JP3425912B2 - Sample processing system - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a sample processing system, and more particularly to a system for automatically preparing a primary mixed sample and a secondary mixed sample from an original sample.

[0002]

2. Description of the Related Art Blood test centers carry out various tests on blood samples (original samples) sent from blood collection centers in various regions. The number of samples to be inspected at an inspection center per day has reached 10,000, for example, and there is a strong demand for rationalization and efficiency of inspection. Note that some blood serological tests are also performed as primary screening at blood collection centers, but a wider range and higher accuracy of tests are performed at test centers.

In recent years, a nucleic acid amplification test (NAT: Nucleic
The acid amplification test) method has been put to practical use, and highly sensitive blood tests are becoming possible. However, the cost per inspection is relatively high and the process is complicated. Therefore, the number of NAT inspections per day cannot be increased so much at present.

Therefore, a method of collectively testing a large number of specimens is used. Specifically, first, for example, 50 original specimens are combined into one to create a primary mixed specimen (primary pool specimen), and then, for example, 10 primary mixed specimens are combined into one.
A secondary mixed sample (secondary pool sample) is created collectively. The primary mixed sample and the secondary mixed sample are stored for a certain period of time. In parallel with the storage, the test by the NAT method is performed on the secondary mixed sample. If the result of the test is positive, a test by the NAT method is performed on a plurality of primary samples used when creating the secondary sample as the positive sample, and further, it is determined to be positive. A test by the NAT method is performed on a plurality of original samples used when creating the primary mixed sample. This identifies the positive original sample. Various methods have been proposed as a method for tracking a positive original sample.

[0005] Usually, since the probability of occurrence of positive specimens is extremely low, the collective examination of mixed specimens as described above makes it possible to reliably determine positive specimens while improving the examination efficiency.

[0006]

However, in the prior art, a lot of manual work was required to prepare a mixed sample by the above-mentioned pretreatment, and efficient treatment was difficult. Therefore, there is a demand for an automated system that efficiently performs a series of steps from the reception of the original sample to the preparation of the secondary mixed sample while taking into consideration the specific circumstances regarding the mixed sample.

The present invention has been made in view of the above conventional problems, and an object thereof is to provide a sample processing system having a high processing capacity.

Another object of the present invention is to provide a sample processing system capable of flexibly coping with an increase or decrease in the number of samples.

[0009]

[Means for Solving the Problems] (1) In order to achieve the above object, the present invention is a primary dispensing in which a fixed amount is sampled from m original samples and mixed to prepare a primary mixed sample. The correspondence between the means and the secondary dispensing means for collecting a fixed amount from n primary mixed samples and mixing them to form the secondary mixed sample, the original sample, the primary mixed sample and the secondary mixed sample A storage means for storing and a tracking means for identifying the primary mixed sample and the original sample corresponding to the positive sample by referring to the correspondence relationship when one of the secondary mixed samples is designated as a positive sample , A dummy sample holding a dummy sample
Holding means, including the primary dispensing means and the secondary dispensing means
At least one of the injection means is necessary when preparing a mixed sample
In this case, the dummy sample is dispensed .

According to the present invention, as shown in FIG. 1 (A), first, a predetermined amount is sampled from the m original specimens 30 by the primary dispensing means, which is mixed as one primary mixed specimen 32. To be done. Here, for example, the original sample is a blood sample that has been subjected to centrifugation after collection. As shown in (B), when n primary mixed samples are created by the above process,
A predetermined amount of each primary mixed sample is sampled by the secondary dispensing means and mixed as one secondary mixed sample 34 (see (C)). Here, the primary dispensing means and the secondary dispensing means may be the same dispensing device, but if they are configured as separate dispensing devices, efficient dispensing can be realized.
As shown in (D), a predetermined test is performed on the secondary mixed sample, and if the test result is positive, the tracking means causes the primary mixed sample and the original sample corresponding to the secondary mixed sample. Can be easily specified. Then, the positive source sample is discriminated using various methods.

According to the present invention, the work of preparing the primary mixed sample and the secondary mixed sample can be automated, and the positive sample can be efficiently tracked according to the stored correspondence between the samples. The parameter m is 50, for example, and the parameter n is 10. Under this condition, the secondary mixed sample is a sample in which 500 samples are mixed.

Preferably, the original sample, the primary mixed sample, and the secondary mixed sample are managed by a label containing sample identification information, and the sample identification information of each sample is registered in the storage means. According to this label management, individual management of each sample can be surely performed. If necessary, a label reader or a label sticker is provided at a required position on the system.

Preferably, the apparatus includes a mixing number setting means for variably setting the parameters m and n, and the primary dispensing means and the secondary dispensing means operate according to the mixing number condition set by the mixing number setting means. To do. With this configuration, it is possible to freely set an appropriate mixing ratio, the number of mixing, and the like according to the inspection condition, and the automatic dispensing is performed according to the setting.

[0014] Desirably, includes n rounded hand stage specimens shortage when creating the primary mixing analyte to execute the dispensing of the dummy sample by that lack a few minutes in the event of. According to this configuration, when a secondary mixed sample is sequentially created in units of m × n original samples for a large number of original sample groups, the last remaining number of original samples is m × n. Even if the number is less than the number, it is possible to make up a predetermined amount of the secondary sample by supplementing the insufficient number with the dummy sample. Here, a liquid (such as physiological saline) that does not interfere with the test is used as the dummy sample. The supplementation of the dummy sample is executed at least during the preparation of the primary mixed sample and the preparation of the secondary mixed sample.

[0015] Desirably, when the test body suction abnormality is detected in accordance with a predetermined condition, comprising a suction abnormality handling manual stage to perform the dispensing of the dummy sample in place of the sample. According to this configuration, when a dispensing abnormality occurs, it is possible to perform the alternative dispensing of the dummy sample and maintain a predetermined mixing ratio or mixing amount. Therefore, it is possible to individually cope with the dispensing abnormality and prevent the work efficiency from being lowered without hindering the flow of the entire system.

(2) In order to achieve the above object, the present invention provides a sample processing system including at least one sample processing station, wherein the sample processing station comprises:
An opening device that opens the original sample, a primary dispensing device that collects a fixed amount of m original samples after opening and mixes them to create a primary mixed sample, and n primary mixing A secondary dispensing device that collects a fixed amount of each sample and mixes them to create a secondary mixed sample, a capping device that caps each sample described above, and a dummy sample storage device that holds a dummy sample.
Holding means, and the primary dispensing means and the secondary dispensing means
At least one of the means is necessary for preparing the mixed sample.
In this case, the dummy sample is dispensed.

According to the above construction, in the preparation of the primary mixed sample and the secondary mixed sample, the stopper of the original sample (blood collection tube) is automatically removed and the stopper is attached to each sample (test tube) after dispensing. Then, it is possible to facilitate the subsequent storage. In this way, the series of flow is automated, and the number of processes per day can be significantly improved as compared with the conventional method.

Preferably, the sample processing station includes a centrifuge for performing a centrifugal separation process on the original sample prior to the opening in order to prevent droplets from scattering when opening the stopper. The sample may be attached to the back side of the stopper due to transportation or transportation. In that case, if the plug is opened randomly, the sample may be scattered and contamination may occur. On the other hand, if the centrifugal separation process is performed before opening,
It is possible to prevent contamination by shaking off the sample attached to the back of the stopper.

Preferably, the capping device includes a handling unit for grasping the plug and a robot mechanism for three-dimensionally transporting the handling unit. If the handling unit is configured to be movable three-dimensionally in this way, the degree of freedom in positioning the original sample, the primary mixed sample, and the secondary mixed sample can be increased.

Desirably, the apparatus further comprises a sample extracting device for executing an appropriateness test for each original sample and extracting an unsuitable sample prior to the introduction of the original sample into the sample processing station. According to this configuration, for example, a sample for which a positive test result has already been obtained in a preliminary test, a sample having a management problem, or the like can be excluded from the processing target.

(3) In order to achieve the above object, the present invention provides a plurality of sample processing stations that can operate in parallel with each other, an original sample supply device that distributes an original sample to the plurality of sample processing stations, and the plurality of sample processing stations. In the sample processing system including the operation management device that manages the operation of the sample processing station, each of the sample processing stations includes an opening device that opens the original sample and m original samples after opening. A secondary dispensing device that collects a fixed amount of each and mixes them to create a primary mixed sample, and a fixed amount of each of n primary mixed samples, and mixes them to create a secondary mixed sample Dispensing device, capping device for capping each of the above samples, and dummy sample holding means holding a dummy sample
And, only including, of the primary dispensing means and the secondary dispensing means
If at least one is needed when preparing a mixed sample
It is characterized in that the dummy specimen is dispensed .

According to the above configuration, sample processing stations having the same function are installed in parallel, and the number of operating sample processing stations can be adjusted appropriately according to processing conditions such as the number of processed samples. Further, even if a trouble occurs in one sample processing station, it is possible to proceed with the sample processing by using another sample processing station.

[0023]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT A preferred embodiment of the present invention will be described below with reference to the drawings.

FIG. 2 conceptually shows each process in the test center 12 in which the sample processing system according to the present invention is installed. In FIG. 2, the original sample group transported from the blood collection centers 10 of various places is the test center 1
2 (see reference numeral 14), and then an unsuitable specimen is extracted from the original specimen group (reference numeral 1).
6). Here, the unnecessary specimen to be extracted is
For example, a positive sample determined to be positive in the pre-examination at the blood collection center 10, a reserved sample whose determination is suspended in the pre-examination, an information-unregistered sample to which sample information is not attached, and a barcode attached to each sample Examples include unreadable samples that could not be read. As described above, since the unsuitable sample is extracted prior to the preparation of the primary mixed sample and the secondary mixed sample, there is an advantage that wasteful sample processing can be excluded and the processing efficiency can be improved. By the way, the result of the pre-examination at the blood sampling center 10 is
It is sent to the inspection center 12 as electronic information stored in, for example, or as electronic information transmitted online.

After the unsuitable sample is removed, as shown by reference numeral 18, a primary mixed sample is prepared. As described with reference to FIG. 1, for example, one primary mixed sample is created from m original samples, and by repeating this, n primary mixed samples are created. Then, as indicated by reference numeral 20, one secondary mixed sample is created from the n primary mixed samples. Here, when m is 50 and n is 10, the secondary mixed sample corresponds to a sample in which 500 original samples are mixed.
By the way, the primary mixed sample preparation step and the secondary mixed sample preparation step shown by the reference numerals 18 and 20 are executed by using an automatic pipetting device described later.

The above-mentioned steps are repeatedly executed, and the inspection based on the above-mentioned NAT method is executed as shown by the reference numeral 24 on the secondary mixed specimens which are sequentially prepared. Incidentally, the original sample, the primary mixed sample, and the secondary mixed sample are respectively stored and prepared for later tracking (see reference numeral 22). Of course, the correspondence of each sample is managed electronically,
Specifically, the correspondence relationship is managed by the sample correspondence table.

If a negative test is made on the secondary mixed sample by the test based on the NAT method, the negative test is uniformly found on the original samples, for example, 500 original samples. On the other hand, when the secondary mixed sample is determined to be positive, for example, any of the original samples in 500 samples is considered to be a positive sample. Therefore, as indicated by reference numeral 26, the tracking process of the positive sample is executed in accordance with the above-mentioned correspondence between the samples.

In this case, for example, first, retesting is performed on each of the n primary mixed samples corresponding to the secondary mixed sample, and if a positive sample is present therein, the positive sample is detected. The m original samples that make up a certain primary mixed sample are specified, and the positive original sample is finally specified from among them. Incidentally, various methods can be adopted for this tracking method, and in any case, the correspondence relationship between the samples is referred to when performing such tracking.

In FIG. 2, reference numeral 100 and reference numeral 102
All or part of the function shown by is realized by the sample processing system according to the present embodiment. In the tracking shown by reference numeral 26, the re-inspection itself is performed by the inspection device that executes the inspection step shown by reference numeral 24. Of course, it is possible to integrate both such an inspection device and the sample processing system to form an integrated inspection system.

Next, a preferred embodiment of the sample processing system according to this embodiment will be described with reference to FIG. This sample processing system is a pretreatment system that creates a primary mixed sample and a secondary mixed sample from a plurality of original samples prior to a sample test.

In FIG. 3, the sample processing system is roughly divided into a system controller 36, a receiving device 38, a transport system 40, and a plurality of basic systems 42. The system controller 36 is composed of, for example, a computer machine, and the data of the pre-inspection result is input to the system controller 36 via a recording medium or a network. Also, data of the NAT inspection result is input from an inspection device (not shown) via a recording medium or a network. The pre-inspection result is used in a sampling process in the reception device 38 described later, and the NAT inspection result is used as a precondition for performing the tracking shown in FIG.

The system controller 36 has a display section 46.
And the input unit 48 is connected. The display unit 46 is a display, and the display unit 46 displays various kinds of information such as operating conditions in the present system. The input unit 48 includes various user interfaces such as a keyboard and a mouse, and specifies the number of basic systems 42 actually operated via the input unit 48 and the number of original samples to be supplied to each basic system 42. It can be performed. That is, the system according to the present embodiment includes a plurality of basic systems 42 connected in parallel in order to realize the most efficient pretreatment in accordance with the change in the number of specimens transported in large quantities to the inspection center. It is possible to operate only an arbitrary number of basic systems 42 among the plurality of basic systems 42. For example, it is possible to operate all the basic systems 42 in the normal state and to operate only some of the basic systems 42 at the end stage of the pretreatment. Further, even if a trouble occurs in some of the basic systems 42, there is an advantage that the other basic systems 42 can be operated to prevent the entire system from being down.

The system controller 36 includes a storage device 5
0 is connected. The storage device 50 is a device such as a RAM or a hard disk.
A sample correspondence table 51, which will be described later with reference to the drawings, is stored above the table. When tracking a positive sample, the sample correspondence table 51 is referred to.

The received original sample group is put into the accepting device 38, and the check is performed for each sample. Specifically, the sample extracting process indicated by reference numeral 16 in FIG. 2 is executed. That is, the barcode label attached to the original sample (blood collection tube) is read, and unsuitable samples such as positive samples and judgment-pending samples are automatically extracted according to the contents and the results of previous tests, and the primary mixed sample and secondary sample are collected. Only the original sample suitable for the preparation of the next mixed sample will be discharged. By the way, the sample extraction is performed in sample units or rack units. The original sample that has been subjected to the predetermined processing by the reception device 38 is mounted on the loading device 52 in the transport system 40 in rack units.

The loading device 52 has two mounting tables, and the original sample rack is set on each table. Then, each rack is sequentially flown from the two tables to the transfer line 54, and the rack is transferred from the transfer line 54 to each basic system 42. Here, such transportation is managed by the transportation system 40 controlled by the system controller 36.

In the system according to the present embodiment, a bar code reader and a bar code label affixing device are provided at required locations on the system, and the I of each sample is examined at each stage.
The D number etc. have been confirmed. For example, a label reader is provided in the input device 52, a label reader is also provided in a required portion of the basic system 42, and a dispensing unit 60, which will be described later, is provided for the created primary mixed sample and secondary mixed sample. A sticker for sticking the barcode label is provided.

As described above, in this embodiment, a plurality of basic systems 42 are connected in parallel, and an appropriate number of basic systems 42 can be operated according to the increase or decrease in the number of samples. Here, this basic system 42
Functions as a sample processing station composed of a plurality of units or devices.

In the basic system 42, two centrifugal units 56 are provided on the transfer line. Each centrifuge unit 56 has two rotors 56A-56D. And those four rotors 56A-56D
Is used as appropriate to perform the centrifugation process on each sample. Here, by performing such a centrifugal separation process before opening the cap, the blood sample adhering to the back side of the stopper of the blood collection tube can be shaken down, and the blood sample generated during opening can be scattered. It is possible to effectively prevent such problems. Therefore, as long as such an effect is obtained, the rotation speed, the rotation time, etc. may be set appropriately. In this embodiment, each centrifuge unit 56 has an automatic balance mechanism and the like.

The original sample after the centrifugal separation treatment is the opening unit 5
It is thrown in 8. The opening unit 58 is a device for removing the stopper provided on the upper part of the blood collection tube. Here, in order to more reliably prevent contamination during opening, a protective shutter that can be opened and closed is provided between the opening device and the location of the original sample after opening. The original sample after opening is the dispensing unit 6
Transported to 0.

The dispensing unit 60 is roughly divided into a first unit 60A and a second unit 60B. First
The unit 60A has, for example, two nozzles, and the first mixed sample is created by the first unit 60A. On the other hand, the second unit 60B has, for example, one nozzle, and the second mixed sample is created by the second unit 60B. Each of the units 60A and 60B has a configuration similar to that of a conventional automatic dispensing device, and a sample is sucked or discharged from a metallic nozzle base portion and a disposable tip attached to the tip thereof by the nozzle. By the way,
Each disposable chip is automatically replaced for each sample.

In this embodiment, since two dispensing devices for preparing the primary mixed sample and two dispensing devices for preparing the secondary mixed sample are provided, both can be operated in parallel for efficient processing. . Especially, since there is a difference in the capacity of each dispensing device, N
Dispensing suitable for pretreatment in AT inspection method can be realized.

In this embodiment, the dispensing unit 60 has a dummy dispensing function. This will be described later in detail with reference to FIG. By the way, in order to make the concentration of the mixed sample uniform, the sample is agitated by using suction and discharge. The original sample, the primary sample, and the secondary sample after dispensing are respectively sent to the capping unit 62.

In this embodiment, the capping unit 62 is composed of a handling unit and a carrying mechanism for carrying it three-dimensionally. The handling unit is for grasping the stopper and attaching it to a desired test tube. In the present embodiment, the handling unit is configured to be movable three-dimensionally, so that the original sample to which the stopper is attached, the primary There is an advantage that the degree of freedom of arrangement positions of the mixed sample and the secondary mixed sample can be expanded.

The original sample after being closed is discharged to the discharging unit 64. Incidentally, the primary mixed sample and the secondary mixed sample may be further discharged to the discharge unit 64. Alternatively, only the primary mixed sample may be discharged to the discharge unit 64, and the secondary mixed sample may be left on the dispensing unit. Each sample after dispensing is transferred to a predetermined cool box by an artificial work.

FIG. 4 shows a concrete image of the sample processing system according to this embodiment shown in FIG.

The system configuration described above is an example, and various system configuration examples can be adopted as long as each process shown in FIG. 1 or 2 can be realized.

FIG. 5 shows a specific example of the sample correspondence table 51 formed on the storage device 50 shown in FIG. As shown in the figure, the primary mixed sample is associated with the secondary mixed sample, and the original sample is associated with each primary mixed sample. Here, each sample is managed by barcode label information. By storing the correspondence relationship between each sample in this manner, the corresponding sample can be instantly specified when the NAT test result is obtained.
As a result, there is an advantage that a follow-up investigation of a positive sample can be performed quickly. In addition, it is possible to specify the original sample without error.

FIG. 6 is a flow chart showing the dummy processing function of the dispensing unit 60. This dummy process is to supplement the insufficient sample by using the dummy sample, is executed at the time of individual dispensing of each sample, and is finally executed even when the original sample is insufficient. In addition,
Although each step shown in FIG. 6 is executed at the time of preparing the primary sample, the same processing is further executed at the time of preparing the secondary sample, if necessary.

In S101, the nozzle sucks the predetermined amount of the original sample. In S102, the suction abnormality is determined based on the fluctuation of the air pressure in the pipe. here,
If there is no such suction abnormality, in S107, the sucked original sample is discharged into the container for the primary mixed sample.
Thereafter, the disposable chip is replaced in S108 prior to the next dispensing of the original sample.

On the other hand, if it is determined in S102 that the suction is abnormal, the ejection will be insufficient if the ejection is performed as it is. Therefore, in this embodiment, the aspirated original sample is again exhaled into the original blood collection tube in S103. Will be returned. Then, in S104, the disposable chip is replaced,
If it is the first abnormality determination in S105, S10 is executed again.
At 1, the original sample is aspirated. If it is determined to be normal in S102 after such re-suction, S
When each step after 107 is executed and the second abnormality determination is made in S102, S103 to S103 are executed.
After passing through 105, S106 is executed to suck the dummy sample.

Here, the dummy sample is the dispensing unit 60.
For example, physiological saline or distilled water contained and held in a container provided in the container. As these liquids, various liquids can be selected as long as they do not interfere with the inspection in the NAT inspection.

After the dummy sample is sucked in S106, the dummy sample is discharged into the primary sample container instead of the original sample in which the suction abnormality is determined in S107. Then, the disposable chip is replaced in S108 as described above.

In S109, it is determined whether or not the final sample has been processed. If the final sample has not been processed, S109 is performed.
In 111, it is determined whether a predetermined number of original samples have been dispensed, that is, whether the mixing number has reached a predetermined number, and if not, the original sample that has become the suction source is S11.
3 and the steps from S101 are repeatedly executed. On the other hand, when it is determined in S111 that the number of mixtures reaches the predetermined number, the primary sample container of the discharge destination is replaced in S112, and S113 and S10.
Each step from 1 is repeatedly executed.

When it is determined in S109 that the processing has reached the final sample, S110 is executed. In S110, as in S111, it is determined whether or not the mixing number has reached a predetermined value, and if it is determined that the mixing number is still less than the predetermined number even when the final original sample is dispensed. , S106, the dummy sample is aspirated in the same manner as described above, and is discharged into the primary sample container (S
107). Then, in S110, the above steps are repeated until the number of mixing (the number of mixing) reaches a predetermined number,
When the mixed number reaches the predetermined number, this routine ends.

Therefore, according to the above processing, the dummy sample can be used to make up for the deficiency when there is an abnormal dispensing, and when the original sample number is less than the predetermined number, the dummy sample is used. There is an advantage that the production amount of the primary mixed sample defined by supplementing it can always be secured. Furthermore, FIG.
If the process shown in (1) is also applied to the preparation of the secondary sample, a predetermined amount of the secondary mixed sample having a constant mixing ratio can be always obtained. Therefore, there is an advantage that efficient pretreatment corresponding to the varying number of original samples can be realized. It should be noted that a record is kept for the sample for which the alternative dispensing of the dummy sample has been performed, and an alarm is output if necessary.

[0056]

As described above, according to the present invention,
A sample processing system having a high processing capacity can be realized, and in particular, it becomes possible to flexibly deal with an increase or decrease in the number of samples.

[Brief description of drawings]

FIG. 1 is a conceptual diagram showing a principle of creating a primary mixed sample and a secondary mixed sample.

FIG. 2 is a conceptual diagram showing each processing step in an inspection center.

FIG. 3 is a block diagram showing an overall configuration of a sample processing system according to this embodiment.

FIG. 4 is a diagram showing an actual image of the sample processing system according to the present embodiment.

FIG. 5 is a diagram showing an example of a sample correspondence table.

FIG. 6 is a flowchart of a dispensing process.

[Explanation of symbols]

10 Blood collection center, 12 Testing center, 30 original sample, 32 Primary mixed sample, 34 Secondary mixed sample, 36
System controller, 38 acceptance device (sampling device), 40 transfer system, 42 basic system.

─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Masaaki Hibino 6-22-1, Mure, Mitaka City, Tokyo Aloka Co., Ltd. (72) Inventor Hiroaki Niwayama 6-22-1, Mure, Mitaka City, Tokyo Aloka Incorporated (56) Reference JP-A-9-196913 (JP, A) Yoshinobu Asada, Don S. Varnum, Wayne N.V. Frankel, Joseph H.M. Nadeau, Nature Genetics, USA, Nature Publication, April 1994, Vol. 6, pp. 363-368 A. Darvasi, M .; Soller, Genetics, USA, Genetics Society of America, December 1994, Vol. 138, No. 4, pp. 1365-1373 (58) Fields surveyed (Int.Cl. ⁷ , DB name) G01N 35/00-35/10 G01N 1/00-1/44 JISST file (JOIS)

Claims (10)

(57) [Claims] 1. A primary dispensing means for collecting a fixed amount from m original samples and mixing them to form a primary mixed sample, and a fixed amount from n primary mixed samples, and mixing them And a secondary dispensing means for creating a secondary mixed sample, and a storage means for storing the correspondence between the original sample, the primary mixed sample, and the secondary mixed sample, and one of the secondary mixed samples as a positive sample. When specified, including the tracking means for identifying the primary mixed sample and the original sample corresponding to the positive sample by referring to the corresponding relationship, and the dummy sample holding means holding the dummy sample , the primary dispensing Means and at least one of the secondary dispensing means
If necessary when preparing a mixed sample, the dummy test should be performed.
A sample processing system that dispenses the body . 2. The system according to claim 1, wherein the original sample, the primary mixed sample, and the secondary mixed sample are managed by a label including sample identification information, and the sample identification information of each sample is the storage unit. A sample processing system characterized by being registered in. 3. The system according to claim 1, further comprising a mixing number setting means for variably setting parameters m and n, wherein the primary dispensing means and the secondary dispensing means are set by the mixing number setting means. A sample processing system, wherein the sample processing system operates according to the specified mixing number condition. 4. A system of claim 1, comprising n rounded hand stage specimens shortage when creating the primary mixing analyte to execute the dispensing of the dummy sample by that lack a few minutes in the event of A sample processing system characterized by the above. 5. The system according to claim 1, wherein when a sample suction abnormality is detected, according to a predetermined condition,
Sample processing system characterized in that it comprises a suction abnormality handling manual stage to perform the dispensing of the dummy sample in place of the sample. 6. A sample processing system including at least one sample processing station, wherein the sample processing station comprises a cap opening device for opening the original sample and a fixed amount of m original samples after opening. A primary dispensing device that mixes them to create a primary mixed sample, and a secondary dispensing device that collects a fixed amount from n primary mixed samples and mixes them to create a secondary mixed sample. A capping device for capping each of the above-mentioned samples, and a dummy sample holding means holding a dummy sample, and at least one of the primary dispensing device and the secondary dispensing device.
If necessary when preparing a mixed sample, the dummy test should be performed.
A sample processing system that dispenses the body . 7. The apparatus according to claim 6, wherein the sample processing station performs a centrifugal separation process on the original sample prior to the opening to prevent droplet scattering when opening the stopper. A sample processing system comprising a device. 8. The sample processing system according to claim 6, wherein the capping device includes a handling unit for gripping the stopper, and a robot mechanism for three-dimensionally transporting the handling unit. 9. The system according to claim 6, further comprising a sample extracting device for executing an adequacy test for each original sample and extracting an unsuitable sample prior to the introduction of the original sample into the sample processing station. Sample processing system. 10. A plurality of sample processing stations that can operate in parallel with each other, an original sample supply device that distributes an original sample to the plurality of sample processing stations, and an operation management device that manages the operation of the plurality of sample processing stations. In each of the sample processing stations, the sample processing station includes a cap opening device for opening the original sample, and a fixed amount of each of the m original samples after opening, which are mixed to perform primary mixing. A primary dispensing device that creates a sample, a secondary dispensing device that collects a fixed amount from n primary mixed samples and mixes them to create a secondary mixed sample, and caps each sample above At least one of the primary dispensing device and the secondary dispensing device , which includes a capping device and a dummy sample holding means holding a dummy sample.
If necessary when preparing a mixed sample, the dummy test should be performed.
A sample processing system that dispenses the body .