JP2976635B2 - Chemical component analysis sensor - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a chemical component analysis sensor for analyzing a chemical component such as a biosensor and a gas sensor, and more particularly to a calibration of its zero point and sensitivity.

[0002]

2. Description of the Related Art A biosensor is mainly used for quantification of a substance related to a living body, and is composed of an immobilized biocatalyst having a function of identifying molecules and an electrochemical device. The electrochemical device is an ISFET (semiconductor field effect ion sensor). ) Or an oxygen electrode using a thin film electrode, a hydrogen peroxide electrode, or an ion-selective electrode on which an enzyme membrane, a microbial membrane, an immune membrane, or the like is attached.

In a sensor for analyzing a chemical component such as a biosensor or a gas sensor, the zero point and the sensitivity greatly differ depending on each product as shown in FIG. 3 due to various parameter fluctuations in a manufacturing stage. .

Therefore, conventionally, as shown in FIG. 4, before the measurement, the sensitive part of the chemical component analysis sensor 101 is moved to the component standard solution 1.
02 or a component standard atmosphere, and the output signal is measured by the measuring device 103 to obtain a calibration curve for correction.

[0005]

However, as described above, if the calibration curve of the sensor is obtained by using the component standard solution or the component standard atmosphere for each measurement to correct the zero point and the sensitivity, the measurement becomes troublesome.

[0006]

According to the present invention, in order to solve the above-mentioned problems, an information storage portion for storing information on a zero point and a sensitivity of a sensor is provided integrally with a chemical component analysis portion.

[0007]

The zero point and sensitivity information stored in the information storage means provided integrally with the chemical component analysis sensor is read for each measurement, and the zero point and sensitivity are corrected based on the read information.

[0008]

Embodiments of the present invention will be described below with reference to the accompanying drawings. Here, FIG. 1 is a schematic diagram of a biosensor to which the present invention is applied, and FIG. 2 is a schematic diagram when information is stored in the sensor.

A biosensor 1 decomposes a substance to be measured by the action of a biocatalyst, converts a change in the amount of electrode active material involved in the reaction into an electric signal, and outputs the signal.
And an information storage portion 3 for storing information on zero point / sensitivity are integrally formed on a substrate. The information storage portion 3 includes three electric fuses 4, 5, formed of a high-resistance metal thin film.
Consists of six.

When information on zero point and sensitivity is stored in the biosensor 1, the chemical component analysis site 2 is first immersed in each component standard solution, and at this time, the output terminals 21, 22, 23 of the chemical component analysis site 2 are stored. Is measured by an external measuring instrument, and the zero point of the sensor 1 is determined based on the measurement information.
A sensitivity correction value or rank value is calculated and encoded.

Then, a voltage is applied between the common terminal 31 of the information storage section 3 and the coded terminals 41, 51, 61 of the respective fuses in accordance with the coded information, whereby the electric fuse of the information storage section 3 is applied. 4, 5, and 6 are blown according to the coded information.

As described above, the information of the zero point and the sensitivity is stored in the information storage portion 3 of the biosensor 1 in the electric fuses 4, 5, and 6.
Since the information is stored as an array of connection / fuse, the information storage unit 3 is energized at the time of measurement to determine the connection / fuse of the electric fuses 4, 5, and 6, so that the zero point and sensitivity information can be read. Based on this information, the zero point and the sensitivity are corrected and measured.

As the information storage means, for example, a storage element using a dielectric thin film or an electrically writable ROM (EPROM) can be used. Further, by adding a configuration method of the storage circuit, it is possible to store the data every time the calibration curve is measured, or it is possible to store the measurement data in addition to the information of the zero point and the sensitivity. Further, the present invention can be similarly applied to a chemical component analysis sensor such as a gas sensor in addition to a biosensor.

[0014]

According to the present invention as described above,
Since the information storage part for storing the zero point and the sensitivity information of the sensor is provided integrally on the substrate etc. together with the chemical component analysis part,
Calibration with a standard sample is not required for each measurement, making measurement easier.

[Brief description of the drawings]

FIG. 1 is a schematic diagram of a biosensor to which the present invention is applied.

FIG. 2 is a schematic diagram when information is stored in the sensor.

FIG. 3 is a diagram showing an output characteristic example of a biosensor.

FIG. 4 is a diagram for explaining a conventional biosensor correction method.

[Explanation of symbols]

DESCRIPTION OF SYMBOLS 1 ... Biosensor, 2 ... Chemical component analysis part, 3 ... Information storage part, 4,5,6 ... Electric fuse.

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Claims (1)

(57) [Claims] 1. A chemical component analysis sensor for analyzing the chemical components, such as biosensors or gas sensors, the sensor chemical component analysis site and a single board with the information storage portion for storing information of zero and sensitivity of the sensor chemical component analysis sensor, characterized in that provided integrally with the.