JP3026016B2 - Cleaning solution for dentures - Google Patents

Description

Description: TECHNICAL FIELD The present invention relates to a denture cleaning solution.

[Conventional technology]

Since dentures and sticky bacteria that cause plaque adhere to the dentures during use and become unsanitary, dental cleaning agents that can remove these quickly and easily are extremely difficult. is important.

However, since the denture cleaner must be safe for the living body, the components that can be used are limited, and the denture cleaners known to date include those containing a surfactant, Those containing an oxygen-based bleach, those containing a protease, and the like can be mentioned.

For example, JP-A-1-238517 discloses a denture cleaning composition comprising a specific fatty acid ester, an anionic surfactant, a nonionic surfactant and cellulose, and this composition is used for dentures. Although it can easily remove the adhered dirt in a short time, it does not have a deodorizing effect or an antibacterial effect.

In addition, a solid foamable composition is used by adding it to an aqueous medium (Japanese Patent Application Laid-Open No. 47-11596), or a mixture of a hydrogen peroxide adduct and a foamable liquid is used (Japanese Patent Application Laid-Open No. 56-14
No. 3300), but the former lacks stability against moisture, and the latter has the problem that two liquids must be mixed at the time of use. Not.

Further, Japanese Patent Application Laid-Open No. 60-87212 discloses a denture cleaning method using a combination of a lytic enzyme type detergent and an alkali oxidation type detergent, and this method is effective for dissolving and removing bacteria. However, it is very inconvenient to change the order of dentures for each liquid.

On the other hand, recently, as a composition having an antibacterial effect, Japanese Patent Publication No. 2-5792, characterized in that it contains an extract of honey bee nest, for oral cavity for prevention and treatment of dental caries and periodontal disease A composition is disclosed.

The extract of beehive's nest contained in this composition is a component called "propolis", which has excellent antibacterial properties against bacteria causing caries and periodontal disease, and gums. It has been shown that bleeding and inflammation can be suppressed. However, the composition described in Japanese Patent Publication No. 2-5729 has substantially no deodorizing effect and cannot be used as a cleaning agent for dentures.

[Problems to be solved by the invention]

It is an object of the present invention to improve the above-mentioned drawbacks, to provide a cleaning solution for dentures having an excellent detergency and an anti-odor effect and / or an antibacterial effect against bacteria growing in the oral cavity.

[Means for solving the problem]

The cleaning solution for dentures of the present invention is characterized in that it is an aqueous solution containing sucrose fatty acid esters, flavonoids and propolis as main components of the cleaning component.

Further, the present invention is also characterized in that the weight ratio of sucrose fatty acid ester: flavonoid: propolis is 10 to 70: 0.05 to 5: 0.05 to 5 in the above-mentioned tooth cleaning solution. .

Furthermore, the present invention relates to the above-mentioned denture cleaning solution,
Sucrose fatty acid esters, flavonoids and propolis were 10-70% by weight, 0.05-5% by weight and 0.05-
It is also characterized by containing 5% by weight.

The sucrose fatty acid esters used as the main component of the detergent component in the denture detergent solution of the present invention have been used as a denture detergent, but none of them are used in combination with flavonoids and propolis. The present inventors have found that an aqueous solution containing these compounds has an effect of quickly removing dirt adhering to dentures, and reached the present invention. In addition, since all of these compounds are approved as food additives, even if accidentally ingested, they do not adversely affect the human body and are safe.

Specific examples of the detergent component that can be used in the present invention include esters of sucrose and a fatty acid selected from the group consisting of lauric acid, palmitic acid, stearic acid, and oleic acid. The sucrose monolaurate having the formula (1) is preferable because of its excellent washing effect. The above detergent components may be used alone or in combination with a plurality of components (sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters). You may. or,
When polyoxyethylene sorbitan fatty acid esters are used in combination, not only can an excellent cleaning effect be obtained,
It is preferable because it acts as a perfume solubilizer when the perfume is added to the aqueous solution as needed.

On the other hand, flavonoids having a deodorizing effect are components extracted from green tea and camellia plants, and contain flavone, flavonol, tannic acid and the like, and exhibit an excellent deodorizing effect particularly on amine odor and sulfur odor. In addition, some effects of inhibiting the growth of Candida bacteria attached to the dentures are also observed.

Further, in the present invention, the propolis added for imparting the antibacterial effect is composed of 50% to 55% by weight of a varnish and aromatic balsam oil, and 30% to 40% by weight of a wax. And a small amount of flavonoids as other components. Propolis has an excellent bactericidal action against Candida bacteria, and has an excellent effect on gum bleeding, inflammation, pain, glossitis, stomatitis and the like.

In the present invention, in addition to the detergent components, the above-mentioned flavonoids and propolis are simultaneously contained, and the mixing ratio at which each component works effectively is 0.05 to 25% by weight of each of the flavonoids and propolis with respect to the detergent components. Is the ratio of In particular, those having a compounding ratio of 0.1 to 10% by weight are preferable.

The cleaning solution for dentures of the present invention is in a liquid form, and contains sucrose fatty acid esters, flavonoids and propolis in a total weight of the solution in a weight ratio of 10 to 70: 0.05 to 5: 0.05 to 5. The most preferable compounding ratio (weight ratio) is 30-50: 0.1-3: 0.1-3. At this time, if the proportion of each component in the mixed solution is smaller than the lower limit of the above range, a sufficient cleaning effect, deodorizing effect and antibacterial effect as a tooth denture cleaning agent cannot be obtained.

The cleaning solution for dentures of the present invention has an excellent cleaning effect,
Not only can a deodorizing effect and / or an antibacterial effect be obtained, but also the resin constituting the denture main body and the teeth is not deteriorated, and the solution itself is excellent in storage stability over time.

Further, in the present invention, in addition to each of the above components, at least one organic acid selected from the group consisting of lactic acid, malic acid, tartaric acid, and citric acid can be added, and these organic acids are added. Thereby, the cleaning effect can be further improved. In particular, malic acid is a sour agent for soft drinks,
Effective as a deodorant and cleaning agent, it is most suitable for addition to a denture cleaning solution. Moreover, all of these organic acids are widely used as food additives, like the above-mentioned detergents, and are safe for living bodies.

The ratio of the organic acid to be added is preferably 1 to 30% by weight based on the above-mentioned detergent component, and when it is 1% by weight or less, a sufficient cleaning effect cannot be obtained. A particularly desirable addition ratio is 1 to 20% by weight.

To the denture cleaning solution of the present invention, as another component, a fragrance component can be added in order to impart a refreshing feel after denture cleaning. And flavors such as mint flavor, lemon mint, lime mint and fruit mint which are used in foods. The amounts of these flavor components added are 10 to 70% by weight, 0.05 to 5% by weight of sucrose fatty acid esters, flavonoids and propolis, respectively.
The effect can be obtained if it is added at a ratio of 0.1% by weight or more based on the total weight of the aqueous solution containing 0.05 to 5% by weight, and 0.1 to 2% by weight is preferable.

Hereinafter, the present invention will be described in more detail with reference to Preparation Examples of the denture cleaning solution of the present invention.

〔Example〕

Example 1 Flavonoids 0.1 Propolis 2.1 Malic acid 1.0 Sucrose monolaurate 30.0 Sorbitan monolaurate 0.5 Water 66.3 Total 100.0 (All the above values represent% by weight.) After preparing a solution having the above composition 2 ml of this was taken and mixed with 180 ml of water to obtain a test solution.

Example 2 Flavonoid 0.2 Propolis 4.2 Malic acid 3.0 Sucrose monolaurate 50.0 Sorbitan monolaurate 0.5 Perfume 1.5 Water 40.6 Total amount 100.0 (The above numerical values represent weight%.) A solution having the above composition is prepared. After that, a test solution was obtained in the same manner as in Example 1.

As comparative examples, the following two types of commercially available detergents for dentures (both tablets) were used.

Comparative Example 1 Trade name: Pica (produced by Rohto Pharmaceutical Co., Ltd.) Comparative Example 2 Trade name: dent-free (produced by Lion Corporation) In Comparative Examples 1 and 2, one tablet was used and 180 ml of water was used. To give a test solution.

Using the test solutions of Examples 1 and 2 and Comparative Examples 1 and 2, the following test items were investigated.

Cleaning effect test After attaching coffee, tobacco tar and curry to the white polymethyl methacrylate resin plate,
Drying was performed to obtain a measurement sample. The measurement samples were immersed in the test solutions described in Examples 1 and 2 and Comparative Examples 1 and 2, respectively, taken out after 30 minutes, and the cleaning effect was visually evaluated.

 The evaluation criteria are as follows.

 ・ ・ ・: Cleaning effect is sufficient Δ: Cleaning effect is slightly insufficient X: No cleaning effect The results are shown in Table 1.

Deodorizing effect test The deodorizing effect of each measurement sample after cleaning by the method described above was evaluated by olfaction.

 The evaluation criteria are as follows.

○ ・ ・ ・ Sufficient deodorant effect △ ・ ・ ・ Slightly inadequate deodorant effect × ・ ・ ・ No deodorant effect Antibacterial effect test against Candida bacteria (agar overlay method) After culturing into a monolayer, an agar layer containing a culture solution is placed thereon, and the test solution described in Examples 1 and 2 and Comparative Examples 1 and 2 is placed on the solidified agar layer. And cultivation (at 37 ° C. for 24 hours).

The antibacterial effect of each sample after the culture was visually evaluated.

 The evaluation criteria are as follows.

 ・ ・ ・: Sufficient antibacterial effect △: Slightly insufficient antibacterial effect ×: No antibacterial effect The results are shown in Table 1.

Degradation test of resin and metal forming dentures Three types of resins commonly used as resin forming dentures: heat-polymerized resin (acrylic resin), immediate-polymerized resin (acrylic resin), and polysulfone resin About 1 in the test solutions of Examples 1 and 2 and Comparative Examples 1 and 2.
The deterioration with time after immersion for months was visually evaluated.

In addition, nickel as a metal used for dentures
About four kinds of metals, a chromium-based alloy, a cobalt-chromium-based alloy, a gold-silver-palladium-based alloy, and titanium, similarly to the above, the deterioration with time after being immersed in each test solution for one month was visually evaluated. .

 The evaluation criteria are as follows.

 ・ ・ ・: No deterioration ×: deterioration This result is shown in Table 2 below.

[Effect of the Invention] The denture cleaning solution of the present invention contains a sucrose fatty acid ester having an excellent cleaning effect, a flavonoid having an excellent deodorizing effect, and propolis having an especially excellent antibacterial effect against Candida bacteria. In addition, it is possible to quickly remove dirt and smell attached to the denture after use, thereby suppressing the growth of the remaining bacteria.

Moreover, the cleaning solution for dentures of the present invention does not damage the denture body and the resin constituting the teeth,
Denture does not deteriorate even after repeated use.

Further, in the present invention, an organic acid can be added. Particularly, when malic acid is used, an excellent washing effect and an odor eliminating effect can be obtained at the same time.

In addition, the components contained in the cleaning solution for dentures of the present invention include:
Since both are used for food applications, there is no need to worry about toxicity and they are safe for the human body.

In addition, in the present invention, various flavors used for foods can also be appropriately added, and in the case where such a flavor is added, a refreshing feel is imparted after washing the dentures. It will be.

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Toshio Hakata 995-4, Fukakusa-Kitagaya-cho, Fushimi-ku, Kyoto-shi, Kyoto (72) Inventor Naotoku Muromachi 31-1 Orie, Oyamazaki-cho, Otonun-gun, Kyoto (56) References JP-A-62-205016 (JP, A) JP-A-1-238517 (JP, A) JP-A-61-289025 (JP, A) JP-A-2-45413 (JP, A) JP-A-1-246215 (JP, A) JP-A-63-264516 (JP, A) JP-A-2-59513 (JP, A) JP-A-2-45414 (JP, A) Japan Patent Office, "Known and Collected Techniques (Cosmetics) And similar products) ”(Showa 59-8-21), pp. 133-146

Claims (4)

(57) [Claims] 1. A denture cleaning solution comprising an aqueous solution containing sucrose fatty acid esters, flavonoids and propolis as main components of the cleaning component. 2. Sucrose fatty acid esters: flavonoids:
The denture cleaning solution according to claim 1, wherein the weight ratio of propolis is 10-70: 0.05-5: 0.05-5. 3. The sucrose fatty acid ester, flavonoid and propolis are each contained in an amount of 10 to 70% by weight, 0.05 to 5% by weight.
The cleaning solution for dentures according to claim 1 or 2, wherein the solution is contained in an amount of 0.05 to 5% by weight. 4. The method according to claim 1, further comprising at least one organic acid selected from the group consisting of lactic acid, malic acid, tartaric acid and citric acid. Cleaning solution for dentures.