JP2909876B2 - Contrast agent - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an improved contrast agent.

[0002]

2. Description of the Related Art Conventionally, computer tomography and magnetic resonance tomography have been widely used for esophageal diseases such as esophageal cancer and rectal cancer such as rectal cancer. There is no useful and highly safe contrast agent, and it is difficult to perform accurate preoperative diagnosis for these diseases.

[0003]

In computer tomography and magnetic resonance tomography for esophageal diseases such as esophageal cancer and rectal diseases such as rectal cancer, oral and / or non-venous X-ray contrast agents are used. By using a new highly safe contrast agent that can stay in the esophagus and rectum transanally, it is possible to more accurately understand the positional relationship with surrounding organs and vessels and the progress of disease. This allows more accurate surgical indications to be determined and treatment options to be selected.

[0004]

SUMMARY OF THE INVENTION The present invention relates to sodium amide trizoate meglumine, iron ammonium citrate or barium sulfate which has been conventionally used as a contrast agent, or soluble ferric pyrophosphate or sugar-containing iron oxide which will be used in the future. Carboxymethylcellulose or its salts, alginate, cellulose sulfate, hydroxypropylcellulose, methylcellulose, starch, polyacrylic acid, based on iron compounds of iron sulfate, ferrous sodium citrate, chondroitin sulfate iron and ferric chloride This is a new contrast agent which is capable of increasing the viscosity by containing one or more of sodium and gum arabic, thereby being able to stay in the esophagus and the rectum, and being highly safe, and an imaging method using these contrast agents. .

Examples of the iron compound in the present invention include ammonium iron citrate, soluble ferric pyrophosphate, sugar-containing iron oxide, iron sulfate, ferrous sodium citrate, chondroitin sulfate, and ferric chloride. Particularly, ammonium iron citrate is preferred. On the other hand, examples of the salts of carboxymethylcellulose, alginic acid, and cellulose sulfate include sodium salts, potassium salts, calcium salts, ammonium salts and the like, with sodium salts being particularly preferred.

The amount of sodium amidotrizoate meglumine and / or iron compound is appropriately selected according to the purpose of use, and carboxymethylcellulose or a salt thereof, alginate, cellulose sulfate, hydroxypropylcellulose, methylcellulose, starch, sodium polyacrylate And at least one or more selected from the group consisting of gum arabic (A) by 1 to 5% by weight to increase the viscosity of a solution of sodium amidotrizoate meglumine and / or an iron compound, thereby increasing the viscosity of the solution in the esophagus and rectum. A desired contrast agent that can stay can be prepared. Furthermore, these contrast agents may contain an appropriate amount of barium sulfate.

In some cases, carboxymethylcellulose or a salt thereof, alginate, cellulose sulfate,
One or more of hydroxypropylcellulose, methylcellulose, starch, sodium polyacrylate and gum arabic can be used as a contrast agent.

On the other hand, when barium sulfate and one or more kinds selected from the above (A) are contained, the amount of barium sulfate is appropriately selected from the range of 1 to 3% by weight depending on the purpose of use. Carboxymethylcellulose or a salt thereof, alginate, cellulose sulfate, hydroxypropylcellulose, methylcellulose, starch, sodium polyacrylate and gum arabic 1 to 5% by weight, preferably 2 to 4% by weight By increasing the viscosity of the barium sulfate solution, the esophagus,
In addition, a contrast agent that does not overlook even minute organ diseases can be prepared by retaining it in the large intestine or rectum. The contrast agent obtained is particularly suitable for computed tomography of the esophagus and rectum.

The contrast agent of the present invention may further contain various additives such as a wetting agent, an antifoaming agent, a sweetening agent, a flavor, a preservative and the like. Hereinafter, in order to explain the present invention in more detail, examples and test examples of a contrast agent will be described.

[0010]

Example 1 Contrast agent for computed tomography 485 ml of purified water was added to 15 g of sodium carboxymethylcellulose, and the mixture was sufficiently stirred, sterilized by heating, and then purified.
% Sodium carboxymethylcellulose aqueous solution is prepared. On the other hand, amidotrizoic acid (anhydride) 597.40
g, sodium hydroxide 6.29 g and meglumine 15
9.20 g is made up to a total volume of 1000 ml with an appropriate amount of purified water to prepare a 76% sodium amidotrizoate meglumine solution. Next, 2 ml of a 76% sodium amidotrizoate meglumine solution was added to 98 ml of a 3% aqueous solution of sodium carboxymethylcellulose, and the mixture was sufficiently stirred to obtain a contrast agent for computed tomography.

[0011]

Example 2 Contrast Agent for Magnetic Resonance Tomography To 100 ml of the 3% sodium carboxymethylcellulose aqueous solution prepared in Example 1, ammonium iron citrate 2 was added.
Then, 00 mg was added and mixed well to obtain a contrast agent for magnetic resonance tomography.

[0012]

Example 3 Contrast agent for computer tomography Purified water was added to 35 g of sodium carboxymethylcellulose and 20 g of barium sulfate to make a total volume of 1,000 ml, and sufficiently stirred and mixed to contain 3.5% of 2% barium sulfate.
% Aqueous sodium carboxymethylcellulose was prepared to obtain a contrast agent for computed tomography.

[0013]

Example 4 Contrast agent for computed tomography Using 30 g of sodium carboxymethylcellulose, 10 g of potato starch and 20 g of barium sulfate,
It was prepared in the same manner as in Example 3 to obtain a contrast agent for computed tomography.

[0014]

Example 5 A contrast agent for computed tomography using 30 g of methylcellulose and 20 g of barium sulfate was used.
It was prepared in the same manner as in Example 3 to obtain a contrast agent for computed tomography.

[0015]

Example 6 Using a contrast agent for computed tomography, 35 g of methylcellulose and 20 g of barium sulfate,
It was prepared in the same manner as in Example 3 to obtain a contrast agent for computed tomography.

[0016]

Example 7 A contrast agent for computer tomography using 35 g of methylcellulose and 15 g of barium sulfate,
It was prepared in the same manner as in Example 3 to obtain a contrast agent for computed tomography.

[0017]

Test Example 1 100 ml of the contrast agent prepared in Example 1 was
For patients with esophageal cancer, an x-ray contrast agent was injected intravenously during computed tomography and orally administered. As a result, the lumen of the esophagus as well as the surrounding large blood vessels were simultaneously imaged. As a result, the degree of progression of esophageal cancer to surrounding organs and tissues and the state of lymphadenopathy were accurately grasped, and more accurate determination of surgical indication and selection of treatment method became possible.

[0018]

Test Example 2 100 ml of the contrast agent prepared in Example 2 was
It was orally administered to patients with esophageal cancer during magnetic resonance tomography. As a result, the degree of progression of esophageal cancer to surrounding organs and tissues, the positional relationship with large blood vessels, and the presence / absence of cancer invasion were accurately determined. In particular, the ability to obtain sagittal images of esophageal cancer, that is, the anterior-posterior images in the longitudinal direction of the body, makes it easier to grasp the positional relationship with the heart and large blood vessels, and has advantages that are different from computed tomography images. It is. by this,
More accurate determination of surgical indication and selection of treatment method became possible.

[0019]

Test Example 3 100 ml of the contrast agent prepared in Example 3 was
For patients with esophageal cancer, an x-ray contrast agent was injected intravenously during computed tomography and orally administered. As a result, the lumen of the esophagus as well as the surrounding large blood vessels were simultaneously imaged. As a result, the degree of progression of esophageal cancer to surrounding organs and tissues and the state of lymphadenopathy were accurately grasped, and more accurate determination of surgical indication and selection of treatment method became possible.

[0020]

Industrial Applicability The present invention is a new contrast agent which stays in the esophagus and rectum and is highly safe, and enables accurate grasp of a disease.

Claims (4)

(57) [Claims] A computer tomography of the esophagus or rectum, characterized by containing 1 to 5% by weight of barium sulfate and 1 to 5% by weight of at least one selected from the group consisting of sodium carboxymethylcellulose and methylcellulose. Contrast agent. 2. A contrast agent for computed tomography of the esophagus or rectum, comprising 1 to 3% by weight of barium sulfate and 1 to 5% by weight of sodium carboxymethylcellulose. 3. A contrast agent containing 1 to 3% by weight of barium sulfate and 1 to 5% by weight of sodium carboxymethylcellulose, which is orally administered, for use in computed tomography of the esophagus. 4. A contrast agent containing 1 to 5% by weight of barium sulfate and 1 to 5% by weight of sodium carboxymethylcellulose, wherein the contrast agent is for rectal administration of computed tomography.