JP3426413B2 - Cosmetics - Google Patents

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to cosmetics having extremely low skin irritation, excellent storage stability and excellent organoleptic properties.

[0002]

2. Description of the Related Art Conventionally, (a) salts of sulfuric acid esters of aliphatic higher alcohols, phosphoric acid esters of aliphatic higher alcohols, N-long chain acylglutamic acid, etc. and basic substances such as caustic soda, caustic potash, triethanolamine, etc. Anionic surfactants, (b) ether type nonionic surfactants such as ethylene oxide adducts of aliphatic higher alcohols, (c) ester type nonionic surfactants composed of higher fatty acids and polyhydric alcohols, etc. Skin cosmetics containing as an emulsifier main component are known. However, these skin cosmetics cannot be said to have sufficient skin safety for consumers with sensitive skin disorders, and improvement thereof has been desired.

[0003]

The problem to be solved by the present invention is to develop a skin cosmetic having sufficient skin safety to satisfy consumers with sensitive skin disorders.

[0004]

Means for Solving the Problems As a result of intensive studies in view of the above circumstances, the present inventors have found that the specific skin cosmetics described below have excellent skin safety and surprisingly excellent storage stability. The present invention has been completed by finding out that they also have sensory characteristics. That is, claim 1 of the present invention is defined by the general formula (1)

[0005]

[Chemical 3]

(However, the carbon number of RCO in the formula is 20, 1
8, 16, 14, 12, 10, and 8, X is any one of a sulfone group, a sulfate group, a carboxyl group, and a phosphate group, and M is a monovalent or divalent alkali metal ion,
Ammonium ion, organic ammonium ion)
The cosmetic is characterized by blending an anionic surfactant containing 2 hydrophobic groups, 2 hydrophilic groups and a peptide group represented by Further, claim 2 of the present invention is defined by the general formula (2)

[0007]

[Chemical 4]

(However, the carbon number of RCO in the formula is 20, 1
8, 16, 14, 12, 10, 8 and n is 2 to 10
A nonionic surfactant containing 2 hydrophobic groups, 2 hydrophilic groups, and a peptide group represented by 0) is blended.

Next, the structure of the present invention will be described. The anionic surfactant containing 2 hydrophobic groups, 2 hydrophilic groups and peptide group in the present invention has the general formula (3)

[0010]

[Chemical 5]

(However, the carbon number of RCO in the formula is 20, 1
Is 8, 16, 14, 12, 10, and 8),

[0012]

[Table 1]

A polar group such as a sulfone group, a sulfuric acid group, a carboxyl group and a phosphoric acid group is added to the primary hydroxyl group of the compound synthesized by the reaction represented by the method known in the art (for example,
"Surface," Volume 32, No. 8, 1994). It should be noted that, here, "part" such as sulfone group, sulfuric acid group, carboxyl group, and phosphoric acid group.
The reason for expressing as is, for example, the acetic acid group introduced by reacting the compound represented by the general formula (3) with halogenated acetic acid is collectively referred to as a carboxyl group part, and is referred to as including a linking group and a polar group. This is because. As counterions of these polar groups, monovalent or divalent alkali metal ions such as sodium, potassium and magnesium, ammonium ions,
Organic bases such as triethanolamine, isopropanolamine, lysine or ammonium ions such as basic amino acids are applied.

The peptide group-containing 2-hydrophobic group 2-hydrophilic group type nonionic surfactant of the present invention comprises a compound represented by the general formula (3) in a predetermined amount when heated in the presence of an alkali catalyst in a closed container. Obtained by reacting with ethylene oxide. Although the peptide group-containing 2-hydrophobic group 2-hydrophilic group type nonionic surfactant of the present invention may be obtained as a mixture, the desired surfactant can be isolated by an appropriate purification means.

The anionic and nonionic surfactants containing 2 hydrophobic groups, 2 hydrophilic groups and peptide groups of the present invention 0.0
An aqueous solution containing 01 mol in 100 g was used as a sample,
A skin safety test was carried out according to the “human skin patch test” described below. The results are shown in Tables 2 and 3.

[0016]

[Table 2]

[0017]

[Table 3]

The cosmetic of the present invention comprises the two hydrophobic groups as described above,
2 A hydrophilic group, a peptide group-containing anion, and a nonionic surfactant, but other surfactants, emulsification aids, fragrances, colorants, preservatives, pigments, etc. may be added according to the invention. It may be appropriately blended within a range that achieves the above purpose.
The skin cosmetics of the present invention include skin milk, skin cream, foundation cream, massage cream,
Face cleansing cream, lotion, scalp treatment,
It is applied to basic cosmetics such as hair cream, hair shampoo and hair conditioner, makeup cosmetics and hair cosmetics.

[0019]

EXAMPLES The present invention will be described below with reference to examples. The storage stability test, human skin patch test, and feel (sensory test during use) test methods or measurement methods described in Examples are shown below.

(1) Storage stability test The sample was placed in a thermostatic chamber at 45 ° C., and after standing for 6 months, the emulsified state and appearance were observed and no abnormalities were observed (emulsion state was uniform and homogeneous emulsion. When formed), it was evaluated as good, and when abnormalities were observed (when oil was separated, when particles became coarse, etc.), it was evaluated as poor.

(2) Human Skin Patch Test On the skin of the forearm flexor side of 25 subjects, 0.1 g of the sample was occluded for 24 hours by using a patch test plaster with a circular lint cloth having a diameter of 1.0 cm. After the cloth was applied, the skin condition of 25 test subjects was evaluated for each sample according to the criteria shown in Table 4 below. As the determination result, the one with the strongest reaction was used after 1 hour and 24 hours after the removal of the adhesive bandage, and the evaluation was shown by the number of persons with (±) or more.

[0022]

[Table 4]

(3) Feeling (sensory test during use) Twenty female test subjects were applied twice a day in the morning and evening for 30 days to perform a sensory test to test the moisturizing and irritating properties. Moisture retention is evaluated as "moist after use"
The number of respondents who answered "I feel irritation after use" was indicated by the number of respondents who answered "I feel irritation after use."

Examples 1 to 4 and Comparative Examples 1 to 3 [Skin milk] Examples and Comparative Examples were prepared by mixing various emulsifier components as shown in Table 5 and various raw materials as shown in Table 6. An example skin milk was prepared and tested for various properties.

[0025]

[Table 5]

(1) Composition

[0027]

[Table 6]

(2) Preparation Method Component (A) and component (B) are uniformly dissolved at a temperature of 80 ° C., and component (B) is injected while stirring component (A) and emulsified and dispersed. Prepare by cooling to a temperature of 30 ° C. with stirring. (3) Characteristics Table 5 shows the results of testing the various characteristics according to each example and comparative example. From these results, it is clear that the skin milk of the present invention is excellent in skin safety, storage stability and sensory characteristics during use.

Example 5 [Scalp Treatment (Scalp Treatment)] (1) Composition (1) The acyl group of the general formula (1) has 18 carbon atoms (stearoyl group) and is 0.5, and X is ethane sulfone. Anionic surfactant of the present invention in which M is a potassium ion (2) 1,3-butylene glycol 6.5 (3) polyethylene glycol 1500 5.0 (4) ethanol 5.5 (5) causticari. 05 (6) Purified water Residue (7) Carboxyvinyl polymer 0.2 These values are wt% with respect to the total amount of the composition, and the same applies to the following examples.

(2) A scalp treatment was obtained according to the above-mentioned formulation and the usual method.

(3) Characteristics The scalp treatment of the present invention was excellent in skin safety, storage stability and sensory characteristics during use.

Example 6 [Cream foundation] (1) Composition   (1) cetostearyl alcohol 1.0   (2) Jojoba oil 15.0   (3) Glycerin monostearate 2.0   (4) Propylene glycol monolaurate 3.0   (5) The acyl group of the general formula (1) has a carbon number of 18 (stearoyl group) and is 0.5       Where X is an acetate group and the counterion is an ammonium ion       Anionic surfactant of the invention   (6) Propylene glycol 4.0   (7) Methylparaben 0.3   (8) Perfume 0.1   (9) Purified water Residue of all components   (10) Titanium oxide 8.0   (11) Talc 4.0   (12) Iron oxide 0.5

(2) Preparation method Oil phase components (1), (2), (3), (4) and aqueous phase components (5), (6)
, (7), (8) and (9) and pigment components (10), (11) and (12) were mixed by a conventional method to obtain a cream foundation.

(3) Characteristics The cream foundation of the present invention was excellent in skin safety, storage stability and sensory characteristics during use.

Example 7 [Lotion] (1) Composition   (1) The acyl group of the general formula (1) has 8 carbon atoms, and 0.5       X is a propane sulfone group and M is a sodium ion       Anionic surfactant of the present invention   (2) Glycerin 4.0   (3) 1,3 butylene glycol 4.0   (4) Ethanol 7.0   (5) Methylparaben 0.5   (6) Citric acid 0.01   (7) Sodium citrate 0.1   (8) Perfume 0.05   (9) Purified water Residue of all components

(2) Preparation method The above components were mixed by a conventional method to obtain a lotion.

(3) Characteristics The lotion of the present invention was excellent in skin safety, storage stability and sensory characteristics during use.

Examples 8 to 14 and Comparative Examples 4 and 5 [skin milk] Examples and Comparative Examples in which various emulsifier components are blended as shown in Table 7 and various raw materials are blended as shown in Table 8. An example skin milk was prepared and tested for various properties. (1) Composition

[0039]

[Table 7]

[0040]

[Table 8]

(2) Preparation method The components (A) and (B) are uniformly dissolved at a temperature of 80 ° C., and the components (B) are injected with stirring to emulsify the components. Prepare by cooling to a temperature of 30 ° C. with stirring. (3) Characteristics Table 7 shows the results of testing the various characteristics according to each example and comparative example. From these results, it is clear that the skin milk of the present invention is excellent in skin safety, storage stability and sensory characteristics during use.

Example 15 [Scalp Treatment (Scalp Treatment)] (1) Composition (1) The acyl group of the general formula (2) has 18 carbon atoms (stearoyl group) of 4.5, and n is 20. Certain nonionic surfactants of the present invention (2) 1,3-butylene glycol 4.5 (3) polyethylene glycol 1500 3.0 (4) ethanol 5.5 (5) causticus 0.05 (6) purified water Remainder of components (7) Carboxyvinyl polymer 0.2 (2) A scalp treatment was obtained according to the above-mentioned formulation and the usual operating method. The scalp treatment of the present invention was excellent in skin safety, storage stability, and sensory characteristics during use.

Example 16 [Cream foundation] (1) Composition   (1) cetostearyl alcohol 1.0   (2) Jojoba oil 15.0   (3) Glycerin monostearate 2.0   (4) Propylene glycol monolaurate 3.0   (5) The number of carbon atoms of the acyl group of the general formula (2) is 18 (stearoyl group) and is 0.5.       And n is 10, the nonionic surfactant of the present invention   (6) Propylene glycol 4.0   (7) Methylparaben 0.3   (8) Perfume 0.1   (9) Purified water Residue of all components   (10) Titanium oxide 8.0   (11) Talc 4.0   (12) Iron oxide 0.5

(2) Preparation method Oil phase components (1), (2), (3), (4) and aqueous phase components (5), (6)
, (7), (8) and (9) and pigment components (10), (11) and (12) were mixed by a conventional method to obtain a cream foundation.

(3) Characteristics The cream foundation of the present invention was excellent in skin safety, storage stability and sensory characteristics during use.

Example 17 [Lotion] (1) Composition   (1) The acyl group of the general formula (1) has 8 carbon atoms and n is 4. 1.0       Nonionic surfactant of the present invention   (2) Glycerin 4.0   (3) 1,3 butylene glycol 4.0   (4) Ethanol 7.0   (5) Methylparaben 0.5   (6) Citric acid 0.01   (7) Sodium citrate 0.1   (8) Perfume 0.05   (9) Purified water 83.34

(2) Preparation Method The above components were mixed by a conventional method to obtain a lotion. (3) Characteristics The lotion of the present invention was excellent in skin safety, storage stability and sensory characteristics during use.

[0048]

As described above, the cosmetics of the present invention are excellent in skin safety, storage stability and sensory characteristics during use, and are extremely useful.

─────────────────────────────────────────────────── ─── Continuation of the front page (56) Reference JP-A-7-206878 (JP, A) JP-A-6-271893 (JP, A) JP-A-6-80987 (JP, A) JP-A-6- 305931 (JP, A) JP-A-6-172783 (JP, A) JP-A-57-42799 (JP, A) (58) Fields investigated (Int.Cl. ⁷ , DB name) A61K 7/00-7 / 50 CA (STN)

Claims (2)

(57) [Claims] 1. A compound represented by the general formula (1): (However, the carbon number of RCO in the formula is 20, 18, 16, 1
4, 12, 10, 8 and X is any one of a sulfone group, a sulfate group, a carboxyl group and a phosphoric acid group,
M is a monovalent or divalent alkali metal ion, ammonium ion, or organic ammonium ion) 2
A cosmetic comprising an anionic surfactant containing a hydrophobic group, a hydrophilic group and a peptide group. 2. A general formula (2): (However, the carbon number of RCO in the formula is 20, 18, 16, 1
4, 12, 10, 8 and n is 2 to 100), wherein the cosmetic is characterized by blending a nonionic surfactant containing 2 hydrophobic groups, 2 hydrophilic groups and a peptide group.