JP3316005B2 - Multi-cylinder connection mechanism between drug container and solution container - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a combination of a multi-cylinder connecting mechanism and a coronal lid capable of connecting a medicine container and an injection cylinder while maintaining watertightness. Accordingly, the present invention relates to a coupling mechanism further incorporating an annular lock mechanism.

Further, as another aspect, the present invention relates to a multi-cylinder connecting mechanism in which a mounting member is used in place of a crown-shaped lid and an annular locking mechanism is further combined with the mounting member if necessary.

[0003]

2. Description of the Related Art A so-called "therapeutic kit" in which a drug container and its solution container are accommodated in a coupling mechanism and a solution can be started as required has been already provided in various forms, particularly for infusion. However, in these kits, the combination of the drug container and the solution container cannot be changed at a stage close to the use site as desired. The reason is that both are already assembled in a state of being housed in the coupling mechanism. Therefore, a situation may occur in which the kit of the required combination is not present in the existing product, or even if the kit is not available at the time of use, even if the kit is not available.

[0004]

SUMMARY OF THE INVENTION The present invention has been completed in order to solve the situation remaining in the prior art, and
The purpose is to select the optimal one from the medicine containers that contain the types and amounts of medicines that are available at hand, and then select this from the solution containers that contain the types and amounts of the solution that are available at hand. It is an object of the present invention to provide a coupling mechanism that can be used for a wide range of use purposes, in particular, for therapeutic purposes by forming a drug solution near the stage of use in combination with an optimal one.

[0005]

As a result of various studies on the means for solving the above-mentioned problems, the present inventors have taken out only the connecting mechanism from the kit and not the method of accommodating the medicine container in the kit. With the adoption of a system that allows the drug container to be detachable to the outside, and finding that it is possible to cope with a remarkably wide range of usage purposes by combining this system with a system in which a syringe is directly used as a stored solution container, The present invention has been completed as a result of developing a mechanism adapted to this.

That is, as a basic aspect of the present invention, there is provided a multi-cylinder connecting mechanism comprising a syringe containing a lysis solution, a connecting inner tube, a connecting outer tube, a puncture needle member and a drug container mounting member. A connection outer cylinder engaged with the member, an injection cylinder fitted inside the connection outer cylinder from the upstream side of the connection outer cylinder,
A connection inner cylinder fitted from the downstream side between the injection cylinder and the connection outer cylinder and having a diameter-enlarging area on the inner wall of the downstream area, which is movable and watertight in a double pipe inner pipe provided at the downstream end of the injection cylinder. The upper portion of the puncture needle member is movably fitted to the plug and the inner tube of the double tube portion, and the expanding wall extending from the vicinity of the middle portion of the piercing needle member to the upstream side has an inner wall of the connection inner cylinder. Is a multi-cylinder connection mechanism between a drug container and a dissolution liquid container, each of which is formed of a puncture needle member that is in sliding contact with the puncture needle member. It expands when accommodated in the enlarged diameter portion provided on the inner wall of the downstream region, and between the inside of the expandable leg and the outside of the outer tube in the double tube portion provided at the downstream end of the syringe barrel. This is a multi-tubular coupling mechanism in which a configuration in which the held lock is released is added to the basic mode. When the injection cylinder further descends in the connection inner cylinder after the lock in the suitable mode 1 is released, the convex portion near the inner middle step of the expandable leg and the diameter reduction near the middle step of the outer tube outer wall in the double pipe section of the injection cylinder are reduced. This is a multi-cylinder connection mechanism in which a configuration in which a step is engaged is added to the basic aspect. As a preferred aspect 3, the shape of the inner wall near the inner pipe downstream end in the double pipe portion at the downstream end of the injection cylinder is the puncture needle upstream section A multiplex structure that forms a watertight structure with the outer wall and a mechanism in which the shape of the outer wall near the downstream end of the outer tube in the double pipe portion forms an airtight structure with the inside near the downstream end of the expanding leg is added to the basic mode. A preferred embodiment 4 of the tubular connecting mechanism is a multi-cylinder connecting mechanism including a medicine container mounting member, a connecting inner tube, a connecting outer tube, an injection tube containing a solution, a stopper, and a hollow puncture needle member. , A hakama formed by extending the puncture needle from near the middle stage to the upstream side A hollow puncture needle member in which at least one expandable leg extending from the skirt tube portion to the upstream side is annularly connected near the upstream end thereof, and an inner diameter capable of accommodating the expandable leg in its expanded state. The present invention is a multi-cylinder connection mechanism obtained by adding a configuration including a connection inner cylinder having an enlarged portion on an inner wall near an upstream end thereof to a basic aspect, and the present invention further includes a medicine container mounting member, a connection inner cylinder, and a connection. In a multi-cylinder connection mechanism including an outer cylinder, a syringe containing a solution, a stopper, and a hollow puncture needle member, one or more expandable legs formed by extending from near the middle stage of the puncture needle to the upstream side. The part is connected annularly near its upstream end and has a double-ended hollow puncture needle member having pointed ends at both ends, and is fitted in a watertight and hardly movable manner in a double tube opening provided at the downstream end of the syringe barrel. The upstream end is an enlarged inner diameter portion capable of accommodating the plug and the expanding leg in the expanded state. A multi-cylinder type connecting mechanism constituted by a connecting inner cylinder provided on the nearby inner wall can be adopted. [Description Based on Drawings] The present invention will be described below in detail with reference to the drawings. In the following drawings, unless otherwise specified, the medicine container side will be described as downstream and the injection cylinder side as upstream for convenience. It should be noted that the positional relationship between the medicine container and the plunger is reversed (inverted) after (l) in FIG.

FIG. 1 shows a medicine container A according to a specification in which a multi-cylinder coupling mechanism of the present invention further incorporates a coronal lid with an annular lock mechanism.
FIG. 4 is a schematic cross-sectional view showing a state of being externally fitted to the mouth of FIG. In FIG. 1, A is a container (hereinafter, may be referred to as a “drug container”) containing a drug or the like used for treatment or the like,
A stopper A1 made of an elastic material is fitted and fixed in the mouth. However, when the multi-cylinder coupling mechanism of the present invention further incorporates an annular lock mechanism, the mounting member is an integral structure of the crown lid, that is, the crown lid body 11 (annular portion of the crown lid) and the top plate 32. There is no necessity, and it goes without saying that a configuration in which the mounting ring 11 and the septum plate (bottom plate) 32, which are components of the connecting inner cylinder 3, are divided into two parts. However, here, for convenience, the case where both are formed as an integral structure will be described as a basic mode.

[Basic Aspect] A coronal lid 1 is fitted on the mouth A2 of the medicine container A. A holding projection (also called “undercut”) 11u is provided on the inner wall near the middle of the coronal lid 1, and a recess 11c is usually provided near the middle of the outer wall of the coronal lid 1. Neither the holding protrusion 11u nor the recess 11c need be continuous over the entire circumference. One or more cutouts may be several projections existing in at least one of the holding projection 11u and the depression 11c, or may be several projections scattered.

A fastening ring 2 is often fitted on the outer wall of the crown-shaped lid 1. The lower half inner wall of the tightening ring 2 exerts a tightening action on the coronal lid 1. The tightening ring 2 is usually substantially tubular, and an engaging projection 2 is provided on an outer wall near its upper end.
1 is usually provided. The cross-sectional shape of the convex portion 21 is formed on a slope that opens downward on the upstream side and a rising surface that is substantially perpendicular to the ring surface on the downstream side (lower surface). Also, the concave portion 11c on the inner wall surface of the coronal lid 1 is a convex portion,
The convex portion 22 on the inner wall surface of the tightening ring 2 may be configured to engage with each other as a concave portion. The tightening ring 2 does not need to be used depending on the application of the multi-tubular coupling mechanism of the present invention.

In the basic mode, the connecting inner cylinder 3 includes a ceiling flat plate portion 32 (hereinafter, sometimes referred to as a “top plate”) constituting the coronal lid 1 and a tubular portion 31 rising upward from the upper surface of the top plate 32. And is effectively part of the coronal lid. However, a different coding system will be described.

The inner diameter of the downstream portion of the tubular portion 31 constituting the connecting inner cylinder 3 is formed to be larger than the inner diameter of the upstream portion, and the expandable sliding leg 43 of the descending puncture needle member 4 is formed. Is set to be able to be accommodated in an expanded state. This requirement is necessary for the multi-cylinder coupling mechanism of the present invention to operate in a predetermined order and timing. A puncture needle member 4 and an injection cylinder 5 are fitted in an upstream region in the connection inner cylinder 3. A through hole 33 is provided at a substantially central portion of a top plate (septum plate) 32 connecting the connection inner cylinder 3 and the coronal lid 1, and the puncture needle 41 of the puncture needle member 4 is made of an elastic material. A passage for piercing the stopper A1 is provided.

The vicinity of the upstream end 34 of the tubular portion 31 constituting the connecting inner cylinder 3 extends at least partially further in the upstream direction and has a holding projection (upward opening) 36 on the inner wall of the upstream end and a recess on the inner wall on the downstream side thereof. 35 are formed. These holding projections 36
When the connection inner cylinder 3 relatively rises between the connection outer cylinder 7 and the injection cylinder 5, the recess 35 finally forms the protrusions 55 and 56 provided on the outer wall near the upstream end of the injection cylinder 5. It is of a shape that engages.

The puncture needle member 4 in the basic mode includes a hollow puncture needle 41 having a pointed tip on the downstream side, a hakama cylinder 42 turning from a support wall protruding outward from a substantially middle stage to the upstream, and a shoulder of the hakama cylinder 42. And an expandable sliding leg 43 that protrudes outward from the vicinity and then turns to the upstream side.

A convex portion 45 is provided on the inner wall near the upstream end of the expandable sliding leg 43, and the convex portion 45 is a downstream end of the outer tube 52 in the downstream end double tube portion of the injection cylinder 5 fitted therein. It abuts on an inclined portion (upward opening) 57 provided on the outer wall in the vicinity to prevent the injection cylinder 5 from lowering alone. That is, the shape of the convex portion 45 is a sawtooth shape, and has a slope that opens to the upstream side. The inclination of the convex portion 45 on the upstream side serves to prohibit the lowering of the syringe barrel 5 as long as the inclined portion 57 can be kept in a state of receiving the inclined portion 57 from the downstream side. If the expandable sliding leg 43 expands, the convex portion 45 loses the prohibiting action, and the injection cylinder 5 can be further lowered in the connecting inner cylinder 3.

Although two or more expandable sliding legs 43 are usually provided side by side, they may be cylindrical. However, it is important that the structure be expandable if it is cylindrical, for example, that two or more cuts are provided in the vertical direction.

The skirt tube 42 of the puncture needle member 4 does not have to be a complete tube. Since its function is to guide the puncture needle 41, the puncture needle 41 is not limited to a single body, and may be formed from two or more vertically divided portions, and a through hole or a cutout is provided in a shoulder or a body. Is also good.

The puncture needle 41 has a flow passage 4 running in the axial direction therein.
6, and a liquid passage hole 44 is opened near the shoulder on the downstream side of 41. Usually, two liquid passage holes 44 are provided, but the number thereof can be selected as needed. In addition, a downstream piston / plug 6 is fitted in an upstream region in the inner tube of the double tube portion provided at the downstream end of the injection cylinder 5 in which the puncture needle 41 is fitted. The downstream-side piston / plug 6 prevents the solution contained in the syringe barrel 5 from flowing out or leaking into the flow passage 46 in the puncture needle member 4.

The inner space of the double-pipe portion protruding from the downstream end of the syringe barrel 5 is provided in the annular gap formed between the inside of the skirt tube 42 constituting the puncture needle member 4 and the outside of the upstream portion of the puncture needle 41. 51
The inner wall of the expandable sliding leg 43 constituting the puncture needle member 4 is in contact with the outside of the outer tube 52.

The injection tube 5 is formed by the double tube portions 51 and 52 and a main body 53 connected to the upstream end thereof. As described above, the downstream piston / plug 6 made of an elastic material is provided in the inner diameter region of the inner tube 51 in the double tube portion of the injection tube 5.
Is fitted inside. The inner diameter of the upstream area 54 in the inner pipe 51 is enlarged.

The significance of the expansion of the inner diameter (expansion of the diameter) is that when the downstream-side piston / plug 6 moves to this area, the space is expanded to such an extent that the liquid can flow outside (a gap between the inner tube wall and 6). It is in. This securing of the distribution space has a significant significance in realizing the effects of the present invention.

On the other hand, an upstream side piston / plug 8 is fitted in an upstream region of the injection cylinder 5. The upstream piston / plug 8 serves to prevent the leakage of the solution contained in the syringe barrel and, when the plunger 9 is mounted on the upstream side, serves as a component of the syringe. is there.

In order to ensure this function, the upstream piston / plug 8 is made of an elastic material, and preferably, the upstream piston / plug 8 is provided in a locking groove provided substantially horizontally on the inner wall surface of the syringe barrel 5. Are configured to engage with the ridges provided on the outer peripheral surface of the. In the vicinity of the outer wall of the upstream end of the injection cylinder 5, a convex portion 55 is provided.
And a projection 56 are provided. Here, the protrusion 56 is formed to have a lower (lighter) protrusion degree than the protrusion 55. A connection outer cylinder 7 is fitted outside the injection cylinder 5.

The connecting outer cylinder 7 is usually provided with an upper half portion 72 (small diameter portion).
The lower half 71 has a larger diameter (larger diameter). The large-diameter portion 71 is formed on the inner wall near the downstream end by a convex portion 75 provided on the upstream end edge portion of the tightening ring 2 by a convex portion 75.
To prevent it from being pulled out in the upstream direction and to have gently convex portions 73 and 74 on the inner wall near the upstream end, and a concave portion formed between the two convex portions is a convex portion of the outer wall of the injection cylinder 5. Engage the part 55.

The length (height) of the large-diameter portion 71 of the connecting outer cylinder 7 is such that the connecting outer cylinder descends toward the medicine container and the convex portion 1 at the downstream end of the coronal lid.
f The transition area from the large-diameter portion 71 to the small-diameter portion 72 is set so that it does not contact the upstream end of the tightening ring 2 even when engaged with the outer edge. FIG. 1 shows a shape (in the form of a paragraph) in which the transition from the large diameter portion 71 to the small diameter portion 72 is abruptly performed like a cliff, but it is not limited to this. As long as the above requirements are satisfied, a gradually changing shape may be used.

FIG. 2A is a longitudinal sectional view of the syringe barrel 5.
Inner cylinder 5 in a double pipe portion protruding from the downstream end of injection cylinder 5
A downstream piston / plug 6 is fitted inside 1 . FIG. 2B shows a state in which the injection cylinder 5 is fitted inside the connecting outer cylinder 7. The concave portion between the gentle convex portions 73 and 74 provided on the inner wall at the upstream end of the connecting outer cylinder 7 engages with the convex portion 55 provided on the outer wall near the upstream end of the injection cylinder 5. FIG. 2 (c)
Is protruded from the downstream end of the syringe barrel 5 in FIG.
The inner tube 51 and the outer tube 52 in the double tube portion
Shows the upper half of the multi-cylinder connection mechanism fitted with.

FIG. 2D is a longitudinal sectional view of the medicine container A. As shown in FIG. 2 (e), a coronal lid 1 is placed at the mouth of A.
The upper slope of the holding projection (undercut) 11u provided on the inner wall of the coronal lid 1 is engaged with the lower shoulder A2b of the mouth of the medicine container A.

FIG. 2 (e) shows a top plate 32 of the coronal lid 1 externally fitted to the mouth of the medicine container A, which serves as a bottom plate of the connecting inner cylinder 3. Shows a state in which is loosely fitted.

A recess 12 is provided on the outer wall near the downstream end of the coronal lid body 11. The recess 12 may be a continuous groove, a series of discontinuous grooves, or a plurality of interspersed pits. The fastening ring 2 connected to the outer peripheral edge of the bottom plate (septum plate) 32 so as to be able to be broken is usually a tubular member.
A projection 21 is provided on the outer wall near the upstream end. This projection 21 may be a continuous flange or a series of discontinuous ridges,
A plurality of scattered protrusions may be used.

FIG. 2F shows a state in which the tightening ring 2 is externally fitted to the coronal lid 1 which is externally fitted to the mouth of the medicine container A. The tightening ring 2 is slid toward the medicine container, and is fitted outside until it abuts against a flange 11f provided at the downstream end of the coronal lid 1. As a result, the concave portion 12 provided on the middle outer wall of the coronal lid 1 is provided with the convex portion 2 provided on the lower inner wall of the tightening ring 2.
2 prevent engagement of the tightening ring 2. The convex portion 22 may be continuous with the entire inner wall, a ridge having one or more notches, or a plurality of scattered protrusions.

Further, a convex portion 22 is usually provided on the inner wall of the downstream region (lower stage) of the tightening ring 2. Its role is to fix the tightening ring 2 to the coronal lid 1 (mounting member 1) . The projection 22 may be a continuous flange, a series of discontinuous ridges, or a plurality of scattered projections. However, the above-mentioned concavo-convex relationship may be reversed, and other methods may of course be used.

[Another Embodiment] As another embodiment of the connecting mechanism of the present invention, the mechanism is not the structure of the connecting inner cylinder 3 integrated with the coronal lid 1 but the coronal lid 1.
Can be exemplified by a connecting ring member 1 and a connecting inner cylinder 3 with a bottom plate 32 (the top plate of the coronal lid 1 in the basic embodiment). In this embodiment, the clamping ring 2 is often used.
Is further assembled. A convex portion 23 may be provided on the inner wall near the middle stage of the tightening ring 2. Its role is mainly to press and fix the outer peripheral edge of the bottom plate 32 to the top surface of the mounting ring member 1. The convex portion 23 may be a continuous ridge over the entire circumference of the inner wall, a ridge divided into two or more, or a plurality of scattered protrusions.

For example, both the convex portions 22 and 23 provided on the inner wall of the tightening ring 2 are concave portions, the outer peripheral edge of the bottom plate 32 of the connecting inner cylinder 3 projects further outward, and the mounting ring member 1
Even if the concave portion 12 of the outer wall is a convex portion, there is no problem as long as the pressing and fixing functions described above are performed.

[0033]

[Action]

[Basic Mode] When the upstream part of the multi-cylinder connection mechanism shown in FIG. 2C is fitted to the downstream part of the multi-cylinder connection mechanism shown in FIG. The assembled state before use shown in (g) of FIG. When the product is shipped as a product, usually, a protective fixing means is attached to the outer shell. This is a measure for preventing an unexpected start of operation.

In FIG. 3 (g), a concave portion 75 provided on the inner wall of the downstream end of the connecting outer cylinder 7 is engaged with and fixed to a convex portion provided on the outer wall of the upstream end 21 of the tightening ring 2. ing. When the assembly in this state is pressed from above and the upper half of the multi-tubular coupling mechanism is slid downward along the long axis, FIG.
(H). In the sliding process, the puncture needle 41 located at the tip of the puncture needle member 4 penetrates near the center of the stopper A1 of the medicine container A.

The circulation port 44 located at the shoulder of the puncture needle 41
When entering the container from the inner wall surface of the stopper A1, the inside of the injection cylinder 5 and the inside of the medicine container A communicate. At the same time, the puncture needle member 4 is accommodated in the downstream-side enlarged-diameter portion 31e of the connection inner cylinder 3, and as a result, the expandable sliding leg 43 of the member expands and the downward prohibition of the injection cylinder 5 is released.

When the injection cylinder 5 is pressed downward at the time point shown in FIG. 3 (h), the connected outer cylinder 7 further descends, and
The concave portion 76 of the inner wall at the lower end is the flange-like overhang 1 at the downstream end of the coronal lid 1.
FIG. 4 (i), which engages with the outer edge 1f . At this stage, the puncture needle member 4 has completely penetrated the stopper A1 of the medicine container A.

At the point of time (i) in FIG. 4, a plunger 9 is mounted on the upstream-side top surface of the upstream piston / plug 8 mounted in the injection cylinder 5 to obtain (j) in FIG. 4. , 9 is pressed downward to move the solution from the syringe 5 into the medicine container A.
When the movement of the solution is completed, the process reaches (k) in FIG.

In the process up to (k) of FIG. 5 or after the end of the movement, the entire system connected, particularly the medicine container A side, is effectively subjected to mechanical means such as vibration and rotation or physical means such as heating and ultrasonic application. Means are utilized as needed to fully dissolve or disperse the drug. Next, when the system is inverted and the plunger 9 is moved away from the medicine container A to accommodate the medicine solution in the medicine container A in the injection cylinder 5, the state shown in FIG .

When the connecting outer cylinder 7 is further pushed and moved in the direction of the medicine container A at the point of (l) in FIG . 5 , the connecting inner cylinder 3 relatively enters the connecting outer cylinder 7. The upstream end of the connection inner cylinder 3 continues to enter while being expanded by the convex portion 57 of the outer wall of the injection cylinder 5. When the ingress is further continued, the upstream end of the connecting inner cylinder 3 comes into contact with the convex portion 73 provided on the inner wall near the upper end of the connecting outer cylinder to further expand the connecting outer cylinder. Therefore, the vicinity of the upper end of the connection outer cylinder 7 is expanded, and the locking projection 56 on the outer wall near the upper end of the injection cylinder 5 is formed.
Is disengaged from the concave portion between the convex portion 74 and the convex portion 73 on the inner wall near the distal end of the coupling outer cylinder 7.

As a result, as shown in FIG. 6 (m), the syringe barrel 5 is ready to be pulled out of the connecting outer barrel 7. Subsequently, if the injection needle is attached to the puncture needle 41 after the injection cylinder 5 is pulled out, the state shown in FIG. 1C or FIG. 6N, that is, the injection preparation is completed. [Another Embodiment] FIG. 7 shows another embodiment of the multi-cylinder connecting mechanism of the present invention, which is provided with a crown-shaped lid with an annular locking mechanism in many cases. The difference between the different embodiment and the basic embodiment is that a downstream plug has a fixed plug 6a instead of the downstream piston plug 6 and a downstream puncture needle having a cusp downstream instead of the puncture needle member 4 having a cusp downstream. The point is that a double-sided pointed puncture needle member 4v composed of an upstream side puncture needle 41b having a pointed tip on the upstream side is used.

FIG. 7A is a schematic longitudinal sectional view showing a state in which a plunger is further attached to the embodiment. In FIG.
(b), the injection cylinder 5 of the multi-cylinder coupling mechanism according to another embodiment of the present invention moves toward the medicine container A in a state of engagement with the coupling outer cylinder 7,
Double-pointed puncture needle member 4 attached to the tip of syringe barrel 5
The downstream puncture needle 41a of v passes through the stopper A1 of the medicine container A to open a flow passage, and the upstream puncture needle 41b penetrates the fixed stopper 6a wrapped around the inner tube 51 of the syringe double tube to be distributed. Plunger 9 in addition to opening
FIG. 4 is a schematic longitudinal sectional view showing a state where the bottom is pushed down to the bottom. FIG. 7 (c) is a schematic longitudinal sectional view showing a state in which the syringe 5 is extracted after the dissolution of the drug is completed and the injection needle is attached to the downstream puncture needle 41a, and can be used for injection at any time. In state.

[0042]

According to the present invention, the multi-cylinder type connecting mechanism can be set in a state where all the various functions can be exhibited simply by mounting the mounting member on the opening of the medicine container and performing necessary operations. .Relationships between holding members, mounting members, connecting inner cylinders, injection cylinders, connecting outer cylinders, and holding projections, flanges, projections, depressions, and the like provided on them with tightening rings added as necessary. Can be reliably operated in a predetermined operation sequence and operation timing. Since the injection cylinder also functions as a dissolving solution container, a drug solution containing a desired type of drug at a predetermined concentration can be obtained by routine operation. That is, a syringe containing a desired type of dissolving solution by a predetermined volume and a desired type of drug container are connected by a multi-cylinder connecting mechanism of the present invention to form a kit. A dissolved or dispersed injection is obtained. -Combinations that do not exist in existing commercial products-types and amounts of drugs and types and amounts of lysing solutions-can also be created. Combinations arising from storage conditions, handling restrictions and other constraints among non-commercially available combinations have the potential to be realized by the coupling mechanism of the present invention.

[Brief description of the drawings]

FIG. 1 (a) is a schematic longitudinal sectional view showing a state in which a plunger is attached to a basic mode in which a multi-tubular coupling mechanism of the present invention has a crown-shaped lid with an annular locking mechanism, and FIG. 1 (b). ) Indicates that the syringe of the multi-cylinder coupling mechanism of the present invention moves to the medicine container side, the puncture needle attached to the tip of the syringe pierces the stopper of the medicine container, opens a flow passage, and the plunger moves the syringe. FIG. 1 is a schematic vertical cross-sectional view of a state where it is pushed down to the bottom.
(c) is a schematic vertical cross-sectional view showing a state in which the syringe is withdrawn after the dissolution of the drug is completed, and the injection needle is externally fitted to the puncture needle, and is ready for injection at any time.

2 (a) to 2 (c) illustrate the upstream structure of a multi-cylinder portion in a basic mode in which a multi-cylinder connecting mechanism of the present invention includes a crown-shaped lid with an annular lock mechanism, according to the assembling order. FIGS. 2 (d) to 2 (f) are schematic longitudinal sectional views illustrating the process of fitting the multiple cylindrical portion to the mouth of the medicine container in accordance with the assembling order.

FIG. 3 (g) is a schematic longitudinal sectional view showing a state in which the multiple cylindrical coupling mechanism of the present invention is fitted to the mouth of the medicine container, and FIG. 3 (h) is the present invention. FIG. 7 is a schematic longitudinal sectional view showing a state in which the multi-cylinder coupling mechanism moves to the medicine container side, and the puncture needle pierces the stopper of the medicine container to open the flow passage.

FIG. 4 (i) shows that the multi-cylinder connection mechanism of the present invention includes a coronal lid with an annular lock mechanism, and the connection outer cylinder and the injection cylinder of the multi-cylinder connection mechanism are further moved to the medicine container side. FIG. 4 (j) is a schematic vertical cross-sectional view showing a state in which the downstream end of the connection outer cylinder is fitted to the overhang of the base of the coronal lid main body, and the puncture needle has reached the downstream end of the connection inner cylinder. It is a typical longitudinal section showing the state where plunger 9 was attached to the upper stream side of upstream side piston dual use plug 8 in i).

FIG. 5 (k) is a schematic view showing a state in which the plunger 9 is pushed down to the downstream end of the injection cylinder 5 in the basic mode in which the multi-cylinder connection mechanism of the present invention includes a coronal lid with an annular locking mechanism. FIG. This state is also shown in FIG. FIG. 5 (l) is a schematic longitudinal sectional view showing a state where the system is changed to the inverted state and the plunger 9 is pulled out.

FIG. 6 (m) shows the connection inner cylinder 3 entering between the connection outer cylinder 7 and the injection cylinder 5 in the basic mode in which the multi-cylinder connection mechanism of the present invention includes a coronal lid with an annular locking mechanism. FIG. 6 is a schematic longitudinal sectional view showing a state where the engagement between the two is released.
(N) is a schematic vertical cross-sectional view showing a state in which the injection needle is externally fitted and fixed to the puncture needle located at the distal end of the injection cylinder 5 pulled out of the connection outer cylinder 7 due to the release of the engagement. This is
It matches the state shown in (c).

FIG. 7 shows another embodiment in which the multi-tubular coupling mechanism of the present invention includes a crown-shaped lid with an annular locking mechanism. FIG. 7 (a) is a schematic longitudinal sectional view showing a state in which a plunger is further attached to the embodiment, and FIG. 7 (b) shows that the injection cylinder of the mechanism moves to the medicine container side, and is provided at the tip of the injection cylinder. In addition to the fact that the downstream puncture needle of the attached double-pointed puncture needle member pierced the stopper of the drug container and that the upstream puncture needle penetrated the fixed stopper covered by the double-walled syringe. FIG. 7 (c) is a schematic longitudinal sectional view showing a state in which the plunger is pushed down to the bottom of the syringe barrel, and FIG. 7 (c) shows a state in which the syringe is pulled out after the dissolution of the drug is completed, and the needle is attached to the downstream puncture needle. FIG. 3 is a schematic longitudinal sectional view.

[Explanation of symbols]

DESCRIPTION OF SYMBOLS 1 Coronal lid which comprises the multi-cylinder connection mechanism of the present invention 2 Tightening ring 3 Connection inner cylinder 4 Puncture needle member 5 Injection cylinder 6 Downstream piston / plug 7 Connection outer cylinder 8 Upstream piston / plug 9 Plunger A Drug container DESCRIPTION OF SYMBOLS 11 Coronal lid main body 12 Recessed part of coronal lid main body outer wall 21 Convex part of the upstream end edge outer wall of the tightening ring 22 Convex part of the inner wall of the downstream side of the tightening ring 23 Convex part of the inner wall of the tightening ring 31 Enlarged part of the downstream area of the connecting inner cylinder part 32 The top plate part 33 constituting the lid 33 The through hole near the center of the top plate part 34 The upstream end area of the connection inner cylinder 35 The concave part provided on the inner wall of the upstream end area of the connection inner cylinder 36 The upper part provided at the upstream end of the connection inner cylinder Open holding protrusion (undercut) 41 Puncture needle of puncture needle member 42 Hakama barrel of puncture needle member 43 Expandable sliding leg of puncture needle member 44 Liquid passage hole (liquid passage port) of puncture needle shoulder 45 Expansion Near the upstream end of the open sliding leg The inner tube in the double tube at the downstream end of the injection tube 52 The outer tube in the double tube at the downstream end of the injection tube 53 The main body of the injection tube 54 The downstream end of the injection tube The enlarged diameter part of the inner wall of the inner tube in the double tube part 55 The strong convex part of the outer wall near the upstream end of the injection cylinder 56 The light convex part of the outer wall near the upstream end of the syringe cylinder 57 The outer pipe downstream of the double pipe part at the downstream end of the syringe cylinder Holding projection (undercut) at the outer edge of the end 4v Both-end pointed puncture needle member 41a composed of an upstream puncture needle and a downstream puncture needle 41a Downstream puncture needle 41b Upstream puncture needle 44a Passing through the downstream puncture needle shoulder Fluid hole (fluid port) 44b Fluid hole (fluid port) at the shoulder of the puncture needle on the upstream side 6a Plug covered by the inner pipe port of the double pipe at the downstream end of the syringe 71 Expanded portion 72 Connected outer cylinder main body portion 73 Slow convex portion on inner wall of upstream area of connected outer cylinder 74 Connected Projection on the inner wall near the upstream end of the outer cylinder A1 Plug fitted inside the medicine container mouth A2 Medicine container mouth 11c Depression in outer wall of coronal lid main body 11f Overhang of base of coronal lid main body 11u Holding projection on inner wall of coronal lid main body 31e Diameter enlarged part of the inner wall downstream of the connected inner cylinder part A2b Lower shoulder part of medicine container mouth

──────────────────────────────────────────────────続 き Continuation of the front page (72) Inventor Naoto Ikuda 1-6-6, Torocho, Omiya City, Saitama Prefecture Heights 507, Omiya-Toro Ekimae Heights (56) References JP-A-5-176970 (JP, A) JP-A-4-132554 (JP, A) JP-A-54-52194 (JP, U) JP-T-62-500427 (JP, A) JP-T-61-502170 (JP, A) (58) (Int.Cl. ⁷ , DB name) A61J 1/20 B65D 83/00

Claims (6)

(57) [Claims] 1. A coupling engaged with a drug container tightening ring in a multi-cylinder coupling mechanism comprising an injection cylinder containing a solution, a coupling inner cylinder, a coupling outer cylinder, a puncture needle member, and a medicine container mounting member. An outer cylinder, an injection cylinder internally fitted from the upstream side of the connection outer cylinder and engaged with the connection outer cylinder, fitted between the injection cylinder and the connection outer cylinder from the downstream side and having a diameter-increased area on the inner wall of the downstream area; A stopper that is movable and watertightly fitted into the inner pipe of the double pipe section provided at the downstream end of the connecting inner cylinder and the injection pipe, and the upstream part of the puncture needle member is movably fitted to the inner pipe of the double pipe section. A multi-cylinder coupling mechanism for connecting a drug container and a lysing solution container, each comprising a puncture needle member having an expandable leg portion extending from the vicinity of the middle stage of the member to the upstream side and slidingly contacting the inner wall of the connection inner cylinder. 2. The expandable leg that constitutes the puncture needle member expands when housed in an enlarged diameter portion provided on the inner wall of the downstream area of the connecting inner cylinder, and the expandable leg inside and outside the expandable leg. 2. The multiple-cylinder connection mechanism according to claim 1, wherein the lock held between the double-pipe portion provided at the downstream end of the syringe and the outside of the outer pipe is released. 3. When the injection cylinder further descends in the connection inner cylinder after the lock of claim 2 is released, the convex portion near the middle step inside the expandable leg and the outer tube outer wall in the injection tube double tube portion. 2. The multi-cylinder coupling mechanism according to claim 1, wherein the reducing step near the middle step is engaged with the step. 4. The outer wall near the downstream end of the outer tube in the double tube portion, wherein the shape of the inner wall near the inner tube downstream end forms a watertight structure with the outer wall of the upstream portion of the puncture needle at the downstream end of the syringe barrel. 2. The multi-cylinder coupling mechanism according to claim 1, wherein said shape forms an airtight structure with the inside near the downstream end of the expandable leg. 5. A multi-cylinder connecting mechanism comprising a medicine container mounting member, a connecting inner tube, a connecting outer tube, a syringe containing a lysis solution, a stopper, and a hollow puncture needle member, wherein the puncture needle is upstream from near the middle stage. A hollow puncture needle member and an expandable leg in which a hakama tube formed by extending to the side, one or more expandable legs extending from the hakama tube to the upstream side are annularly connected near the upstream end thereof. The multi-cylinder connecting mechanism according to claim 1, comprising a connecting inner cylinder provided on the inner wall near its upstream end with an inner diameter enlarged portion capable of accommodating the expanded state. 6. A multi-cylinder connection mechanism comprising a medicine container mounting member, a connection inner tube, a connection outer tube, a syringe containing a lysis solution, a stopper, and a hollow puncture needle member, wherein the puncture needle is upstream from near the middle stage. One or more expandable legs formed by extending to the side are annularly connected in the vicinity of the upstream end thereof, and are provided at both ends of a hollow puncture needle member having a point at both ends, and provided at the downstream end of the syringe barrel. It is composed of a connecting inner cylinder provided on the inner wall near the upstream end thereof with a plug fitted in a double-pipe opening so as to be watertight and hard to move, and an inner diameter expanding portion capable of accommodating the expanding leg in the expanded state. Multi-tube type coupling mechanism.