JP3143694B2 - 血小板活性の測定 - Google Patents

血小板活性の測定

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Publication number
JP3143694B2
JP3143694B2 JP06500887A JP50088794A JP3143694B2 JP 3143694 B2 JP3143694 B2 JP 3143694B2 JP 06500887 A JP06500887 A JP 06500887A JP 50088794 A JP50088794 A JP 50088794A JP 3143694 B2 JP3143694 B2 JP 3143694B2
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JP
Japan
Prior art keywords
platelets
thrombin
amount
sample
enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP06500887A
Other languages
English (en)
Japanese (ja)
Other versions
JPH06509479A (ja
Inventor
ヘムカー，ヘンドリック，ツェー
ヴァーゲンフォート，ローバート，イォット
Original Assignee
バクスター、ダイアグノスチックス、インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by バクスター、ダイアグノスチックス、インコーポレイテッド filed Critical バクスター、ダイアグノスチックス、インコーポレイテッド
Publication of JPH06509479A publication Critical patent/JPH06509479A/ja
Application granted granted Critical
Publication of JP3143694B2 publication Critical patent/JP3143694B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96444—Factor X (3.4.21.6)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/04—Phospholipids, i.e. phosphoglycerides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP06500887A 1992-06-03 1993-06-03 血小板活性の測定 Expired - Lifetime JP3143694B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/892,865 US5266462A (en) 1992-06-03 1992-06-03 Measurement of platelet activities
US892,865 1992-06-03
PCT/US1993/005436 WO1993024840A1 (en) 1992-06-03 1993-06-03 Measurement of platelet activities

Publications (2)

Publication Number Publication Date
JPH06509479A JPH06509479A (ja) 1994-10-27
JP3143694B2 true JP3143694B2 (ja) 2001-03-07

Family

ID=25400634

Family Applications (1)

Application Number Title Priority Date Filing Date
JP06500887A Expired - Lifetime JP3143694B2 (ja) 1992-06-03 1993-06-03 血小板活性の測定

Country Status (9)

Country Link
US (1) US5266462A (de)
EP (1) EP0605674B1 (de)
JP (1) JP3143694B2 (de)
AT (1) ATE162632T1 (de)
AU (1) AU658073B2 (de)
CA (1) CA2114719C (de)
DE (1) DE69316572T2 (de)
ES (1) ES2114053T3 (de)
WO (1) WO1993024840A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9306053D0 (en) * 1993-03-24 1993-05-12 Nycomed Pharma As Method and assay
EP0772778B1 (de) 1994-07-23 1999-10-27 Roche Diagnostics GmbH Verfahren zur bestimmung des präthrombotischen status
US5763199A (en) * 1994-09-29 1998-06-09 Mount Sinai School Of Medicine Of The City University Of New York Platelet blockade assay
US6221672B1 (en) 1996-04-30 2001-04-24 Medtronic, Inc. Method for determining platelet inhibitor response
DE29723808U1 (de) * 1996-04-30 1999-11-04 Medtronic Inc Vorrichtung zur Bestimmung der Blutplättcheninhibitor-Ansprechempfindlichkeit
US5951951A (en) * 1997-04-30 1999-09-14 Medtronic, Inc. Platelet function evaluation technique for citrated whole blood
US6010911A (en) * 1997-04-30 2000-01-04 Medtronic, Inc. Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
WO1999002992A1 (en) * 1997-07-11 1999-01-21 The Mount Sinai School Of Medicine Of The City University Of New York Assays for diagnosis of thrombophilic disease
US20040219682A1 (en) * 1997-09-18 2004-11-04 Ridgway Helen Jane Single-tube method and system for platelet function analysis
US20040219681A1 (en) * 1997-09-18 2004-11-04 Ridgway Helen Jane Two-tube method and system for platelet function analysis using platelet count
US6410337B1 (en) * 1997-09-18 2002-06-25 Helena Laboratories Corporation Method of platlet function analysis using platelet count
JP2002506038A (ja) * 1998-03-10 2002-02-26 バクスター・インターナショナル・インコーポレイテッド トロンビン調製およびトロンビン産物ならびにそれを使用するフィブリンシーラント方法
WO2001044493A2 (en) * 1999-12-15 2001-06-21 Pentapharm Ag Hematological assay and reagent
WO2004024026A2 (en) * 2002-09-10 2004-03-25 Ericson Daniel G Method and device for monitoring platelet function
US20070243632A1 (en) * 2003-07-08 2007-10-18 Coller Barry S Methods for measuring platelet reactivity of patients that have received drug eluting stents
US7790362B2 (en) * 2003-07-08 2010-09-07 Accumetrics, Inc. Controlled platelet activation to monitor therapy of ADP antagonists
US7422905B2 (en) 2004-02-27 2008-09-09 Medtronic, Inc. Blood coagulation test cartridge, system, and method
US7439069B2 (en) 2004-02-27 2008-10-21 Nippoldt Douglas D Blood coagulation test cartridge, system, and method
US7399637B2 (en) 2004-04-19 2008-07-15 Medtronic, Inc. Blood coagulation test cartridge, system, and method
WO2005111231A2 (en) * 2004-05-11 2005-11-24 Heptest Laboratories, Inc. Compositions, kit and one-step method for monitoring compounds having anti-factor xa and/or anti factor iia activities
EP1747451B1 (de) * 2004-05-17 2011-11-02 Medtronic, Inc. Point-of-care-heparinbestimmungssystem
US20060269978A1 (en) * 2005-04-25 2006-11-30 Haworth William S Method and device for monitoring platelet function
WO2008070324A2 (en) * 2006-10-25 2008-06-12 Placor, Inc. Methods and devices for monitoring platelet function

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4900679A (en) * 1983-01-26 1990-02-13 University Of Medicine And Dentistry Of New Jersey Method for determining the existence and/or the monitoring of a pathological condition in a mammal and a test kit therefor
US4728660A (en) * 1984-06-11 1988-03-01 University Of Miami Method of treating diseases arising from platelet hyperactivation
DE3533516A1 (de) * 1984-09-21 1986-04-03 Boehringer Ingelheim KG, 6507 Ingelheim Blutgerinnungshemmende proteine, verfahren zur herstellung sowie deren verwendung
US5066788A (en) * 1984-09-21 1991-11-19 Boehringer Ingelheim International Gmbh Blood coagulation inhibiting proteins, processes for preparing them and their uses
US4871677A (en) * 1985-02-25 1989-10-03 Hemotec, Inc. Method of collecting and analyzing a sample of blood when monitoring heparin therapy
US5017556A (en) * 1986-11-04 1991-05-21 Genentech, Inc. Treatment of bleeding disorders using lipid-free tissue factor protein
US4880788A (en) * 1987-10-30 1989-11-14 Baylor College Of Medicine Method for preventing and treating thrombosis
US5120537A (en) * 1989-06-14 1992-06-09 Oklahoma Medical Research Foundation Factor xa based anticoagulant compositions

Also Published As

Publication number Publication date
JPH06509479A (ja) 1994-10-27
AU658073B2 (en) 1995-03-30
ES2114053T3 (es) 1998-05-16
EP0605674B1 (de) 1998-01-21
DE69316572D1 (de) 1998-02-26
EP0605674A1 (de) 1994-07-13
ATE162632T1 (de) 1998-02-15
WO1993024840A1 (en) 1993-12-09
CA2114719C (en) 1997-08-26
CA2114719A1 (en) 1993-12-09
DE69316572T2 (de) 1998-09-10
AU4409093A (en) 1993-12-30
US5266462A (en) 1993-11-30

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