JP2917592B2 - Biological rhythm control system - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention aims at measuring biological rhythms, applying appropriate external stimuli to control the rhythms, adjusting circadian rhythms in accordance with work systems and time zones, It allows you to target the time of important games and negotiations throughout the day and to achieve an optimal alertness level.

[0002]

2. Description of the Related Art Conventionally, as this type of apparatus, there is a "biological rhythm detecting apparatus (Japanese Patent Laid-Open No. 1-236033)" which detects a biological rhythm during sleep from a pulse rate, a respiratory rate and body movement.
"Circadian rhythm curve estimating device (Japanese Patent Laid-Open No. 1-29)
No. 7053), and “Sleep state change detection device and sleep state control device (Japanese Unexamined Patent Publication No. 3-41926), which detects a sleep state and wakes up comfortably by applying an arousal stimulus to the living body. "was there. On the other hand, there is a phototherapy device (Japanese Patent Application Laid-Open No. 2-302276) as a therapeutic device for symptoms caused by disturbance of biological rhythm such as sleep disorder and seasonal emotional disorder.

[0003]

However, the "biological rhythm detecting device" and the "circadian rhythm curve estimating device" only perform detection and do not perform control. The “sleep state change detection device and sleep state control device” only perform control from sleep to awakening. The “phototherapy device” is intended to forcibly synchronize the biological rhythm (circadian rhythm) with the circadian cycle by giving the light stimulus to the circadian cycle regardless of the phase of the biological rhythm. There was a drawback that the stimulation energy was required and the device became large. Thus, so far, there is no biological rhythm control device of the concept of enabling control such as setting a desired arousal level at a desired time, and can respond to differences in stimulus responsiveness of individual living bodies. There was nothing.

[0004] Therefore, in the present invention, a biological rhythm control system capable of inputting when and what kind of state is desired as a control target and enabling control such that a desired awakening level is obtained at a desired time. The purpose is to get.

[0005] In addition, it is not generated by external stimulus of each living body.
It is another object of the present invention to obtain a biological rhythm control system that can cope with a difference in phase reactivity or aging within an individual.

[0006]

A biological rhythm control system according to the present invention comprises a physiological response measuring unit for measuring a physiological response reflecting a change in arousal level, and a circadian rhythm (about 24 hours) based on the measured physiological response. A living body that is a rhythm (a fluctuation having a cycle of about 1.5 to 2 hours)
A biological rhythm extracting unit for extracting rhythms , an input unit for inputting a control target, and a predicted rhythm song based on the extracted biological rhythms
Creating a line, obtains a phase control amount from the difference between the control target and the predicted curve generated using the phase control amount, the phase response curve data indicating the phase change with respect to external stimuli stored in advance, a predetermined A control output determining unit for determining parameters of an external stimulus for causing a phase change of the control output;
A stimulus presentation unit that provides an external stimulus based on the control output of the fixed unit
It is provided with.

Further, the actual phase change of the biological rhythm due to the presentation of the stimulus is obtained, and from the difference from the intended phase control amount,
A phase response curve data correction unit for correcting the stored phase response curve data is provided .

[0008]

[Action] From the biological rhythm extracted by measuring the phase reactivity of the physiological response, a predicted rhythm curve when no control is applied is obtained, and a target rhythm curve is obtained from this and the input control target. By determining the phase control amount from the difference and determining the external stimulus parameters using the phase response curve data, it is possible to efficiently and finely control according to the purpose with a small stimulus.

Further, by correcting the phase response curve data based on the result of the actual stimulus, it is possible to cope with individual differences in response characteristics of the living body and aging within the individual.

[0010]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS One embodiment of the present invention will be described below with reference to the drawings. FIG. 1 is a block diagram of an embodiment in which the invention described in claim 1 is added to the invention described in claim 1. The elements surrounded by solid lines relate to the invention of claim 1, and the elements surrounded by broken lines relate to the invention of claim 2. In the figure,
11 is a physiological response measuring unit, 12 is a biological rhythm extracting unit, 13
Denotes a control target input unit, 14 denotes a control output determination unit, 15 denotes a stimulus presentation unit, and 16 denotes a phase response curve data correction unit.

Next, the operation will be described. The physiological response measurement unit 11 measures a physiological response that reflects fluctuations in the arousal level, such as the body temperature, electrocardiogram, pulse wave, and brain wave of the subject.
The biological rhythm extracting unit 12 performs data analysis on the measured physiological response, converts the measured physiological response into a parameter representing a change in arousal level, and when a plurality of parameters are obtained, combines a plurality of parameter values to extract a biological rhythm. . For example, as parameters, body temperature is a measured value or a moving average, a heart (pulse) pulse value obtained from an electrocardiogram or a pulse wave and its fluctuation components (thermothermic, blood pressure, respiratory), and a T wave height of the electrocardiogram , Pulse wave height, and frequency components of brain waves. As a method of extracting a biological rhythm by synthesizing a plurality of parameter values, a predetermined time shift is applied to each parameter value, multiplied by a previously set coefficient, added, and added together. May be output as the biological rhythm of the subject, or using a physiological response model, the internal parameters of the living body, such as the activity of the sympathetic nervous system,
It may be synthesized after converting into parasympathetic activity, central activity, or the like. The biological rhythm is obtained by superimposing the circadian rhythm and the daily rhythm, but either one may be extracted according to the purpose. For example, for the purpose of adjusting the deviation of the circadian rhythm due to the time difference, a rhythm having a short cycle may be removed by moving average or filtering. Conversely, if the purpose is to perform detailed control during the day, the circadian rhythm may be subtracted to extract only the daily rhythm.

The control target input section 13 inputs a control target. The control target relates to when and what state (how much arousal level) one wants to be, and information about time (what day or how many hours later) and state (awake level) (for example, ,
Wake up from sleep, the most awake state, just before the peak of awakening, the falling period of the arousal level, etc.) are input as one or more pairs. The input method may be a numerical value, a selection of a verbal expression as described above, or a graph input.

The control output determining unit 14 first obtains a predicted rhythm curve of a biological rhythm up to a time corresponding to a control target using a rhythm extracted from a physiological response. This includes
A method relating to prediction of a time-series signal, such as prediction using an AR model or a curve fitting method, is applied. When the circadian rhythm and the intra-day rhythm are extracted separately, they may be separately predicted and synthesized. At the same time, a target rhythm curve is obtained according to the control target input. If the degree of freedom of the control target is large, the one closest to the predicted rhythm curve is determined as the target rhythm curve. The phase control amount is determined from the difference between the target rhythm curve and the predicted rhythm curve thus determined, and the parameters of the external stimulus are determined using this and the phase response curve data stored in advance. The phase response curve represents a phase change when an external stimulus is applied to a system generating a rhythm (vibration) as a function of the phase of the vibration at the time of the stimulus. Since the phase response curve differs depending on the type and size of the stimulus, the phase response curve data has a four-dimensional data structure of the type and size of the stimulus, the phase to which the stimulus is applied, and the phase change due to the stimulus. Therefore,
Once the phase control amount is determined, select a set of stimulus parameters (type of stimulus, magnitude, and phase to apply stimulus) that is equal to or closest to the phase change, within the limits of the stimulable phase. Can be. The limitation of the stimulable phase occurs when the rhythm is less than one cycle from the control target input time to the control target time, but is easily obtained from the predicted rhythm curve. Further, since the optimal stimulus parameter set is not always determined uniquely, when a plurality of candidates are generated, they are determined to be one by deciding the priority order. The stimulus application phase is easily converted to stimulus timing using the predicted rhythm curve.

The stimulus presentation section 15 presents necessary stimuli in accordance with the control output (stimulus type, size, timing). The type of stimulus changes the level of arousal,
Anything that does not harm the living body, such as light and sound,
Vibrations, temperature changes, scents, etc. are possible.

The phase response curve data correction unit 16 calculates the actual phase change of the biological rhythm due to the presentation of the stimulus, and corrects the stored phase response curve data based on the difference from the intended phase control amount. As a correction method, the corresponding part of the phase response curve data may be replaced with actual phase change data, or a new value may be obtained from the stored data and the phase change data obtained by multiplying the correction coefficient. Also,
The timing of the correction may be corrected each time the control is performed, or may be performed after accumulating data of a plurality of results.

In the above embodiment, the control output for producing the target phase change is obtained by one stimulus. However, especially when the time to the control target time is long, the phase change is divided into a plurality of times. Phase control amount that causes
It is more desirable to adjust the phase control amount for each stimulus.

In the above embodiment, the phase response curve data is used. However, it goes without saying that the same can be performed by using the phase transition curve data representing the phase after stimulation as a function of the phase at the time of stimulation.

[0018]

As described above, according to the present invention, a predicted rhythm curve when no control is applied is obtained from a biological rhythm extracted by measuring a physiological response, and a target rhythm curve is obtained from the input control target. The rhythm curve to be obtained, the phase control amount is obtained from the difference between the two, using the phase response curve data,
Since the external stimulus parameters are determined, there is an effect that fine control according to purpose can be efficiently performed with a small stimulus.

Further, since the phase response curve data is modified based on the result of the actual stimulus, there is an effect that it is possible to cope with individual differences in response characteristics of the living body and aging within the individual.

[Brief description of the drawings]

FIG. 1 is a block diagram showing a biological rhythm control system according to an embodiment of the present invention.

[Explanation of symbols]

 Reference Signs List 11 Physiological response measurement unit 12 Biological rhythm extraction unit 13 Control target input unit 14 Control output determination unit 15 Stimulus presentation unit 16 Phase response curve data correction unit

──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Chie Akashi 8-1-1, Tsukaguchi-Honmachi, Amagasaki City Mitsubishi Electric Corporation Central Research Laboratory (56) References Japanese Utility Model No. 2-71299 (JP, U) (58) ) Field surveyed (Int. Cl. ⁶ , DB name) A61M 21/00

Claims (2)

(57) [Claims] 1. A physiological response measuring unit that measures a physiological response reflecting a change in arousal level, and a circadian rhythm (a variation having a cycle of about 24 hours) and a circadian rhythm (1.5 to 2) based on the measured physiological response. Biological variation that has a cycle of about
A biological rhythm extracting unit that extracts a prism, an input unit for inputting a control target, the extracted rhythm above from the biological rhythm
Creating a prediction curve, we obtain a phase control amount from the difference between the prediction curve and the control <br/> objectives created, the phase control amount
And the phase change for the external stimulus stored in advance
Using the phase response curve data indicating a predetermined phase change
A control output determining unit for determining parameters of an external stimulus to be caused, and an external control unit based on a control output of the control output determining unit.
Biorhythm control system that includes a stimulus presentation portion for giving a stimulus. 2. A search of the actual phase change in the biological rhythm by stimulus presentation, that the difference between the intended phase control amount, provided the phase response curve data correcting unit make modifications to the phase response curve data stored The biological rhythm control system according to claim 1, wherein: