JP3411031B1 - Cartridge syringe, cartridge and ophthalmic syringe set provided with the syringe - Google Patents

Abstract

The present invention provides a cartridge syringe that can be used repeatedly by simply replacing a cartridge containing an ophthalmic treatment agent, and an ophthalmic syringe set provided with the syringe to reduce waste and secure a storage space for the ophthalmic treatment agent. And make it easier to replace the syringe by separating the plunger from the piston stopper. SOLUTION: A syringe body 3 or a connection portion between the syringe body 3 and the plunger 7 is provided with a one-touch loading mechanism capable of temporarily changing the position of the plunger 7 so that the cartridge 9 can be loaded into the syringe body 3. On the distal end side of the pusher 37, there is formed a pushing portion 41 which is formed in a tapered shape toward the distal end. The pushing portion 41 is formed in an insertion hole 43 formed on the proximal end side of the piston plug 39 of the cartridge 9. Can be inserted into

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cartridge injector used to administer an ophthalmic therapeutic agent, a cartridge, and an ophthalmic injector set including the cartridge.

[0002]

2. Description of the Related Art In a conventional ophthalmic syringe, as shown in FIG. 7, a syringe body 101 contains a drug solution container 103 containing an ophthalmic therapeutic agent, and a plunger 105 is provided on the proximal end side of the syringe body 101. Are connected. A piston 107 is formed at the tip of the plunger 105,
The piston 107 closes the drug solution container 103 on the proximal side of the drug solution container 103. A rubber stopper 109 is provided at the tip of the drug solution container 103 so that a needle can be inserted into the rubber stopper 109 when the ophthalmic syringe 100 is used.

As described above, the conventional ophthalmic syringe has a syringe body 101, a liquid medicine container 103, and a plunger 105.
Since it is a disposable type that is integrated, it must be discarded together when disposing after use.
It caused a large amount of waste.

Further, the ophthalmic syringe is hermetically packaged in a blister case together with the syringe to prevent contamination from microorganisms and the like, and is further packaged in an outer box to protect the blister case and / or the syringe. The blister case is made of plastic and has a size of about 16 cm in width, about 4.5 cm in height, and about 3 cm in height even if it is relatively small. The outer box is made of paper and is larger, and even a relatively small one has a width of about 16.5 cm, a length of about 5 cm, and a height of about 3.5 cm.

Therefore, the packaged syringe becomes very large, and a large storage space is required to store a large number of the syringes. In addition, the weight of the used ophthalmic syringe, including the blister case and the outer box, is about 28.5 g, and the presence of such packaging material also causes an increase in waste.

Since the problem of the storage space is generally easily decomposed by heat or light, it is remarkable in an ophthalmic therapeutic agent which is often stored in refrigeration. For example, in an ophthalmic syringe using an aqueous solution containing a high molecular weight sodium hyaluronate as an active ingredient as an ophthalmic therapeutic agent, it is preferable to store it refrigerated because the viscosity decreases when the storage temperature is high. If it is large, it will occupy a large space in the refrigerator for storing chemicals.

Particularly in the case of a syringe filled with a viscoelastic substance used for cataract surgery, 15 eyes of cataract surgery are performed per day in a hospital with many cases of surgery due to the improvement of the technique of cataract surgery. In such a hospital, as described above, the syringe stored in the large and bulky outer box has a size of 15 to 30.
The problem of occupying the storage space in the refrigerator for storing medicines has become a serious problem because it is necessary to keep it in a box.

[0008] Further, in a syringe for an ophthalmic therapeutic agent, since the drug is often injected into the tissue after the incision, the syringe is not used for the purpose of suction like blood sampling, and the piston stopper of the cartridge and the plunger are not used. It is convenient for frequent use of the syringe to facilitate separation of the plunger from the piston stopper after drug injection, rather than to emphasize integrity.

[0009]

SUMMARY OF THE INVENTION The object of the present invention is made in view of the background of the invention described in the above-mentioned prior art. Only the cartridge containing the ophthalmic therapeutic agent is replaced, and only the cartridge is used after use. Disposable, syringe itself provides a cartridge syringe that can be used repeatedly, a cartridge and an ophthalmic syringe set including the syringe, through which the waste is reduced and a storage space for the ophthalmic treatment agent is secured, and a plunger is provided. The purpose is to facilitate separation from the piston plug and replacement of the cartridge.

[0010]

That is, the cartridge syringe of the present invention is a cartridge type syringe which uses a cartridge with a flange filled with an ophthalmic therapeutic agent, wherein the syringe has a cartridge body having a cartridge accommodating portion, and the syringe. A needle holding member connectably provided on the distal end side of the main body, and a plunger having a pusher at the distal end slidably provided on the proximal end side of the syringe body, the syringe body or the syringe body and the plunger. A one-touch loading mechanism that can temporarily change the position of the plunger so that the cartridge can be loaded into the syringe body is provided at the connecting part of the, and the pusher formed in a taper shape toward the tip is located on the tip side from the pusher. And a push-in portion is formed on the base end side of the piston plug of the cartridge. It is characterized in that the formed insertion hole is insertable.

In the cartridge syringe, the one-touch loading mechanism is constructed by connecting the syringe body and the plunger so as to be bendable via a knuckle, and the cartridge can be loaded by bending the plunger. You may

Further, in the cartridge syringe, a cartridge holding portion which is slidable with respect to the syringe body and biased toward the tip of the syringe is provided around the plunger, and the cartridge is accommodated in the cartridge housing portion. The cartridge holding portion may be capable of holding the cartridge by pushing the base end side of the cartridge in a state where the cartridge is loaded. A cam surface is formed at the tip of the knuckle, and the knuckle is rotatable by sliding the cam surface along a cam slide surface formed on the proximal end side of the syringe body, and the knuckle is fully filled with the plunger. Even when it is possible to bring the plunger into a bent posture by sliding the cam surface with respect to the cam slide surface when performing a bending operation to the side where the cam surface is formed in the state of being pulled Good. Further, the plunger may be configured to be bent in only one direction.

A flange support portion is formed on the base end side of the syringe body, and when the cartridge is loaded in the cartridge storage portion, the flange of the cartridge abuts the flange support portion, May be restricted from further insertion.

Further, on the base end side of the syringe main body, two opposed locking claws protruding in the longitudinal direction thereof are formed, and two locking claws for restricting the orientation of the cartridge formed on the flange of the cartridge are formed. The loading of the cartridge is completed when the surface is positioned so as to face the inside of the locking claw, and the locking surface of the cartridge is engaged with the inside of the locking claw when the loading is completed. Free rotation about the longitudinal axis of the cartridge may be restricted.

Further, when the plunger is rotated so as to be linear with the syringe main body in a state where the cartridge is loaded in the cartridge storage portion, the cartridge holding portion is urged toward the syringe main body side. Thus, the flange of the cartridge may be held between the cartridge holding portion and the flange support portion.

Further, in the cartridge syringe, the one-touch loading mechanism may have a structure that can be disassembled by slightly rotating a plunger holder holding a plunger with respect to a syringe body around a longitudinal axis. Further, in the cartridge injector, the one-touch loading mechanism may have a structure in which a plunger holder holding a plunger is slid in a direction orthogonal to a longitudinal axis with respect to the injector body.

The present invention also relates to a cartridge filled with an ophthalmic therapeutic agent for use in combination with the aforementioned cartridge injector of the present invention. An ophthalmic syringe set of the present invention is characterized by including the cartridge syringe according to any one of the above and a cartridge filled with an ophthalmic therapeutic agent.

In the ophthalmic syringe set, the ophthalmic therapeutic agent filled in the cartridge may be a viscoelastic substance. Further, in the above-mentioned ophthalmic syringe set, the ophthalmic therapeutic agent filled in the cartridge may be an aqueous solution containing hyaluronic acid or a salt thereof as an active ingredient. Further, in the ophthalmic syringe set, the ophthalmic therapeutic agent filled in the cartridge may be an aqueous solution containing sodium hyaluronate as an active ingredient. In the ophthalmic syringe set, the cartridge has a capacity of 1.0 mL to 20.
It may be 0 mL.

Further, in the above-mentioned ophthalmic syringe set, an integral connection structure is provided between the pusher provided at the tip of the plunger and the piston plug provided at the base end side of the cartridge so as to integrally connect the two. May be. Further, in the ophthalmic syringe set, the integrally coupled structure may be configured by a push-in portion provided for the pusher and an insertion hole formed in the piston plug.

[0020]

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described below with reference to the drawings. 1 is an exploded perspective view showing a cartridge syringe of the present invention and an ophthalmic syringe set including the syringe, FIG. 2 is a side view showing a state when the same cartridge is mounted, and FIG. FIG. 3B is a plan view showing the state after the cartridge is mounted, as seen from the longitudinal direction of the syringe.

The cartridge syringe 1 comprises a syringe body 3 and
A needle holding member 5 provided on the distal end side of the syringe body 3,
It is basically configured by including a plunger 7 provided on the proximal end side of the syringe body 3. In this specification, the side where the needle of the cartridge injector 1 is provided is the tip side and the opposite side is the base side.

The syringe body 3 is a cylindrical member, and a cartridge housing portion 11 having an inner diameter slightly larger than the outer diameter of the cartridge 9 is formed inside. Syringe body 3
A residual amount confirmation window 13 is provided on the side circumferential surface of, and a scale 14 is provided near the residual amount confirmation window 13 for knowing the approximate residual amount of the ophthalmic treatment agent. The remaining amount confirmation window 13 is provided for confirming the remaining amount of the ophthalmic treatment agent filled in the cartridge 9, and its shape and number can be variously selected. Incidentally, the number of the remaining amount confirmation windows 13 is preferably about 1 to 4 in consideration of the strength and visibility of the syringe body, but in the embodiment shown in FIGS. Three are provided on the surface to be used.

A flange-shaped grip portion 15 is provided on the proximal end side of the syringe body 3. When the cartridge syringe 1 is used, the grip portion 15 is provided for the purpose of, for example, putting the index finger and the middle finger on it to hold the syringe body 3 and to assist the pushing operation of the plunger 7 described later. Therefore, the shape can be variously selected as long as it is easy to put a finger on, but it is preferable that the shape is a polygonal shape of a triangle or more in a front view. Incidentally, in the embodiment shown in FIGS. 1 to 3, the grip portion 15 having a hexagonal shape in front view is used in consideration of the stability when placed on a desk. Further, in the present example, such a grip 15
With the fulcrum as a fulcrum, the weight of the plunger 7 side is increased to prevent the tip of the needle inserted into the eye from coming into contact with other objects such as the surface of the desk or the bottom of the sterilization tray. As a result, it is possible to prevent bacteria and foreign substances from adhering to the tip of the needle, so that the risk of postoperative inflammation (infection, etc.) can be reduced. In addition, a stand (the wall of the sterilization tray, tweezers, etc.) that prevents the needle tip from contacting the surface of the desk or the bottom of the sterilization tray, which was used in the conventional ophthalmic syringe of this type (ophthalmic syringe). Is unnecessary.

A portion of the base end side of the grip portion 15 is a connecting portion with a plunger 7 which will be described later. A one-touch loading mechanism that allows the cartridge 9 to be loaded into the syringe body 3 by a simple operation is provided at this connecting portion. Figures 1-3
In the embodiment shown in (1), a mechanism for connecting the syringe body 3 and the plunger 7 with the knuckle 17 is adopted as a one-touch loading mechanism, and accordingly, the connecting portion serves as a rotation axis of the knuckle 17. Two screw holes 21 for attaching the fixing screw 19 are provided.

Further, 2 is provided on the end face of the syringe body 3 on the base end side.
Two locking claws 23 are provided so as to project in the longitudinal direction and face each other, and a flange support portion 26 is formed between the locking claws 23 at a position one step lower than the locking claws 23. Locking claw 2
3 engages with two linearly cut opposing locking surfaces 27 of the flange portion 25 formed at the proximal end of the cartridge 9, so that the cartridge 9 is moved around its longitudinal axis. It plays the role of preventing rotation.
Further, the flange support portion 26 is in contact with the flange portion 25 of the cartridge when the cartridge is loaded, and serves to restrict the further insertion of the cartridge.

Further, the flange portion 2 having the engaging surface 27 is formed.
So that 5 is naturally guided between the two locking pawls 23,
As shown in FIGS. 4A and 4B, a guide edge 48 in which the locking claw 23 is formed obliquely may be used. As a result, after the flange portion 25 of the cartridge 9 comes into contact with the guide edge 48, as shown in FIG.
Rotates naturally in the direction of the slant, and the flange 2
5 comes to fit naturally between the two locking claws 23. Further, instead of forming the locking claw 23 obliquely, the cartridge 9 may be tapered.

The needle holding member 5 has a needle 29 that directly administers an ophthalmic therapeutic agent, and a socket portion 33 that holds the needle 29 and fits into the small diameter portion 31 on the tip side of the cartridge 9.
A flange portion 34 is formed on the base end side of the socket portion 33, and the flange portion 34 has a structure to be screwed and connected to a female screw engraved on the inner peripheral surface of the distal end side of the syringe body 3. There is. In addition, you may employ | adopt the form which presses the socket part 33 into the inside of the front end side of the syringe main body 3, and / or the small diameter part 31 of the front end side of the cartridge 9.

The plunger 7 is formed by forming a handle 35 at the base end of the round rod-shaped shaft and a pusher 37 at the end thereof. When the cartridge injector 1 is used, the handle 35 is a portion where, for example, a thumb is hung here, the cartridge injector 1 is held by the clamping action with the grip portion 15, and the pusher 37 is actually pushed. Therefore, the shape can be variously selected as long as it is suitable for pushing. By the way, Figure 1
In the embodiments shown in FIGS. 3 to 3, a handle 35 having a circular shape in a front view and having a slightly depressed center so as to be suitable for being pushed in by a thumb is adopted. The pusher 37 comes into contact with the piston plug 39 that is initially located on the base end side of the cartridge 9, and
It is a portion that acts to directly push 9 into the tip side. Incidentally, in the embodiment shown in FIGS. 1 to 3, a disk-like shape having a larger diameter than the shaft body is used. Further, the pusher 37 is provided on a tip end side end surface thereof with a tapered push-in portion 41 which is reduced in diameter in the tip end direction. The push-in portion 41 has a role of connecting the piston stopper 39 and the pusher 37 by being inserted into the insertion hole 43 formed in the end face of the piston stopper 39, and at the same time enabling the piston stopper 39 to move. There is. The mechanism for integrally connecting the piston plug 39 and the pusher 37 in this way is defined as an integral connection structure in this specification.

Since the push-in portion 41 is in the form of a truncated cone having a reduced diameter, the push-in operation of the plunger 7 allows the piston plug 39 to be firmly fitted into the insertion hole 43, while the plunger 7 can be firmly fitted. 7
When the pulling operation of the
When the piston plug 39 is pulled out, the piston plug 39 is released.
It is possible to prevent the transition to the proximal side together with. The ophthalmic therapeutic agent used in the present invention may be poured out to the outside by pushing the plunger 7, but such an ophthalmic therapeutic agent is not used for sucking a liquid like blood sampling, and thus has such a configuration. Further, by adopting such a configuration, when the plunger 7 is pulled, the piston plug 3
9 moves to the base end side of the cartridge 9, and the piston plug 39 and the plunger 7 are not separated after that,
It is possible to prevent the adverse effect of hindering the operation of bending the plunger 7, and it is possible to easily replace the cartridge. Further, by adopting such a configuration, it is possible to prevent the generation of bubbles in the cartridge caused by the piston plug 39 returning backward, and during surgery due to the narrowing of the surgical field due to the bubbles that have flowed into the eye together with the drug solution. This eliminates the need for complicated work such as removing the air bubbles from the anterior chamber after the operation of the patient.
In particular, in an ophthalmic therapeutic agent such as hyaluronic acid or a salt thereof, it is very difficult to remove air bubbles once formed in the cartridge because of its high viscosity.

As described above, the one-touch loading mechanism is provided at the connecting portion between the syringe body 3 and the plunger 7. In the embodiment shown in FIGS. 1 to 3, a mechanism for flexibly connecting the syringe body 3 and the plunger 7 with a knuckle 17 is adopted. The knuckle 17 has a cylindrical holder portion 45, and extends in a tongue shape from the tip side of the holder portion 45.
It is composed of rotating wing pieces 47. Then, the fixing screw 19 is inserted from the outside of the rotating wing piece 47, and after passing through the convex washer 18 provided so that the convex side faces the outside with respect to the inside of the rotating wing piece 47, the fixing screw 19 is screwed. Hole 21
The knuckle 17 is rotatable with respect to the syringe body 3 by being screwed into. The washer 18 smoothes the rotation of the rotary wing piece 47, and
It suppresses the generation of frictional heat generated during rotation of the member and prevents fusion of the members.

An arcuate cam surface 24 is formed on one side of the tip of the rotary wing piece 47, and the cam surface 24 is on a cam slide surface 28 formed on the proximal end side of the syringe body 3. The knuckle 17, that is, the plunger 7 can be rotated by sliding. The cam surface 24 is not formed on the other side of the tip of the rotating wing piece 47, so that the plunger 7 can rotate only on the side where the cam surface 24 is formed. Since the plunger 7 can be bent only in one direction in this way, the stability when pushing the plunger 7 becomes excellent as compared with the structure in which the plunger 7 can be bent in both directions. Also, inside the holder part 45,
The compression coil spring 49 and a part of the cartridge holding portion 51 on the base end side of which the compression coil spring 49 has a tendency to project toward the front end are housed.

The cartridge holding portion 51 is a sleeve-like member having a multi-stepped outer diameter, which has a through hole in the center for slidably fitting with the shaft of the plunger 7. The small diameter portion located on the base end side is slidably fitted in the fitting hole 53 formed on the base end side end surface of the holder portion 45, and the large diameter portion located on the tip end side is directly in the cartridge 9. The pusher 37 is in contact with the end face of the flange portion 25 to perform a pressing action, and the pusher receiving hole 55 formed therein abuts the end face of the pusher 37 on the proximal end side to prevent the pusher 37 from falling off. The middle diameter portion located in the middle has a function as a pedestal of the compression coil spring 49.

The knuckle 17, which is constructed in this way,
The compression coil spring 49 and the cartridge holding portion 51 are assembled to the syringe body 3 and the plunger 7 as shown in FIGS. 1 to 3 and are rotatably or slidably attached by a fixing screw 19.

The constituent members of the cartridge injector 1 excluding the needle holding member 5, specifically, the injector body 3, the plunger 7, and the knuckle 1 which constitutes the one-touch loading mechanism.
7, members such as the cartridge holding portion 51 are made of a robust material that can be repeatedly used. As an example, a metal material such as titanium, stainless steel, or aluminum, or an alloy containing these as main components can be applied. Particularly, titanium, which is excellent in chemical resistance, heat resistance, weight reduction, strength, etc., can be said to be a preferable material. Of course, if there is another metal material or a non-metal material such as synthetic resin having the same performance as these, it is possible to use the material.

Next, the cartridge 9 which is loaded in the cartridge syringe 1 of the present invention and is a constituent element of the ophthalmic syringe set of the present invention will be described. As shown in FIGS. 1 to 3, the cartridge 9 has a small diameter portion 31 formed by slightly narrowing the tip side portion of the cylindrical cartridge body 57, and the flange portion 25 with the locking surface 27 is formed at the base end portion. After filling the ophthalmic treatment agent, the base end side open surface of the cartridge main body 57 is closed by a piston plug 39 that functions as a piston for pushing out the ophthalmic treatment agent. As the material of the cartridge body 57, glass having excellent visibility, polyolefin plastics such as polyethylene and polypropylene, plastics such as polyethylene terephthalate and polycarbonate can be applied, and glass should be used in consideration of stability of contents. Is preferred. Reference numeral 59 is a rubber plug that closes a small hole formed at the center of the small diameter portion 31. Furthermore, by using a cartridge having a small diameter portion with a narrowed tip, it is not necessary to install a reverse needle-shaped needle as shown in FIG. When the reverse needle is pierced into the rubber stopper, it is possible to prevent the rubber fragments from being mixed into the medicine.

The capacity of the cartridge 9 is 1.0 mL to 2
The volume of the ophthalmic therapeutic agent that can be filled in the cartridge 9 is 0.1 mL to 20.0 mL. Incidentally, when an aqueous solution containing sodium hyaluronate as an active ingredient is filled as the ophthalmic therapeutic agent, the volume of the ophthalmic therapeutic agent to be filled is 0 in view of the amount used in the operation and the filling efficiency into the cartridge 9. .4
It is preferably within the range of mL to 2.0 mL.

The ophthalmic therapeutic agents used in the present invention include viscoelastic substances, perfusates, mydriatics, miotics, antibiotics, antibacterial agents,
An anti-inflammatory agent etc. are mentioned. Examples of the viscoelastic substance include aqueous solutions containing sodium hyaluronate, chondroitin sulfate, chitin, chitosan, collagen, cellulose derivatives, or a mixture of the above components as an active ingredient. As the perfusate, an isotonic aqueous solution (containing monovalent and / or divalent ions such as sodium ion, potassium ion, calcium ion, and magnesium ion, p
H is 6.4 to 8.2, and may contain glutathione or glucose).

[0038] Examples of the mydriatic agent include ebinephrine or the same drug (including derivatives). Examples of miotic agents include acetylcholine and the like drugs (including derivatives and cholinesterase inhibitors) and the like. Examples of antibiotics include aminoglycosides and β-lactam antibiotics.
Examples of antibacterial agents include quinolone synthetic antibacterial agents.
Further, examples of the anti-inflammatory agent include steroids and non-steroidal anti-inflammatory agents.

Such an ophthalmic therapeutic agent is, for example, as a drug for the treatment and / or prevention of ophthalmic diseases of mammals including humans, particularly cataracts, etc., by locally administering to the diseased site or intraocularly. It can be used as an ophthalmic surgery adjunct when inserting a lens. As the salt of hyaluronic acid, a sodium salt is usually used, but a potassium salt or the like may be used. Hyaluronic acid or a salt thereof that can be used in the present invention has a molecular weight of 50.
It is preferably from 10 to 8 million, more preferably from 500,000 to 3.9 million.

Further, those having an endothelium-protecting effect are preferably those having a molecular weight of 500,000 to 1,200,000 and, when used for anterior chamber retention, having a molecular weight of 1.9 to 3.9 million. Furthermore, in terms of operability during surgery, the molecular weight is 1.5 million to 3
Some operators prefer those within the range of 900,000, and the molecular weights are used differently depending on the above-mentioned purposes and the like. In addition, the molecular weight used in this specification means a viscosity average molecular weight.

The concentration of hyaluronic acid or its salt is preferably in the range of 200 to 5,000 μg / mL. By the way, the concentration of hyaluronic acid or its salt is less than 200 μg / mL or 5,000 μg / mL.
If it exceeds mL, the spreading promoting action of the corneal epithelial layer decreases, which is not preferable. In the case of liquid ophthalmic formulations, 5,0
When it exceeds 00 μg / mL, handling and administration (application) become difficult, which is not preferable.

When an aqueous solution containing hyaluronic acid or a salt thereof as an active ingredient is used as an ophthalmic therapeutic agent, additives other than hyaluronic acid, such as sodium chloride,
Salts such as disodium hydrogen phosphate and monopotassium hydrogen phosphate, and anti-inflammatory agents such as chondroitin sulfate and glycyrrhizin may be added as appropriate.

When the ophthalmic therapeutic agent using hyaluronic acid or a salt thereof used in the present invention is clinically applied as an ophthalmic liquid preparation, a phosphate buffered physiological saline solution has a molecular weight of 500,000 to 8,000,000, preferably 500,000-3.9 million sodium hyaluronate 200-5,000 μg / mL
0.1-2 mL of the solution dissolved at the concentration of is administered once. Incidentally, regarding the safety (toxicity / non-inflammatory) of hyaluronic acid, many experiments have already been conducted, and its safety has been confirmed. For example, for ocular toxicity, irritation by experiments in rabbits, it is no antigenicity have been identified (Norio Ueno Other: Japan Ophthalmology Bulletin 35, 584
(1984) and 35 , 803 (1984)).

The cartridge injector 1 of the present invention and the ophthalmic injector set including the injector have the above-described structure, and the operation thereof will be described below.
First, the handle 35 is pulled to pull the plunger 7 to the most proximal position. In this state, when the plunger 7 is bent toward the side where the cam surface 24 is formed, the cam surface 24 slides on the cam slide surface 28 so that the plunger 7 can rotate.

In addition, a cartridge 9 is prepared separately from the cartridge injector 1, and the cartridge 9 is inserted from the open end of the injector body 3 on the proximal end side, and the cartridge housing portion 11 is inserted.
Load inside. At this time, the engagement surface 27 formed on the flange portion 25 of the cartridge 9 is aligned so as to engage with the inside of the engagement claw 23 formed on the syringe body 3.

Then, the plunger 7 is rotated in the opposite direction,
The syringe body 3 is again positioned so as to be straight. When the plunger 7 is positioned linearly, the cartridge holding portion 51 is moved toward the tip side by the urging force of the compression coil spring 49, and the flange portion 25 of the cartridge 9 is moved to the cartridge holding portion 51 and the flange supporting portion 2.
It will be held between 6 and. In this way, the cartridge 9 is fixed to the syringe body 3.

Next, the plunger 7 is pushed in in the axial direction,
The push-in portion 41 provided in the pusher 37 is inserted into the insertion hole 43 formed in the piston plug 39 of the cartridge 9, and the piston plug 39 and the plunger 7 are inserted.
Combine so that and can move together. Then, the rubber stopper 59 fitted to the tip of the cartridge 9 is removed, and the needle holding member 5 is attached to the cartridge 9 from the tip side of the syringe body 3.
When the cartridge injector 1 is attached to the small-diameter portion 31 in Fig. 3, the cartridge syringe 1 becomes ready for use as shown in Fig. 3 (a).

In use, for example, the index finger and the middle finger are hung on the grip portion 15 of the syringe main body 3, and the thumb is hung on the handle 35 of the plunger 7, and the plunger 7 is pushed toward the distal end side. When the plunger 7 is pushed in, the piston plug 39 fixed to the pusher 37 via the pushing portion 41 and the insertion hole 43.
Also moves toward the distal end side, and the ophthalmic therapeutic agent filled in the cartridge main body 57 is pushed out through the needle 29 to be used for administration of the ophthalmic therapeutic agent.

When the plunger 7 is pulled after the administration of the ophthalmic therapeutic agent, the pushing portion 4 is pushed from the insertion hole 43 of the piston plug 39 due to the pushing portion 41 having a tapered shape.
Since 1 can be easily removed, it is possible to pull the plunger 7 to the most proximal position and easily bend the plunger 7 again in the same manner as described above. If the used cartridge 9 is removed in this state, the next new cartridge 9 can be used immediately.

When the plunger 7 is bent, the plunger 7 is pulled to the most proximal position because the pusher 3 is pushed in when the plunger 7 is pushed to some extent.
This is because the peripheral surface of 7 contacts the inner peripheral surface of the syringe main body 3 or the inner peripheral surface of the cartridge main body 57, so that the plunger 7 has a structure that cannot rotate. By the way, by adopting such a structure, it is possible to prevent the accident that the plunger 7 is unexpectedly bent against the intention of the operator during use and the cartridge 9 is dropped.

Next, another embodiment of the present invention will be described. FIG. 5 shows that the cartridge 9 can be loaded into the cartridge housing portion 11 from the relatively large receiving opening 61 formed in the syringe body 3 without basically disconnecting the connection between the syringe body 3 and the plunger 7. It is an embodiment. Even if such a configuration is adopted, it is the same in that the cartridge 9 can be stored in the cartridge storage portion 11 by a simple operation, and it is included in the one-touch loading mechanism used in this specification.

In the embodiment shown in FIG. 5, the grip 1
5 is formed separately from the syringe main body 3, and
It is also possible to have a form fixed to the syringe body 3 as in the embodiment shown in FIG. However, in the case of the embodiment shown in FIG. 5, there is a tendency that the syringe main body 3 becomes long due to its structure. The embodiment shown in FIGS. It is an embodiment shown.

That is, FIG. 6 shows still another embodiment of the one-touch loading mechanism, of which FIG.
Shown in FIG. 8 is an embodiment of a disassembly type in which the syringe body 3 and the plunger 7 can be removed by a simple operation.
Specifically, the engaging claw 63 is provided at the base end of the syringe body 3,
By providing the engaging groove 65 that engages with the engaging claw 63 on the plunger holder 67, the plunger 7 can be detached from the syringe body 3 by only slightly rotating the plunger holder 67.

The one shown in FIG. 6 (b) is the syringe body 3
On the other hand, it is a slide type embodiment in which the plunger 7 can be displaced in a direction orthogonal to the axial direction by a simple operation. Specifically, a guide rail 69 is provided on the syringe body 3 side,
By providing a slider 73 that engages with the guide rail 69 on the side of the plunger holder 71 that holds the plunger 7, the plunger 7 can be displaced laterally of the syringe body 3.

[0055]

According to the inventions of claims 1 to 9,
As the cartridge syringe can be used more often,
Since the waste is only the cartridge, the waste can be considerably reduced as compared with the conventional disposable type syringe. In addition, the one-touch loading mechanism allows loading of the cartridge into the cartridge injector with a simple operation in a short time. Furthermore, since the sealed packaging in the blister case to prevent contamination from microorganisms only needs to target only the cartridge, the blister case and the outer box can be downsized, and the storage space in the refrigerator for drug storage can be occupied. Problems are avoided. Therefore, in order to reduce the amount of waste and the storage space, it is indispensable to supply only the cartridge filled with the ophthalmic therapeutic agent. Incidentally, in the present invention, the effect of reducing the volume of the blister case and the outer box and the weight of the waste was confirmed as compared with the conventional one.

Further, according to the invention of claim 1, since the pushing portion of the plunger has a taper shape of which the diameter is reduced as it goes toward the front end direction, when pushing the plunger, the pushing portion enters the insertion hole of the piston plug and a stable pushing operation can be performed. On the other hand, during the pulling operation of the plunger, the push-in portion is easily removed from the insertion hole of the piston plug, so that it is possible to pull the plunger to the most proximal position and bend the plunger 7 again easily. According to the first aspect of the invention, the loading depth of the cartridge can be reliably regulated when the cartridge is loaded in the cartridge housing portion. According to the invention of claim 3,
Since the cartridge is firmly held in the cartridge housing, there is no risk of the cartridge coming off the cartridge housing.

According to the fourth aspect of the invention, the cartridge can be easily inserted and removed by bending the plunger. Further, according to the invention described in claim 5, the stability at the time of pushing the plunger 7 becomes excellent as compared with the structure capable of being bent in both directions.

Further, according to the invention described in claim 6, since the rotation around the longitudinal axis of the cartridge is prevented,
The cartridge does not move when the plunger is pushed in, and the drug can be stably injected.

According to the invention of claim 7, the flange of the cartridge is held between the cartridge holding portion and the flange support portion, so that the cartridge can be prevented from wobbling in the cartridge housing portion.

According to the eleventh aspect of the present invention, the above excellent effects can be realized in the ophthalmic syringe set.
Further, according to the invention described in claims 12 to 14, it can be widely used for treatment and prevention of ophthalmic diseases such as cataract due to its efficacy and safety.

According to the invention as set forth in claim 15, the cartridge can be selected so as to be suitable for the amount of the ophthalmic therapeutic agent used in the surgery, and an appropriate amount of the ophthalmic therapeutic agent can be used at one time. Become. According to the sixteenth or seventeenth aspect of the invention, the movement of the plunger appears as the movement of the piston plug as it is, so that the operability of the plunger and the followability of the piston plug are improved, and it is possible to administer a minute amount of an ophthalmic therapeutic agent become able to.

[Brief description of drawings]

FIG. 1 is an exploded perspective view showing a cartridge injector of the present invention and an ophthalmic injector set including the injector.

FIG. 2 is a side view showing a state when the cartridge is loaded in the cartridge injector of the present invention.

FIG. 3A is a plan view showing a state after mounting the cartridge, and FIG. 3B is a plan view of the state when mounting the cartridge as seen from the longitudinal direction of the syringe.

FIG. 4A is a perspective view showing a state immediately before the flange of the cartridge is guided by the guide edge and automatically enters between the two locking pawls, and FIG. 4B is the locking of the flange of the cartridge. It is a perspective view showing the state where the surface entered between the locking claws.

FIG. 5 is an exploded perspective view showing another embodiment of the present invention.

FIG. 6 is a plan view showing another two embodiments of the one-touch loading mechanism.

FIG. 7A is a side view showing a state before use in a conventional disposable type syringe, and FIG. 7B is a side view showing a state after use in a conventional disposable type syringe.

[Explanation of symbols]

1 cartridge syringe 3 syringe body 5 Needle holding member 7 Plunger 9 cartridges 11 Cartridge compartment 13 Remaining amount confirmation window 14 scale 15 grip 17 knuckles 18 washers 19 fixing screw 21 screw holes 23 Locking claw 24 Cam surface 25 Flange 26 Flange support 27 Locking surface 28 Cam slide surface 29 needles 31 Small diameter part 33 Socket 34 Flange 35 handle 37 pusher 39 Piston stopper 41 Push-in section 43 insertion hole 45 Holder 47 Rotating wings 48 guide edge 49 compression coil spring 51 Cartridge holding part 53 Mating hole 55 Pusher receiving hole 57 Cartridge body 59 rubber stopper 61 Reception opening 63 Engaging claw 65 engagement groove 67 Plunger holder 69 Guide rail 71 Plunger holder 73 Slider 100 ophthalmic syringe 101 Syringe body 103 Chemical solution container 105 Plunger 107 piston 109 rubber stopper

─────────────────────────────────────────────────── ─── Continued Front Page (72) Inventor Yoshihiro Shishido 1-38-18 Higashiyamada, Tsuzuki-ku, Yokohama, Kanagawa Prefecture (72) Takahiro Endo 3-21-19 Aoi, Naka-ku, Nagoya, Aichi Menicon Co., Ltd. (72) Inventor Naoki Kondo 3-21-19 Aoi, Naka-ku, Nagoya-shi, Aichi Menicon Co., Ltd. (72) Inventor Kenji Takeshita 3-21-19 Aoi, Naka-ku, Nagoya-shi, Aichi Menicon Co., Ltd. ( 56) References JP-A-11-104241 (JP, A) JP-A 2002-201143 (JP, A) JP-A 61-356 (JP, A) Jikken 5-1013 (JP, Y1) Jikken Sho 13-9205 (JP, Y1) Actual public 31-16899 (JP, Y1) Actual public 49-1993 (JP, Y1) Special table 6-504217 (JP, A) Special table 3-502417 (JP, a) (58) investigated the field (Int.Cl. ^7, DB ) A61M 5/24 A61M 5/28

Claims (17)

(57) [Claims] 1. A cartridge type syringe using a flanged cartridge filled with an ophthalmic therapeutic agent, wherein the syringe has a syringe body having a cartridge storage portion, and a needle holder provided at the distal end side of the syringe body so as to be connectable thereto. A member and a plunger having a pusher at the tip, which is slidably provided on the base end side of the syringe body, and the cartridge is mounted on the syringe body at the syringe body or the connecting portion between the syringe body and the plunger. A one-touch loading mechanism that can temporarily change the position of the plunger is provided so that a push-in portion that is tapered toward the tip is formed on the tip side of the pusher. The syringe is insertable into an insertion hole formed on the proximal end side of the piston stopper of the cartridge, and A flange support portion is formed on the base end side of the main body, and when the cartridge is loaded into the cartridge storage portion, the flange of the cartridge abuts the flange support portion to prevent further insertion of the cartridge. Cartridge injector characterized by being regulated. 2. The one-touch loading mechanism according to claim 1, wherein the syringe main body and the plunger are foldably connected via a knuckle,
A cartridge injector, wherein the cartridge can be loaded by bending the plunger. 3. The cartridge holding part according to claim 1 or 2, wherein a cartridge holding part slidable with respect to the syringe main body and biased toward a distal end of the syringe is provided around the plunger. A cartridge injector, wherein the cartridge holding portion can push and hold the base end side of the cartridge with the cartridge loaded in the cartridge. 4. The method according to claim 2 or 3,
A cam surface is formed at the tip of the knuckle, and the knuckle is rotatable by sliding the cam surface along a cam slide surface formed on the proximal end side of the syringe body, and the knuckle is fully filled. When the bending operation is performed to the side where the cam surface is formed in the pulled state, the cam surface slides with respect to the cam slide surface, so that the plunger can be in a bent posture. And a cartridge syringe. 5. The cartridge injector according to claim 4, wherein the plunger can be bent in only one direction. 6. The syringe body according to any one of claims 1 to 5, wherein two proximal engaging claws projecting in a longitudinal direction of the syringe body are formed on a proximal end side of the syringe body, and the two engaging claws are formed on a flange of the cartridge. Control the orientation of the cartridge
The loading of the cartridge is completed when the two locking surfaces are positioned so as to face the inside of the locking claw, and the locking surfaces of the cartridge are engaged with the inside of the locking claw when the loading is completed. The cartridge injector is characterized in that free rotation is restricted around the longitudinal axis of the cartridge. 7. The cartridge according to claim 3, wherein when the cartridge is loaded in the cartridge storage portion, the plunger is rotated so as to be linear with the syringe body. The cartridge injector, wherein the holding portion is biased toward the syringe body side so that the flange of the cartridge is held between the cartridge holding portion and the flange support portion. 8. The cartridge according to claim 1, wherein the one-touch loading mechanism has a structure that can be disassembled by slightly rotating a plunger holder holding a plunger with respect to a syringe body around a longitudinal axis. Syringe. 9. The cartridge syringe according to claim 1, wherein the one-touch loading mechanism has a structure in which a plunger holder holding a plunger is slid in a direction orthogonal to a longitudinal axis with respect to a syringe body. 10. A cartridge filled with an ophthalmic therapeutic agent for use in combination with the cartridge injector according to any one of claims 1 to 9. 11. An ophthalmic syringe set comprising the cartridge injector according to claim 1 and a cartridge filled with an ophthalmic therapeutic agent. 12. The ophthalmic syringe set according to claim 11, wherein the ophthalmic therapeutic agent filled in the cartridge is a viscoelastic substance. 13. The ophthalmic syringe set according to claim 11, wherein the ophthalmic therapeutic agent filled in the cartridge is an aqueous solution containing hyaluronic acid or a salt thereof as an active ingredient. 14. The ophthalmic syringe set according to claim 11, wherein the ophthalmic therapeutic agent filled in the cartridge is an aqueous solution containing sodium hyaluronate as an active ingredient. 15. The cartridge according to claim 11, wherein the cartridge has a capacity of 1.0 mL to 20.0 m.
An ophthalmic syringe set characterized by being L. 16. The integrated connection structure according to claim 11, wherein a pusher provided at a tip of the plunger and a piston plug provided at a base end side of the cartridge are integrally connected to each other. An ophthalmic syringe set comprising: 17. The ophthalmic syringe set according to claim 16, wherein the integrally connected structure includes a push-in portion provided to the pusher and an insertion hole formed in the piston plug.