JP2997726B2 - Bandage replacement composition - Google Patents

Description

The present invention relates to bandage replacement compositions. For more information,
The present invention relates to a bandage replacement composition capable of forming a film that replaces a bandage covering a damaged part of the skin such as a cut, abrasion, and a burn.

[Prior Art] In recent years, various bandage replacement compositions have been developed, and for example, those described in JP-A-55-122557 are known.

However, although the conventional bandage replacement composition contains an antibacterial agent that maintains antibacterial properties for a long period of time, the antibacterial agent is simultaneously applied when the bandage replacement composition is applied to the skin and the solvent evaporates. Because it evaporates and the antibacterial effect may disappear, the persistence of the antibacterial effect for a long time is small,
Bacteria that invade wounds from the outside could not be sufficiently prevented.

[Problems to be Solved by the Invention] Thus, the present inventors have conducted intensive studies to develop a bandage replacement composition that can maintain antibacterial properties over a long period of time in view of the above-mentioned conventional technology. In addition, they found that when an antibacterial zeolite was added, the antibacterial effect was long-lasting.

The present inventors have further studied and found that when an antibacterial zeolite and an anti-inflammatory analgesic are used in combination, the anti-inflammatory effect is long-lasting.

The present invention has been completed based on the above findings, and provides a bandage replacement composition that has a long-lasting antibacterial effect and can sufficiently prevent bacteria from invading a wound or the like from the outside. The purpose is to:

[Means for Solving the Problems] The present invention provides a bandage replacement composition containing an antibacterial zeolite, a film-forming polymer and a solvent, and a bandage replacement composition for an aerosol containing the bandage replacement composition and a propellant. And / or a dressing replacement composition comprising an anti-inflammatory analgesic.

[Action and Examples] The bandage replacement composition of the present invention contains an antibacterial zeolite.

The antibacterial zeolite has extremely high safety to the human body, exhibits an excellent antibacterial effect against various bacteria and molds for a long period of time, and has heat resistance of being stable up to about 550 ° C. The antibacterial zeolite is obtained by ion-exchanging a part or all of ion-exchangeable ions in the zeolite with antibacterial metal ions.

Examples of the ion-exchangeable ions in the zeolite include sodium ions, calcium ions, potassium ions, magnesium ions, iron ions, and the like.

Specific examples of the antibacterial metal ion include metal ions such as silver, copper, and zinc. Also,
Some of the ion-exchangeable ions in the antibacterial zeolite used in the present invention may be ion-exchanged with ammonium ions. Films containing antimicrobial zeolites containing ammonium ions are particularly preferred because they rarely discolor over time.

When silver ion is used as the antibacterial metal ion, the content of silver ion in the antibacterial zeolite is preferably 0.1 to 15% (% by weight, the same applies hereinafter), particularly preferably 0.1 to 5%. When copper ions or zinc ions are used as antibacterial metal ions, the content of copper ions or zinc ions in the antibacterial zeolite is preferably 0.1 to 8%. When the content of the antibacterial metal ion is smaller than the above range, the antibacterial activity tends to be too small, and even when the content exceeds the above range, the antibacterial effect does not change but is economically disadvantageous. Tend to be.

Further, when ammonium ions are contained in the antibacterial zeolite, the content of the ammonium ions in the antibacterial zeolite should be 0.5 to 5%, preferably 0.5 to 2%, so that the antibacterial zeolite discolors. This is appropriate from the viewpoint of effectively preventing

As the zeolite used for the antibacterial zeolite in the present invention, any of a natural zeolite and a synthetic zeolite can be used.

The zeolite is generally aluminosilicate having a three dimensional skeletal structure represented by the general _{formula: XM 2 / nO · Al 2} O 3 · YSiO 2 · ZH 2 O ( wherein, M represents an ion exchangeable ion, usually Is 1
A divalent or divalent metal ion, n is the valence of the metal ion,
X and Y each represent a molar ratio of the metal oxide and silica, and Z represents the number of water of crystallization). Specific examples of such zeolites include synthetic zeolites such as A-type zeolites, X-type zeolites, and Y-type zeolites; and natural zeolites such as mordenite, clinoptilolite, chabazite, and erionite.

The ion exchange capacity of these exemplified zeolites is A
Type zeolite 7 meq / g, X type zeolite 6.4 meq / g, Y type zeolite 5 meq / g, mordenite 2.6 meq / g, clinoptilolite 2.6 meq
/ g, chabazite 5 meq / g, erionite 3.8
Both are equivalent to milliequivalents / g, and each has a sufficient capacity for ion exchange with ammonium ions and antibacterial metal ions.

As a natural zeolite, its particle size is usually 100-250
It is desirable to use a relatively fine mesh because of its good dispersibility in the film.

When a synthetic zeolite is used, the average particle size is 0.5 to 10 μm, preferably 2 to 3 μm, and the maximum particle size is 10 μm or less, preferably 6 μm or less. It is desirable because the spray state when contained is good.

An example of a method for producing the antibacterial zeolite used in the present invention will be described below.

An aqueous solution of a salt containing an antibacterial metal ion is prepared in advance, and the prepared antibacterial metal ion (silver ion,
Zeolite is brought into contact with a mixed aqueous solution containing copper ions, zinc ions) and, if necessary, ammonium ions to replace the ion-exchangeable ions in the zeolite with the antibacterial metal ions. The condition for contact is that the temperature is
The temperature is 10 to 70 ° C, preferably 40 to 60 ° C, the time is 3 to 24 hours, preferably 10 to 24 hours, and the method is a batch type or a continuous type (eg, a column method). The mixed aqueous solution
The pH is adjusted to 3 to 10, preferably 5 to 7, in order to prevent silver oxide and the like from depositing on the zeolite surface or in the pores. Each ion in the mixed aqueous solution is usually supplied in the form of a salt. Silver ions are, for example, silver nitrate and silver sulfate, and copper ions are, for example, copper nitrate (I
Zinc ions such as copper nitrate (I) and copper sulfate
Ammonium ions such as I) and zinc sulfate are supplied in the form of salts such as ammonium nitrate, ammonium sulfate and ammonium acetate.

The content of the antibacterial metal ion or ammonium ion in the zeolite is determined by the ratio of each ion (salt)
The concentration can be appropriately controlled by adjusting the concentration. For example, when the zeolite contains silver ions and ammonium ions, the target ammonium is adjusted by setting the ammonium ion concentration in the mixed aqueous solution to 0.85 to 3.1 mol / l and the silver ion concentration to 0.002 to 0.15 mol / l. A zeolite having an ion content of 0.5 to 5% and a silver ion content of 0.1 to 5% can be obtained.
Further, when copper ions and zinc ions are contained in the zeolite, the copper ion concentration in the mixed aqueous solution is 0.
By setting the zinc ion concentration to 1 to 0.85 mol / l and the zinc ion concentration to 0.15 to 1.2 mol / l, a zeolite having a copper ion content of 0.1 to 8% and a zinc ion content of 0.1 to 8% can be obtained.

In the present invention, in addition to the mixed aqueous solution as described above, using an aqueous solution containing ions of each antibacterial metal alone,
Ion exchange can also be performed by sequentially contacting each aqueous solution with zeolite. The concentration of each ion in each aqueous solution can be determined according to each ion concentration in the mixed aqueous solution.

The antibacterial zeolite is obtained by thoroughly washing the ion-exchanged zeolite with water or hot water and then drying. Such drying is 105-115 ° C. at normal pressure,
Alternatively, it is preferable to carry out the reaction at 70 to 90 ° C. under reduced pressure (1 to 30 torr).

The content of the antibacterial zeolite in the bandage replacement composition of the present invention is usually desirably 1 to 10%. When the content of the antibacterial zeolite is less than the above range, sufficient antibacterial properties tend to be hardly imparted, and when the content is more than the above range, the antibacterial effect does not change, but economically. Tends to be disadvantageous.

The dressing replacement composition of the present invention contains a film-forming polymer and a solvent in addition to the antibacterial zeolite.

As the film-forming polymer, those capable of peeling the film after use without depositing the medicinal component when applied are preferable. Specific examples of such a film-forming polymer include, for example, polyacrylic acid, polyacrylate, acrylate copolymer, acrylate-vinyl acetate copolymer, sodium polyacrylate, polyvinylpyrrolidone, and polyvinyl acetate. , Polyvinylpyrrolidone-vinyl acetate copolymer, polyvinyl alcohol, polyvinyl ether, acrylamide-polyvinyl alcohol copolymer, ethylene-vinyl acetate copolymer, sodium carboxymethyl cellulose, phenol resin, petroleum resin, maleic acid resin, butyral resin,
Acrylic resin, terpene resin, rosin, styrene resin,
Petroleum resin-maleic anhydride copolymer, polybutyl methacrylate and the like. These film-forming polymers may be used alone or in combination of two or more.

The amount of the film-forming polymer is desirably adjusted to be 0.1 to 60%, preferably 20 to 25%, in the obtained dressing replacement composition. When the amount of the film-forming polymer is less than the above range, the film formation is not sufficient, and when the amount exceeds the above range, the viscosity of the obtained bandage replacement composition becomes too high, resulting in a problem in working. There is a tendency for sex to become worse.

Further, the solvent is used to dissolve the film-forming polymer, and specific examples of such a solvent include, for example, acetone, isopropyl alcohol, ethyl alcohol, ethyl ether, methylene chloride, ethyl acetate, isopropyl acetate, and the like. Cyclohexane, carbon tetrachloride, secondary butyl alcohol, propyl alcohol, benzene, methyl alcohol, methyl ethyl ketone, trichloromonofluoromethane, trichlorotrifluoroethane, dibromotetrafluoroethane, purified water, isobutyl alcohol, xylene, butyl acetate, cellosolve, carb Tall, benzyl alcohol, butyl cellosolve,
Butyl carbitol, kerosene, toluene and the like. These solvents are used alone or in combination of two or more.

The amount of the solvent may range from 1 to 80 in the resulting dressing replacement composition.
%, Preferably 40 to 45%. When the amount of the solvent is smaller than the above range, the valve of the aerosol container tends to be clogged. When the amount is larger than the above range, drying tends to be slow.

As described above, the bandage replacement composition of the present invention contains an antibacterial zeolite, and has excellent permanence of the antibacterial effect. Can be blended. Thus, when the anti-inflammatory analgesic is blended, the synergistic effect with the antibacterial zeolite contained in the bandage replacement composition,
There is an advantage that the antiphlogistic analgesic effect lasts for a long time.

Specific examples of the anti-inflammatory analgesic include, for example, methyl salicylate, glycol salicylate, menthol, camphor, benzyl nicotinate, capsaicin, and the like. These anti-inflammatory analgesics are usually used alone or in combination of two or more. .

The content of the antiphlogistic analgesic is 1 to 15%, preferably 8%.
It is preferably adjusted to be about 12%.

When an antiphlogistic analgesic is added, it is preferable to add a surfactant for emulsification.

Specific examples of the surfactant include ester surfactants such as hardened castor oil and polyoxyethylene sorbitan fatty acid ester; ether surfactants such as polyoxyethylene alkyl ether and polyoxyethylene-polyoxypropylene alkyl ether. Agents; natural surfactants such as lecithin and saponin; and nonionic surfactants. These surfactants are usually used alone or in combination of two or more.

The content of the surfactant is preferably about 0.1 to 5%, and more preferably about 0.8 to 2%.

The bandage replacement composition of the present invention may be used as it is on the skin by a method such as application to the skin, or may be used as a bandage replacement composition for aerosol using a propellant.

The dressing replacement composition for aerosol is composed of the dressing replacement composition and a propellant.

Specific examples of the propellant include, for example, dichlorodifluoromethane, monochlorodifluoromethane, dichlorotetrafluoroethane, dichloromonofluoromethane,
Monochlorotrifluoromethane, monobromotrifluoromethane, trifluoromethane, monochloroheptafluoroethane, hexafluoroethane, monochlorodifluoroethane, difluoroethane, dimethyl ether, liquefied petroleum gas (propane, n-butane, iso-butane as a main component), etc. Can be These propellants are used alone or in combination of two or more.

The amount of the propellant used is preferably adjusted so as to be contained in the obtained aerosol dressing replacement composition in an amount of about 20 to 50%, preferably about 25 to 40%. When the use amount of such a propellant is less than the above range, the ejection power becomes too weak, and when the use amount exceeds the above range, the amount of the film-forming polymer and the solvent is relatively small, and the scattered component is large. It tends to be too much.

The aerosol dressing replacement composition of the present invention having the above-mentioned component composition is filled into an aerosol container according to a conventional method, and an aerosol valve and a button are attached thereto, thereby obtaining an aerosol product.

Next, a method for producing the antibacterial zeolite used in the bandage replacement composition of the present invention will be described based on production examples.

Production example (manufacture of antibacterial zeolite) A-type zeolite (Na ₂ O.Al ₂ O ₃ :
1.9 SiO ₂ XH ₂ O (X = 3-5), average particle size 1.5 μm) powder
1 kg of water was added to make a 1.3 liter slurry, stirred and degassed, and a proper amount of 0.5 N nitric acid solution and water were added to adjust the pH to 5 to 7 to obtain a 1.8 liter slurry with a total volume of 1.8 liter. . Next, for ion exchange, NH ₄ NO ₃ 1.5 mol / l, AgN
3 liters of a mixed aqueous solution of O ₃ 0.10 mol / l and Zn (NO ₃ ) ₂ 0.35 mol / l was prepared and added to the slurry, and the slurry was stirred at 40 to 60 ° C. for 10 to 24 hours while performing ion exchange. It was kept in equilibrium with possible sodium, antimicrobial metal and ammonium ions. After ion exchange,
The zeolite phase was filtered and washed with warm water until there was no excess silver and zinc ions in the zeolite phase. Next, the obtained zeolite was heated and dried at 110 ° C. in a ventilation dryer to obtain an antibacterial zeolite.

When the physical properties of the antibacterial zeolite were measured, the following results were obtained.

Silver ion content: 2.53% Zinc ion content: 13: 78% Ignition loss: 5.5% Average particle size: 2.30 μm pH: 9.33 (1% suspension) True specific gravity: 2.168 [−] Bulk specific gravity: 0.31 [-] [Effect of the Invention] Since the bandage replacement composition of the present invention exhibits excellent antibacterial properties over a long period of time, it replaces a bandage covering a damaged portion of the skin such as cuts, abrasions and burns. It can be suitably used as a product.

Further, the bandage replacement composition containing the anti-inflammatory analgesic of the present invention has a long-lasting anti-inflammatory analgesic effect due to the synergistic effect of the combination with the antibacterial zeolite, and therefore has a long-lasting anti-inflammatory analgesic effect on the skin. It can be suitably used as a substitute for a bandage to be applied.

──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Masataka Kosegawa 1-52-49 Kashima, Yodogawa-ku, Osaka-shi, Osaka Takeuchi Press Kogyo Co., Ltd. Osaka Plant (58) Field surveyed (Int. Cl. ⁷ , DB name) ) A61K 15/44 A61K 9 / 12,9 / 70

Claims (3)

(57) [Claims] A bandage replacement composition comprising an antimicrobial zeolite, a film-forming polymer and a solvent. 2. An aerosol dressing replacement composition comprising the dressing replacement composition according to claim 1 and a propellant. 3. The bandage replacement composition according to claim 1, further comprising an anti-inflammatory analgesic.