JP3345312B2 - Granular raffinose - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to the production of granular raffinose and its use.

[0002]

2. Description of the Related Art Raffinose is a functional oligosaccharide having an excellent physiological activity such as a bifidobacterium and liver function-improving activity, and its industrial production has recently started. However, since crystalline raffinose has low solubility and is a needle-shaped crystal, when it is taken orally, the crystal remains in the mouth, dissolves in the mouth, has a poor texture, and is suitable for adults as well as infants, the elderly, and the sick. However, this disadvantage is recognized not only when raffinose is used alone, but also when it is mixed with other foods, and the improvement is strongly demanded in the art.

[0003]

In view of the fact that raffinose is a natural product that is very useful as a functional oligosaccharide, it has the disadvantages described above and has a problem in terms of edibility. The present inventors have recognized for the first time the need to facilitate oral ingestion of raffinose and have decided to develop a raffinose product that is easy to ingest.

[0004]

DISCLOSURE OF THE INVENTION The present invention has been made for the purpose of newly developing a raffinose product having the above-mentioned properties. A typical sugar, sucrose, is composed of crystalline sucrose and granular sucrose. It is naturally expected that there is no significant difference in the amount of dissolution per unit time (hereinafter referred to as the amount of dissolution), and as will be apparent from the following description (see FIG. 1), the results of the actual measurement of the amount of dissolution ,
As expected, there is no particular difference in the amount of dissolution between the crystals and the granules.

Therefore, it is expected that there is no particular difference in the amount of raffinose dissolved between the crystal and the granules. When the amount of raffinose dissolved was measured, there was a large difference in the amount of dissolution between crystals and granules, which was quite unexpectedly unexpected, and the amount of dissolution was significantly higher in granules than in crystals. That is a very useful new finding.

Accordingly, the present inventors have paid attention to granular raffinose for the first time, and examined the properties of the raffinose from various directions. As a result, compared with crystalline raffinose, the mouth melting and sweetness were improved and the texture was significantly improved. In addition, the inventors have also confirmed that various properties useful especially when taken orally can be obtained, that is, the sweetness is also enhanced, and finally completed the present invention.

That is, the present invention has been successful for the first time in the production of granular raffinose, and is excellent in edibility.
In particular, the present invention provides, for the first time, raffinose suitable for oral ingestion and a preparation such as a tablet using the same, which enables many people to utilize the physiological activity of raffinose. Hereinafter, the present invention will be described in detail.

In order to carry out the present invention, it is necessary to subject raffinose to a granulation treatment. As the granulation treatment, any of a wet granulation method and a dry granulation method can be used.

In the wet granulation method, raffinose crystals (anhydrous crystals or hydrated crystals such as monohydrate to pentahydrate may be used, but pentahydrate is the most stable, and industrially, It is advantageous to use a pentahydrate salt), to wet the powder particles, to aggregate the individual particles with each other, and to enlarge the shape, for example, the following method is exemplified. Of these, the extrusion granulation method is industrially preferred.

Rolling granulation method: A granulation method in which an inclined drum or an inclined dish type container is rotated, and raw material powder and water are continuously supplied therein. -Extrusion granulation method: A method in which physical properties suitable for granulation are given to raw materials by performing pre-processes such as water addition, heating, and kneading, and the material is extruded from a screen or a die hole by an appropriate extrusion mechanism. -Crushed granulation: A method in which a relatively large amount of water is added to the raw material powder to form large agglomerates, which are sheared by high-speed rotating blades into spherical or irregular granules. Agitation granulation method: A method of granulating a humidified powder by giving a mixing action.

The raffinose crystals may be formed into a solution and formed into granules. For example, the following methods are exemplified. Among them, the spray granulation method is industrially preferable. . Fluid drying type: A method in which crystals are placed in a fluidized state by hot air, an aqueous solution of the same substance is sprayed into a fluidized bed to coat the crystal surface, and water is evaporated to increase the crystal grain size. -Spray granulation method: A method in which a liquid material is sprayed in a countercurrent or cocurrent stream to obtain spherical particles by transferring heat and substances between the droplets and the stream. In this case, as the raffinose solution, aqueous solutions having various concentrations can be appropriately used. However, it is preferable to use a solution as thick as possible, and it is preferable to use a saturated solution industrially.

In addition to the above-mentioned wet granulation method, a dry granulation method can also be used. For example, a method of rolling and molding raffinose with a high-pressure roller and then coarsely crushing and sizing the raffinose, A method of pulverizing the powder, putting it in a mold, and tableting can be used as appropriate.

[0013] The granular raffinose produced in this way has much improved melting, mouthfeel, sweetness, and sweetness crispness than crystalline raffinose, and it does not have a rough texture even when it is put in the mouth. Moreover, the sweetness is increased and the aftertaste is refreshing, making it very suitable for oral consumption.

[0014] Therefore, granular raffinose can be used as a functional oligosaccharide by itself or directly added to other foods and drinks to be used in healthy children as well as infants, the elderly, sick and post-sick patients. It can be taken orally as needed.

Further, the granular raffinose according to the present invention can be formulated into tablets by adding necessary additives and tableting. Alternatively, it is also possible to add a necessary additive, mix and fill the mixture into a container such as a capsule to prepare a preparation.

In the preparation of pharmaceutical preparations, after adding additives as needed to granular raffinose as the main drug, excipients, binders, disintegrants, lubricants, flavoring agents, solubilizing agents, suspensions The preparation may be carried out using known auxiliaries usually used in the technical field of tablet or capsule preparation such as turbidity agents and coating agents.

For processing into tablets, general tableting techniques such as wet granulation, dry granulation, and direct powder compression can be used as appropriate. For raffinose, the granulation technique for the first time according to the present invention is used. As a result, the use of the former two tableting technologies became possible. Among them, the tablet obtained by the wet granule compression method is particularly excellent in strength.

As additives, vitamins such as vitamin C; minerals such as calcium; sweeteners such as glucose, lactose, maltose, sucrose, stevia; sugar alcohols such as maltitol; acidulants such as citric acid; Various oligosaccharides; dairy products; and other food additives are appropriately used.

In the production of raffinose tablets and capsules, the content of granular raffinose depends on the purpose of use, age of the user, etc. and is not strictly specified, but is not limited to 50% or more of granular raffinose. It is preferable that the additive be less than 50% and 1% or more.
Hereinafter, examples of the present invention will be described.

[0020]

Example 1 After raffinose crystals were pulverized in a mortar,
Water 10 was added to raffinose 100 and mixed uniformly. This was extruded by a granulator (Fuji Paudal Co., Ltd., FI
NERYUZER Model EXR-60, processing capacity 40-150kg / hr), granulated, 70 ° C blast constant temperature thermostat (Yamato Scientific Co., Ltd. model)
DN910) for 3 hours to produce granular raffinose.

Crystalline raffinose and finely ground raffinose,
A sensory test of granular raffinose was performed. The results obtained are shown in Table 1 below. As shown in Table 1, the sweetness of the finely ground raffinose was stronger than that of the crystalline raffinose, the melting in the mouth and the cut of sweetness were improved, and the overall favorable results were obtained. Further, the granular raffinose did not change the sweetness intensity compared to the finely ground raffinose, but improved melting in the mouth and sweetness, and the overall evaluation was also high.

[0022]

[Table 1]

From the above, needle-like crystalline raffinose, which had a surface that was avoided in terms of taste and texture, such as a feeling of melting in the mouth and a lack of sweetness, was improved by pulverization and further granulation to improve these points. We were able to.

[0024]

Example 2 The amounts of raffinose and sucrose dissolved into crystals and granules processed over time were compared. 100 g of demineralized water was placed in a shaking thermostat adjusted to 37 ° C. 50
A 0 ml Erlenmeyer flask was set, and after acclimation to 37 ° C., 50 g of sugar was added, and the mixture was shaken at 150 rpm. The supernatant was collected over time, immediately filtered through a 0.45 μm membrane filter, and the sugar concentration was measured. As shown in FIG. 1, sucrose dissolved almost completely in a short time, but crystalline raffinose showed slow dissolution. On the other hand, granular raffinose showed a high amount of dissolution in a short time, and reached almost saturated concentration after 120 seconds.

[0025]

Embodiment 3 In accordance with the flowchart shown in FIG.
Raffinose tablets were produced. Granular raffinose 70
Parts by weight and 30 parts by weight of vitamin C were weighed and mixed well. 20% 0.3% guar gum solution as binder
% (W / w), and granulated by fluidized bed granulation (trade name: Flow Coater FLO-120 type). In addition, 1.5% β-carotene powder was dissolved in the binder.

After this was dried to a water content of 6% or less, it was sieved with a circular shifter (sieved with 16 mesh).
Next, using a conical mixer, a fragrance and a lubricant (magnesium stearate) were added to perform secondary mixing.

The tableting process was performed using a tableting machine FY30 (trade name of Fuji Pharmaceutical Machinery Co., Ltd.) (formulation 18φ; filling amount 150).
0 mg; tablet thickness 5.0 ± 0.3 mm; hardness 7 kg ± 3; moisture 8% or less), and a raffinose-containing tablet was produced.

[0028]

Example 4 400 parts by weight of granular raffinose, 10 parts by weight of crystalline glucose, 7 parts by weight of citric acid, Na-Caseinate
Using 7 parts by weight, 5 parts by weight of ascorbic acid, and 3 parts by weight of hardened oil, raffinose-containing tablet confections were produced according to a conventional method.

[0029]

Example 5 125 parts by weight of granular raffinose, 20 parts by weight of purified calcium carbonate, 103 parts by weight of lactose, and 2 parts by weight of magnesium stearate were used. A capsule containing 125 mg of raffinose was produced.

[0030]

According to the present invention, the production of granular raffinose has become possible for the first time. Granular raffinose is not only sweeter than crystalline raffinose, it also has a smooth mouth-melt without roughening in the mouth, has a good texture, and has a refreshing back mouth, making it very easy to take Has become.

Therefore, raffinose, which was conventionally difficult to ingest, can be easily ingested by infants, the elderly, sick or post-sick, and fully utilize the various physiological activities inherent in raffinose. Can be.

[Brief description of the drawings]

FIG. 1 shows a comparison of the amount of sugar dissolved over time.

FIG. 2 is a flowchart of a raffinose tablet manufacturing process.

Continuation of front page (72) Inventor Tsukasa Emoto 2-3-13 Kyobashi, Chuo-ku, Tokyo Inside of Sugar Beet Sugar Co., Ltd. (56) References JP-A-62-126951 (JP, A) JP-A-9-92 199 (JP, A) JP-A-61-9266 (JP, A) JP-A-5-211900 (JP, A) JP-A-9-224665 (JP, A) JP-A-54-49345 (JP, A) (58) Field surveyed (Int.Cl. ⁷ , DB name) A23L 1/236 A23L 1/22 C07H 3/06

Claims (6)

(57) [Claims] 1. A method for producing granular raffinose, comprising the steps of: pulverizing raffinose crystals; wetting the powder particles to cause the individual particles to aggregate with each other; 2. The process for producing granular raffinose according to claim 1, wherein the process is performed by an extrusion granulation method. 3. The method for producing granular raffinose according to claim 1, wherein the raffinose crystal powder particles are wetted by adding water. 4. The method according to claim 1, wherein the raffinose crystals are pulverized, water 10 is added to raffinose 100, the mixture is mixed, and the mixture is extruded and granulated by an extruder. A method for producing the granular raffinose as described above. 5. A granular raffinose produced by the method according to any one of claims 1 to 4. 6. It shows a high solubility of reaching a substantially saturated concentration after 120 seconds, and at least one of melting in the mouth, sweetness and sweetness is improved.
The granular raffinose according to claim 5, characterized in that: