JP3276724B2 - Skin protection composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin protectant composition for preventing skin roughness during water work, skin washing and the like, and protecting the skin. It relates to a skin protection composition.

[0002]

2. Description of the Related Art Conventionally, hand creams have been widely used for the purpose of protecting the skin from rough skin due to water work or the like. The hand cream replenishes sebum lost due to water work, etc., and further protects the skin by adding a moisturizer to the skin to provide appropriate moisture. However, conventional hand creams tend to give a sticky feeling to the skin after use and are easily washed away by washing with water, so that the skin protection effect was not always satisfactory. For this reason, many housewives are troubled by rough hands in order to frequently perform water work such as cooking and washing. In addition, many hairdressers complain of inflammation due to hair dyes, perm solution, and the like, in addition to rough hands caused by repeated shampooing. As a skin protective agent which has improved the drawbacks of the conventional hand cream, for example, an acrylic polymer comprising ethyl acrylate and methacrylic acid and a cellulose derivative dissolved in aqueous alcohol have been proposed (Japanese Patent Publication (Kokoku)). No. 2-9006). However, this skin protective agent has an alkali-soluble acrylic polymer as its main component,
When the skin is washed with soap, which is widely used as a base for skin cleansing agents, or when it comes into contact with a perm solution that is usually alkaline, it has a disadvantage that its protective function is not sufficient. .

[0003]

SUMMARY OF THE INVENTION Accordingly, the present invention forms a film with good spreadability and less sticky feeling, and is not easily washed away by water work or a skin washing process using soap. An object of the present invention is to provide a skin protective agent composition capable of protecting the skin for a long time.

[0004]

Under such circumstances, the present inventors have conducted intensive studies and as a result, have found that by using a specific oil agent and a specific organopolysiloxane in a specific ratio as an oily component, the above-mentioned requirements are met. The present inventors have found that a skin protective agent composition that satisfies the above conditions can be obtained, and completed the present invention.

That is, the present invention relates to the following components (A) and (B): (A) a linear or cyclic compound represented by the general formula (2) or (3)
-Like low molecular weight silicone oil and isopara with 8 to 20 carbon atoms
Excluding fin-based hydrocarbons , dimethylpolysiloxane of 1 to 1000 cs, methylphenylpolysiloxane of 1000 cs or less, squalane, liquid paraffin , branched alcohols, branched fatty acids, higher fatty acid esters, benzoic esters, triglycerides and At least one oil selected from diglycerides at 25 ° C.,

Embedded image (X represents 0 to 3, y represents 4 to 6) (B) In the molecule

[0006]

Embedded image

(R ¹ and R ² each represent an alkyl group having 1 to 4 carbon atoms, R ³ represents a linear, branched or cyclic alkyl or alkenyl group having 1 to 40 carbon atoms;
⁴ represents a linear, branched or cyclic alkyl or alkenyl group having 7 to 40 carbon atoms, 1 represents a number of 2 or more, m represents a number of 3 or more, and l + m = 200 to 30
Wherein the organopolysiloxane has a weight ratio of (A) :( B) of 10: 1 to 1: 5 in the total oily component. The present invention provides an agent composition.

The liquid oil as the component (A) of the present invention is not particularly limited as long as it is a liquid oil at 25 ° C., for example, 1 to 1000 cs of dimethylpolysiloxane, 100 cs
Hydrocarbons such as methylphenylpolysiloxane, squalane and liquid paraffin of 0 cs or less, branched alcohols, branched fatty acids, higher fatty acid esters, benzoic acid esters, triglycerides, diglycerides , and the like .

Here, the term "liquid at 25 ° C."
In a constant temperature water bath, put the sample up to the height of the A line in a flat bottom test tube with an inner diameter of 30 mm and a height of 120 mm with a marked line at the height of 55 mm (A line) and 85 mm (B line) from the bottom of the tube. After the sample was left at 25 ° C. for 10 minutes or more, it was dropped on a horizontal table, and the time required for the liquid tip to reach the B line was within 90 seconds. These liquid oils can be used alone or in combination of two or more.

The organopolysiloxane of the component (B) used in the present invention can improve the oily component of the component (A), such as poor spreadability, stickiness, poor skin feel after washing, and the like. Has the effect of improving the properties and sustainability, and has at least 3 carbon atoms of 7 to 4 per molecule.
It has 0 hydrocarbon groups. The organopolysiloxane may be branched or cyclic.

The R contained in the organopolysiloxane (B)
The alkyl group represented by ¹ and R ^2, a methyl group, an ethyl group, n- propyl group, an isopropyl group, n- but-butyl group and the like, preferably especially a methyl group. Also,
The alkyl or alkenyl group represented by R ³ and R ⁴ may be any of linear, branched and cyclic.
Preferably, ³ is an alkyl group having 1 to 4 carbon atoms, and R ⁴ is an alkyl group or an alkenyl group having 7 to 40 carbon atoms (more preferably, 12 to 22, particularly preferably 16 to 18). Specific examples of R ⁴ are octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, eicosyl, heneicosyl, docosyl, tetracosyl, pentacosyl, hexacosyl, heptacosyl, octacosyl, triacontyl, Tetratriacontyl, octatriacontyl, tetracontyl, 2-heptylundecyl, 2-undecylpentadecyl, 2-decyltetradecyl, 2-decylpentadecyl, 2-ethylhexyl, 2-octyldodecyl, 2-undecyl Examples include tetradecyl, methyl-branched isostearyl, methyl-branched dodecyl (propylene tetramer), and methyl-branched nonyl (propylene trimer) groups. Also, l + m is 200-3000, and furthermore, l = m = 150-750 and l + m is 300
It is preferably from 1500 to 1500. Here, l and m are determined as the average degree of polymerization calculated from the weight average molecular weight.

Further, the organopolysiloxane (B) is
Those having a melting point of 10 to 50 ° C, particularly 20 to 40 ° C, are preferred. The melting point of the organopolysiloxane was measured using a differential scanning calorimeter (DSC).

The organopolysiloxane (B) may have a structure having both polysiloxane units at any position in the molecule, but from the viewpoint of easy production,
It is preferable that the simple structure in which one block of both units is directly bonded, and both terminal residues are bonded thereto. Further, it is preferable that the both-terminal residues that are ^{-OSiR 5 R 6 R 7 (R} 5 ~R 7 represents an alkyl group having 1 to 4 carbon atoms). Specific examples of the organopolysiloxane (B) include those represented by the following general formula (1).

[0014]

Embedded image

(In the formula, l, m and R ⁴ have the same meanings as described above.) As a commercial product represented by the general formula (1), XF42-A71 manufactured by Toshiba Silicone Co., Ltd.
54, XF-A5048 and XF42-A5047.

The components (A) and (B) are blended in the skin protective composition of the present invention in a weight ratio of 10: 1 to 1: 5, and a preferred blending ratio is 3: 1 to 3: 1. 1: 3
It is. When the amount of the component (A) exceeds 10 times the amount of the component (B), the feeling of use such as stretching and stickiness deteriorates,
When the amount of the component (B) exceeds 5 times the amount of the component (A), the storage stability of the skin protective agent composition of the present invention is reduced. Further, in the skin protective agent composition of the present invention,
It is preferred that the component (A) and the component (B) are combined in a total amount of 20% by weight or more of the total oil component. Here, amphiphilic substances to be mixed for the purpose of emulsification, such as glyceryl monostearate, are not included in the oily substances.

The skin protective composition of the present invention contains, in addition to the above essential components, an aqueous component, an emulsifier, a preservative, an antioxidant, a fragrance, etc. within a range that does not impair the effects of the present invention depending on the purpose.
Various components such as solid, paste, water-in-oil or oil-in-water emulsions can be obtained by appropriately mixing optional components such as powder.

[0018]

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto. Example 1 Hand creams having the compositions shown in Tables 1 to 3 were produced. That is, after stirring and dissolving all the components shown in Tables 1 to 3 except for purified water at 70 to 80 ° C, the mixture was stirred at 70 to 80 ° C.
Of purified water was added, and the mixture was cooled while continuing stirring to obtain each hand cream. About each obtained hand cream,
A practical test and a skin protection effect test were performed based on the following test methods. Tables 1 to 3 show these results. (1) Practical test (panel test) Each of the hand creams was actually used by a hand of ten specialized panelists, and the practical evaluation was performed. The evaluation items were three items: good spreadability at the time of application, low stickiness, and moist feeling of the hand skin after washing with soap. Evaluation results were based on the following four criteria.

◎: 9 or more out of 10 respondents good: 6 to 8 out of 10 respondents good: 3 to 5 out of 10 respondents good: good Less than 3 out of 10 respondents

(2) Skin protection effect test (Test method and evaluation method) Evaluation of protection effect on rough skin A glass cup (2 cm inner diameter) containing acetone / ether (1: 1 by volume) was attached to the inside of a human forearm. Then, a degreasing treatment was performed for 10 minutes to induce rough skin. The four samples shown in Table 1 were uniformly applied to the rough skin (20 μl / 3.14)
cm ² ) and dried for 10 minutes. Then, a cup was attached again to the part where the skin protective agent solution was applied to the rough skin and the part where the skin protective agent solution was not applied, and 1.0 ml of a surfactant solution (0.1% polyoxyethylene (40E.O.) hydrogenated castor oil) was added. Rub the skin surface with a Teflon stick for 1 minute. After collecting the treatment solution, the detached keratinocytes were stained with basic fuchsin-crystal violet, and the number of cells was measured with a microscope. As a comparison, the same measurement was performed for a site (healthy skin) that was not subjected to a degreasing treatment. The result is the number of cells × 10 ⁴ cells / cm
Indicated by ³ . Since the cell number is the number of shed cells, the smaller the value, the higher the effect of protecting the skin. That is, if this value is 0.8 or less, it indicates that the health of the skin is very high, and if it exceeds 0.8 and is 1.4 or less, it indicates that the health of the skin is normal, and 1 If it exceeds 0.4, it indicates that the skin is rough.

[0021]

[Table 1]

[0022]

[Table 2]

[0023]

[Table 3]

[0024]

[Table 4] (Notes in Tables 1 to 3) 1): In the formula (1), l = 750, m = 750, R ⁴ = C
₁₈ H ₃₇ 2): In the formula (1), l = 500, m = 500, R ⁴ = C
₁₈ H ₃₇ 3): In the formula (1), l = 50, m = 50, R ⁴ = C ₁₈ H
₃₇ 4): In the formula (1), l = 500, m = 500, R ⁴ = C
₁₆ H ₃₃ 5): In the formula (1), l = 75, m = 75, R ⁴ = C ₁₆ H
₃₃ 6): In the formula (1), l = 750, m = 750, R ⁴ = C ₈
H ₁₇₇ ): In the formula (1), l = 500, m = 500, R ⁴ = C
₂₂ H ₄₅ 8): Dow Corning Toray Silicone Co., Ltd. SH244 9): dimethylsiloxane-methyl (polyoxyethylene-polyoxypropylene) siloxane copolymer (Toray Dow Corning Silicone Co., BY- 22-0
12)

As is clear from Tables 1 to 3, it can be seen that the skin protective agent composition of the present invention has a better feeling in use and an excellent skin protective effect as compared with the comparative product.

Example 2 Skin protection ointment

(5% by weight) (1) Squalane 70.0 (2) Cholesteryl isostearate 10.0 (3) Glycerin trimyristate 3.0 (4) Celesin 2.0 (5) Octadecyl-modified silicone [Formula ( 1), R ⁴ = C ₁₈ H ₃₇ , 1 = 750, m = 750] 15.0

After heating and dissolving the components (1) to (4) at 70 to 80 ° C., the component (5) was added with stirring, and the mixture was cooled while stirring to obtain a skin protective ointment. The obtained ointment had good spreadability and little stickiness, and the skin was kept smooth even after washing three times with soap.

Example 3 Emulsion

(% By weight) (1) Dimethylpolysiloxane (KF96, 6cs, manufactured by Shin-Etsu Chemical Co., Ltd.) 2.0 (2) Hexadecyl-modified silicone ¹⁾ 3.0 (3) Octamethylcyclotetrasiloxane 10.0 ( 4) Squalane 2.0 (5) Glyceryl monostearate 1.5 (6) Glyceryl monostearate 1.0 (7) Polyoxyethylene (20) sorbitan monostearate 1.5 (8) 1,3-butylene glycol 10.0 (9) Purified water balance 1): hexadecyl-modified silicone [in the formula (1), l =
750, m = 750, R ⁴ = C ₁₆ H ₃₃ ]

(1) to (6) were mixed and dissolved by heating.
Keep at 0 ° C to make oil phase. Separately, (7) to (9) are dissolved by heating and maintained at 70 ° C. to obtain an aqueous phase. The oil phase is added to the aqueous phase and sufficiently emulsified by an emulsifier. After emulsification, the mixture was cooled with stirring to obtain a product. This emulsion was a fresh emulsion having a refreshing feel.

Example 4 Essence

(Table 7) (% by weight) (1) Ethanol 10.0 (2) Tetradecyl-modified silicone ¹⁾ 2.0 (3) Carbopol 0.3 (4) Dimethylsiloxane methyl (polyoxyethylene / polyoxypropylene) Copolymer 0.3 (5) Squalane 5.0 (6) Octamethylcyclotetrasiloxane 5.0 (7) Glycerin 10.0 (8) Dipropylene glycol 25.0 (9) Oleyl alcohol 0.2 (10 ) L-ascorbic acid 0.5 (11) Purified water balance 1): tetradecyl-modified silicone [in the formula (1), l =
750, m = 750, R ⁴ = C ₁₄ H ₂₉ ]

(1) to (11) are heated and dissolved at 70 ° C. This essence was refreshing and had a moist feeling.

[0032]

As described above, the skin protective agent composition of the present invention has a high effect of protecting the skin from water work, skin washing process and the like, and has a good feeling of use, such as good spreadability and low stickiness. Is also excellent.

────────────────────────────────────────────────── ─── Continuation of the front page (56) References JP-A-2-295912 (JP, A) JP-A-5-39216 (JP, A) JP-A-5-262637 (JP, A) (58) Field (Int.Cl. ⁷ , DB name) A61K ^7/ 00-7/50

Claims (1)

(57) [Claims] 1. The following components (A) and (B): (A) a linear or cyclic compound represented by the general formula (2) or (3)
-Like low molecular weight silicone oil and isopara with 8 to 20 carbon atoms
Excluding fin-based hydrocarbons , dimethylpolysiloxane of 1 to 1000 cs, methylphenylpolysiloxane of 1000 cs or less, squalane, liquid paraffin , branched alcohols, branched fatty acids, higher fatty acid esters, benzoic esters, triglycerides and Jiguriserai <br/> earth or these one or more selected, liquid oil at 25 ° C., ## STR1 ## (X represents 0 to 3, y represents 4 to 6) (B) In the molecule: (R ¹ and R ² each represent an alkyl group having 1 to 4 carbon atoms, R ³ represents a linear, branched or cyclic alkyl group or alkenyl group having 1 to 40 carbon atoms, and R ⁴ represents 7 carbon atoms. Represents a linear, branched or cyclic alkyl group or alkenyl group of -40, 1 represents a number of 2 or more, m represents a number of 3 or more, and l + m = 200 to 3000)
20% by weight or more in the total oil component of the organopolysiloxane having the formula (A):
(B) The skin protective agent composition characterized in that the weight ratio is 10: 1 to 1: 5.