JP3184052B2 - Blood component separation device - Google Patents
Blood component separation deviceInfo
- Publication number
- JP3184052B2 JP3184052B2 JP21429394A JP21429394A JP3184052B2 JP 3184052 B2 JP3184052 B2 JP 3184052B2 JP 21429394 A JP21429394 A JP 21429394A JP 21429394 A JP21429394 A JP 21429394A JP 3184052 B2 JP3184052 B2 JP 3184052B2
- Authority
- JP
- Japan
- Prior art keywords
- pressing plate
- blood
- bag
- blood component
- component separation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012503 blood component Substances 0.000 title claims description 58
- 238000000926 separation method Methods 0.000 title claims description 52
- 238000003825 pressing Methods 0.000 claims description 135
- 210000004369 blood Anatomy 0.000 claims description 32
- 239000008280 blood Substances 0.000 claims description 32
- 230000003287 optical effect Effects 0.000 claims description 24
- 238000003860 storage Methods 0.000 claims description 14
- 238000005119 centrifugation Methods 0.000 claims description 11
- 238000007789 sealing Methods 0.000 claims description 6
- 210000003743 erythrocyte Anatomy 0.000 description 22
- 238000000034 method Methods 0.000 description 19
- 238000005303 weighing Methods 0.000 description 13
- 230000006837 decompression Effects 0.000 description 10
- 239000000306 component Substances 0.000 description 7
- 230000001276 controlling effect Effects 0.000 description 7
- 210000000265 leukocyte Anatomy 0.000 description 7
- 239000010836 blood and blood product Substances 0.000 description 6
- 229940125691 blood product Drugs 0.000 description 6
- 238000010586 diagram Methods 0.000 description 6
- 230000005484 gravity Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000004555 blood preservation Methods 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000003761 preservation solution Substances 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 238000004891 communication Methods 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
Description
【０００１】[0001]
【産業上の利用分野】本発明は血液成分分離装置に関す
るもので、血液（全血）を収納した血液バッグを遠心分
離処理した後、分離した各血液成分を自動的に各血液成
分の分離容器（子バッグ）に分取する血液成分分離装置
を提供するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an apparatus for separating blood components, in which a blood bag containing blood (whole blood) is subjected to centrifugal separation, and then each separated blood component is automatically separated into containers for separating each blood component. (Child bag) is provided.
【０００２】[0002]
【従来の技術および発明が解決しようとする課題】現在
使用されている血液成分分離装置は、押圧方式が採用さ
れている。押圧方式は固定した垂直な平滑面からなるあ
るいは血液成分の移動量および移動速度を低下させるた
めの凹面を設けた受圧板に対して、平行に押圧あるいは
支点を中心にして、例えばスプリング圧、圧搾空気圧、
モ−タの駆動力などで押圧するほかの平滑な押圧板より
構成される。2. Description of the Related Art At present, a blood component separation apparatus employs a pressing system. The pressing method is such that a pressure receiving plate having a fixed vertical smooth surface or a concave surface provided with a concave surface for reducing the moving amount and moving speed of blood components is pressed in parallel or centered on a fulcrum, for example, spring pressure, squeezing. air pressure,
It is composed of another smooth pressing plate pressed by the driving force of the motor.
【０００３】押圧板方式の血液成分分離装置は、容器へ
の接触状態で支点が上部に設けられた血液成分分離装置
と支点が下部に設けられた血液成分分離装置および受圧
板に対して平行に容器を押圧する押圧板が設けられた血
液成分分離装置が使用されているが、各装置とも二枚の
押圧板で容器を押しつぶして、容器内の血液成分を押し
出し、各血液成分の純度を高めるために、分離工程中に
おいて界面部（白血球等）を光学検出手段等を用いて検
出し、クランプ手段を用いて各血液成分を分離容器（子
バッグ）に分取している。血液成分の分離作業および作
業によって製造される血液製剤において、分離した上層
（血漿層）および下層（赤血球層）に、界面部（白血球
等）が混入することは極めて重度な不良となる。[0003] A pressure plate type blood component separation device is provided in parallel with a blood component separation device having a fulcrum provided at an upper portion and a blood component separation device having a fulcrum provided at a lower portion and a pressure receiving plate in contact with a container. A blood component separation device provided with a pressing plate for pressing the container is used, but each device crushes the container with two pressing plates, extrudes the blood component in the container, and increases the purity of each blood component. For this purpose, an interface (white blood cells, etc.) is detected using an optical detection means or the like during the separation step, and each blood component is fractionated into a separation container (child bag) using a clamp means. In the blood component separation operation and the blood product produced by the operation, it is extremely severe that the interface (white blood cells, etc.) is mixed into the separated upper layer (plasma layer) and lower layer (red blood cell layer).
【０００４】また、使用されるバッグシステムには、日
本国内で通常使用されているＴＯＰｉｎ ＴＯＰ ｏｕ
ｔ方式と、海外で普及し始めたＴＯＰ ｉｎ ＢＯＴＴ
ＯＭ ｏｕｔ方式とがあるが、分離によって得られる界
面部（白血球等）を、血液（全血）を収納した血液バッ
グに残し、上層（血漿層）はバッグのＴＯＰより、下層
（赤血球）はバッグのＢＯＴＴＯＭより排出するＴＯＰ
ｉｎ ＢＯＴＴＯＭ ｏｕｔ方式のバッグシステムに
よって得られる血液製剤の品質が良好なことから同方式
（ＴＯＰ ｉｎ ＢＯＴＴＯＭ ｏｕｔ方式）のバッグ
システムの導入が日本でも検討され始めた。また血液
（全血）は、供血者によって同量の血液中の赤血球の割
合はまちまちであり、即ち遠心分離処理後の界面部の位
置はまちまちである。[0004] Further, the bag system used includes TOPin TOP out which is generally used in Japan.
t method and TOP in BOTT which started to spread overseas
There is an OM out method, but the interface (white blood cells, etc.) obtained by separation is left in a blood bag containing blood (whole blood), the upper layer (plasma layer) is below the TOP of the bag, and the lower layer (red blood cells) is the bag. TOP discharged from BOTTOM
Since the quality of blood products obtained by the in-BOTTOM out bag system is good, the introduction of a bag system of the same (TOP in BOTTOM out system) has begun to be considered in Japan. In blood (whole blood), the proportion of red blood cells in the same amount of blood varies depending on the donor, that is, the position of the interface after the centrifugation treatment varies.
【０００５】従来の分離装置では、ＴＯＰ ｉｎ ＢＯ
ＴＴＯＭ ｏｕｔ方式のバッグシステムの分離作業にお
いて、まずバッグを押圧板にて押圧しながら、バッグの
上部および下部の連結チューブを通して排出される血液
成分の流出を制御するクランプを解放し、血液成分の比
重および粘度の違いから、バッグ上部の流出量、流出速
度がバッグ下部より多く速いため、結果的にバッグ内部
の界面部が上昇してくる。この界面部を光学的検出手段
等で検出し、バッグ上部のクランプのみ予め定められた
期間だけ閉じ、この期間中に下降した界面部を、再度バ
ッグ上部のクランプを開いて、上昇してきた時に検出
し、この制御を繰り返すものがほとんどである。遠心分
離後の血液バッグ中で界面部が上昇、下降を繰り返すこ
とは、その界面部中の白血球成分を上層の血漿成分、下
層の赤血球成分中に混入させることとなり、好ましくな
い。[0005] In a conventional separation apparatus, TOP in BO
In the separating operation of the TTOM out type bag system, first, while pressing the bag with the pressing plate, the clamp for controlling the outflow of the blood component discharged through the connection tubes at the upper and lower portions of the bag is released, and the specific gravity of the blood component is released. Due to the difference in viscosity and the difference in viscosity, the outflow amount and outflow speed at the upper part of the bag are higher than those at the lower part of the bag, and as a result, the interface inside the bag rises. This interface is detected by optical detection means or the like, and only the clamp at the top of the bag is closed for a predetermined period, and the interface that has fallen during this period is detected when the clamp at the top of the bag is opened again and rises. In most cases, this control is repeated. Repetition of rising and falling of the interface in the blood bag after the centrifugation is not preferable because the white blood cell component in the interface is mixed into the upper plasma component and the lower red blood cell component.
【０００６】[0006]
【課題を解決するための手段】本発明は、（ａ）血液収
納容器（血液成分分離容器）を外部から減圧吸引する手
段と、（ｂ）血液成分分離容器内の重量の変化量の測定
手段と、（ｃ）血液収納容器を容量変化に応じて押圧す
る手段と、（ｄ）血液収納容器（血液成分分離容器）の
遠心分離処理後の血液成分の界面の変化の検出手段と、
（ｅ）血液収納容器と血液成分分離容器の連結チューブ
のクランプ／シール手段、（ｆ）血液成分分離容器を外
部から減圧吸引または加圧する手段、（ｇ）前記各手段
（ａ）から（ｆ）を連動制御する主制御部とからなり、
前記（ｃ）の押圧手段は、補助押圧板１０と上部押圧板
１１及び下部押圧板１２と上部押圧板１１及び下部押圧
板１２の移動制御装置４０とからなり、該移動制御装置
４０は、上部押圧板１１及び下部押圧板１２の駆動モー
タ４７と、上部押圧板１１及び下部押圧板１２の移動量
を検出するロータリーエンコーダ４２と、上部押圧板１
１及び下部押圧板１２の移動量の確認、是正を行う光学
的位置センサ４３とから構成され、前記光学的位置セン
サ４３は、界面待ち位置センサ４５、原点センサ４６及
び押圧板位置検出片４７より構成されている血液成分分
離装置を提供する。According to the present invention, there are provided (a) means for suctioning a blood storage container (blood component separation container) from the outside under reduced pressure, and (b) means for measuring a change in weight in the blood component separation container. (C) means for pressing the blood storage container in accordance with the change in volume, (d) means for detecting a change in the interface of the blood component after centrifugation of the blood storage container (blood component separation container),
(E) means for clamping / sealing the connecting tube between the blood storage container and the blood component separation container, (f) means for applying reduced-pressure suction or pressure to the blood component separation container from outside, and (g) means (a) to (f) above And a main control unit that controls
The pressing means (c) comprises an auxiliary pressing plate 10, an upper pressing plate 11, a lower pressing plate 12, and a movement control device 40 for the upper pressing plate 11 and the lower pressing plate 12, and the movement control device 40 A drive motor 47 for the pressing plate 11 and the lower pressing plate 12; a rotary encoder 42 for detecting the amount of movement of the upper pressing plate 11 and the lower pressing plate 12;
1 and confirmation of the movement amount of the lower pressing plate 12 is composed of the optical position sensor 43 for performing corrective, the optical position sensor
The sensor 43 includes an interface waiting position sensor 45, an origin sensor 46,
And a blood component separation device comprising a pressure plate position detecting piece 47 .
【０００７】[0007]
【作用】前記（ａ）から（ｆ）の各手段を主制御部によ
り連動制御することにより、血液成分の界面部の位置を
頻繁に上下動させることなく、他の血液成分分離容器に
血液成分を移送することができる。By interlocking and controlling the means (a) to (f) by the main control unit, the position of the interface of the blood component is not frequently moved up and down, and the blood component is transferred to another blood component separation container. Can be transported.
【０００８】[0008]
【実施例】図１は本発明の血液成分分離装置３０の概略
図、図２は血液成分分離装置３０のブロック図である。
血液成分分離装置１は、（ａ）血液収納容器を外部から
減圧吸引する手段（以下「減圧吸引手段」）と、（ｂ）
血液成分分離容器内の重量の変量の測定手段と、（Ｃ）
血液収納容器を容量変化に応じて押圧する手段（以下
「押圧手段」）と、（ｄ）血液収納容器（血液成分分離
容器）の遠心分離処理後の血液成分の界面の変化の検出
手段（以下「界面検出手段」）と、（ｅ）血液収納容器
と血液成分分離容器の連結チュ−ブのクランプ／シ−ル
手段、（ｆ）血液成分分離容器を外部から加圧する手
段、（ｇ）前記各手段（ａ）から（ｆ）を連動制御する
主制御部とから構成される。1 is a schematic view of a blood component separation device 30 according to the present invention, and FIG. 2 is a block diagram of the blood component separation device 30.
The blood component separation device 1 includes (a) means for suctioning the blood storage container from the outside under reduced pressure (hereinafter, “pressure-reducing suction means”), and (b)
Means for measuring the weight variation in the blood component separation container; (C)
Means for pressing the blood storage container in accordance with the change in volume (hereinafter referred to as "pressing means"); and (d) means for detecting a change in the interface of blood components after centrifugation of the blood storage container (blood component separation container) (hereinafter referred to as "pressure means") "Interface detection means"); (e) means for clamping / sealing the connecting tube between the blood storage container and the blood component separation container; (f) means for externally applying pressure to the blood component separation container; A main control unit that controls each of the means (a) to (f) in an interlocked manner.
【０００９】血液成分分離装置３０を構成する前記各手
段（ａ）から（ｆ）は図１と図２に示すように主制御部
２５により連動制御される。前記手段（ａ）は減圧ポン
プＰ １ と減圧室１３、１５より構成され、前記手段
（ｂ）は秤量器１４、１６、１７により構成され、前記
手段（ｃ）は上部押圧板１１、下部押圧板１２及び補助
押圧板１０とこれを駆動するモータと、前記各押圧板１
１、１２の動きを制御する押圧板の移動制御装置４０
（後述する図７参照、ロータリエンコーダ４２と光学的
位置センサ４３より構成される。）により構成され、前
記手段（ｄ）は光学検出手段或いは重量変化検出手段或
いは、押圧板隙間検出手段より構成され、前記手段
（ｅ）はクランプ５、６、７、８及び高周波発振部によ
り構成される。前記手段（ｆ）は減圧／加圧室１５内の
第２の血液成分分離容器３（以下第２子バッグ３）を直
接加圧或いは他の密閉式の可撓性の容器で間接的に加圧
する手段（例えば加圧ポンプ等）により構成される。図
２の記憶部は、ＲＯＭ、ＥＥＰＲＯＭ、ＲＡＭからなり
停電時でも設定記憶内容を保持させることができる。The means (a) to (f) constituting the blood component separating apparatus 30 are interlocked and controlled by the main control unit 25 as shown in FIGS. The means (a) is composed of a decompression pump P 1 and decompression chambers 13 and 15, the means (b) is composed of weighers 14, 16 and 17, and the means (c) is an upper press plate 11 and a lower press Plate 12 and auxiliary pressing plate 10, a motor for driving the same,
Press plate movement control device 40 for controlling movements of 1, 12
(See FIG. 7, which will be described later, is composed of a rotary encoder 42 and an optical position sensor 43.) The means (d) is composed of an optical detecting means, a weight change detecting means, or a pressing plate gap detecting means. The means (e) includes the clamps 5, 6, 7, 8 and a high-frequency oscillator. The means (f) directly pressurizes or indirectly pressurizes the second blood component separation container 3 (hereinafter referred to as the second child bag 3) in the decompression / pressurization chamber 15 with another closed flexible container. It is constituted by means for pressing (for example, a pressurizing pump or the like). The storage unit in FIG. 2 includes a ROM, an EEPROM, and a RAM, and can retain the settings stored even during a power failure.
【００１０】次に、四連バッグシステムで構成される血
液バッグを用いて、血液を各成分に分離する場合の実施
例について説明する。本発明の血液成分分離装置３０に
は、血液収納容器（以下、親バッグ１）を連結チュ−ブ
９ａを介して第２子バッグ３、連結チュ−ブ９ｂを介し
て第１の血液成分分離容器２（以下、第１子バッグ
２）、連結チュ−ブ９ｃを介して第３の血液成分分離容
器４（以下、第３の子バッグ４）と接続することにより
構成される血液バッグシステム（図３）が装着される。
これらの各容器１、２、３、４と連結チュ−ブ９ａ、９
ｂ、９ｃはすべて可撓性合成樹脂により形成されてい
る。Next, an embodiment in which blood is separated into each component using a blood bag constituted by a quadruple bag system will be described. In the blood component separation device 30 of the present invention, a blood container (hereinafter referred to as a parent bag 1) is connected to a second child bag 3 via a connecting tube 9a and a first blood component is separated via a connecting tube 9b. A blood bag system (hereinafter, referred to as a first child bag 2) connected to a third blood component separation container 4 (hereinafter, third child bag 4) via a connecting tube 9c. 3) is attached.
Each of these containers 1, 2, 3, 4 and connecting tubes 9a, 9
b and 9c are all formed of a flexible synthetic resin.
【００１１】また前記親バッグ１の上部と、前記第３子
バッグ４の上部には、遮断開放部１８、１９が配置され
ている。該遮断開放部１８（１９）は、例えば外部より
力を加えると破壊されて連結チュ−ブ９ｂを経て第１子
バッグ２に血液成分を移送できる連通ピ−スが使用され
る。また該遮断開放部１８（１９）は第１子バッグ２、
第２子バッグ３にも設けることができ、前記連通ピ−ス
を外部から破壊することのできる手段（手動、自動でも
可）を設けることもできる。On the upper part of the parent bag 1 and on the upper part of the third child bag 4, blocking and opening parts 18, 19 are arranged. The cut-off opening 18 (19) is, for example, a communication piece that can be broken when a force is applied from the outside and can transfer blood components to the first child bag 2 via the connecting tube 9b. Further, the shutoff opening 18 (19) is provided in the first child bag 2,
It can be provided in the second child bag 3 and means (manual or automatic) capable of breaking the communication piece from the outside can also be provided.
【００１２】前記親バッグ１は補助押圧板１０に装着さ
れ、前記第１の子バッグ２は秤量器１４を備えた減圧室
１３に配置され、前記第２子バッグ３は秤量器１６を備
えた減圧／加圧室１５に配置される。前記連結チュ−ブ
９ａ、９ｂ，９ｃの途中にはシ−ル機能（例えば高周波
ウェルダ−方式、加熱方式）を有するクランプ５、６、
７、８が配置される。The parent bag 1 is mounted on an auxiliary pressing plate 10, the first child bag 2 is disposed in a decompression chamber 13 having a weighing device 14, and the second child bag 3 is provided with a weighing device 16. It is arranged in the decompression / pressure chamber 15. In the middle of the connecting tubes 9a, 9b, 9c, clamps 5, 6, having a sealing function (for example, a high-frequency welding system, a heating system) are provided.
7 and 8 are arranged.
【００１３】前記親バッグ１の押圧部は補助押圧板１
０、上部押圧板１１、下部押圧板１２から構成されてお
り、上部押圧板１１及び下部押圧板１２はモ−タでそれ
ぞれ単独に駆動させることができる。補助押圧板１０と
上部／下部押圧板１１、１２の押圧・移動方向は図１の
ように矢印の方向でもよいし、補助押圧板１０を下面に
対し垂直に立ててそれに押しつける方向でもよい。ま
た、上部押圧板１１の中央部には光センサＳが配置され
ている。前記光センサＳは上部押圧板１１の縦方向に形
成されており、反射型、透過型どちらでも良く、また一
対でも複数対形成しても良い。また、上部押圧板１１と
下部押圧板１２の移動量を規制するための光学的位置セ
ンサ４３（一部図示せず）が取り付けられている。The pressing portion of the parent bag 1 is an auxiliary pressing plate 1
0, an upper pressing plate 11, and a lower pressing plate 12. The upper pressing plate 11 and the lower pressing plate 12 can be independently driven by a motor. The pressing / moving direction of the auxiliary pressing plate 10 and the upper / lower pressing plates 11 and 12 may be the direction of the arrow as shown in FIG. 1, or may be the direction in which the auxiliary pressing plate 10 is set upright against the lower surface and pressed against it. In addition, an optical sensor S is disposed at the center of the upper pressing plate 11. The optical sensor S is formed in the vertical direction of the upper pressing plate 11, and may be of a reflection type or a transmission type, and may be formed in a pair or a plurality of pairs. Further, an optical position sensor 43 (partly not shown) for regulating the amount of movement of the upper pressing plate 11 and the lower pressing plate 12 is attached.
【００１４】次に本発明の使用方法のうち図３のバッグ
システムを用いた操作法につき説明する。献血者から採
血された全血はまず親バッグ１に収納される。その後遠
心分離機で上層部が血漿Ｐ、中間部が界面層Ｉ、下層部
が赤血球Ｒとなるように遠心分離される。この状態で本
発明の血液成分分離装置３０にかけて親バッグ１の上層
部の血漿Ｐを第２子バッグ３に移送し、次いで中間部の
界面層Ｉを第１子バッグ２に移送してから第３子バッグ
４の血液保存液を親バッグ１に移送して第１段階の分離
操作を終了する。Next, an operation method using the bag system shown in FIG. 3 will be described. First, whole blood collected from a blood donor is stored in the parent bag 1. Thereafter, the mixture is centrifuged by a centrifuge such that the upper layer is plasma P, the intermediate layer is interface layer I, and the lower layer is red blood cells R. In this state, the plasma P in the upper layer portion of the parent bag 1 is transferred to the second child bag 3 through the blood component separation device 30 of the present invention, and then the interface layer I in the intermediate portion is transferred to the first child bag 2, The blood preservation solution in the three-child bag 4 is transferred to the parent bag 1, and the first-stage separation operation is completed.
【００１５】尚、クランプ／シール５、８の動作でチュ
ーブ９ａ、９ｃをシールして切断した後、第１子バッグ
２と第２子バッグ３が連結された状態で第二回目の遠心
分離操作が行われる。この後、第１子バッグ２を、上部
押圧板１１、下部押圧板１２、補助押圧板１０からなる
押圧部に装着し、第２子バッグ３を第１段階の分離操作
時と同様に減圧／加圧室１５に装着し、第２段階の分離
操作を行ない一連の分離動作を完了する。After the tubes 9a and 9c are sealed and cut by the operation of the clamps / seals 5 and 8, a second centrifugal separation operation is performed with the first and second child bags 2 and 3 connected. Is performed. Thereafter, the first child bag 2 is mounted on a pressing portion including the upper pressing plate 11, the lower pressing plate 12, and the auxiliary pressing plate 10, and the second child bag 3 is decompressed / depressed in the same manner as in the first stage separation operation. It is mounted in the pressurizing chamber 15, and a second stage of separation operation is performed to complete a series of separation operations.
【００１６】以上の分離動作を詳細に説明すると次のよ
うである。遠心分離で血漿層Ｐ、界面層Ｉ、赤血球層Ｒ
に分離された親バッグ１を吊具２０に掛止する。この
時、界面層Ｉが乱れないように上部押圧板１１及び下部
押圧板１２と補助押圧板１０の間に親バッグ１を軽く押
圧接触させる。この押圧はあくまでも補助的な弱いもの
である。続いて減圧／加圧ポンプＰ2 の減圧側を駆動さ
せて第２子バッグ３が収納されている減圧／加圧室１５
を減圧にすると、これが駆動となって前記親バッグ１中
の血漿層Ｐは連結チュ−ブ９ａを経て、前記第２子バッ
グ３中へ導入される。第２子バッグ３中へ導入される血
漿層Ｐの増加量は秤量器１６で測定しながら終始検知す
ることができる。The above separating operation will be described in detail as follows. By centrifugation, plasma layer P, interface layer I, erythrocyte layer R
The parent bag 1 separated in the above manner is hooked on the hanger 20. At this time, the parent bag 1 is lightly pressed into contact between the upper pressing plate 11 and the lower pressing plate 12 and the auxiliary pressing plate 10 so that the interface layer I is not disturbed. This pressing is only an auxiliary weak one. Then the second child bag 3 by driving the vacuum side of the vacuum / pressure pump P 2 is accommodated vacuum / pressure chamber 15
When the pressure is reduced, this is driven and the plasma layer P in the parent bag 1 is introduced into the second child bag 3 via the connecting tube 9a. The amount of increase in the plasma layer P introduced into the second child bag 3 can be detected throughout while measuring with the weighing device 16.
【００１７】前記光センサ−Ｓで、界面層Ｉ、赤血球層
Ｒを検知すると前記減圧／加圧室１５に接続された減圧
／加圧ポンプＰ2 と上部押圧板１１、下部押圧板１２と
補助押圧板１０の動きを停止させて、クランプ７で前記
連結チュ−ブ９ａの液体流路を遮断する。この場合、予
め設定した秤量器１６の値で移送量を規制することもで
きる。減圧／加圧ポンプＰ2 の減圧側を駆動すると親バ
ッグ１内の血漿層Ｐが第２子バッグ３中へ移送されるに
つれて親バッグ１の上部が先に凹状になるので上部押圧
板１１が図１で矢印方向により大きく移動（追隨）す
る。When the optical sensor S detects the interface layer I and the red blood cell layer R, the pressure / pressure pump P 2 connected to the pressure / pressure chamber 15, the upper pressing plate 11, the lower pressing plate 12 and the auxiliary The movement of the pressing plate 10 is stopped, and the clamp 7 blocks the liquid flow path of the connecting tube 9a. In this case, the transfer amount can be regulated by a preset value of the weighing device 16. When the decompression side of the decompression / pressurization pump P 2 is driven, as the plasma layer P in the parent bag 1 is transferred into the second child bag 3, the upper part of the parent bag 1 becomes concave first, so that the upper pressing plate 11 It moves (follows) greatly in the direction of the arrow in FIG.
【００１８】前記と同様に減圧ポンプＰ1 を駆動させて
減圧室１３を減圧にし、親バッグ１中の界面層Ｉを連結
チュ−ブ９ｂを経て第１子バッグ２中へ導入する。この
場合も予め設定した秤量器１４の値で移送量を規制する
ことができる。前記光センサＳで赤血球層Ｒを検知する
（界面層Ｉの移送終了である）と同時に前記減圧室１３
に接続された減圧ポンプＰ1 を停止させて、クランプ６
で前記連結チュ−ブ９ｂの流体流路を遮断する。そして
前記クランプ７を開放して、前記第２子バッグ３中へ導
入された血漿層Ｐを連結チュ−ブ９ａ、９ｂを経て第１
子バッグ２へ導入し、クランプ６で連結チュ−ブ９ｂの
液体流路を遮断する。この血漿層Ｐの移送は、前記連結
チュ−ブ９ｂ内に付着した界面層Ｉを洗浄するのが主目
的で少量（例えば５から２０ｍｌ）である。移送量は、
予め設定した秤量器１４の値で設定できる。[0018] under reduced pressure chamber 13 by driving the vacuum pump P 1 in the same manner as described above to a vacuum, an interface layer I in the parent bag 1 connected Ju - introducing into the first child bag 2 in through the blanking 9b. Also in this case, the transfer amount can be regulated by the value of the weighing device 14 set in advance. When the red blood cell layer R is detected by the optical sensor S (the transfer of the interface layer I is completed),
The vacuum pump P 1 connected to be stopped, the clamp 6
To shut off the fluid flow path of the connecting tube 9b. Then, the clamp 7 is opened, and the plasma layer P introduced into the second child bag 3 is connected to the first through the connecting tubes 9a and 9b.
The liquid flow path of the connecting tube 9b is cut off by the clamp 6 after being introduced into the child bag 2. The transfer of the plasma layer P is performed in a small amount (for example, 5 to 20 ml) mainly for the purpose of cleaning the interface layer I adhered in the connecting tube 9b. The transfer amount is
It can be set by the value of the weighing device 14 set in advance.
【００１９】クランプ５、８を開放して第３子バッグ４
中の血液保存液を連結チューブ９ｃ、９ａを介して赤血
球層Ｒの残った親バッグ１中に導入し、クランプ５で連
結チューブ９ａの液体流路を遮断する。第３子バッグ４
から血液保存液を移送する手段としては、例えば落差式
でも良いし、押圧板方式、加圧ポンプ方式でも良い。ク
ランプ５、７はシール機能を有するので、連結チューブ
９ａの液体流路を遮断すると同時に連結チューブ９ａを
シール切断することができる。次に、界面層Ｉが導入さ
れた第１子バッグ２を遠心分離処理し、白血球層等と、
血漿層の成分に分離する。これを前記補助押圧板１０に
配置し、前記と同様の操作により各成分を分離すること
ができる。尚、減圧／加圧室１５を減圧／加圧できるよ
うにしているのは第２子バッグ３の血漿を第１子バッグ
２に移送するためである。The clamps 5 and 8 are opened to release the third child bag 4
The blood preservation solution therein is introduced into the parent bag 1 where the red blood cell layer R remains through the connection tubes 9c and 9a, and the liquid flow path of the connection tube 9a is blocked by the clamp 5. Third child bag 4
As a means for transferring the blood preservation solution from the head, for example, a head type, a pressing plate type, or a pressure pump type may be used. Since the clamps 5 and 7 have a sealing function, it is possible to cut off the liquid flow path of the connecting tube 9a and simultaneously cut off the sealing of the connecting tube 9a. Next, the first child bag 2 into which the interface layer I has been introduced is subjected to a centrifugal separation process, and a leukocyte layer or the like is obtained.
Separates into components of the plasma layer. This is disposed on the auxiliary pressing plate 10, and each component can be separated by the same operation as described above. The reason why the decompression / pressurization chamber 15 can be decompressed / pressurized is that the plasma of the second child bag 3 is transferred to the first child bag.
2 to transfer.
【００２０】次に図４のバッグシステムを用いた場合の
操作法につき説明する。採血された血液は親バッグ１に
収納され、遠心分離処理される。遠心分離で、前記シス
テムと同様に血漿層Ｐ、界面層Ｉ、赤血球層Ｒに分離さ
れた親バッグ１を吊具２０に掛止する。図４のバッグシ
ステムでは親バッグ１の底部から連結チュ−ブ２１Ｃを
介して第３子バッグ４が接続されているが、前記バッグ
システムと同様に血液成分分離装置に装着され分離操作
が行なわれている。但し連結チュ−ブ２１Ｃは、クラン
プシ−ル６、遮断開放部１９を経由し、第３子バッグ４
は秤量器１４に装着される。親バッグ１は、上部押圧板
１１、下部押圧板１２と補助押圧板１０の間に装着され
る。上層の血漿層Ｐは第２子バッグ３に、下層の赤血球
層Ｒは第３子バッグ４に同時に移送される。この時界面
層Ｉは遠心分離後の親バッグ１での位置をほぼ維持する
よう制御する。Next, an operation method using the bag system shown in FIG. 4 will be described. The collected blood is stored in the parent bag 1 and centrifuged. By the centrifugation, the parent bag 1 separated into the plasma layer P, the interface layer I, and the red blood cell layer R is hooked on the hanging device 20 in the same manner as in the above system. In the bag system shown in FIG. 4, the third child bag 4 is connected from the bottom of the parent bag 1 via the connecting tube 21C. ing. However, the connecting tube 21C is connected to the third child bag 4 via the clamp seal 6 and the cut-off opening portion 19.
Is mounted on the weighing device 14. The parent bag 1 is mounted between the upper pressing plate 11, the lower pressing plate 12, and the auxiliary pressing plate 10. The upper plasma layer P is transferred to the second child bag 3 and the lower red blood cell layer R is transferred to the third child bag 4 at the same time. At this time, the interface layer I is controlled so that the position in the parent bag 1 after centrifugation is substantially maintained.
【００２１】この制御方法としては、秤量器１６と秤
量器１４の重量変化がそれぞれ一定になるように制御す
る方法、上部押圧板１１及び下部押圧板１２に設定し
た光センサＳにより制御する方法、上部押圧板１１と
補助押圧板１０間の間隙及び下部押圧板１２と補助押圧
板１０の間隙を一定にする方法がある。秤量器１６、１
４の重量変化を利用する方法としては、例えば、血漿層
Ｐと赤血球層Ｒのおおよその重量比になるようにクラン
プ／シ−ル７、６をＯＮ／ＯＦＦ制御する方法がある。As the control method, a method of controlling the weight change of the weighing device 16 and the weighing device 14 to be constant, a method of controlling by the optical sensor S set on the upper pressing plate 11 and the lower pressing plate 12, There is a method of keeping the gap between the upper pressing plate 11 and the auxiliary pressing plate 10 and the gap between the lower pressing plate 12 and the auxiliary pressing plate 10 constant. Weighers 16, 1
As a method utilizing the weight change of 4, there is, for example, a method of ON / OFF-controlling the clamps / seals 7 and 6 so that the approximate weight ratio between the plasma layer P and the red blood cell layer R is obtained.
【００２２】光センサによる制御方法としては、界面層
Ｉが一定の位置を保持するように、補助押圧板１０或い
は、上部押圧板１１、下部押圧板１２に縦方向（上下方
向）に複数の光センサを配置して界面層Ｉの上下の移動
幅を該光センサで設定し、クランプ／シ−ル７、６のＯ
Ｎ／ＯＦＦと連動制御を行う。押圧板１１、１２の間隙
による制御方法としては、上部押圧板１１と補助押圧板
１０間の間隙及び下部押圧板１２と補助押圧板１０間の
間隙を界面層Ｉが他の子バッグ３、４に移送されないよ
うに、リミットスイッチ、マグネットスイッチ、光セン
サを利用して制御することができる。As a control method by the optical sensor, a plurality of light beams are vertically (upward and downward) applied to the auxiliary pressing plate 10 or the upper pressing plate 11 and the lower pressing plate 12 so that the interface layer I maintains a fixed position. The sensor is arranged, the vertical movement width of the interface layer I is set by the optical sensor, and the O of the clamps / seals 7 and 6 is set.
N / OFF and interlocking control are performed. As a control method based on the gap between the pressing plates 11 and 12, the interface layer I determines the gap between the upper pressing plate 11 and the auxiliary pressing plate 10 and the gap between the lower pressing plate 12 and the auxiliary pressing plate 10. It can be controlled using a limit switch, a magnet switch, and an optical sensor so that it is not transferred to
【００２３】また、界面層Ｉが子バッグ３、４に移送さ
れないために、図５のように、上部押圧板１１の下端と
下部押圧板１２の上端の間隙を若干あけて、この間隙に
界面層Ｉをとじ込める方法とか、図６のように上部押圧
板１１と下部押圧板１２の接する付近をふくらませて、
そのふくらみ中に界面層Ｉを保持する方法がある。界面
層Ｉを親バッグ１の遠心分離後の位置で、一定に維持す
る理由は血漿層Ｐ、赤血球層Ｒに白血球、リンパ球、バ
フィコ−トを混入させない、即ち純度の高い血液製剤を
得るためである。血漿層Ｐと赤血球層Ｒをそれぞれ第２
子バッグ３、第３子バッグ４に移送したあとの操作方法
は図１の操作方法に準ずるので省略する。In order to prevent the interface layer I from being transferred to the child bags 3 and 4, there is a slight gap between the lower end of the upper pressing plate 11 and the upper end of the lower pressing plate 12, as shown in FIG. The method of closing the layer I or inflating the vicinity of the contact between the upper pressing plate 11 and the lower pressing plate 12 as shown in FIG.
There is a method of keeping the interface layer I during the swelling. The reason why the interface layer I is kept constant at the position after the centrifugation of the parent bag 1 is to prevent leukocytes, lymphocytes and buffy coat from being mixed into the plasma layer P and the red blood cell layer R, that is, to obtain a blood product of high purity. It is. The plasma layer P and the red blood cell layer R
The operation method after the transfer to the child bag 3 and the third child bag 4 is similar to the operation method of FIG.
【００２４】次に上部押圧板１１と下部押圧板１２に押
圧板の移動制御装置４０を装着し、図４のバッグシステ
ム（ＴＯＰ ｉｎ ＢＯＴＴＯＭ ｏｕｔ方式）を用い
て、血液を各成分に分離する場合の実施例について説明
する。押圧板１１、１２の移動制御装置４０は図７に示
すように上部押圧板１１の駆動モータ４７と、その出力
軸の回転量を検出するロータリーエンコーダ４２と光学
的位置センサ４３より構成される。光学的位置センサ４
３は端点センサ４４、界面待ち位置センサ４５、原点セ
ンサ４６及び押圧板位置検出片４７より構成される。ロ
ータリーエンコーダ４２は、カップリング４８にて駆動
モータ４７の出力軸と直結されたギヤ４９に接続されて
いる。前記上部押圧板１１の移動量は駆動モータ４７に
カップリング４８とギヤ４９を介して連動した前記ロー
タリエンコーダ４２より検出され、前記光学的位置セン
サ４３により上部押圧板１１の移動量の確認、是正を行
う。下部押圧板１２にも上部押圧板１１と同様に押圧板
の移動制御装置４０が装着されるが図７においては省略
する。Next, when the movement control device 40 of the pressing plate is mounted on the upper pressing plate 11 and the lower pressing plate 12, and the blood is separated into each component by using the bag system (TOP in BOTTOM out system) of FIG. An example will be described. As shown in FIG. 7, the movement control device 40 for the pressing plates 11 and 12 includes a driving motor 47 for the upper pressing plate 11, a rotary encoder 42 for detecting a rotation amount of an output shaft thereof, and an optical position sensor 43. Optical position sensor 4
Reference numeral 3 denotes an end point sensor 44, an interface waiting position sensor 45, an origin sensor 46, and a pressing plate position detecting piece 47. The rotary encoder 42 is connected to a gear 49 that is directly connected to an output shaft of a drive motor 47 by a coupling 48. The amount of movement of the upper pressing plate 11 is detected by the rotary encoder 42 interlocked with the drive motor 47 via a coupling 48 and a gear 49, and the optical position sensor 43 confirms and corrects the moving amount of the upper pressing plate 11. I do. A movement control device 40 for the pressing plate is mounted on the lower pressing plate 12 as well as the upper pressing plate 11, but is omitted in FIG.
【００２５】光学的位置センサ４３（下部押圧板１２の
光学的位センサは図示せず）は、上部押圧板１１の補助
押圧板１０となす隙間がある定められた値にある時、セ
ンサがＯＮするように設置されているため、例えば上部
押圧板１１が初期位置（原点センサ４６がＯＮ、隙間は
５４ｍｍ）より、補助押圧板１０の方向へ移動した時、
その移動量をロータリーエンコーダ４２で検出し、界面
待ち位置まで到達した時、（界面待ち位置センサ４５が
ＯＮ、隙間は１１ｍｍ）、ロータリーエンコーダ４２で
検出され主制御部２５で演算された上部押圧板１１と補
助押圧板１０との隙間が例えば１１．５ｍｍであったと
しても、これは機械的な誤差があると判断し、予め界面
待ち位置センサ４５の隙間設定値である１１ｍｍを正常
隙間として是正する機能をもつ。The optical position sensor 43 (the optical position sensor of the lower pressing plate 12 is not shown) is turned on when a gap between the upper pressing plate 11 and the auxiliary pressing plate 10 is at a predetermined value. For example, when the upper pressing plate 11 moves from the initial position (the origin sensor 46 is ON and the gap is 54 mm) in the direction of the auxiliary pressing plate 10,
When the amount of movement is detected by the rotary encoder 42 and reaches the interface waiting position (the interface waiting position sensor 45 is ON, the gap is 11 mm), the upper pressing plate detected by the rotary encoder 42 and calculated by the main control unit 25. 11 and even the gap between the auxiliary pressing plate 10 was 11.5mm example, it determines that there is a mechanical error, the 11mm in advance gap set value of the surfactant waiting position sensor 4 5 as a normal clearance Has a function to correct.
【００２６】遠心分離で血漿層Ｐ、界面層Ｉ、赤血球層
Ｒに分離した親バッグ１を補助押圧板１０と平行にかつ
同一距離に配置した上部押圧板１１及び下部押圧板１２
の間に係止する。血液成分の分離開始と同時に親バッグ
１の上部と下部に連結されたチューブ２１ａ、２１ｃの
途中に配置されたクランプ５、６を開いて上部押圧板１
１及び下部押圧板１２を補助押圧板１０の方向へ移動量
が同一比率となるように押圧移動させる。親バッグ１の
上部、下部より排出された血液成分は各々秤量器１６、
１４で秤量され、各々の血液成分比重で除算され、移動
容量として管理される。即ち、親バッグ１上部より排出
された血漿重量ＷP ［ｇ］は、血漿比重ρP （標準的に
は１．０２７）、親バッグ１下部より排出された赤血球
重量ＷR ［ｇ］は、赤血球比重ρR （標準的には１．０
９６）で除算され、ｎ（ＷP ／ρP ）＝ＷP ／ρRとな
るように親バッグ１上部、下部に連結されたチューブの
２１ａ、２１ｃの流路に配設されたクランプ５、６をＯ
Ｎ／ＯＦＦ制御する。An upper pressing plate 11 and a lower pressing plate 12 in which the parent bag 1 separated into a plasma layer P, an interface layer I, and an erythrocyte layer R by centrifugal separation are arranged parallel to and at the same distance from the auxiliary pressing plate 10.
Lock between. Simultaneously with the start of blood component separation, the clamps 5 and 6 arranged in the middle of the tubes 21a and 21c connected to the upper and lower portions of the parent bag 1 are opened to open the upper pressing plate 1
1 and the lower pressing plate 12 are pressed and moved in the direction of the auxiliary pressing plate 10 so that the moving amounts are the same ratio. The blood components discharged from the upper and lower portions of the parent bag 1 are respectively weighed by a weighing device 16,
It is weighed at 14, divided by the specific gravity of each blood component, and managed as a transfer volume. That is, the plasma weight W P [g] discharged from the upper part of the parent bag 1 is the plasma specific gravity ρ P (typically 1.027), and the red blood cell weight W R [g] discharged from the lower part of the parent bag 1 is Red blood cell specific gravity ρ R (typically 1.0
Divided by 96), n (W P / ρ P) = W P / ρ R become as parent bag 1 top tube 21a connected to the lower clamp 5 disposed in a flow path of 21c, 6 to O
N / OFF control is performed.
【００２７】この上部押圧板１１と下部押圧板１２が、
補助押圧板１０となす距離を同一かつ平行に移動させ、
親バッグ１上部、下部より排出された血液成分の容量が
ｎ対１となるようにクランプ５、６をＯＮ／ＯＦＦ制御
することにより、遠心分離後の親バッグ１内の界面層Ｉ
の位置の変動を最小限に抑制して血液製剤の調整が可能
となる。上部押圧板１１と下部押圧板１２の補助押圧板
１０となす距離（隙間）が設定された距離に到達した
後、親バッグ１下部のクランプ６を閉止して、下部押圧
板１２を補助押圧板１０の方向へ移動させ、上部押圧板
１１あるいは下部押圧板１２、補助押圧板１０に配置さ
れた光学的位置センサ４３で界面層Ｉを検出するまで、
上層の血漿Ｐを排出することも可能であり、更にその
後、親バッグ１上部のクランプ５を閉止し、親バッグ１
下部のクランプ６を開放して、下層の赤血球Ｒを排出
し、血漿製剤中の血漿Ｐ及び赤血球製剤中の赤血球Ｒ
の、全血よりの回収率を高める分離も可能である。The upper pressing plate 11 and the lower pressing plate 12
By moving the distance between the auxiliary pressing plate 10 and the same and in parallel,
By controlling ON / OFF of the clamps 5 and 6 so that the volume of the blood component discharged from the upper and lower portions of the parent bag 1 becomes n: 1, the interface layer I in the parent bag 1 after centrifugation is performed.
Thus, the blood product can be adjusted while minimizing the fluctuation of the position of the blood product. After the distance (gap) between the upper pressing plate 11 and the lower pressing plate 12 and the auxiliary pressing plate 10 reaches a set distance, the clamp 6 below the parent bag 1 is closed, and the lower pressing plate 12 is moved to the auxiliary pressing plate. 10 until the interface layer I is detected by the optical position sensor 43 disposed on the upper pressing plate 11 or the lower pressing plate 12 and the auxiliary pressing plate 10.
It is also possible to discharge the plasma P in the upper layer, and then close the clamp 5 on the upper part of the parent bag 1 and
The lower clamp 6 is opened to discharge the lower erythrocyte R, and the plasma P in the plasma preparation and the erythrocyte R in the erythrocyte preparation are released.
However, it is also possible to separate the whole blood so as to increase its recovery rate.
【００２８】本実施例は秤量器１６と秤量器１４の重
量変化がそれぞれ一定になるように制御する方法と、
上部押圧板１１と補助押圧板１０間の間隙及び下部押圧
板１２と補助押圧板１０の間隙を一定にする方法を同時
制御後、 上部押圧板１１及び下部押圧板１２に設定し
た光センサＳにより制御する方法により分離を終了させ
る。In this embodiment, the weight of the weighing device 16 and the weighing device 14 is
A method of controlling the amount change to be constant, and
Gap between upper pressing plate 11 and auxiliary pressing plate 10 and lower pressing
At the same time, the method for keeping the gap between the plate 12 and the auxiliary pressing plate 10 constant
After control, Set the upper pressing plate 11 and the lower pressing plate 12
The separation by the method controlled by the light sensor S
You.
【００２９】[0029]
【発明の効果】Ｔｏｐ ｉｎ Ｂｏｔｔｏｍ ｏｕｔ方
式のバッグシステム分離において、遠心分離後の親バッ
グ内の界面層の位置を上昇、下降させることなくバッグ
上部より血漿層を、バッグ下部より赤血球層を排出させ
るので、血漿製剤、赤血球製剤中への界面層、特に白血
球、リンパ球の混入の少ない良質の血液製剤が製造可能
となるIn the bag system separation of the Top in Bottom out system, the plasma layer is discharged from the upper part of the bag and the red blood cell layer is discharged from the lower part of the bag without raising or lowering the position of the interface layer in the parent bag after centrifugation. Therefore, it is possible to produce a high-quality blood product with less interfacial layer in plasma products and erythrocyte products, in particular, leukocytes and lymphocytes.
【図１】本発明の血液成分分離装置の概略図FIG. 1 is a schematic diagram of a blood component separation device of the present invention.
【図２】血液成分分離装置のブロック図FIG. 2 is a block diagram of a blood component separation device.
【図３】本発明に使用されるバッグシステムの概略図FIG. 3 is a schematic diagram of a bag system used in the present invention.
【図４】本発明に使用されるバッグシステムの概略図FIG. 4 is a schematic diagram of a bag system used in the present invention.
【図５】押圧部のその他の実施例を示す概略図FIG. 5 is a schematic view showing another embodiment of the pressing portion.
【図６】押圧部のその他の実施例を示す概略図FIG. 6 is a schematic view showing another embodiment of the pressing portion.
【図７】押圧板の移動制御装置の概略図FIG. 7 is a schematic diagram of a movement control device of the pressing plate.
１ 血液収納容器（親バッ
グ） ２ 第１の血液成分分離容器
（第１子バッグ） ３ 第２の血液成分分離容器
（第２子バッグ） ４ 第３の血液成分分離容器
（第３子バッグ） ５、６、７、８ クランプ／シ−ル ９ａ、９ｂ、９ｃ、２１ａ、２１ｂ、２１ｃ 連
結チュ−ブ １０ 補助押圧板 １１ 上部押圧板 １２ 下部押圧板 １３ 減圧室 １４、１６、１７ 秤量器 １５ 減圧／加圧室 １８、１９ 遮断開放部 ２０ 吊具 ２５ 主制御部 ３０ 血液成分分離装置 ４０ 押圧板の移動制御装置 ４１ ロッド ４２ ロータリエンコーダ ４３ 光学的位置センサ ４４ 端点センサ ４５ 界面待ち位置センサ ４６ 原点センサ ４７ 駆動モータ ４８ カップリング ４９ ギヤ Ｐ1 減圧ポンプ Ｐ2 減圧／加圧ポンプReference Signs List 1 blood storage container (parent bag) 2 first blood component separation container (first child bag) 3 second blood component separation container (second child bag) 4 third blood component separation container (third child bag) 5, 6, 7, 8 Clamp / Seal 9a, 9b, 9c, 21a, 21b, 21c Connecting tube 10 Auxiliary pressing plate 11 Upper pressing plate 12 Lower pressing plate 13 Decompression chamber 14, 16, 17 Weighing device 15 Decompression / pressurization chambers 18, 19 Shut-off opening section 20 Hanging tool 25 Main control section 30 Blood component separation device 40 Movement control device for pressing plate 41 Rod 42 Rotary encoder 43 Optical position sensor 44 End point sensor 45 Interface waiting position sensor 46 Origin sensor 47 drive motor 48 coupling 49 gear P 1 vacuum pump P 2 vacuum / pressure pump
───────────────────────────────────────────────────── フロントページの続き (72)発明者 西 方 勝 巳 神奈川県相模原市横山台１丁目26番７号 川澄化学工業株式会社 相模原事業所 内 審査官 阿部 寛 (56)参考文献 特開 平６−23037（ＪＰ，Ａ) 実開 昭57−163351（ＪＰ，Ｕ) 特公 平５−15963（ＪＰ，Ｂ２) 特公 平４−7922（ＪＰ，Ｂ２) (58)調査した分野(Int.Cl.7，ＤＢ名) A61M 1/02 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Katsumi Nishikata 1-26-7 Yokoyamadai, Sagamihara City, Kanagawa Pref. -23037 (JP, A) Japanese Utility Model Application Sho 57-163351 (JP, U) JP 5-15963 (JP, B2) JP 4-7922 (JP, B2) (58) Fields surveyed (Int. . 7, DB name) A61M 1/02
Claims (1)
を外部から減圧吸引する手段と、（ｂ）血液成分分離容
器内の重量の変化量の測定手段と、（ｃ）血液収納容器
を容量変化に応じて押圧する手段と、（ｄ）血液収納容
器（血液成分分離容器）の遠心分離処理後の血液成分の
界面の変化の検出手段と、（ｅ）血液収納容器と血液成
分分離容器の連結チューブのクランプ／シール手段、
（ｆ）血液成分分離容器を外部から減圧吸引または加圧
する手段、（ｇ）前記各手段（ａ）から（ｆ）を連動制
御する主制御部とからなり、 前記（ｃ）の押圧手段は、補助押圧板１０と上部押圧板
１１及び下部押圧板１２と上部押圧板１１及び下部押圧
板１２の移動制御装置４０とからなり、該移動制御装置
４０は、上部押圧板１１及び下部押圧板１２の駆動モー
タ４７と、上部押圧板１１及び下部押圧板１２の移動量
を検出するロータリーエンコーダ４２と、上部押圧板１
１及び下部押圧板１２の移動量の確認、是正を行う光学
的位置センサ４３とから構成され、前記光学的位置センサ４３は、界面待ち位置センサ４
５、原点センサ４６及び押圧板位置検出片４７より構成
されている ことを特徴とする血液成分分離装置。1. A blood storage container (blood component separation container)
(B) means for measuring the amount of change in the weight in the blood component separation container, (c) means for pressing the blood storage container in accordance with a change in volume, and (d) blood storage container (E) means for detecting a change in the interface of blood components after centrifugation of the (blood component separation container); (e) means for clamping / sealing the connection tube between the blood storage container and the blood component separation container;
(F) means for externally depressurizing or suctioning or pressurizing the blood component separation container, (g) a main control unit for controlling the respective means (a) to (f) in an interlocked manner. It comprises an auxiliary pressing plate 10, an upper pressing plate 11, a lower pressing plate 12, and a movement control device 40 for the upper pressing plate 11 and the lower pressing plate 12. A drive motor 47, a rotary encoder 42 for detecting the amount of movement of the upper pressing plate 11 and the lower pressing plate 12, and an upper pressing plate 1
1 and an optical position sensor 43 for confirming and correcting the amount of movement of the lower pressing plate 12. The optical position sensor 43 is an interface waiting position sensor 4.
5. Composed of origin sensor 46 and pressing plate position detecting piece 47
Blood component separation apparatus characterized by being.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21429394A JP3184052B2 (en) | 1994-08-17 | 1994-08-17 | Blood component separation device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21429394A JP3184052B2 (en) | 1994-08-17 | 1994-08-17 | Blood component separation device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0857040A JPH0857040A (en) | 1996-03-05 |
| JP3184052B2 true JP3184052B2 (en) | 2001-07-09 |
Family
ID=16653332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP21429394A Expired - Lifetime JP3184052B2 (en) | 1994-08-17 | 1994-08-17 | Blood component separation device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3184052B2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1675600A (en) * | 1998-12-24 | 2000-07-31 | Biosafe S.A. | Blood separation system particularly for concentrating hematopoietic stem cells |
| US6348156B1 (en) * | 1999-09-03 | 2002-02-19 | Baxter International Inc. | Blood processing systems and methods with sensors to detect contamination due to presence of cellular components or dilution due to presence of plasma |
| US7806865B1 (en) * | 2009-05-20 | 2010-10-05 | Alcon Research, Ltd. | Pressurized irrigation squeeze band |
-
1994
- 1994-08-17 JP JP21429394A patent/JP3184052B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0857040A (en) | 1996-03-05 |
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