JP3310222B2 - Method of forming a syringe, a slide valve for the syringe, and a cylinder for the syringe - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a kit-type syringe having a simple structure in which a chemical solution can be led out from a gap between the slide valve and a slide valve in an enlarged portion of an integral cylinder, a slide valve for the syringe used therefor, and a syringe. The present invention relates to a method for forming a cylinder for use .

[0002]

2. Description of the Related Art An outline of the background art up to the present invention will be described below. In 1969, L. Ernerot et al. Pointed out the problem of glass shards being mixed into the drug solution during ampoule cutting. Since then, coring problems due to penetration of injection needles into rubber stoppers of vial preparations (phenomena of rubber pieces being scraped off), and more. Has raised a number of serious problems, such as bacterial contamination during the preparation of pharmaceuticals. As a result, a container / syringe, that is, a kit preparation has been developed.

[0003] In a kit preparation, a drug solution is stored in an injection cylinder (cylinder) in advance, so that contamination of foreign substances and bacterial contamination can be prevented, and the burden on medical staff during preparation of the preparation can be reduced. Has many benefits such as
It is anticipated that further development will be achieved in the future.

[0004] At present, the structural form of the kit preparation is roughly classified into two types. On the other hand, a chemical solution is stored in a conventional classical cylinder, and the outside air is shut off only by a cap at the needle connection portion. The other is a mechanism in which a plastic barrel is fitted to a glass cylinder main body, and a front stopper (front sliding valve) intervenes between the chemical liquid and the outside air. In general, in the case of pharmaceuticals, there are regulations that must withstand long-term storage for three years, and it goes without saying that the latter is more preferable than the former.

[0005] Normally, in the case of a glass syringe, it is impossible to process the inside of the cylinder, and a syringe in which a workable plastic barrel and a glass cylinder body are fitted is unavoidable at the time of development. Might have been a choice. In recent years, the U.S. FDA has mandated such kit preparations to be sterilized after filling, as well as before filling with the drug solution.

[0006] However, when the barrel-type syringe is used, there arises a problem that the flowing steam enters the barrel during sterilization. Therefore, a kit-type syringe that does not allow inflow of steam or the like during post-sterilization has become essential. As a prerequisite, it is desirable to have a front stopper. Further, the following conditions must be satisfied. 1. The structure is simple. 2. There is a sense of stability and easy operation. 3. Manufacturing cost is low. 4. Easy disposal of industrial waste (flammable).

Hereinafter, the background art of the related art will be specifically described. FIG. 15 shows a conventional kit type syringe described in Japanese Patent Publication No. 62-58745. This syringe 70 can be easily injected by prefilling and storing an injection 76 in a cylinder 82 and attaching an injection needle at the time of injection, and is made of a cylindrical cylinder body 71 made of glass.
A synthetic resin barrel 72 fitted and fixed to the front end of the cylinder body 71; sliding valves 73 (front stopper rubber) and 75 (end stopper rubber, plunger) arranged in the cylinder body 71; And a chemical liquid 76 filled between them, and a synthetic resin cap 83 covering the injection needle connection portion 78 at the tip of the barrel 72.

The inside diameter of the barrel 72 is formed to be the same as the inside diameter of the cylinder body 71, and the inside wall of the barrel 72 is formed with a groove 81 for drawing out a chemical solution that follows the discharge hole 80 of the injection needle connection portion 78. When the plunger rod 77 is pushed, the sliding valve 73 moves into the barrel 72,
Is introduced from the groove 81 into the discharge hole 80. The slide valve 74 indicated by a chain line is for dispensing two types of chemicals by a single pushing operation of the plunger rod 77.

The above-mentioned syringe 70 is provided with a cap 8 by a medical worker.
3 removes the needle and attaches it, and the patient can be injected immediately without the trouble of filling the medicinal solution. Compared with the existing syringes, contamination of the needle at the time of aspirating the medicinal solution and contamination at the time of filling the medicinal solution can be achieved. Problems such as mixing of glass pieces due to ampoule cutting, mixing of rubber pieces when penetrating the rubber stopper of the vial, and invasion of bacteria are prevented.

[0010] However, since this kit preparation is both a drug container and a syringe, a sterilization step has become important in the production thereof. Specifically, as recently announced by the US FDA, in addition to pre-sterilization before drug filling, post-sterilization after drug filling has been required.
In pre-sterilization, a pharmaceutical manufacturer usually receives a syringe (sterilized) that has been almost assembled from a syringe manufacturer and sterilizes it again at the time of manufacture. On the other hand, the drug is also subjected to treatment such as autoclave or filtration sterilization. Next, as post-sterilization, sterilization is performed again at 100 ° C., 30 minutes or 121 ° C., 20 minutes after filling the drug, and various other conditions. The post-sterilization treatment is performed by spraying the flowing steam at 100 ° C. for 30 minutes or the flowing steam at 121 ° C. for 20 minutes. For example, when a heat-sensitive preparation such as HA (sodium hyaluronate) is used as a drug solution in a syringe, 1
The conditions of 00 ° C. and 30 minutes are set.

However, in the kit-type injector 70 described above, in the post-sterilization step, steam or the like enters into the empty chamber 79 of the barrel 72 as shown by the arrow A in FIG. 15 particularly through a small fitting gap between the barrel 72 and the cylinder body 71. The serious problem that bacteria etc. enter has arisen. There was also a concern that bacteria and the like would enter through the gap during long-term storage. This is because the barrel 72 is attached only by mechanical fitting.
In order to assemble in the first step, since the generation of minute gaps is inevitable and the expansion coefficient of the synthetic resin barrel 72 and the glass cylinder body 71 is significantly different, when heated in the post-sterilization step, This is because this gap increases and it becomes difficult to keep the mechanical fitting dense.

In the kit-type injector 70, the barrel 72 and the cylinder body 71 are separate parts, and
Structure is complicated and the cylinder body 71 is nonflammable.
There was a problem that industrial waste treatment was not easy .

[0013]

SUMMARY OF THE INVENTION It is an object of the present invention has been made in view of the points described above, of course intrusion can be prevented, such as bacteria in infiltration and long-term storage, such as water vapor in the subsequent sterilization process, structure is intended to provide a simple and industrial waste treatment method of molding simplistic <br/> kit expression syringe and syringe sliding valve and syringe cylinder used therefor.

[0014]

SUMMARY OF THE INVENTION In order to achieve the above object, the present invention provides a method for manufacturing a cylinder from a small straight portion of a cylinder.
An annular enlarged diameter portion is formed integrally in the longitudinal direction of the
Outer diameter of the sliding valve inserted in the rate part in the free state
The inner diameter of the enlarged diameter portion is formed larger than that of the enlarged diameter portion.
Sliding through a substantially annular gap between the peripheral surface and the outer peripheral surface of the sliding valve
The medicinal solution behind the valve is drawn out to the syringe needle connection side.
Wherein the enlarged diameter portion has the syringe needle connection portion.
And extend integrally from the bottom wall in the longitudinal direction of the cylinder.
A support projection is formed on the bottom wall of the cylinder or on the front end of the sliding valve.
Formed on the cylinder bottom wall by the supporting projections.
A gap is formed between the valve and the front end face for taking out the chemical solution.
Or, the cylinder bottom wall or the front end face of the sliding valve,
A drug solution outlet groove communicating with the inner hole of the injection needle connection portion is formed,
The chemical solution deriving gap or the chemical solution deriving groove is formed in the enlarged diameter portion.
Communicates with a substantially annular gap between the inner peripheral surface and the outer peripheral surface of the sliding valve
By doing so, the chemical solution behind the slide valve is connected to the injection needle connection part.
It is introduced (claim 1). The slide valve has a plurality of support protrusions radially projecting in the radial direction of the slide valve body, the support protrusions are more elastic than the slide valve body, and the support protrusions are The support projection is in contact with the inner peripheral surface of the enlarged diameter portion, and the diameter of the support projection can be reduced to the same diameter as the sliding valve body in the straight portion. It is also effective that the chemical solution is derived (claim 2). In addition, a series having a needle connection portion is provided.
An annular enlarged diameter section is integrated from the bottom wall of the cylinder in the longitudinal direction of the cylinder.
The cylinder is extended and the small diameter storage
Is extended integrally and inserted into the straight part.
The inner diameter of the enlarged portion is larger than the outer diameter of the sliding valve in a free state.
The diameter is formed to be large, and the inner peripheral surface of the enlarged diameter portion and the outside of the sliding valve are formed.
The chemical solution behind the sliding valve is injected from the substantially annular gap between the peripheral surface
A syringe led out to a needle connection side, wherein the sliding valve
Have multiple supports that protrude radially in the sliding valve body
A projection, and the support projection is more elastic than the sliding valve body.
Abundantly, the support protrusion contacts the inner peripheral surface of the enlarged diameter portion, and
In the straight portion, the support projection is provided on the sliding valve body.
It is possible to reduce the diameter to the same diameter as
The liquid medicine is drawn out from between the support protrusions.
(Claim 3). A support member including the support protrusion is formed of a material having a lower elastic modulus than the sliding valve body, and the supporting member is located at the center of the sliding valve body, and radially from the center. It is also effective that the support protrusion is formed integrally with a plurality of extendable and contractible portions that extend equally, and that the support protrusion is integrally formed on the distal end side of the extendable portion . Further, the sliding valve body has a plurality of support protrusions radially protruding in the radial direction, the support protrusions are more elastic than the slide valve body, and the support protrusions are expanded portions of the cylinder. And the inner diameter of the cylinder excluding the enlarged diameter portion can be reduced in diameter to the same diameter as the sliding valve body. In addition, a sliding valve for a syringe that can draw out the chemical solution behind the sliding valve from the valve is also adopted (claim 5 ). A support member including the support protrusion is formed of a material having a lower elastic modulus than the sliding valve body, and the supporting member is located at the center of the sliding valve body, and radially from the center. It is also effective that the supporting projection is formed integrally with a plurality of extending and contracting portions that extend equally, and that the supporting protrusion is integrally formed on the distal end side of the extending and contracting portion.
6 ). Further, in the method of manufacturing a syringe in which a synthetic resin cylinder is integrally molded between an outer mold and an inner mold, an annular large-diameter portion is formed in the outer mold and the inner mold, and the inner mold has a tapered shape. The inner core is inserted, and the large diameter portion of the inner mold is adjacent to the plurality of split mold portions having an outer arc surface and an inner tapered guide surface, in contact with the core and the tapered guide surface. And a plurality of support portions having an arc surface constituting a part of the outer peripheral surface of the large-diameter portion. The split mold portion is expanded by inserting the core. The support portion is located between the split mold portions, and in this state, the enlarged diameter portion of the cylinder is molded with resin, and by removing the core, the split mold portion and the support portion are smaller than the cylinder inner diameter. The method of manufacturing a syringe which is reduced in diameter and removed from the enlarged diameter portion is also adopted (claim 7 ). It is also effective to use an amorphous polyolefin or the like as the material of the cylinder (Claim 8 ).

[0015]

Embodiments of the present invention will be described below in detail with reference to the drawings. 1 to 10 show an embodiment of a syringe according to the present invention. As shown in FIG. 1, the syringe 85 has an annular enlarged diameter portion 87 having a large inner diameter portion 87a formed integrally with a cylinder bottom wall 93 having an injection needle connection portion 98 at the distal end of the cylinder 86,
From the enlarged diameter portion 87 to the small diameter straight portion 88 of the cylinder 86
Are integrally extended, and a space 8 having a circular cross section in the enlarged diameter portion 87 is formed.
9, a sliding valve 90, 91 in the straight portion 88 can be accommodated with a substantially annular gap 92 (FIGS. 2 and 4) on the outer diameter side. , A plurality of support projections 94 are provided, and a substantially annular gap 92 between the inner peripheral surface of the enlarged diameter portion 87 and the outer peripheral surfaces of the slide valves 90 and 91 is provided.
And a gap 95 (FIG. 9) formed between the support projection 94 and the front end face of the slide valve 90, from a chemical solution (drug) 9 in the cylinder 86.
6, 97 can be introduced into the inner hole 98a of the injection needle connecting portion 98.

Although the cylinder 86 may be made of glass, it is best to use a synthetic resin material such as amorphous polyolefin which has a good moldability and can obtain a mirror-like state. In this example, the outer diameter of the enlarged diameter portion 87 is formed to be larger than the outer diameter of the straight portion 88 of the cylinder 86.
It is sufficient that only the inner diameter portion 87a of the enlarged diameter portion 87 has a larger diameter than the inner diameter of the straight portion 88, and the outer diameter of the enlarged diameter portion 87 and the outer diameter of the straight portion 88 can be formed to have the same size. . In this example, the outer peripheral surface of the enlarged diameter portion 87 is formed in an annular stepped portion 9.
9 and integrally with the outer peripheral surface of the straight portion 88. The enlarged diameter portion 87 is formed by a molding method described later (FIGS. 12 to 14).
Can be formed more easily.

In this embodiment, two rubber sliding valves (front stopper 9) are provided in the straight portion 88 of the cylinder 86.
0 and a middle stopper 91) are arranged to constitute a kit dispenser 85 of a series dispensing type. In FIG. 1, the front sliding valve 90 is located slightly behind the enlarged diameter portion 87 in the straight portion 88, and the intermediate sliding valve 91 is located substantially at the center of the straight portion 88. The first chemical liquid 96 is filled between the front slide valve 90 and the intermediate slide valve 91, and the second chemical liquid 97 is filled between the intermediate slide valve 91 and the rear plunger (end stopper) 100. ing. For example, by using the first drug solution 96 as a local anesthetic and the second drug solution 97 as sodium hyaluronate as a therapeutic agent for osteoarthritis of the knee, it is possible to reduce the pain of the patient when administering the therapeutic agent.

As shown in FIGS. 3 to 5, each sliding valve 90, 9
Numeral 1 is composed of two kinds of different rubber members (sliding valve main body 101 and supporting member 102), and when the sliding valve 90 enters the enlarged diameter portion 87 from the straight portion 88 of the cylinder 86, it expands softly. A part (expandable portion) 103 of one rubber member (support member) 102 that easily shrinks protrudes in the radial direction to support the sliding valve 90 within the enlarged diameter portion 87 of the cylinder 86 without rattling, and Is kept uniform.

In FIG. 3, one rubber member (support member)
102 is incorporated in the straight portion 88 of the cylinder 86 at a higher compression ratio, and when the sliding valve 90 is almost released as shown in FIG. 4, one rubber member (support member)
102 extends more than the other rubber member (sliding valve main body) 101. Since the front sliding valve 90 and the intermediate sliding valve 91 have the same configuration, the cross-sectional shape and operation of the intermediate sliding valve 91 are the same as those in FIGS.

The sliding valve main body 101 is formed in a substantially short cylindrical shape, and the support member 102 has a substantially cylindrical central portion 104 located at the center of the sliding valve main body 101, and slides radially from the central portion 104. The valve body 101 includes a plurality of substantially fin-shaped extending and contracting portions (projecting portions) 103 extending radially.

As shown in FIG. 4, the distal end (supporting projection) 103a of the expansion and contraction portion 103 projects outward from the outer peripheral surface 101a of the sliding valve body 101 in the free state, and the enlarged diameter portion 87 of the cylinder is provided.
Contact with the inner peripheral surface (inner diameter portion) 87a of the second member. Support projection 103
a is formed in a semicircular cross section, and the inner peripheral surface 87 of the enlarged diameter portion 87 is formed.
a with low sliding resistance.

As shown in FIG.
Is provided at a central portion in the axial direction of the sliding valve main body 101, and the axial length of the elastic portion 103 is set to be longer than the plate thickness of the elastic portion 103, and is formed in a substantially rectangular plate shape. Both ends in the axial direction of the sliding valve main body 101 have an annular lip portion 105 slidingly contacting the inner peripheral surface of the straight portion 88 of the cylinder 86 and an annular groove 106 between the lip portions (FIG. 2). A central portion 104 (FIG. 1) of the support member 102 extends in a boss shape to one side in the axial direction.
04a is exposed. As shown in FIG. 5, the central portion of the sliding valve main body 101 is formed to have a slightly smaller diameter than the outer diameter of the annular lip portions 105 at both ends.

The sliding valve main body 101 is formed of a material which is hard and hardly deforms and does not easily expand and contract. The supporting member 102 is soft and greatly deformed, and is as elastic as the sliding valve main body 101 or more (force from outside). An object that has undergone a change in shape or volume within certain limits due to the addition of is formed of a material that is easily stretchable and contractable, which is a property that returns to its original state when the force is removed. That is, the support member 102 is
It is formed of a material having a lower elastic modulus (higher compressibility) than 1. The sliding valve main body 101 and the support member 102 are in close contact with each other.

As an example, the sliding valve body 101 can be made of polyurethane and the support member 102 can be made of synthetic rubber. For reference, the longitudinal modulus of elasticity (ratio of stress to strain that the elastic body has within the elastic limit) is 70 to 700 kgf /.
mm ² approximately, longitudinal elastic modulus of the synthetic rubber is about 5~30Kgf / mm ^2. This numerical value is measured on the premise that the material exhibits isotropic properties, and does not necessarily take into account the form actually used or the direction of external force. As for the elastic modulus, the sliding valve body 101 has a high elastic modulus, and the support member 102 has a low elastic modulus. Note that the support member 102 may be formed of a material having a higher compressibility, such as a porous material (the connection between the holes is not allowed).
Further, even if the same material is used, any material having a different compression ratio (elastic modulus) can be used.

The slide valves 90 and 91 are formed by first molding the slide valve main body 101 by using, for example, a method called insert molding which is known in the art of injection molding, and then mounting the slide valve main body 101 to another metal. It is formed by inserting it into a mold and injection molding the support member 102 here.

When the molding is completed, the sliding valve body 101 and the support member 102 are in close contact with each other at the interface, but as shown in FIG. 3, the expansion and contraction portion 103 of the support member 102 is compressed on the inner wall surface of the straight portion 88 of the cylinder. When this occurs, a part of the expansion and contraction portion 103 moves along the side wall 101b on the side of the sliding valve body 101 and retracts radially inward. Then, the outer peripheral surface (annular lip portion 105) of the sliding valve body 101 comes into close contact with the inner surface (inner diameter portion) 88a of the straight portion 88 to seal the chemical liquid 96 as shown in FIG. The front slide valve 90 isolates the drug solution 96 from the space 89 in the enlarged diameter portion 87 and prevents bacteria and the like from entering the drug solution 96.

When the sliding valve 90 enters the enlarged diameter portion 87 of the cylinder as shown in FIG. 4, the expansion / contraction portion 103 projects radially outward from the sliding valve main body 101 due to its high elasticity. , The sliding valve 90 is stably supported.
The sliding valve body 101 also expands outward due to its elasticity. However, the inner diameter of the enlarged diameter portion 87 is set to be larger than the outer diameter of the sliding valve body 101 in the free state, and the adjacent expansion and contraction portion 103 is expanded. , 103, a gap 92 is formed between the enlarged diameter portion 87 and the sliding valve main body 101 for drawing out a chemical solution.

It is sufficient if the gap 92 is, for example, about 0.1 to 0.5 mm, and the tip (supporting projection) 103a of the radially extending and contracting portion 103 extends around the circumference of the gap 9a.
2 is kept constant, whereby the flow rate and the flow rate of the chemical solution 96 are kept constant, and the operating force of the plunger rod 107 (FIG. 1) is kept constant. The number of the expansion and contraction portions 103 only needs to be at least three. If the number is six as in this example, the posture of the sliding valve 90 in the enlarged diameter portion 87 is reliably stabilized. In FIG. 2, the first chemical solution 96 is discharged from the inner hole 98a of the injection needle connecting portion 98 to the injection needle 107 'through the gap 92 on the outer diameter side of the front slide valve 90.

FIG. 6 shows the cylinder bottom wall 9 following the enlarged diameter portion 87.
3 showing the support projection 94 integrally formed with the support projection 3 in FIG.
It is -C sectional drawing. The cylinder bottom wall 93 has a front sliding valve 90
Is a flat portion facing the front end face of the cylinder bottom wall 9.
3, an inner hole 98a of the injection needle connecting portion 98 is opened.

The support projection 94 is in contact with the front end of the front slide valve 90 to form a radial gap 95 for drawing out the chemical between the front slide valve 90 and the cylinder bottom wall 93. It is formed at a substantially intermediate position between the inner hole 98a of the injection needle connecting portion 98 and the inner wall surface of the enlarged diameter portion 87 of the cylinder.
In this example, four supporting projections 94 are provided evenly, and the front sliding valve 90 can be stably supported. Supporting projection 9
The number of 4 must be at least three or more, and the height of the supporting projection 94 may be about 1 mm.

[0031] Instead of providing the supporting projection 94 on the cylinder 86 side, the front end surface 108 of the front sliding valve 90 ₁ as shown in FIG. 7
Alternatively, a plurality of support projections 109 can be provided on both end surfaces. Further, the front end wall 110 or end walls of the front sliding valve 90 ₂ as shown in FIG. 8, instead of the supporting protrusions 109, also be provided a radial chemical derivation groove 111 communicating with the inner hole 98a of the needle-connecting portion 98 It is possible. Also, the enlarged diameter portion 8
A radial groove (not shown) may be formed in the cylinder bottom wall 93 in the same manner as in the prior art. However, this is a case in which the formation of the groove may be costly.

FIG. 9 shows that the plunger rod 107 is further pushed from the state of FIG.
This shows a state in which the intermediate slide valve 91 has entered the enlarged diameter portion 87 and the discharge of the second chemical liquid 97 has started.

As described above, the intermediate slide valve 91 is connected to the front slide valve 9.
0, a supporting member 102 is provided inside the sliding valve body 101, and the second chemical liquid 97 is supplied to the sliding valve bodies 101 of the intermediate sliding valve 91 and the front sliding valve 90, and the expansion of the cylinder. Diameter 8
The fluid is discharged through the gap 95 on the cylinder bottom wall 93 side, passing through the axial gap 92 between them.

FIG. 10 shows a state in which the discharge of the second chemical liquid 97 has been completed. Two sliding valves 90 and 91 are housed in the enlarged diameter portion 87 of the cylinder, and the plunger 100 comes into contact with the intermediate sliding valve 91 and stops.

Although the above embodiment shows the structure of a dispensing type syringe using a plurality of sliding valves 90 and 91, the syringe according to the present invention is not limited to the dispensing type, but may be a single sliding valve (not shown). The present invention is also applicable to a normal one-liquid injection type kit injector using the front stopper 90) and a dissolution type kit injector 112 as shown in FIG.

In this syringe 112 of the dissolving type at the time of use, a powder drug 113 is put between the front sliding valve 90 and the intermediate sliding valve 91 as in the previous example, and a chemical solution is put between the intermediate sliding valve 91 and the plunger 100. 114, and a cylinder 115
Is a synthetic resin such as amorphous polyolefin,
An enlarged diameter portion 87 similar to the above is formed at the distal end of the cylinder 115, and a bypass groove 116 into which the chemical 114 can be introduced is formed inside the middle portion of the straight portion 88 of the cylinder 115. The bypass groove 116 is described in Japanese Patent Application No.
-516102. This bypass groove 11
Instead of 6, it is also possible to form an enlarged portion 87 similar to the above in the middle of the straight portion 88 of the cylinder.

In each of the above examples, basically, the sliding valve 90,
Even if the supporting member 102 is not provided on the 91, the clearance 9 on the outer diameter side of the sliding valves 90 and 91 that have entered the enlarged diameter portion 87 of the cylinder.
It is possible to derive the chemicals 96 and 97 from 2
Even in this case, it is an essential requirement that the inner diameter of the enlarged diameter portion 87 be set larger than the outer diameter of the sliding valves 90 and 91 in the free state.

Also, in FIG. 5, only the supporting projection 103a is provided on the sliding valve main body 101 (there is no center portion 104 or the like).
In such a case, the support protrusion 10 can be used as shown in FIG.
It is necessary to make the center of the sliding valve body 101 provided with 3a smaller in diameter than the annular lip 105 so as to absorb the bending of the support projection 103a. In the embodiment of FIG. 5, the central portion of the sliding valve body 101 is made smaller in diameter than the annular lip portion 105, so that unnecessary sliding portions with respect to the cylinder inner diameter portion are eliminated, and the front and rear annular lip portions 105, 105 are used. It enables smooth sliding.

FIGS. 12 (a) (b) to 13 (a) (b) show an example of a method for molding a cylinder using a synthetic resin as a method for molding a cylinder for a syringe according to the present invention. is there. The method includes a split outer mold 131, a diameter-reducible inner mold 132 disposed inside the outer mold 131, and an inner mold 132.
Core 133 that is slidably inserted inside
By using these, the cylinder 86 is formed with the enlarged diameter portion 87.

In FIG. 12A, the outer die 131 and the inner die 13
A gap 134 having a cylindrical shape is formed between the gap 2 and the gap 2, and the resin material is injected into the gap 134. The outer die 131 and the inner die 132 have an enlarged diameter portion (86 in FIG. 1) of the cylinder (86 in FIG. 1).
87), large-diameter portions 131a and 132a are respectively formed. The inner die 132 has a large-diameter portion 132a, a support portion 135 having a substantially triangular or trapezoidal cross section as shown in FIG. 12B, and a fan-shaped split die portion 136 in which the support portion 135 supports the inner tapered guide surface 136c. And The support 135 is supported by the core 133. The split mold portion 136 is formed on the outer arc surface 13 forming the inner diameter portion of the cylinder.
6a, and the supporting portion 135 is formed between the adjacent split mold portions 136 so as to form a part of the inner diameter of the cylinder.
5a.

As shown in FIGS. 13A and 13B, the gap 134
After the resin material is filled into the cylinder shape, the core 133 is extracted, so that the diameter of the support portion 135 and the split mold portion 136 is reduced integrally, and the enlarged diameter portion 87 of the cylinder 86 and the inner mold 13 are removed.
A gap 137 is generated between the second large-diameter portion 132a and the step portion 136b of the inner die 132 from the step portion 99 of the large-diameter portion 87. As a result, the inner mold 132 is pulled out, and the outer mold 13 is removed.
1 is divided to complete a resin-integrated cylinder 86. In FIG. 12 (a), by setting the formation position of the protrusion 94 (FIG. 1) at the bottom of the cylinder to the position of the core 133, interference when the inner die 132 is reduced in diameter can be avoided.

FIGS. 14A to 14F show a method of forming a cylinder using glass as a material. First, FIG.
The material glass rod 122 is glowed red as shown in FIG. Then
(b) Insert the material 122 into the mold 123 on the inner surface of the cylinder as shown in FIG.
The punch 124 is inserted from one side. Next, a punch 124 is inserted to a predetermined depth as shown in (c) to produce a preformed product 125 having a constant thickness. Next, as shown in (d), the preformed blind tube 125 is removed from the mold 123, and the product mold 12 is removed.
Attach to 6. This mold 126 has an enlarged diameter portion 127. Next, the blow nozzle 128 is inserted as shown in (e),
The glass 129 is pressed against the inner surface of the mold 126 with high-pressure air. Thereby, the enlarged diameter portion 8 of the cylinder having the step portion 99
7 is formed. Finally, the mold 126 is divided and the product 129 is taken out as shown in FIG.

The method shown in FIG. 14 is known, and the injection needle connection portion is formed separately. In addition, the bottom part 130 forming the injection needle connection part is opened, and the Japanese Patent Application No. 7-5161 is disclosed.
It is also possible to insert the rubber terminal partition proposed in FIG. 2 of No. 02.

[0044]

As described above, according to the first aspect of the present invention, compared with the conventional structure in which a separate barrel is assembled to the cylinder body, the flow of steam and bacteria into the chamber of the cylinder from the middle of the cylinder is reduced. danger at all night both to etc. from entering
In addition, the structure of the cylinder is simplified and the cost is reduced . In addition, when the cylinder is an incinerated synthetic resin cylinder, industrial waste treatment is facilitated. Claims
According to the inventions described in 2, 3, and 5, the chemical liquid is led out from between the plurality of support protrusions of the slide valve at the enlarged diameter portion of the cylinder.
Therefore, there is no need to form a groove for taking out a drug solution on the inner peripheral surface of the cylinder , which simplifies the structure of the syringe and reduces the cost required for forming the groove. The valve is stably supported by multiple support protrusions without rattling
And the gap between the enlarged diameter portion and the sliding valve body is
Is kept constant, so that the flow rate and flow rate of the drug solution are constant,
The operating force during injection is stable. According to the fourth and sixth aspects of the present invention , the support projection is provided at the straight portion of the cylinder.
Part shrinks radially inward with the telescopic part, and the sliding valve
The chemical solution is sealed tightly to the inner surface of the tralate part. Also,
According to the invention described in claim 7 , since the annular enlarged diameter portion can be easily formed on the tip side of the cylinder, compared with the conventional method of assembling a separate barrel to the cylinder body,
There is no danger of water vapor and bacteria entering the cylinder from the middle of the cylinder.
The structure is simplified, the cost is reduced , and the incineration-free synthetic resin cylinder that does not use glass facilitates the treatment of industrial waste. According to the invention of claim 8 , the silicon
Good moldability and a mirror-like surface
You.

[Brief description of the drawings]

FIG. 1 is a longitudinal sectional view showing one embodiment of a syringe according to the present invention.

FIG. 2 is a longitudinal sectional view showing a state in which a first chemical solution is discharged.

FIG. 3 is a sectional view taken along line AA of FIG. 1;

FIG. 4 is a sectional view taken along line BB of FIG. 2;

FIG. 5 is a perspective view showing one embodiment of a sliding valve for a syringe according to the present invention.

FIG. 6 is a sectional view taken along the line CC of FIG.

FIG. 7 is a plan view showing an example in which a supporting projection is formed on a front sliding valve.

FIG. 8 is a plan view showing an example in which a chemical solution outlet groove is formed in a front slide valve.

FIG. 9 is a vertical cross-sectional view showing a state where the first medical solution of the syringe has been discharged.

FIG. 10 is a longitudinal sectional view showing a state in which the second chemical has been discharged.

FIG. 11 is a longitudinal sectional view showing an example in which an integrated cylinder is applied to a syringe for dissolving before use.

FIG. 12 shows a state in which a cylinder is molded from a synthetic resin material as a method of molding a cylinder for a syringe according to the present invention, and (a)
2 is a longitudinal sectional view, and (b) is a sectional view taken along line D ₁ -D ₁ of (a).

[13] Also shown integrally molded state cylinder of synthetic resin, (a) shows the longitudinal sectional view, (b) the D ₂ -D ₂ of (a)
It is sectional drawing.

FIGS. 14 (a) to (f) are longitudinal sectional views showing an example in which a cylinder is formed from a glass material.

FIG. 15 is a longitudinal sectional view showing a conventional syringe.

[Explanation of symbols]

 85, 112 Syringe 86, 115 Cylinder 87 Large diameter portion 88 Straight portion 90, 91 Sliding valve 93 Cylinder bottom wall 94 Supporting projection 95 Clearance 96, 97 Chemical solution 101 Sliding valve main body 102 Supporting member 103 Expandable portion 103a Supporting projection 104 central part 111 chemical solution outlet groove 131 outer die 131a, 132a large diameter part 132 inner die 133 core 135 support part 135a, 136a arc surface 136 split type part 136c taper guide surface

────────────────────────────────────────────────── ─── Continuation of the front page (56) References JP-A-5-31191 (JP, A) JP-A-8-10325 (JP, A) JP-A-8-131544 (JP, A) JP-A-7- 39582 (JP, A) JP-A-2-265568 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61M 5/28 A61M 5/315

Claims (8)

(57) [Claims] 1. A small diameter straight section of a cylinder
An annular enlarged diameter portion is formed integrally in the longitudinal direction of the
Outer diameter of the sliding valve inserted in the rate part in the free state
The inner diameter of the enlarged diameter portion is formed larger than that of the enlarged diameter portion.
Sliding through a substantially annular gap between the peripheral surface and the outer peripheral surface of the sliding valve
The medicinal solution behind the valve is drawn out to the syringe needle connection side.
There are, the enlarged diameter portion is the cylinder bottom wall having a needle-connecting portion
From the cylinder in the longitudinal direction of the cylinder.
A support projection is formed on a bottom wall or a front end surface of the slide valve.
The support projections allow the cylinder bottom wall to be in front of the sliding valve.
A gap for chemical solution derivation is formed between the end face and
The injection needle is provided on the cylinder bottom wall or the front end face of the slide valve.
A chemical solution outlet groove communicating with the inner hole of the connection portion is formed, and
The lead-out gap or the drug solution lead-out groove is formed on the inner peripheral surface of the enlarged diameter portion.
And a substantially annular gap between the sliding valve and the outer peripheral surface of the sliding valve.
With this, the chemical solution behind the slide valve is introduced into the injection needle connection portion.
Syringe characterized in that it is. 2. The sliding valve has a plurality of supporting projections radially projecting in a radial direction of the sliding valve body, and the supporting projections are more stretchable than the sliding valve body. The support protrusion contacts the inner peripheral surface of the enlarged diameter portion, and the support protrusion can be reduced in diameter to the same diameter as the sliding valve body in the straight portion,
2. The syringe according to claim 1, wherein the liquid medicine is led out of the enlarged diameter portion from between the plurality of support protrusions. 3. A cylinder bottom wall having a needle connection.
An annular enlarged portion is formed integrally with the cylinder in the longitudinal direction.
The small diameter straight part of the cylinder is integrated from the enlarged diameter part.
And a sliding valve that is formed in the straight portion and is inserted into the straight portion.
The inner diameter of the enlarged portion is larger than the outer diameter in the free state of
Formed between the inner peripheral surface of the enlarged diameter portion and the outer peripheral surface of the sliding valve.
The chemical solution behind the slide valve flows from the substantially annular gap
Wherein the sliding valve is a sliding valve main body.
It has a plurality of support protrusions that protrude radially in the radial direction of the body,
The supporting projection is more elastic than the sliding valve body,
The protrusion contacts the inner peripheral surface of the enlarged diameter portion, and the
The support projection is reduced to the same diameter as the sliding valve body in the
Diameter, and between the plurality of support projections at the enlarged diameter portion.
Wherein the medicinal solution is derived from the syringe. 4. A support member including said support projection is provided on said sliding member.
The support member is formed of a material having a lower elastic modulus than the valve body.
Is located at the center of the sliding valve body, and
And a plurality of telescopic parts extending radially and equally
The support protrusion is integrally formed on the distal end side of the expansion and contraction portion.
The syringe according to claim 2 or 3, wherein 5. The sliding valve body radially protrudes in the radial direction.
A plurality of support protrusions, wherein the support protrusions are
Is also elastic, and the supporting projection is the inner periphery of the enlarged diameter portion of the cylinder.
The inner diameter of the cylinder that can contact the surface and excluding the enlarged diameter portion
In the portion, the diameter can be reduced to the same diameter as the sliding valve body,
In the enlarged diameter portion, between the plurality of support projections and the rear of the slide valve.
Sliding for syringes characterized by being able to derive a drug solution
valve. 6. A support member including said support projection is provided on said sliding member.
The support member is formed of a material having a lower elastic modulus than the valve body.
Is located at the center of the sliding valve body, and
And a plurality of telescopic parts extending radially and equally
The support protrusion is integrally formed on the distal end side of the expansion and contraction portion.
The sliding valve for a syringe according to claim 5, wherein 7. A synthetic resin syringe between an outer mold and an inner mold.
Injection cylinder molding method
Thus, an annular large diameter portion is formed in the outer mold and the inner mold,
A tapered core is inserted into the mold, and the large diameter portion of the inner mold is
A plurality of splits having an arcuate surface on the side and an inner tapered guide surface.
Contacting the core and the tapered guide surface, and
Into each split mold part, and remove a part of the outer peripheral surface of the large diameter part.
And a plurality of supporting portions having an arc surface to be constituted.
By inserting the core, the split mold part expands its diameter and
The support part is located between the mold parts, and in that state the cylinder is expanded.
The part is molded with resin, and the core is pulled out so that the split mold part and the
The support part is reduced in diameter to the cylinder inner diameter or less and comes off from the enlarged part.
Molding method for syringe cylinder characterized by being pulled out
Law. 8. An amorphous material as a material of the cylinder.
8. The method according to claim 7, wherein a polyolefin or the like is used.
Method for molding the cylinder for syringe described above.