JP3190712B2 - Cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic composition which comprises an amino acid ester and an ultraviolet absorbent, protects the skin from ultraviolet rays, suppresses the occurrence of skin inflammation due to ultraviolet rays, and moisturizes the skin.

[0002]

2. Description of the Related Art Conventionally, cosmetics for protecting the skin from ultraviolet rays have been made of powders or the like which are capable of absorbing ultraviolet rays by blending an ultraviolet absorbent or scattering ultraviolet rays.

[0003]

However, conventional skin external preparations cannot completely block ultraviolet rays when the skin is exposed to excessive ultraviolet rays outdoors, so that erythema, edema,
It had the disadvantage of causing skin inflammation such as blisters.

[0004]

Means for Solving the Problems The present inventors have conducted intensive studies to solve the above problems, and as a result, by blending a specific amino acid ester and an ultraviolet absorber, the skin is protected from ultraviolet rays, The inventors have found that the occurrence of inflammation of the skin due to ultraviolet rays is suppressed and that the skin is moisturized, thereby completing the present invention. That is, the present invention relates to aspartic acid,
Amino acids and lower grades selected from glutamic acid and glycine
It is intended to provide a cosmetic that suppresses the occurrence of skin inflammation and moisturizes the skin by blending an amino acid ester composed of a polyhydric alcohol and an ultraviolet absorber.

Hereinafter, the configuration of the present invention will be described in detail. The amino acid ester used in the present invention is asparagine
Amino acids selected from acid, glutamic acid and glycine and low
An amino acid ester comprising a grade monohydric alcohol ,
For example, glutamic acid monomethyl ester, glutamic acid monoethyl ester, glutamic acid monopropyl ester, glutamic acid dimethyl ester, glutamic acid diethyl ester, glutamic acid dipropyl ester, aspartic acid monomethyl ester, aspartic acid monoethyl ester, aspartic acid monopropyl ester, aspartic acid dimethyl ester , Aspartic acid diethyl ester, aspartic acid dipropyl ester, glycine methyl ester, glycine ethyl ester, glycine propyl ester and the like. The content of the amino acid ester in the present invention is 0.001 to 0.001 in the total amount of the cosmetic.
5.0% by weight, preferred to rather is 0.01 to 2.0% by weight.

[0006] The ultraviolet absorber incorporated in the cosmetic according to the present invention is any ultraviolet absorber conventionally used widely in cosmetics, and is, for example, as follows. (A) Benzoic acid-based ultraviolet absorber para-aminobenzoic acid (hereinafter abbreviated as PABA), PABA
Monoglycerin ester, N, N-dipropoxy PAB
A ester, N, N-diethoxy PABA ethyl ester, N, N-dimethyl PABA ethyl ester, N, N
-Dimethyl PABA butyl ester, N, N-dimethyl PABA amyl ester, N, N-dimethyl PABA octyl ester (b) anthranilic acid-based ultraviolet absorber homomenthyl-N-acetylanthranilate (c) salicylic acid-based ultraviolet absorber amyl salicylate Menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzal salicylate, p-isopropanol phenyl salicylate (d) cinnamic acid ultraviolet absorber octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5- Diisopropyl cinnamate, ethyl 2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl
p-Methoxy cinnamate, isopropyl-p-methixin cinnamate, isoamyl-p-methixin cinnamate, octyl-p-meth xycin namate (2-ethylhexyl-p- methoxy cinnamate), 2-ethoxyethyl -P-Methoxy cinnamate, cyclohexyl-
p-Methoxy cinnamate, ethyl-α-cyano-β-
Phenylcinnamate, 2-ethoxyethyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-
Ethylhexanoyl-diparamethoxycinnamate (E) benzophenone ultraviolet absorber 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone ,
2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone,
-Hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonate, 4-phenylbezophenone, 2-ethylhexyne-4′-phenyl-benzophenone-2-
Carboxylates, 2-hydroxy-4-n-octoxybenzophenones, 4-hydroxy-3-carboxybenzophenones (f) Silicone cinnamic acid derivatives UV absorbers

[0007]

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A siloxane having at least one unit represented by the formula I, wherein the other unit which may be present in the siloxane is

[0009]

[Chemical II]

A silicone cinnamic acid derivative represented by the formula II (wherein R ¹ is an alkyl group or phenyl group having 1 to 4 carbon atoms, and R ² is a divalent hydrocarbon group having at least 2 carbon atoms) , X is an alkoxy group, n is an integer of 0 to 3, a is an integer of 2 or 3, R ³ is an alkyl group or a phenyl group having 1 to 4 carbon atoms, and m represents an integer of 0 to ^3. ) ) Other ultraviolet absorbers 3- (4'methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor, urocanic acid, urocanic acid ethyl ester, 2-phenyl-5
-Methylbenzoxazal, 2,2'-hydroxy-5
-Methylphenylbenzotriazole, 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole, 2- (2'-hydroxy-5'-methylphenyl) benzotriazole, dibenzarazin, dianisylmethane, 4- Methoxy-4'-t-butyldibenzoylmethane) 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one

The ultraviolet absorber used in the present invention is selected from one or more of the above. The amount is not particularly limited, but is generally 0.05% with respect to the cosmetic.
-20% by weight, preferably 0.1-10% by weight. In the cosmetic of the present invention, in addition to the above-mentioned essential components, other components usually used in external preparations such as cosmetics and pharmaceuticals such as oils, humectants, antioxidants, and interface as long as the effects of the present invention are not impaired. Activators, preservatives, humectants, amino acids, fragrances, water, alcohols, thickeners, coloring agents, powders, drugs, etc. can be appropriately compounded as necessary. The dosage form of the cosmetic according to the present invention is arbitrary, and for example, a solubilizing system such as a lotion, an emulsifying system such as an emulsion or a cream, or an ointment or a dispersion can be used.

[0012]

The present invention is a cosmetic that protects the skin from ultraviolet rays, suppresses the occurrence of skin inflammation due to ultraviolet rays, and moisturizes the skin.

[0013]

Next, the present invention will be described in more detail by way of examples, but the present invention is not limited thereto. The amounts are by weight. Prior to the examples, an effect test method will be described.

The effect of promoting the horny layer turnover speed 20 male subjects were divided into 5 groups per group, and the sample was applied to the inner part of the forearm. After this was continued for 5 days, vaseline ointment of dansyl chloride was closed and applied for 24 hours, and then the number of days until the dansyl chloride fluorescence disappeared was measured.

[0015]Measuring method of water content of the stratum corneum (conductance value)  Skin superficial stratum corneum moisture meter (IBS Co., Ltd. MODE)
L: SKICON-200) equipped with a probe having a center electrode of 2 mmφ.
The skin surface conductance value as an index.
Was.

Example 1 Cream stearic acid 6.0 sorbitan monostearate 2.0 polyoxyethylene (20 mole addition) sorbitan mono 1.5 stearate 2- (2'-hydroxy-5'-methylphenyl) benzotri 8.0 azole propylene glycol 10.0 Glutamic acid diethyl ester 0.5 dl-α-tocopherol 0.05 Preservatives Appropriate amount Fragrance Appropriate amount Ion-exchanged water balance (Preparation method) Follow the usual method.

Comparative Example 1 A cream was produced in the same manner as in Example 1 except that diethyl glutamic acid was omitted from Example 1.

Example 2 Water-absorbing ointment Vaseline 40.0 Stearyl alcohol 18.0 Polyoxyethylene (10 mole addition) monooleate 1.5 Glycerin monostearate 0.25 Aspartic acid diethyl ester 1.5 4-Methoxy-4'-tert-butyldibenzoylmethane 3.0 Remaining amount of ion-exchanged water (Production method) Follow the usual method.

Comparative Example 2 A cream was produced in the same manner as in Example 2 except that diethyl aspartate was omitted from Example 2.

Table 1 shows the results of the tests for accelerating the turnover speed of the stratum corneum and the water content (conductance value) of the stratum corneum of Examples 1 and 2 and Comparative Examples 1 and 2.

[0021]

[Table I]

As is evident from Table I, according to the invention:
The effect of suppressing skin inflammation damage due to ultraviolet rays and moisturizing the skin was obtained.

Example 3 Cream Stearyl alcohol 7.0 Stearic acid 2.0 Hydrogenated lanolin 2.0 Squalane 5.0 2-Octyldodecyl alcohol 6.0 Polyoxyethylene (25 mol addition) Cetyl alcohol ether 3.0 Glycerin monostearate 2.0 N, N-dimethyl PABA octyl Ester 10.0 Propylene glycol 5.0 Aspartic acid diethyl ester 1.0 Glutamic acid diethyl ester 0.5 Glycine ethyl ester 0.5 Perfume Appropriate amount Methyl paraben 0.1 Tocopherol 0.1 Ion-exchanged water Residue (Preparation method) Follow the usual method.

Example 4 Cold cream Solid paraffin 5.0 Beeswax 10.0 Vaseline 15.0 Liquid paraffin 4.0 Glycerin monostearate 2.0 Polyoxyethylene (20 mole addition) Sorbitan monolaurate 2.0 Aspartate monopropyl ester 1.0 Glutamate dimethyl ester 2.5 4 -Methoxy-4'-t-butyldibenzoylmethane 3.0 Soap powder 0.1 Borax 0.2 Perfume Appropriate amount Methylparaben 0.1 Ion-exchanged water Remaining (Production method) Follow the usual method.

Example 5 Emulsion Polyoxyethylene (20 mole addition) Polyoxypropylene (2 mole addition) Cetyl alcohol ether 1.0 Silicone KF96 (20CS) (Shin-Etsu Chemical) 2.0 Liquid paraffin 3.0 [3-bis (trimethylsiloxy) methylsilyl- 1-Methyl 5.0 leprovir] -3,4,5-trimethoxycinnamate Glutamic acid dipropyl ester 0.5 Aspartic acid monoethyl ester 1.5 Propylene glycol 5.0 Glycerin 2.0 Ethyl alcohol 15.0 Carboxyvinyl polymer 0.3 Hydroxypropyl cellulose 0.1 2-Aminomethylpropanol 0.1 Phenoxyethanol 0.2 Perfume Appropriate amount Ion-exchanged water Appropriate amount (Production method) Follow the usual method.

Example 6 Beer-off type pack (alcohol phase) 95% ethanol 10.0 Polyoxyethylene (addition of 15 mol) oleyl alcohol ether 2.0 glyceryl mono-2-ethylexanoyl diparamethoxycinnamate 0.5 methyl paraben 0.1 Perfume appropriate amount (water Phase) Polyvinyl alcohol 12.0 Glycerin 3.0 Polyethylene glycol 1500 1.0 Aspartic acid diethyl ester 5.0 Residual ion-exchanged water (Preparation method) Follow the usual method.

The cosmetics of Examples 3 to 6 were excellent in the effects of protecting the skin from ultraviolet rays, suppressing the occurrence of skin inflammation due to ultraviolet rays, and moisturizing the skin.

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[Table 1]

────────────────────────────────────────────────── ─── Continued on the front page (58) Field surveyed (Int. Cl. ⁷ , DB name) A61K ^7/ 00-7/50 CA (STN) WPI (DIALOG)

Claims (1)

(57) [Claims] 1. Aspartic acid, glutamic acid, glycine
Consisting of an amino acid selected from
A cosmetic comprising one or more amino acid esters and one or more ultraviolet absorbers.