%, Licorice extract 0.2 to 5%, horse fat and oil 0.2 to
A hair-growing agent containing at least one member selected from the group consisting of 10% and Assembler extract 0.2-2%.