JP3053480B2 - Animal bite prevention paint composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a coating composition having the property of preventing biting by animals, and is used for preventing biting by rats and other animals.

[0002]

2. Description of the Related Art Prevention of damage to agriculture and forestry by rats and other animals, prevention of intrusion into commercial buildings, condominiums, houses, food warehouses, factories, electrical facilities, communication facilities,
Various repellents have been reported as one of the effective means for preventing bite in packaging materials, electric wires, telephone wires, signal / communication cables, computer facilities, etc., and some of them are actually used. For example, cycloheximide, ZAC (complex of zinc dimethyldithiocarbamate and cyclohexylamine), trialkyltin compound and the like are used as repellents to be treated on the surface of natural resin and synthetic resin, and cycloheximide is used as a repellent that can be mixed with resins. , ZA
C, R-55 (tertiary butylsulfenyl dithiocarbamate) and the like.

[0003] Capsaicins have also been mixed in paints in the past and applied to objects to be used as repellents for protecting plants from wild rats, hares, etc., and children biting or licking objects. There have been attempts to prevent lead poisoning (due to lead-containing paints). This is based on the pungency or irritation of capsaicins.

[0004]

SUMMARY OF THE INVENTION Capsaicins are extremely pungent and irritating, have drawbacks that they are difficult to handle, and are not often used, so that a safe use method is desired. The objective of this study is to develop a capsaicin-type microcapsule that can prevent animal bite with a smaller amount from animal and to develop an animal bite prevention paint that is easy to use without affecting the paint film after coating. The present invention was completed by conducting research on chemical conversion.

[0005]

In order to solve the above-mentioned problems, the present inventors have found that capsaicins have intense pungency and irritation and are difficult to handle, but have excellent repellency to animals. Focusing on the fact that it is present in the natural world and in foods, as a result of intensive research, it has been found that capsaicins are used as the core substance and that the particle size is 90% in the range of 5 μm to 100 μm.
The capsaicin is contained in the paint as it is as described above and the microcapsule preparation of the melamine resin film having an average particle size of 15 μm to 50 μm is contained in the paint, or other than the melamine resin film. Compared with the case where the preparation microencapsulated with the membrane material was used in a paint, the effect of preventing animal bite was enhanced. The pungency and irritancy were reduced as compared with the case where capsaicin was directly contained in the paint or the preparation microencapsulated with a film material other than the melamine resin film was used in the paint. If capsaicin is contained in the oil-based paint as it is, or when a formulation microencapsulated with a film material other than the melamine resin film is used in the oil-based paint, the hardening of the coated film is hindered and the coated surface is sticky forever, The coating containing the microcapsule preparation of the melamine resin film had no effect on the curing of the coating film. Hereinafter, the present invention will be described in detail.

[0006] The present invention relates to a paint composition for preventing animal bite, which comprises capsaicin represented by the formula (1) as a core substance and microcapsules coated with the core substance with a melamine resin film.

[0007]

Embedded image (In the formula, R represents an alkyl group or an alkenyl group having 7 to 12 carbon atoms.)

The more preferable R in the formula (1) include, but are not limited to, those having 7 to 10 carbon atoms as shown below.

Wherein R is CH ₃ (CH ₂ ) _6- (caprylic acid vanillylamide), and R is CH ₃ (CH ₂ )
₇ - one (Noni Rick A Sid vanillylamide), R is CH ₃ (CH _{2) 8} - one (Desi Rick A Sid vanillylamide) of, R is _{(CH 3) 2 CH (CH} 2) 5 - ones (Nordihydrocapsaicin I), where R is (CH ₃ ) ₂
CH (CH ₂ ) _6- (dihydrocapsaicin),
R is (CH ₃ ) ₂ CH (CH ₂ ) ₇ — (homodihydrocapsaicin I), and R is CH ₃ CH ₂ CH (C
_{H 3) (CH 2) 4} - one (nordihydrocapsaicin), R is _{CH 3 CH 2 CH (CH 3} ) (CH 2) 6
-(Homodihydrocapsaicin), wherein R is (CH
₃ ) ₂ CHCH ＝ CH (CH ₂ ) ₄ — (capsaicin), where R is (CH ₃ ) ₂ CHCH ₂ CH ＝ CH (CH
_{2) 4} - one (homocapsaicin I), R is CH ₃ C
H ₂ CH (CH ₃ ) CH ＝ CH (CH ₂ ) ₄ — (homocapsaicin).

The compound of the formula (1) of the present invention can also be extracted from capsicum, and the capsicum extract can be obtained as follows.

The dried and pulverized pepper is converted into an alcohol-based solvent such as methanol and ethanol, an ether-based solvent such as ethyl ether, a ketone-based solvent such as acetone, an aromatic-based solvent such as benzene, and a chlorine-based solvent such as dichloroethane and chloroform. After extraction and filtration, the filtrate is heated by an evaporator and reduced in pressure to remove the solvent, thereby obtaining a pepper extract. In addition, a capsicum extract containing a higher concentration of capsaicin can be obtained by using this extract by column chromatography using silica gel or alumina.

The concentration of capsaicins in the microcapsule preparation used in the present invention is generally effective at 0.01 to 10%, preferably 0.1 to 5%, based on the whole coating composition. Should be determined in consideration of the efficacy and economics.

[0013] The advantages of capsaicins being preliminarily converted into microcapsules of a melamine resin film and contained in a paint are as follows. That is, capsaicins are
It has strong pungency and irritation, and has drawbacks that it is difficult to handle. However, capsaicins microencapsulated with a melamine resin film are advantageous without any problems. In addition, when capsaicin is directly or simply microencapsulated and mixed into a coating and applied to electric wires, cables, etc., there is a disadvantage that the coating is not cured and the coated surface is sticky forever. There was no problem when the microencapsulated capsaicins were mixed in the paint.

Further, although the pungency and irritation were suppressed and the handling became easier, it was confirmed that the effect of preventing bites against rats was not suppressed but rather increased.
This is presumed to be due to the fact that the capsule membrane was destroyed when the rodents bite the target, and the high concentration of capsaicin in the capsule became intense pungent and stimulated to work more effectively.
The method of microencapsulation of capsaicins with a melamine resin film may be microencapsulation by a known in situ polymerization method, and the resin used as a wall material may be a commercially available initial polymerized product, or melamine and formalin may be converted to an alkali. A melamine formaldehyde precondensate obtained by heating under the region may be used.

In microencapsulation, the core substance is preferably in a liquid state. In this case, the core substance may be in a liquid state by heating, or may be in a liquid state by dissolving capsaicins in a solvent. , Ethers such as ethyl vinyl ether, heptane, aliphatic hydrocarbons such as xylene, aromatic hydrocarbons such as dichloromethane and trichloroethane, mineral oils such as machine oil, vegetable oils, phthalate esters, adipate esters, Examples include, but are not limited to, solvents mainly used as plasticizers for resins, such as low molecular weight epoxy compounds such as phosphate esters and maleate esters.

In a microencapsulation method using an in situ polymerization method in which a core substance is dispersed in water as fine particles and a film is formed on the surface of the particles, a dispersant is used to control the dispersed particles and to perform efficient encapsulation. Play an important role. As the dispersant, a water-soluble one is used, for example,
Acrylic acid polymer, (meth) acrylic acid copolymer (copolymer with acrylic ester such as methyl acrylate, acrylamide, acrylonitrile, styrenesulfonic acid, vinyl acetate, etc.), maleic acid copolymer (styrene ,
Copolymers with ethylene, propylene, methyl vinyl ether, vinyl acetate, isobutylene), high molecular substances such as carboxymethyl cellulose, methyl cellulose, and polyvinyl alcohol; natural polysaccharides such as xanthan gum, gum arabic, and sodium alginate; and polyoxyethylene alkyl Allyl ether, polyoxyethylene alkyl ether, polyoxyethylene alkyl ester, polyoxyethylene alkylphenyl condensate, polyoxyethylene alkylamino ether, polyoxyethylene alkylamide, polyoxyethylene polyoxypropylene block polymer, polyoxyethylene sorbitan fatty acid Surfactants such as esters, sorbitan fatty acid esters, and (alkyl) naphthalenesulfonic acid formaldehyde condensates. Al can combine one or more, usually 0.01% to 10% relative to the total system for dispersing the core material, preferably using 0.1 to 5.0%.

As a method of use, a predetermined amount of these dispersants is dissolved in water to be used, and a poorly water-soluble or water-insoluble core substance is added thereto with stirring, or the mixture is stirred after addition. Create a distributed system. However, the surfactant soluble in the core substance may be dissolved in the core substance.

In general, the microencapsulation step by the in situ polymerization method includes (1) a step of preparing a dispersion system by suspending capsaicins in water, and (2) reacting a film agent on the surface of the dispersed particles. Is divided into two stages of a polymerization reaction step of preparing microcapsules by a resin film, and the particle diameter of the microcapsules is almost determined in the step of preparing the dispersion system of (1), and extremely small in the polymerization reaction step of (2). The particle size is hardly affected as long as the stirring is performed normally instead of the rapid stirring. Therefore, it is important to select a dispersant, a stirring method (a stirrer, a stirring speed, and the like) and the like in accordance with the design of the capsule particles in the step of preparing the dispersion system.
Further, if necessary, other auxiliary agents such as an antioxidant for preventing the oxidation of capsaicins can be included.

The microcapsule preparation which can be used in the present invention is a powder containing at least 1% (by weight), preferably 5% to 80% (by weight) of capsaicins. Is a spray dryer,
Any method such as a multi-stage hot air dryer and a vacuum dryer may be used,
There is no particular limitation. In addition, when using with water-based paint,
In particular, it can be used without drying. Also,
The weight ratio of the core material to the membrane material in the microcapsules is usually 1: 0.01 to 1:10, preferably 1: 0.1 to 1: 2.
, But is not particularly limited to this range.

Further, the average particle size of the microcapsules varies depending on the needs and is usually adjusted to be in the range of 1 to 150 μm. Over 90% in the range,
Further, it is preferable to adjust the average particle size to 15 μm to 50 μm. The particle size is adjusted by adjusting the viscosity of the core material, the temperature at the time of dispersion,
It is affected by the dispersing device, its rotational speed / number of revolutions, dispersing time, type of dispersant and the amount added. For example,
When obtaining 1 liter of dispersion (dispersion system) in a 1 liter household mixer, the temperature of the dispersion is 20 to 50 ° C.
The desired particle size can be obtained by performing the treatment at 1,000 to 1500 rpm for 5 minutes. When a 1-liter dispersion (dispersion system) is obtained in a 1-liter round bottom flask, a stirring blade having a length of 7 cm is used, the temperature of the dispersion is 50 to 85 ° C., and the rotation speed is 500 rpm. ~
The desired particle size is obtained by treating at 700 rpm for 30 minutes.

In the coating composition of the present invention, the coating into which the microcapsules of capsaicin are mixed is not particularly limited. For example, looking at the classification by raw materials, there are oil-based paints, alcoholic paints, cellulose paints, synthetic resin paints, water-based paints, lacquer-based paints, and rubber-based paints.
For natural oil varnish, synthetic resin varnish, cellulose paint, clear lacquer, lacquer enamel, synthetic resin paint for water-based paint varnish, synthetic resin enamel, emulsion polymerization paint for boil oil, oil paint, oil varnish, enamel, alcoholic paint Water-based paints include water-based paints, emulsion oil paints, emulsion polymerization paints, lacquer-based paints include lacquer and cashew varnishes, and rubber-based paints include synthetic rubber paints such as chlorinated rubber paints and SBR.

Among them, synthetic resin varnishes can be mentioned. Among them, phenol resin varnish, phthalic acid resin varnish, maleic acid resin varnish, urea resin varnish, melamine resin varnish, vinyl resin varnish, epoxy resin varnish , Silicone resin varnish, furanic acid resin varnish, and polyester resin varnish. Among them, vinyl resin varnish is particularly useful, and examples thereof include vinyl acetate resin varnish, vinyl chloride vinyl acetate copolymer varnish, styrene resin varnish, acrylate resin varnish, and polyvinyl butyral varnish.

Among these paints, practically, plasticizers, drying agents, curing agents, dispersants,
An anti-skinning agent, a thickening agent, a leveling agent, an anti-sagging agent, a fungicide, an ultraviolet absorber or a pigment may be mixed or added.

The paint for preventing animal bite in which the above-mentioned paint is mixed with microcapsules of capsaicins is used as it is, such as a PVC sheet used for communication, signal, power, electric wire and cable covering, a flexible container and the like, or a paper bag, a wall cloth, or the like. Applied to interior and exterior materials for construction, used as animal bite prevention cable, animal bite prevention flexible container, animal bite prevention paper bag, animal bite prevention cloth, animal bite prevention interior and exterior material respectively You can do it.

As a method of applying the animal bite prevention paint to an object to obtain a processed product for animal bite prevention, a commonly used coating method may be used, for example, brushing,
It may be applied by applying a printing technique such as spray coating, electrostatic coating, electrodeposition or screen printing, or by applying various coating machines such as a blade coater, a gravure coater, and an air knife coater. In these animals咬害prevention coatings may be well preferably about 0.05g~0.8g / m ² coating if about 0.01g~2g / m ² coated at a coverage of capsaicin compounds, paints The content of the capsaicin in the capsaicin microcapsules and the content of the capsaicin microcapsules when mixed into the paint may be appropriately determined in consideration of the economy and the function of the coating film.

[0026]

The present invention will be described below in more detail with reference to examples and experimental examples.

Example 1 Nonionic acid vanillylamide (80 parts) was dissolved in dioctyl phthalate (51.5 parts), and the resulting solution was dissolved in a styrene maleic anhydride resin together with a small amount of sodium hydroxide. 5 in 150 parts of a 3% aqueous solution
Put into a 00 ml round bottom flask, length 7c
m, and the dispersion was processed at a temperature of 85 ° C. and a rotation speed of 700 rpm for 30 minutes to prepare an O / W emulsion. On the other hand, 160 parts of a 50% aqueous solution of a melamine formalin prepolymer aqueous solution “SUMIREZRESIN 613” (trade name, manufactured by Sumitomo Chemical Co., Ltd.) was dropped into the emulsion while stirring at a rotation speed of 350 rpm.
Stirring was continued for an hour to prepare microcapsules in suspension of the melamine resin film in water. The particle size of this microcapsule is
94% in the range of 5 μm to 100 μm, and the average particle size is 2
It was 5 μm. Dry this with a spray dryer,
A microcapsule containing 40% nonylic acid vanillylamide was obtained.

One part of this microcapsule was used in Comparative Example 1 described below.
Was mixed uniformly with the oil-based paint of No. 1 to prepare a paint containing 0.4% of nonylic acid vanillylamide.

Example 2 In the dispersion of Example 1, the rotational speed was set at 700 rpm to 100
The mixture was treated at 0 rpm for 30 minutes to obtain an O / W emulsion, and microcapsules in suspension of a melamine resin film in water were prepared in the same manner as in Example 1. The particle size of the microcapsules is 83% in the range of 5 μm to 100 μm.
And the average particle size was 11 μm. This was dried in the same manner as in Example 1 and mixed with an oil-based paint to prepare a paint containing 0.4% of nonylic acid vanillylamide.

Example 3 80 parts of the nonionic acid vanillylamide of Example 1 was
Substituting with 80 parts of capsaicin, a microcapsule containing 40 parts of capsaicin was obtained in the same manner as in Example 1. The particle size of the microcapsules is 5 μm to 10
95% was in the range of 0 μm, and the average particle size was 35 μm. This was mixed with an oil paint in the same manner as in Example 1 to prepare a paint containing 0.4% of capsaicin.

Example 4 In the decentralization of Example 3, 700 rpm was set to 10
The mixture was treated at 30 rpm for 30 minutes to obtain an O / W emulsion, and capsaicin 40 was obtained in the same manner as in Example 3.
% Was obtained. The particle size of this microcapsule is 87% in the range of 5 μm to 100 μm.
And the average particle size was 10 μm. This was mixed with an oil paint in the same manner as in Example 1 to prepare a paint containing 0.4% of capsaicin.

Example 5 One part of the microcapsule of Example 1 was mixed uniformly with the water-based coating of Control Example 2 described later to prepare a coating containing 0.4% of nonylic acid vanillylamide. did.

Example 6 One part of the microcapsules of Example 2 was mixed uniformly with the water-based coating of Control Example 2 described later to prepare a coating containing 0.4% of nonylic acid vanillylamide. did.

Example 7 One part of the microcapsule of Example 3 was mixed uniformly with the water-based coating of Control Example 2 described later to prepare a coating containing 0.4% of capsaicin.

Example 8 One part of the microcapsule of Example 4 was mixed uniformly with the water-based coating of Control Example 2 described later to prepare a coating containing 0.4% of capsaicin.

Example 9 One part of the microcapsules of Example 1 was mixed uniformly with the water-based coating of Comparative Example 2 described below to prepare a coating containing 0.2% of nonylic acid vanillylamide. did.

Comparative Example 1 Oil-based synthetic resin (alkyd resin) paint [manufactured by Asahipen Co., Ltd.]

Comparative Example 2 Aqueous synthetic resin (acrylic resin) paint [manufactured by Asahi Pen Co., Ltd.]

COMPARATIVE EXAMPLE 3 0.4 part of nonionic acid vanillylamide was mixed and dissolved in 99.6 parts of the oil-based paint of Comparative Example 1 as it was, and a paint containing 0.4% of nonylic acid vanillylamide was used. Was prepared.

Control Example 4 In 97 parts of dioctyl phthalate, 80 parts of nonylic acid vanillylamide and 15 parts of Millionate MR-400 (manufactured by Nippon Polyurethane) were dissolved and added to 300 g of a 1% aqueous solution of polyvinyl alcohol. Dispersion temperature 25 ° C,
Treated and dispersed at a rotation speed of 1000 rpm for 10 minutes,
/ W emulsion was prepared. On the other hand, 2.5 g of each of ethylenediamine and diethylenetriamine was dissolved in 95 g of water, and the above emulsion was added dropwise while stirring at a rotation speed of 250 rpm. The reaction was continued at 60 ° C. for 3 hours, and the microcapsules in water suspension of a polyurea film were suspended. Was prepared.
The particle size of the microcapsules was 96% in the range of 5 μm to 100 μm, and the average particle size was 35 μm. This was dried with a spray drier to remove water and obtain a microcapsule containing 40% nonionic acid vanillylamide. One part of this microcapsule was used as control example 1.
Was mixed uniformly with the oil-based paint of No. 1 to prepare a paint containing 0.4% of nonylic acid vanillylamide.

Control Example 5 In 97 parts of dioctyl phthalate, 80 parts of nonylic acid vanillylamide and 15 parts of sebacic chloride were dissolved.
This was added to 300 parts of a 1% aqueous solution of polyvinyl alcohol, and treated and dispersed at a rotation speed of 1000 rpm for 10 minutes to prepare an O / W emulsion. On the other hand, water 87.
5 parts of ethylenediamine, 2.5 parts of diethylenetriamine and 7.5 parts of sodium hydroxide were dissolved, and the above emulsion was added dropwise with stirring at a rotation speed of 250 rpm, and the reaction was continued at 60 ° C. for 3 hours. Microcapsules in suspension of the membrane in water were prepared. The particle size of the microcapsules is 9 μm in the range of 5 μm to 100 μm.
5%, and the average particle size was 23 μm. This was dried with a spray drier to obtain a microcapsule containing 40% nonionic acid vanillylamide. One part of this microcapsule was mixed uniformly with the oil-based paint of Comparative Example 1 to prepare a paint containing 0.4% of nonylic acid vanillylamide.

Comparative Example 6 Nonionic acid vanillylamide 40 was added to 50 parts of xylene.
And 20 parts of Newcargen 2720 × 75 (emulsifier, manufactured by Takemoto Yushi Co., Ltd.) were dissolved to obtain an emulsion containing 40% of nonylic acid vanillylamide. One part of this emulsion was mixed uniformly with the aqueous coating composition of Comparative Example 2 to prepare a coating composition containing 0.4% of nonylic acid vanillylamide.

Control Example 7 One part of the microcapsules of Control Example 4 was mixed uniformly with the water-based coating of Control Example 2 to prepare a coating containing 0.4% of nonylic acid vanillylamide. .

Control Example 8 One part of the microcapsules of Control Example 5 was mixed uniformly with the aqueous coating composition of Control Example 2 to prepare a coating containing 0.4% of nonylic acid vanillylamide. .

COMPARATIVE EXAMPLE 9 Non-ionic acid vanillylamide (0.8 part) was mixed and dissolved in 99.2 parts of the oil-based paint of Comparative Example 1 as it was, and a paint containing 0.8% of nonylic acid vanillylamide was used. Was prepared.

Test Example 1-1 Bite Prevention Effect in Rats Test sample; Examples 1, 2, 3, 4 and Control 1 Test method: Vinyl compound S containing plasticizer, pigment, etc.
Example 1, Example 2, Example 3, Example 4, and Control Example 1 were applied at 100 g / m ² on one surface of a polyvinyl chloride sheet prepared by E24 (manufactured by Mitsui Toatsu Chemicals, Inc.). 24
After drying for a period of time, the sheet was cut into a size of 75 × 150 mm, and the sheet was folded in two with the coated surface facing up. Six rat solid feeds were put in this, three sides were stapled, and used as test samples. This sample was placed in a breeding cage containing three rats weighing about 380 g and allowed to stand overnight, and the bite area of the sheet by the rat was examined. Each cage contains one control and one example.
Each was tested in five cages. Result Cage No. Bite area (cm ² ) Sample 1 2 3 4 5 Average Example 1 0 0 0 0 0 0 Example 2 0 0 0.5 0.7 0 0.24 Example 3 0 0 0.1 0 0 0.02 Example 4 0.10 0.6 0.5 0 0.24 Control Example 1 14.2 9.3 12.8 11.1 15.0 12.48 Examples 1 to 4 had a remarkable effect of preventing bite damage as compared with Control Example 1, and were practical. Further, as in Example 1 and Example 3, microcapsules having a particle size of 90% or more in the range of 5 μm to 100 μm and an average particle size of 15 μm to 50 μm are out of the above ranges for both the particle size and the average particle size. The effect of preventing bite damage was superior to the microcapsules of Examples 2 and 4.

Test Example 1-2 Bite Prevention Effect in Rats Test sample; Examples 5, 6, 7, 8 and Control 2 Test method; Test sheet prepared in the same manner as in Test Example 1-1 The rats were placed in a breeding cage and left overnight, and the bite area of the rats was examined. Result Cage number Bite area (cm ² ) Sample 1 2 3 4 5 Average Example 5 0.1 0 0 0 0 0.02 Example 6 0.4 0 0.6 0 0 0.2 Example 7 0.1 0 0 0 0 0.02 Example 8 0.7 0 0.5 0 0 0.24 Control Example 2 13.5 23.2 13.1 10.2 12.7 14.54 Examples 5 to 8 had a remarkable effect of preventing bite damage as compared with Control Example 2 and were practical. Further, as in Examples 5 and 7, microcapsules having a particle size of 90% or more in the range of 5 μm to 100 μm and an average particle size of 15 μm to 50 μm both fall outside the above ranges. The effect of preventing bite damage was superior to the microcapsules of Examples 4 and 6.

Test Example 1-3 Effect of Preventing Bite in Rats Test sample; Example 1, Controls 1, 3, 4, and 5 Test method; Test sheet prepared in the same manner as in Test example 1-1 The animals were placed in a breeding cage and left overnight, and the bite area of the sheets by the rats was examined. Result Cage No. Bite area (cm ² ) Sample 1 2 3 4 5 Average Example 1 0 0 0.2 0 0 0.04 Control 1 11.1 9.0 17.5 8.9 12.6 11.82 Control 3 8.6 9.7 11.2 10.4 12.2 10.42 Control 4 5.8 6.7 8.5 3.9 6.8 6.34 Comparative Example 5 7.1 6.2 6.1 4.4 8.7 6.5 Example 1 using microcapsules of melamine resin film
Showed a remarkable effect of preventing bite damage as compared with any of the control examples, and was practical. Control Example 4 using the microcapsules of the polyurea film and Control Example 5 using the microcapsules of the polyamide film showed a slight bite prevention effect as compared with Control Example 1, but were far inferior to Example 1. .
In Control Example 3 using the drug substance, little bite prevention effect was observed. In Control Examples 3, 4, and 5, no coating film was completely formed even after 24 hours, and stickiness was observed.

Test Example 1-4 Bite Prevention Effect on Rats Test sample; Example 5, Control examples 2, 6, 7, and 8 Test method; Test sheet prepared in the same manner as in Test example 1-1 Was placed in a breeding cage and allowed to stand overnight, and the bite area of the sheet rat was examined. Result Cage No. Bite area (cm ² ) Sample 1 2 3 4 5 Average Example 5 0 0 0 0 0 0 Control 2 10.2 11.2 12.6 10.8 14.7 11.9 Control 6 4.9 7.4 5.3 5.7 8.1 6.28 Control 7 2.7 0 1.3 0.9 0 0.98 Control Example 8 1.9 0.3 0.2 3.4 0 1.16 Example 5 Using Microcapsules of Melamine Resin Film
Showed a remarkable effect of preventing bite damage as compared with any of the control examples, and was practical. Comparative Example 7 using the microcapsules of the polyurea film and Control Example 8 using the microcapsules of the polyamide film were inferior to Example 5, but the effect of preventing bite was recognized. In Control Example 6 using the drug substance, a slight bite prevention effect was recognized as compared with Control Example 2.

Test Example 1-5 Bite Prevention Effect on Rats Test Samples; Examples 5 and 9 Control Examples 2, 6 and 9 Test Methods; Test Sheets Prepared in the Same Method as Test Example 1-1 The rats were placed in a cage and left overnight, and the area of bite damage by the rats of the sheets was examined. Results Cage No. Bite area (cm ² ) Sample 1 2 3 4 5 Average Example 5 0 0 0.2 0 0 0.04 Example 9 0 2.4 3.5 0 0.3 1.24 Control 2 21.6 15.2 8.9 19.5 10.6 15.16 Control 6 8.1 9.3 4.1 12.7 10.8 9.0 Comparative Example 9 0 2.2 4.9 0.4 3.9 2.28 Example 5 Using Microcapsules of Melamine Resin Film
Showed a remarkable effect of preventing bite damage as compared with any of the control examples, and was practical. Example 9 is also inferior to Example 5, but
A high bite prevention effect was observed. Control Example 9 containing 0.8% drug substance shows a higher anti-bite effect as compared to Control Example 2, but 0.1%.
Example 9 containing 5% microcapsules (0.2% in drug form)
Slightly inferior.

Test Example 2 Skin irritation test by human Test method: A 3 cm square sheet coated with Examples 1 to 9 and Controls 1 to 9 was stuck on the inside of a human arm and irritated for 2 hours. investigated. Result Sample Irritable erythema Sample Irritable erythema Example 1--Control 1--Example 2--Control 2--Example 3--Control 3 + + Example 4--Control 4 ± ± Example 5--Control Example 5 ± Example 6--Control Example 6 ± Example 7--Control Example 7--Example 8--Control Example 8--Example 9--Control Example 9 + + -; No irritation, erythema ± ~ ++; irritation, degree of erythema No irritation was felt in the sheets to which Examples 1 to 9 and Control Examples 1, 2, 7, and 8 were applied. Control Examples 3, 4,
In the sheets coated with Nos. 5, 6, and 9, irritation was felt shortly after adhesion, and slight erythema was observed.

[0052]

The paint containing capsaicins microencapsulated with a melamine resin film of the present invention has an excellent effect of preventing animal bite, especially when the particle size of the microcapsules is in the range of 5 μm to 100 μm. The coating containing 90% or more and microcapsules having an average particle size of 15 μm to 50 μm was more effective.

In addition, there was no effect on the curing of the coating film after application, and the irritancy and pungency to humans were remarkably reduced, and the handling became easy.

Continuation of front page (58) Field surveyed (Int.Cl. ⁷ , DB name) A01N 37/18 A01N 25/28 C09D 5/00

Claims (1)

(57) [Claims] [Claim 1] a core supplies a capsaicin compound represented by the formula (1) and covering the core material with a melamine resin film, the particle size
Is 90% or more in the range of 5 μm to 100 μm and
A coating composition for preventing animal bite, comprising macrocapsules having an average particle size of 15 μm to 50 μm . Embedded image (In the formula, R represents an alkyl group or an alkenyl group having 7 to 12 carbon atoms.)