JP3211221B2 - Prefilled syringe - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a syringe filled with an injection solution in advance. More specifically, the present invention relates to a prefilled syringe in which the syringe outer cylinder is formed of glass and the position and shape of the injection needle attachment portion can be arbitrarily selected.

[0002]

2. Description of the Related Art Conventionally, when manufacturing a prefilled syringe using a glass syringe barrel, an injection needle mounting portion is
The outer shape of a luer tip is formed in a hollow nozzle whose diameter is reduced in a tapered shape. This luer tip L may be formed by processing a glass tube to form a shape as shown in FIG. When a luer tip member L1 as shown in FIG. 9 is inserted into the opening of FIG. 9 and the packing P is bitten between the opening and the luer tip member L1 and fixed with an aluminum caulking tool F, the opening of the glass tube In some cases, a rubber plug holding member L2 with a luer tip made of hard plastic as shown in FIG.

[0003] In the case of FIG. 8, since the method is such that the glass tube is heated and melted and embossed, dimensional accuracy is not obtained, and therefore, a portion to be fitted to a mating part (a needle hub, a female luer connector, etc.). It was necessary to improve the dimensional accuracy by polishing with a grindstone or the like. The polishing is difficult to automate, and it is necessary to individually check all the performances. Therefore, the productivity is extremely low and the cost is high. Also,
In the case of FIG. 9, since metal aluminum is used as the caulking tool, fine powder of aluminum is generated when the luer tip member is wound around the mouth of the glass tube, contaminating the sterile room, and the chemical solution as foreign matter. There is a drawback that it may be mixed into the inside, and that it is necessary to separate and discard. Also, in the case of FIG. 10, since the dimensional accuracy of the outer diameter of the flange at the mouth of the glass tube is required, the polishing is performed, and a luer tip made of hard plastic (polycarbonate, etc.) is forcibly pressed. Therefore, cracks often occur in the press-fit portion of the rubber stopper, which is a problem.
In addition, since the position of the tip of the glass syringe outer cylinder is located on the center line of the glass tube due to the processing of the glass, a syringe having a capacity of 20 ml or more generally has a problem that it is difficult to penetrate the injection needle when injecting into a human body. there were.

[0004]

SUMMARY OF THE INVENTION The present invention has been made in view of the above circumstances, and does not require polishing of a luer tip or a flange of a glass syringe outer cylinder. An object of the present invention is to provide an inexpensive prefilled syringe without fear. Another object of the present invention is to provide a prefilled syringe in which the position and shape of a luer tip can be arbitrarily selected.

[0005]

SUMMARY OF THE INVENTION In order to solve the above-mentioned problems, the present invention provides a glass syringe outer cylinder in which a chemical solution outlet at the tip is formed in the shape of a vial, and a top surface having a through hole. A cap-shaped member having a lower end inner wall with an engagement claw and a lower end outer wall with an undercut, and a slit formed in the axial direction of the skirt, and a skirt having an engagement claw at a lower end; It has a top surface, an injection needle attachment portion protruding outside the top surface, and a chemical solution passage extending through the top surface and the injection needle attachment portion, and is slidable along the outer wall of the cap-shaped member. A cap-shaped tip member, a sealing member for sealing the injection needle mounting portion of the tip member, and a sealing member for sealing between the medical solution discharge port of the syringe outer cylinder and the tip member, Discharge the cap-shaped member The cap member is attached to the mouth, the seal member is bitten between the medical solution discharge port, and the tip member is attached to the cap member and slid along the outer wall of the cap member. Is deformed inward and engaged with the chemical solution discharge port, and a prefilled syringe is used in which the tip member is liquid-tightly attached to the chemical solution discharge port of the syringe outer cylinder. Here, the chemical passage is
This may be extended coaxially to the opposite side of the injection needle mounting portion to form a conduit having an outer diameter equal to the inner diameter of the drug solution outlet, and the conduit may be liquid-tightly inserted into the drug solution outlet. Good. The sealing member may be a disk-shaped packing having a through hole on the shaft, or a rubber stopper having a flange on the top surface and having a through hole on the shaft. Incidentally, the position of the injection needle mounting portion may be formed eccentrically.

[0006]

According to the above construction, the tip member can be mounted in a liquid-tight manner on the chemical solution discharge port of the syringe outer cylinder by a simple operation of sliding the tip member downward along the outer wall of the cap-shaped member. . That is, a seal member is mounted on the inner side of the top surface of the cap-shaped member, and a tip member in which a cap member is shallowly mounted on the cap-shaped member is prepared. When pressed downward, the cap-shaped member moves downward along the chemical solution discharge port of the syringe outer cylinder, stops at the position shown in FIG. 6, and engages the seal member with the chemical solution discharge port. Let When the downward movement of the cap member stops, the tip member slides downward along the outer wall of the cap member while deforming the cap member inward. When the tip member comes to the position as shown in FIG. 7, the downward movement of the tip member stops, and the engaging claw engages with the undercut formed at the lower end of the skirt of the cap-like member. Is firmly engaged with the chemical solution discharge port.

[0007]

Next, an embodiment of the present invention will be described with reference to the drawings. 1 is a longitudinal sectional view of a prefilled syringe according to one embodiment of the present invention, FIG. 2 is a plan view of a cap-like member shown in FIG. 1, FIG. 3 is a sectional view of FIG. 2, and FIG. FIG. 5 to FIG. 7 are explanatory views showing a process of attaching the tip member to the syringe outer cylinder of the present invention. Fig. 1 (O
As shown in FIG. 2 and FIG. 2) , the prefilled syringe of the present invention comprises a syringe barrel 1 made of glass and this syringe barrel 1.
A tip member 2 attached in a liquid-tight manner to a chemical solution discharge port 11 at the tip of the device, a sealing member (packing 4) for sealing between the chip member 2 and the chemical solution discharge port 11 in a liquid-tight manner, It includes a cap-shaped member 3 for caulking and fixing to the outlet 11, and a sealing member 5 for sealing the injection needle mounting portion 23 at the tip of the tip member 2, and is filled with a chemical solution (not shown). Syringe barrel 1
The rear end opening is closed by a plunger 6 inserted in a liquid-tight manner.

The syringe outer cylinder 1 is a glass cylindrical container having both ends opened, and a chemical solution discharge port 11 at the tip is formed in the shape of a vial, and the tip part protrudes outward in a ring shape. I have. A flange 12 is formed at the rear end, and the plunger 6 is inserted from the rear end opening in a liquid-tight manner. This plunger 6 is a plunger rod 62
And a gasket 61 attached to the tip of the plunger rod 62. The gasket 61 slides in the bore of the syringe outer cylinder 1. The gasket 61 is usually formed of a rubber-like elastic material such as natural rubber or synthetic rubber such as butyl rubber or isoprene rubber, or an elastomer, and has a conical front end and a plunger rod 62 at the rear end. A concave portion 64 for connecting the head 63 is formed.

A packing 4 as a seal member is attached to the tip surface of the chemical liquid discharge port 11 at the tip of the syringe outer cylinder 1. The packing 4 is a sheet-like member having a through hole having substantially the same diameter as the inside diameter of the chemical solution discharge port 11, and is caulked to the chemical solution discharge port 11 by the cap-like member 3. The packing 4 is formed of a rubber-like elastic body similar to the gasket 61. As a sealing member, a rubber stopper R having a flange with a through-hole formed on a shaft as shown in FIG. 10 of the related art may be adopted, and this may be inserted into the chemical solution outlet 11. In this case, the flange portion of the rubber stopper R is
Thus, the space between the tip end surface 1 and the tip member 2 is sealed.

The cap-shaped member 3 for caulking the packing 4 into the chemical solution discharge port 11 is generally formed of a synthetic resin such as polypropylene, polyethylene, polycarbonate, ABS resin, etc., and as shown in FIGS. And a skirt 32 whose diameter gradually increases in a tapered shape downward.
Consists of On the top surface 31, a through hole 33 larger than the through hole of the packing 4 and smaller than the outer diameter of the packing 4 is formed.
If necessary, a window 35 for pulling out at the time of molding is provided.
One or more slits 34 are formed in the skirt 32 in the longitudinal direction, and an engagement claw 36 is provided on the lower end inner wall of the skirt 32 to engage with the chemical solution discharge port 11 of the syringe outer cylinder 1. An undercut 3 that engages with an engaging claw 24 of the tip member 2 described below is provided on an outer wall at a lower end portion of the skirt 32.
7 are provided. The slits 34 are for making the skirt 32 easily bendable, and the number thereof is preferably 3 to 4. When the tip member 2 slides down along the outer wall of the skirt 32, the skirt 32, which expands in a tapered shape downward, is pressed and bent inward, and its engaging claw 3 is formed.
6 is adapted to engage with the chemical liquid discharge port 11 of the syringe outer cylinder 1. On the other hand, the engagement claw 24 formed on the inner wall at the lower end of the tip member 2 is such that the tip member 2 slides on the outer wall of the skirt 32 of the cap member 3 and the inside of the top surface 21 of the tip member 2 is just the cap member. At a position where the cap 3 collides with the packing 4, the cap 3 is engaged with an undercut 37 formed on the outer wall at the lower end. Note that a shallow engagement groove 38 that engages with the engagement claw 24 of the chip member 2 may be provided on the upper part of the skirt 32 of the cap member 3. In this case, the chip member 2 is attached to the cap member 3. Since the state can be maintained, the tip member 2, the cap-shaped member 3, and the seal member 4 can be attached to the chemical solution discharge port 11 of the syringe outer cylinder 1 by one operation.

A tip member 2 is mounted on the chemical liquid discharge port 11 of the syringe outer cylinder 1 from above the cap-shaped member 3. The tip member 2 is generally formed of the same synthetic resin as the cap-shaped member 3, and includes a top surface 21, a skirt 22, and an injection needle mounting portion 23 formed to protrude outside the top surface 21. The injection needle mounting portion 23 is a pipe-shaped projection formed with a drug solution passage 25, and its outer diameter is normally tapered toward the distal end, and is closed by a sealing member 5 such as a rubber stopper. . In the case of the syringe barrel 1 having a large capacity, to make it easier for the injection needle to pierce the patient's skin, etc.
The injection needle mounting portion 23 may be formed eccentrically with respect to the axis of the top surface 21 of the tip member 2. The skirt 22 is provided with an inward engaging claw 24 at the lower end. When the tip member 2 slides along the outer wall of the skirt 32 of the cap-like member 3 and reaches the slide end point, the cap-like member 3 Undercut 3 formed at the lower end of the skirt 32
7. The chemical solution passage 25 is formed to penetrate the top surface 21 of the tip member 2 and the injection needle attachment portion 23, and the chemical solution in the syringe outer cylinder 1 is supplied to the chemical solution outlet 1.
1 and this chemical solution passage 25. As shown in FIG. 1, the chemical solution passage 25 extends this to the skirt 22 side, that is, to the opposite side coaxially with the injection needle attachment portion 23, and forms a conduit 26 having an outer diameter equal to the inner diameter of the chemical solution discharge port 11. In this case, the conduit 26 is inserted into the chemical solution discharge port 11 in a liquid-tight manner.

Next, the assembly of the prefilled syringe of the present invention will be described with reference to FIGS. First, FIG.
As shown in (1), a cap-shaped member 3 on which a packing 4 is attached on the inner side of the top surface is prepared by mounting the tip member 2 shallowly on the cap-shaped member, and the cap member 3 is pressed down by applying it to the chemical solution discharge port 11 of the syringe outer cylinder 1. And the cap-shaped member 3 is the syringe barrel 1
6 moves downward along the liquid discharge port 11 and stops at a position as shown in FIG. At this time, the packing 4 is bitten between the cap-shaped member 3 and the chemical solution discharge port 11. When the downward movement of the cap-like member 3 stops, the tip member 2 slides down along the outer wall of the skirt 32 of the cap-like member 3 and deforms the cap-like member 3 inward, thereby causing the engaging claw 36 to move. It is firmly attached to the chemical solution discharge port 11. The downward movement of the tip member 2 stops at a position where the top surface 21 of the tip member 2 collides with the cap-like member 3 and the packing 4 as shown in FIG. It engages with the lower cut 37 at the lower end, and is attached to the chemical liquid discharge port 11 of the syringe outer cylinder 1 in a liquid-tight manner.

[0013]

As is apparent from the above description, the prefilled syringe of the present invention uses a cap-shaped member to attach the chemical liquid discharge port to the chemical liquid discharge port of the glass syringe outer cylinder. Since the rubber packing is swaged and the chip member is mounted on it, the dimensional accuracy may be higher than the conventional one, the number of parts is small, it is easy to assemble, and it is suitable for mass production. It is possible to provide a prefilled syringe provided with a syringe barrel at a low cost, and since the injection needle mounting portion can be decentered, a prefilled syringe having a large-capacity glass syringe barrel can be produced. Since the shape of the injection needle mounting part can be selected to any shape, it can be applied to a syringe barrel with a large capacity, etc. It has the advantage.

[Brief description of the drawings]

FIG. 1 is a longitudinal sectional view of a prefilled syringe according to one embodiment of the present invention.

FIG. 2 is a plan view of the cap-like member shown in FIG.

FIG. 3 is a sectional view of FIG. 2;

FIG. 4 is a bottom view of FIG. 2;

FIG. 5 is an explanatory view showing a step of attaching a tip member to a syringe outer cylinder of the present invention.

FIG. 6 is an explanatory view showing a step of attaching a tip member to a syringe outer cylinder of the present invention.

FIG. 7 is an explanatory view showing a step of attaching a tip member to the syringe outer cylinder of the present invention.

FIG. 8 is an explanatory diagram showing an example of a conventional prefilled syringe.

FIG. 9 is an explanatory view showing another example of a conventional prefilled syringe.

FIG. 10 is an explanatory view showing still another example of the conventional prefilled syringe.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Syringe outer cylinder 2 Tip member 23 Injection needle attachment part 24 Engagement claw 25 Chemical solution passage 3 Cap-shaped member 33 Through hole 34 Slit 36 Engagement claw 37 Undercut 4 Packing 5 Sealing member 6 Plunger

Continuation of the front page (72) Inventor Kenji Himejima 3-9-3 Honjo Nishi, Kita-ku, Osaka Examiner, Nissha Co., Ltd. Examiner Hidetaka Kitamura (56) References JP-A-5-237188 (JP, A) 2-58446 (JP, U) JP-A-2-49540 (JP, U) JP-A-59-2343 (JP, U) Table 6-500939 (JP, A) (58) Fields surveyed (Int. Cl. ⁷ , DB name) A61M 5/34 A61M 5/178

Claims (5)

(57) [Claims] 1. A glass syringe outer cylinder in which a chemical solution discharge port at the tip is formed in the shape of a vial, a top surface having a through hole, an engagement claw on a lower end inner wall, and an undercut on a lower end outer wall. A skirt having a slit in the axial direction of the skirt, a skirt having an engagement claw at a lower end, a top surface, and an injection needle mounting protruding outside the top surface. And a cap-shaped tip member slidable along an outer wall of the cap-shaped member, and a needle attachment portion of the tip member. And a seal member for sealing between the liquid discharge port of the syringe barrel and the tip member. The cap-shaped member is mounted on the liquid discharge port to discharge the liquid medicine. Between the outlet and the outlet Furthermore, by capping the tip member on the cap member and sliding along the outer wall of the cap member, the cap member is deformed inward to engage with the chemical solution discharge port, and the tip member is removed. A prefilled syringe which is attached in a liquid-tight manner to a chemical solution discharge port of the syringe outer cylinder. 2. A drug solution passage extending coaxially to the opposite side of the injection needle mounting portion to form a conduit having an outer diameter equal to the inner diameter of the drug solution discharge port, and the conduit is inserted into the drug solution outlet in a liquid-tight manner. The pre-filled syringe according to claim 1, which is worn. 3. The prefilled syringe according to claim 1, wherein the sealing member is a disk-shaped packing having a through hole on a shaft. 4. The prefilled syringe according to claim 1, wherein the sealing member is a rubber stopper having a flange on a top surface and a through hole on a shaft. 5. The prefilled syringe according to claim 1, wherein the position of the injection needle mounting portion is eccentric from the axis of the tip member.