JP3450131B2 - Bone repair material - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [0001] TECHNICAL FIELD The present invention relates to collagen and kiti.
Made of materials obtained from natural tissues such as bones, bone defects,
Used for surgical treatment such as injury and tooth extraction, orthopedic surgery
Bone repair material. [0002] 2. Description of the Related Art Conventionally, biological tissues such as collagen and chitin
Biomaterial consisting of material obtained from
And filling the tooth extraction fossa etc. in a block shape and prosthesis
It has been used to maintain its shape. [0003] Among such biomaterials, block-shaped fillers are used.
As the filler, for example, the invention of JP-A-62-39506
Porous sponge is made by crosslinking chitin with a drug.
It is non-absorbable in vivo and excellent in shape retention. [0004] Further, the invention disclosed in Japanese Patent Application Laid-Open No. 3-23864 is a duplicate of the invention.
The composite material is used as a block-shaped filler.
The composite material consists of collagen sponge and polylactic acid
Absorbable within. [0005] However, the prior art described above has the following problems.
There were the following issues. That is, the porous sponge
Di is not completely replaced by bone itself because it is non-absorbable
Risk of infection and the risk of material being detached.
There was ruggedness. On the other hand, the composite material is atelocollagen.
Has some antigenicity, and when polylactic acid is decomposed and absorbed
There is a problem that it causes an inflammatory reaction in living tissue. [0007] In the bone defect space, as shown in FIG.
A portion (hereinafter, referred to as a proximal portion) a1 close to the mother bed bone surface B4
There is a distant part (hereinafter referred to as a distal part) a2,
There is also a difference in speed when returning. And the composite material A
In the case of, the whole material is almost uniform
Dissolution absorption proceeds. Therefore, the distal part a2 is replaced with bone.
By the time, a large amount of the composite material A is absorbed in the distal portion a2.
The bone mass seems to be short due to being lost
Tended to be. [0008] Means for Solving the Problems To solve the above problems,
Therefore, the present invention relates to a chitin derivative proximal to bone.
Carboxymethyl chitin (hereinafter abbreviated as CM chitin)
), But so that the chitin is located at the distal part,
Chitin and carboxyl chitin were provided. [0009] [Action] Chitin is degraded and absorbed in bone compared to CM chitin
Slowness. In the present invention, these materials are decomposed and absorbed in vivo.
Utilizes the difference in acquisition speed. That is, implanted in the bone
Is a derivative of chitin proximal to the bone when
Carboxymethyl chitin and chitin in the distal part
Chitin and carboxyl chitin
In the proximal part of the bone defect to the bone,
In the early stage of implantation, CM chitin is actively absorbed into the body and bone
Is replaced by In contrast, the distal part is made of chitin.
Chitin is absorbed more quickly than CM chitin.
Slow, enough for distal part to begin to be replaced by bone
Large amounts of chitin remain, which can lead to bone defects
In this case, a sufficient amount of bone at a distal portion with respect to the bone is also ensured. [0010] BRIEF DESCRIPTION OF THE DRAWINGS FIG.
It will be described using FIG. 1 to 3 show a bone repair material according to the present embodiment.
The bone repair material 10 of FIG. 1 has a columnar shape and is in contact with bone.
Outer part 1 is made of CM chitin sponge,
Position 2 consists of a chitin sponge. Also, the bone repair shown in FIG.
The material 20 has a roughly bowl-shaped outer peripheral portion 1 made of CM chitin sponge.
The inner part 2 is made of a chitin sponge. Ma
In addition, the block-shaped bone repair material 30 of FIG.
The left and right sides are separated from the bone
Plant chitin
It consists of a sponge made of chitin and a sponge made of chitin. Next, FIGS. 4 to 6 show the bone repairs shown in FIGS.
FIG. 4 shows an application example of the reclaimed materials 10, 20, and 30, and FIG.
The columnar bone repair material 10 is pressed into the defect b1 of the long bone B1.
Indicates the specified state. FIG. 5 shows a hollow defect on the surface of bone B2.
A state in which the restoration material 20 of FIG. 2 is press-fitted and fixed to the portion b2 is shown.
FIG. 6 shows a bone B3 and an implant I (for example, an artificial hip joint).
The bone repair material 3 of FIG.
0, and the bone contact portion 4 faces the bone B3.
At the same time, the implant contact portion 5 is
It is fixed to the surface of the runt I face to face. The bone repair materials 10, 20, 3 of these embodiments
0 is the proximal part (peripheral part 1, bone)
CM chitin with fast absorption rate in the body
The site is quickly replaced by bone and
When the bone is replaced with bone, the distal part (inner part 2,
The chitin that constitutes the abutment site 5) is compared to CM chitin
Since the absorption rate is low, a large amount remains.
Good because the bone mass is sufficiently secured when the bone is replaced with bone
Bone repair is possible. The bone repair materials 10, 20, 30
There are the following methods as a manufacturing method. First chitin solution
For example, put in a cylindrical container and freeze-dried,
Preferably in a vacuum at a crosslinking temperature of 120 ° to 180 °,
Thermally crosslinks by heating for about 24 hours,
Distal part (inner part 2, implant contact part 5)
Is prepared. Next, in an appropriately shaped container
The chitin body is set in the container, and CM chitin is inserted into the space in the container.
Pour the solution, freeze-dry and heat crosslink again
Therefore, the distal part (inner part 2, implant contact part)
5) Proximal part of CM chitin (peripheral part 1, bone abutment)
Bone repair materials 10, 20, 30 integrally formed with site 4)
Get. [0014] 【Example】Example 1 Dissolve 1.0 g of 50% deacetylated chitin in distilled water
Then, a 1.0 wt% aqueous solution was prepared, and this was
Pour into containers, freeze quickly at -20 ° C, freeze-dry
Was done. Next, the dried chitin is cooled to a temperature of 30 ° or less.
After air-drying, thermal crosslinking in vacuum at 140 ° C for 24 hours
Processing was performed. [0015] The solid chitin thus obtained is sized.
Set in the center of the bottomed cylindrical container. And mosquito
CM chitin powder with a ruboxyl methylation degree of 60% is distilled water
CM chitin obtained by dissolving in a 3.0 wt% aqueous solution
The solution is poured around solid chitin and at -20 ° C
It was quick-frozen and freeze-dried. Next, the dried kiti
Air at 30 ° C or less, then at 140 ° C for 24 hours.
During that time, a thermal crosslinking treatment was performed in a vacuum. In the manner described above, a columnar shape is formed,
The outer peripheral part 1 in contact is made of CM chitin sponge,
A bone repair material 10 in which the side part 2 is made of a chitin sponge is made.
Made. [0017]Example 2 Particle size 1 equivalent to 1.0 g of 50% deacetylated chitin
50 μm hydroxyapatite (hereinafter abbreviated as HAP)
The granules are mixed with distilled water, and the HAP granules are evenly dispersed in the solution.
Stir well with a stirrer so that
An aqueous solution having a tin concentration of 1.0 wt% was prepared. Next,
The mixed solution is made of metal, hard glass or polypropylene
Pour into a Petri dish and in a dry ice ethanol bath
(Approximately minus 40 ° C) while HAP is uniformly dispersed
And the whole container was freeze-dried. Then dry
The material is subjected to a thermal crosslinking treatment in a vacuum at 160 ° C. for 24 hours.
Was. CM having a degree of carboxylmethylation of 60%
Distillation of HAP granules with a particle size of 150μm equivalent to chitin powder
Dissolve in water and adjust the CM chitin concentration 3.0 wt% aqueous solution
The CM chitin solution obtained above containing the HAP granules,
Pour into a Petri dish containing flat chitin
In a dry ice ethanol bath (about -40 ° C)
Frozen while HAP is uniformly dispersed in
Lyophilized. Then, dry the product at 160 ° C for 24 hours
During that time, a thermal crosslinking treatment was performed in a vacuum. In the above manner, as shown in FIG.
The right is divided into bone contact part 1 and implant contact part 2.
And CM chitin sponge and chitin sponge respectively
A two-layered bone repair material 10 was prepared. [0020] According to the present invention, when implanted in bone,
Carboxylme, a derivative of chitin, proximal to
Til chitin and chitin at the distal part
As described above, chitin and carboxyl chitin are arranged,
By taking advantage of the difference in absorbability in vivo,
The proximal part is quickly and quickly replaced by bone, while the distal part
Sufficient amount of chitin is placed in the distal
And the distal part is replaced with sufficient bone mass
You. Therefore, there is no problem of insufficient bone mass at the distal portion.
It is a very good bone repair material.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a perspective view of a bone repair material according to an embodiment of the present invention. FIG. 2 is a cross-sectional view of a bone repair material according to another embodiment of the present invention. FIG. 3 is a perspective view of a bone repair material according to another embodiment of the present invention. FIG. 4 is a cross-sectional view showing a state in which the bone repair material of FIG. 1 is applied to a bone defect of a long bone. 5 is a cross-sectional view showing a state in which the bone repair material of FIG. 2 is applied to a bone defect. 6 is a side view showing a state in which the bone repair material of FIG. 3 is filled in a space between the implant and the bone. FIG. 7 is a cross-sectional view showing a distal portion and a proximal portion of a bone repair material filled with a bone defect. [Description of Signs] 10, 20, 30 ··· Bone repair material, 1 ··· Outer perimeter, 2
..Inner part, 3 ..Partition plane, 4 ..Bone contact part, 5 ..Implant contact part, B1 ..Long tubular bone,
B2, B3 ··· bone, b1 ··· defect part, b2 ··· hollow defect part, b3 ··· void, I ··· implant

Claims (1)

(57) Claims 1. When implanted in a bone, carboxylmethyl chitin, which is a derivative of chitin, is placed in a portion proximal to the bone, and chitin is placed in a distal portion, respectively. A bone repair material comprising chitin and carboxychitin.