JP2911573B2 - Detergent composition - Google Patents

Description

Description: FIELD OF THE INVENTION The present invention relates to a cleaning composition having extremely low skin irritation and ocular mucous membrane irritation.

[Prior art] As cleaning surfactants, anionic surfactants,
Nonionic surfactants, and amphoteric surfactants, and the like.

Representative examples of anionic surfactants include alkyl sulfate, alkyl ether sulfate, and the like.
Since these are excellent in detergency, they have been used in cleansing agents such as facial cleansing agents and shampoos. However, these have a drawback that they are highly irritating to the skin and easily cause skin disorders such as rough hands. In addition, since it is easily adsorbed on hair and has high detergency, the smoothness and combability of hair are deteriorated, and improvement thereof is strongly desired.

Nonionic surfactants are examples of surfactants with low skin irritation. Representative examples include glycerin higher fatty acid esters, sucrose higher fatty acid esters, and sorbitan higher fatty acid esters.

Although these nonionic surfactants are less irritating than anionic surfactants, they do not foam well and cannot satisfy the requirements of shampoos, facial cleansers, body cleaners and kitchen detergents.

Examples of nonionic surfactants that are commonly used include amides, which are condensates of fatty acids and amines, and are often used in combination with anionic surfactants. For this reason, at present, the effect is further enhanced, rather than improving the skin irritation.

Examples of the amphoteric surfactant include imidazoline-type betaine, which is said to have relatively little irritation, and dimethyl betaine and amine oxide, which have the same degree of irritation as anionic surfactants. Since these amphoteric surfactants have weaknesses in terms of foam quality, detergency, etc., they are rarely used alone and are often used in combination with anionic surfactants in recent years.
Further, there is a characteristic that irritation is improved by blending a specific ratio with a specific anionic surfactant.
However, the degree of the reduction is not sufficient, and a significant improvement is desired.

With the background and the sophistication of living standards, the development of low-irritant surfactants and cleaning compositions having properties safe for the human body has been strongly demanded at present.

[Problems to be Solved by the Invention] In view of such circumstances, the inventors of the present invention have the skin irritation and ocular mucosa irritation of anionic surfactants and amphoteric surfactants used for cleaning. As a result of diligent studies, the present inventors have found out that the problem can be solved by blending these surfactants and a specific compound at a specific ratio, and have completed the present invention.

[Means for Solving the Problems] That is, the first aspect of the present invention relates to (I) polyoxyethylene hydrogenated castor oil, and (II) the following general formulas [A] to [D]
And one or more polyoxyalkylene-modified organopolysiloxanes selected from the compounds represented by
(I) containing one or more selected from the group consisting of anionic surfactants and amphoteric surfactants;
A cleaning composition characterized in that the weight ratio of + (II) / (III) is 9/1 to 1/5.

(Wherein R is an alkyl group having 1 to 3 carbon atoms or a phenyl group, R ′ is hydrogen or an alkyl group having 1 to 12 carbon atoms,
p is an integer of 1 to 5, m is an integer of 0 to 100, n and x are integers of 1 to 50, and t and y are integers of 0 to 50. Hereinafter, the configuration of the present invention will be described in detail.

The polyoxyethylene hydrogenated castor oil used in the present invention is represented by the following general formula [E] and has a long-chain ethylene oxide group. The number of moles of ethylene oxide added to the cured castor oil molecule is: 20-300 is suitable, preferably 40-200. If the number of moles of ethylene oxide added is less than 20, it is difficult to form a uniform mixed system, and if it exceeds 300, the viscosity increases too much, which is not preferable.

(Where a, b, and c represent the number of moles of the polyoxyethylene group added, and a + b + c = 20 to 300). As the anionic surfactant used in the present invention,
Fatty acid soap, alkanediol acetate ether, ether carboxylate, α-acyl sulfonate, alkyl sulfonate, alkyl sulfosuccinate, sulfate of fatty acid ester, alkyl sulfate, alkyl amide sulfate, alkyl Examples include amide sulfonates, alkyl phosphates, and alkyl amide phosphates.

Examples of the amphoteric surfactant used in the present invention include betaine type (carboxybetaine and sulfobetaine), aminocarboxylate type, and imidazoline derivative type.
Particularly, an imidazoline derivative type is preferable.

The polyoxyalkylene-modified organopolysiloxane used in the present invention is a compound represented by the above general formulas [A] to [D]. The average molecular weight is preferably one having 3000 or more, more preferably 5000 or more. Further, those containing 2 to 40% by weight of a polyoxyalkylene group in the polyoxyalkylene-modified organopolysiloxane molecule are preferable, and from the viewpoint of exhibiting the effect, more preferably 2 to 29%
% By weight.

In the cleaning composition of claim 1 of the present invention, the total amount of polyoxyethylene hydrogenated castor oil and polyoxyalkylene-modified organopolysiloxane, and one or more of anionic surfactant and amphoteric surfactant Should be in the range of 9/1 to 1/5, and particularly preferably,
9/1 to 3/5. If the ratio is outside the above range, the effects of the present invention cannot be obtained.

In the present invention, it is particularly preferable to mix ethanol in an appropriate amount when preparing the detergent composition. As a preparation method, for example, after dissolving one or more of anionic surfactant and amphoteric surfactant in a small amount of water, polyoxyethylene hydrogenated castor oil or polyoxyethylene hydrogenated castor oil and polyoxyethylene It is obtained by adding an alkylene-modified organopolysiloxane, heating, mixing and stirring, and diluting with water at the same temperature. As a particularly preferable adjustment method, a desired composition can be easily obtained by a method of adding an appropriate amount of ethanol when mixing and stirring these two components.

The cleaning composition of the present invention is a transparent or opaque homogeneous system, and the composition obtained by adding water to this composition is useful in a transparent or opaque homogeneous system.

The cleaning composition of the present invention may optionally contain oily substances such as hydrophobic silicones, higher grade alcohols, liquid hydrocarbons, and liquid ester oils.

The cleaning composition of the present invention may further contain a humectant, a fragrance, a preservative, and the like, if necessary. These must be used under qualitative and quantitative conditions that do not impair the purpose of the present invention.

The detergent composition of the present invention can be used for various other uses, such as shampoos, body cleaners, facial cleansers, makeup remover detergents, baby shampoos, kitchen liquid detergents, medical detergents, and the like.

[Effects of the Invention] The present invention provides a polyoxyethylene hydrogenated castor oil or
Non-irritating detergent composition comprising a specific ratio of polyoxyethylene hydrogenated castor oil, polyoxyalkylene-modified organopolysiloxane, and one or more anionic surfactants and amphoteric surfactants Is provided.

[Examples] Next, the present invention will be specifically described with reference to Examples and Comparative Examples. The present invention is not limited by this. The compounding amount is% by weight. Prior to the examples, the evaluation method will be described below.

Cumulative skin irritation test A 0.3 ml sample is applied to the skin of a healthy Hartley guinea pig weighing 300 to 500 g and left for 24 hours. Twenty-four hours later, the skin reaction is determined, and then a second application is performed. And
Determined after 24 hours. Thereafter, the third application is performed, and the determination is made 24 hours later. The average value of the skin reaction based on these three applications was calculated, and the skin cumulative irritation was evaluated.

◎: Little irritation ○: Weak irritation △: Medium irritation ×: Strong irritation Ocular mucosa irritation test Using rabbits weighing 3 to 3.5 kg, 6 rabbits per group, right 0.1 ml of the sample was instilled into each eye, and three of the six animals were left intact without washing eyes, and the remaining three animals were instilled 10 seconds after instillation.
Eye washing was performed with ml of warm water.

As a determination method, the degree of irritation was observed using a slit lamp for 24, 48, 72, 96 and 168 hours after instillation, using the left eye as a control.

These determinations were made on the conjunctiva, cornea, iris and the like. The stimulus response of each of these parts was based on the Draize score evaluation standard.

 ◎: almost no irritation ○: weak irritation △: moderate irritation ×: strong irritation Examples 1 to 9, Comparative Example 1 The cleaning compositions shown in Table 1 below were prepared and evaluated. did.

As is evident from Table 1, the composition of the present invention is a cleaning composition with very little irritation.

Examples 10 to 13 and Comparative Examples 2 to 4 The cleaning compositions shown in Table 2 below were prepared and evaluated.

* 8 Polyoxyethylene hydrogenated castor oil (number of moles of ethylene oxide added: 100) As is clear from Table 2, the composition of the present invention was found to be a detergent composition with very little irritation.

Examples 14 to 16 and Comparative Examples 5 to 7 The cleaning compositions shown in Table 3 below were prepared and evaluated.

As is evident from Table 3, the composition of the present invention is a cleaning composition with very little irritation.

Examples 17 to 20, Comparative Examples 8 to 10 The cleaning compositions shown in Table 4 below were prepared and evaluated.

As is evident from Table 4, the composition of the present invention is a cleaning composition with very little irritation.

────────────────────────────────────────────────── ─── Continuation of the front page (56) References JP-A-2-32008 (JP, A) JP-A-1-151510 (JP, A) JP-A-52-5683 (JP, A) JP-A-55-568 90598 (JP, A) JP-A-63-17998 (JP, A) JP-A-63-122618 (JP, A) JP-A-63-207900 (JP, A) JP-A-61-300 (JP, A) (58) Field surveyed (Int.Cl. ⁶ , DB name) C11D 1 / 74,1 / 83,3 / 37 A61K 7/075

Claims (1)

(57) [Claims] 1. One or two of (I) a polyoxyethylene hydrogenated castor oil and (II) a polyoxyalkylene-modified organopolysiloxane selected from the compounds represented by the following general formulas [A] to [D]: (I) + (II) / (II) containing at least one kind selected from the group consisting of (III) an anionic surfactant and an amphoteric surfactant.
A cleaning composition, wherein the weight ratio of I) is from 9/1 to 1/5. (Wherein R is an alkyl group having 1 to 3 carbon atoms or a phenyl group, R ′ is hydrogen or an alkyl group having 1 to 12 carbon atoms,
p is an integer of 1 to 5, m is an integer of 0 to 100, n and x are integers of 1 to 50, and t and y are integers of 0 to 50. )