JP3049564B2 - Indoor dust mite control agent - Google Patents

Description

Description: TECHNICAL FIELD The present invention relates to an indoor mite control agent.

[Conventional technology]

In recent years, due to changes in lifestyle and housing structure, mites such as dust mites, acarid mites and dust mites have been generated in the home, causing not only discomfort to residents but also causes such as allergic asthma and atopic dermatitis. It is becoming a social problem.

Conventionally, as a controlling agent for such mites, for example, organophosphorus compounds such as fenitrothion and diazinon, pyrethroid compounds such as resmethrin and permethrin, and the like, are directly sprayed in the form of emulsions, oils and the like. It is used for impregnating insect-proof paper, carpet and the like, smoking, and the like.

[Problems to be solved by the invention]

However, many organic phosphorus compounds are generally highly toxic and many have a peculiar odor.

Although pyrethroid compounds generally have low toxicity, they are not necessarily sufficient in terms of their effects on mites and mites.

[Means for solving the problem]

The present inventors have conducted intensive studies to solve the above problems, and as a result, 2-tert-butylimino-3-isopropyl-5-phenyl-3,4,5,6-tetrahydro-2H-1,
The inventors have found that 3,5-thiadiazin-5-one (hereinafter referred to as buprofezin) is extremely effective in controlling house dust mites, and completed the present invention.

Therefore, the indoor mite control agent of the present invention is characterized by containing buprofezin as an active ingredient.

The buprofezin used in the present invention is a known compound as an acaricide for agricultural and horticultural use in Japanese Patent Application Laid-Open No. 54-3083, but it has been known from the prior knowledge that these are effective for house dust mites. That was completely unexpected.

As indoor dust mites to be targeted in the present invention,
For example, Dermatophagoides such as Dermatophagoides farinae and Dermatophagoides farinae, Dermatophagoides farinae such as Dermatophagoides farinae, Dermatophagoides farinae, Dermatophagoides farinae such as Dermatophagoides farinae, Dermatophytes sp.

The acaricide of the present invention can be applied to the compound as it is, but it is usually preferable to use various forms such as powders, wettable powders, granules, emulsions, and the like according to the purpose of use using an appropriate carrier or other compounding agents. Used as liquids, suspensions, aerosols and the like. As a liquid carrier, water, carbon tetrachloride, methylene chloride, ethylene dichloride, ethyl alcohol, isopropyl alcohol, ethylene glycol, propylene glycol, diethyl ether, dioxane, tetrahydrofuran, acetone, cyclohexanone, ethyl acetate, dibutyl phthalate, toluene, Solvents such as xylene, kerosene, and methylnaphthalene are suitable, and one or a mixture of two or more thereof is used.

As the solid carrier, kaolin, bentonite, talc, pumice, silica, calcium carbonate, activated carbon, diatomaceous earth, vegetable powder, and the like are suitable, and one or a mixture of two or more of them is used.

As the compounding agent, a wetting agent, a spreading agent, a dispersing aid, an emulsifier, a stabilizer or a suspending agent is used, and one or a mixture of two or more of them is used. As these, those usually used in this field can be used.

The amount used in the tick control agent of the present invention is appropriately selected depending on its dosage form, application target, application method, application location, etc.
Usually, the active ingredient in the case of buprofezin, the use concentrations are used in the range of 1 m ² per 0.001 to 1 g.

(Prescription agent)

Next, prescription examples of the acaricide of the present invention are shown, but the present invention is not limited only to these.

Formulation Example 1 Compound of the present invention 50 parts Mixture of diatomaceous earth / clay 45 parts Polyoxyethylene nonylphenyl ether 5 parts The above are uniformly mixed and pulverized to obtain a wettable powder.

Formulation Example 2 20 parts of the compound of the present invention 20 parts of tetrahydrofuran 45 parts of xylene 15 parts of a mixture of polyoxyethylene nonylphenyl ether and alkylbenzenesulfonic acid are uniformly mixed and dissolved to form an emulsion.

Formulation Example 3 Compound of the present invention 4 parts Mixture of diatomaceous earth / clay / talc 95 parts Calcium stearate 1 part The above components are uniformly mixed and dissolved to form a powder.

Formulation 4 An aerosol is prepared by adding 23 parts of liquefied petroleum gas as a propellant to a solution prepared by dissolving 2 parts of the compound of the present invention and 75 parts of propylene glycol monomethyl ether to make the total amount 100 parts by volume and pressurized to form an aerosol.

〔The invention's effect〕

Next, the effects of the acaricide of the present invention will be described with reference to test examples, but the present invention is not limited thereto.

Test Example 1 A tick culture medium (mouse feed: Ebios = 1: 1) was treated with an equal volume of a twice-diluted acetone solution at a predetermined concentration and air-dried to evaporate acetone. / 100mg) mix 50mg and put into 10ml tube bottle,
Immerse the bottom of the vial in saturated aqueous potassium nitrate
The sample was stored in a constant temperature and humidity room at a temperature of 75 ° C. and a humidity of 75 to 85%. In the investigation, the number of live mites in 100 mg of the medium was counted after a predetermined number of days. Table 1 shows the results for one district and three consecutive studies.

Test Example 2 A mite medium (mouse feed: Ebios = 1: 1) was treated with an equal volume of a twice-concentrated acetone-diluted drug solution, air-dried to evaporate acetone, and 50 mg of a medium containing Dermatophagoides farinae (61.3 animals) / 100mg) mix 50mg and put into 10ml tube bottle,
Immerse the bottom of the vial in saturated aqueous potassium nitrate
The sample was stored in a constant temperature and humidity room at a temperature of 75 ° C. and a humidity of 75 to 85%. In the investigation, the number of live mites in 100 mg of the medium was counted after a predetermined number of days. Table 2 shows the results for one ward and three consecutive schools.

Test Example 3 A filter paper having a diameter of 8.5 cm in a petri dish having a diameter of 9 cm was treated with 1.5 ml of a predetermined concentration of an acetone-diluted chemical solution, air-dried to evaporate the acetone, and then a medium containing a migrating mites (5)
6.7 heads / 100mg) 100mg is spread open, cover, 28 ℃
It was stored in a constant temperature and humidity room with a humidity of 75 to 85%. In the investigation, the number of live mites in 100 mg of the medium was counted after a predetermined number of days. Table 3 shows the results for three districts in one district.

Test Example 4 A medium of mite (mouse feed: Ebios = 1: 1) was treated with an equal volume of 2 volumes of a diluted solution of acetone diluted to a predetermined concentration, air-dried to evaporate acetone, and 500 mg of a medium containing Dermatophagoides farinae (59.3 animals) 500 mg was mixed and placed in a 10-ml tube bottle, and the lower portion of the tube bottle was immersed in a saturated aqueous solution of sodium chloride and stored in a thermo-hygrostat at 28 ° C. and a humidity of 75 to 85%. In the investigation, the number of live mites in 100 mg of the medium was counted after a predetermined number of days. Table 4 shows the results for one ward and three consecutive schools.

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Claims (1)

(57) [Claims] (1) 2-tert-butylimino-3-isopropyl-5-phenyl-3,4,5,6-tetrahydro-2H
An agent for controlling indoor dust mites, comprising -1,3,5-thiadiazin-5-one as an active ingredient.