JPH01261335A - Barium sulfate contrast medium for x ray - Google Patents
Barium sulfate contrast medium for x rayInfo
- Publication number
- JPH01261335A JPH01261335A JP63088489A JP8848988A JPH01261335A JP H01261335 A JPH01261335 A JP H01261335A JP 63088489 A JP63088489 A JP 63088489A JP 8848988 A JP8848988 A JP 8848988A JP H01261335 A JPH01261335 A JP H01261335A
- Authority
- JP
- Japan
- Prior art keywords
- barium sulfate
- viscosity
- contrast medium
- gum
- suspension
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 title claims abstract description 56
- 239000002872 contrast media Substances 0.000 title claims abstract description 20
- 239000000725 suspension Substances 0.000 claims abstract description 15
- 239000007864 aqueous solution Substances 0.000 claims abstract description 9
- 239000006185 dispersion Substances 0.000 claims abstract description 7
- 239000003381 stabilizer Substances 0.000 claims abstract description 7
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 13
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 13
- 239000002253 acid Substances 0.000 description 8
- 239000002270 dispersing agent Substances 0.000 description 7
- 239000000203 mixture Substances 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- -1 alginate propylene glycol ester Chemical class 0.000 description 3
- 229910052788 barium Inorganic materials 0.000 description 3
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 210000004051 gastric juice Anatomy 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 229920000084 Gum arabic Polymers 0.000 description 2
- 241000978776 Senegalia senegal Species 0.000 description 2
- 239000000205 acacia gum Substances 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 241000588810 Alcaligenes sp. Species 0.000 description 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- WDIHJSXYQDMJHN-UHFFFAOYSA-L barium chloride Chemical compound [Cl-].[Cl-].[Ba+2] WDIHJSXYQDMJHN-UHFFFAOYSA-L 0.000 description 1
- 229910001626 barium chloride Inorganic materials 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229940039231 contrast media Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000002594 fluoroscopy Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明はＸ線写真撮影によって人体検査を行なう際に用
いる硫酸バリウム造影剤に関する。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a barium sulfate contrast agent used in human body examination by X-ray photography.
［従来の技術］
硫醜バリウムは化学的に非常に安定で且つ生理的に無害
な化合物であり、又強力なｘＢ遮蔽作用を有する。それ
故硫酸バリウムはＸ線造影剤に広く使用されている。[Prior Art] Barium sulfate is a chemically very stable and physiologically harmless compound, and also has a strong xB shielding effect. Barium sulfate is therefore widely used as an X-ray contrast agent.
一般にＸ線用硫酸バリウム造影剤は硫酸バリウムの濃度
が高く、シかも服用し易い低粘度であって、沈殿しにく
い、１Ｔ）ｆ酸性が優れているなどの諸条件を具えてい
ることが要求されている。In general, barium sulfate contrast agents for X-rays are required to have a high concentration of barium sulfate, a low viscosity that is easy to take, difficult to precipitate, and excellent acidity. has been done.
従来からこの種の硫酸バリウム造影剤の懸濁分散安定剤
としては種々のものが知られているが１上記諸条件を十
分に満足させることの出来る分散剤は未だ見当らない、
今までに知られている分散剤としてはアラビアガム、ア
ルギン酸プロピレングリコールエステル、ポリアクリル
Ｒｆｆｉ、ＰＶＡ、ＣＭＣなどがあるが、分散性、耐酸
性の挙動などの点で欠点を有している。Various kinds of suspension dispersion stabilizers for this type of barium sulfate contrast agent have been known so far, but 1. A dispersing agent that can fully satisfy the above conditions has not yet been found.
Dispersants known so far include gum arabic, alginate propylene glycol ester, polyacrylic Rffi, PVA, and CMC, but these have drawbacks in terms of dispersibility, acid resistance behavior, and the like.
［発明が解決しようとする問題点１
分散剤を含んでいる硫酸バリウム造影剤の大きな欠点は
胃の造影を行なう場合に、上記分散剤が胃液の塩酸の作
用を受けて凝固変化したり、あるいは粘度上ｙを起こし
たりすることである。特に二重造影を行なう場合に消化
管壁細部にある壁の奥まで硫酸バリウム粒子が入りにく
く、均一に伺若しにくいため消化管壁の状態を正確に造
影し得なくなる欠点を有している。その結果、Ｘ線透視
、あるいは写真による正確な判断が不可能となる場合が
多い。[Problem to be Solved by the Invention 1] A major drawback of barium sulfate contrast media containing a dispersing agent is that when contrasting the stomach, the dispersing agent may coagulate or change due to the action of hydrochloric acid in the gastric juice. This may cause y to increase in viscosity. In particular, when performing double contrast imaging, barium sulfate particles are difficult to penetrate deep into the walls of the gastrointestinal tract, making it difficult to visualize them uniformly, making it impossible to accurately image the condition of the gastrointestinal wall. . As a result, accurate judgment using X-ray fluoroscopy or photography is often impossible.
［ｌ？！］２１１Ｉ点を解決するための手段］本発明者
らは、前述の問題点を解消するためにＸ線用硫酸バリウ
ム造影剤用に優れた分散剤を開発すべく鋭意研究の結果
、懸濁分散安定剤としてラムザンガムと２％水溶液粘度
（２５℃における測定値、以下同じ）が２０ｃＰ以下で
あるカルボキシメチルセルロースナトリウム（以下ＣＭ
Ｃと略称する）を使用することによって、高濃度硫酸バ
リウム造影剤であっても１服用し易い低粘度であって、
沈殿しにくい、耐酸性が優れているなどの諸条件を同時
に満たすことが出来ることを見出して本発明に至ったも
のである。[l? ! [Means for solving the 211I point] In order to solve the above-mentioned problems, the present inventors have conducted intensive research to develop an excellent dispersant for barium sulfate contrast agents for X-rays, and as a result, the present inventors have developed a suspension dispersion agent. As a stabilizer, Ramsan gum and sodium carboxymethyl cellulose (hereinafter referred to as CM
By using a high-concentration barium sulfate contrast agent, it has a low viscosity that is easy to take in one dose.
The present invention was achieved by discovering that various conditions such as being hard to precipitate and having excellent acid resistance can be satisfied at the same time.
即ち１本発明は硫酸バリウ１１造影剤の懸濁分散安定剤
としてラムザンガム、および２％水溶液粘度が２０ｃＰ
以下であるＣＭＣを含有することを４、ν徴とするＸ線
用硫酸バリウム造影剤を提供するものである。That is, 1. The present invention uses Ramsan gum as a suspension dispersion stabilizer for barium sulfate 11 contrast agent, and the viscosity of the 2% aqueous solution is 20 cP.
The object of the present invention is to provide a barium sulfate contrast agent for X-rays containing the following CMC.
本発明による造影剤中の硫酸バリウム汝度は一般に５０
〜２００（ｗ／マ％）の範囲である。 ゛本発明にお
いて、使用するラムザンガムは醗酵供
多糖類であり、徴６性物Ａｌｃａｌｉｇｅｎｅｓ−ｓｐ
ｅｃｉｅｓ、 ＡＴＣＣ３１９６１（Ａｍｅｒｉｃａ
ｎ Ｔｙｐｅ Ｃｕ１Ｌｕｒｅ Ｃ。The barium sulfate consistency in the contrast agent according to the invention is generally 50
~200 (w/ma%).゛In the present invention, the Ramsan gum used is a fermented polysaccharide, and the characteristic substance Alcaligenes-sp.
ecies, ATCC31961 (America
n Type Cu1Lure C.
１１ｅｃｔｉｏｎに登録されたＮｏ、）がグルコースを
醗酵させてその菌体外に蓄積した多糖類を、精製し粉末
にした天然ガム質である。その化学構造は、下記に示す
ように、主鎖は、２個のグルコースと、グルクロン酸と
ラムノースが各１個、側鎖は、２個のグルコースより構
成されている。No. 11ection) is a natural gum substance made by refining and powdering polysaccharides accumulated outside the bacterial cells by fermenting glucose. Its chemical structure is as shown below, the main chain is composed of two glucose, one each of glucuronic acid and rhamnose, and the side chain is composed of two glucose.
本発明において、使用するＣＭＣは２％水溶液粘度が２
０ｃＰ以下のものを使用する。In the present invention, the CMC used has a 2% aqueous solution viscosity of 2
Use one with 0 cP or less.
本発明によるｉ酸バリウム造影剤中のラムザンガムは主
としてスラリーの懸濁性付与と耐酸性付与剤として働き
、２％水溶液粘度が２０ｃＰ以下であるＣＭＣは主とし
て分散剤としてｌ？Ｊ＜、ＣＭＣの２％粘度が２０ｃＰ
以上になると硫酸バリウムスラリーの粘度が高くなり服
用し易い特徴がなくなるのでＣＭＣの２％粘度は２０ｃ
Ｐ以下が良い０本発明はこのように２種類の異なった水
溶性高分子を併用することによって、高濃度硫酸バリウ
ム造影剤であっても、服用し易い低粘度であって、沈殿
しにくい、ＦｆａＪ酸性が優れているなどの諸条件を同
時に満たすことが出来る組成物となしうる。Ramsan gum in the barium chloride contrast agent according to the present invention mainly acts as an agent for imparting suspension and acid resistance to the slurry, and CMC whose viscosity of a 2% aqueous solution is 20 cP or less mainly acts as a dispersing agent. J<, 2% viscosity of CMC is 20cP
If it exceeds this, the viscosity of the barium sulfate slurry becomes high and it loses its characteristic of being easy to take, so the 2% viscosity of CMC is 20c.
By using two different types of water-soluble polymers in combination, the present invention has a low viscosity that is easy to take, and is difficult to precipitate, even with a high concentration barium sulfate contrast agent. The composition can simultaneously satisfy various conditions such as excellent FfaJ acidity.
尚、本発明の実施に際し、ラムザンガムとＣＭＣ以外に
他の分散剤、アラビアガム、アルギン醜プロピレングリ
コールエステル、ポリアクリル酸Ｊ！！、ＰＶＡ等の増
粘剤を併用することは、なんら差し支えない。In carrying out the present invention, in addition to Ramsan gum and CMC, other dispersants, gum arabic, alginic propylene glycol ester, and polyacrylic acid J! ! There is no problem in using a thickener such as , PVA, etc.
次に本発明を実施例により具体的に説明するが、本発明
は、これら実施例に限定されるものでない。EXAMPLES Next, the present invention will be specifically explained with reference to Examples, but the present invention is not limited to these Examples.
実施例１ Ｅｔａバリウムは日本薬局方グレードを用いた。Example 1 Japanese Pharmacopoeia grade Eta barium was used.
又、ラムザンガムとしてＤＫラムザンＥ第一工業製薬株
式会社商品名、ラムザンガム］を用いた。In addition, DK Ramzan E Daiichi Kogyo Seiyaku Co., Ltd. (trade name, Ramzan Gum) was used as the Ramzan gum.
本実施例において表−１に示す配合で以下の方法により
各硫酸バリウム懸濁１（原ゾル）を得た。In this example, each barium sulfate suspension 1 (original sol) was obtained according to the following method using the formulations shown in Table 1.
水１４４ｍＵでＣＭＣ＋ラムザンガムを溶解後硫酸バリ
ウム２４０ｇを加えホモミキサーで８００Ｏｒｐｍ
２分間攪拌分散させた。After dissolving CMC + Ramsan gum in 144 mU of water, add 240 g of barium sulfate and mix with a homomixer at 800 rpm.
The mixture was stirred and dispersed for 2 minutes.
このｇ酸バリウム懸Ｆ３液の粘度及び安定性を以下の方
法により評価した。The viscosity and stability of this F3 solution suspended in barium acid were evaluated by the following method.
■粘度
被試験懸濁液２００ｍ文をトールビーカーにとり、２５
℃の恒温槽に３０分放置後Ｂ型粘度計（東京計器）使用
３０ｒｐｍ、２分間ローターを回転させて測定した。■Viscosity Take 200 m of the suspension to be tested in a tall beaker and
After being left in a constant temperature bath at 0.degree. C. for 30 minutes, measurements were taken using a B-type viscometer (Tokyo Keiki) by rotating the rotor at 30 rpm for 2 minutes.
■人工胃液添加による粘度変化
原ゾル１００ｍＪＬに人工胃液（特級塩酸１７ｍ１／１
０００ｍＪｌ）１３ｍＪｌを加えよく攪拌後、上記同様
の条件で粘度を測定した。■ Change in viscosity due to the addition of artificial gastric juice to the original sol 100mJL and artificial gastric juice (special grade hydrochloric acid 17ml 1/1
After adding 13 mJl (000 mJl) and stirring well, the viscosity was measured under the same conditions as above.
粘度測定後の被試験懸濁液を１００ｍ文メスシリンダー
に入れて静置し、１０日後の上澄液の容植を測定した。After measuring the viscosity, the test suspension was placed in a 100 m graduated cylinder and allowed to stand, and the concentration of the supernatant liquid was measured after 10 days.
表−１から明らかな如く、ラムザンガムと２％水溶液粘
度が２０ｃＰ以下であるＣＭＣを使用すると、硫酸バリ
ウム懸濁液は耐酸性、沈降防止の点でラムザンガム単独
或いはＣＭＣ単独使用に比べて驚異的な効果を示すこと
が判明した。As is clear from Table 1, when using Ramsan gum and CMC with a 2% aqueous solution viscosity of 20 cP or less, the barium sulfate suspension has amazing acid resistance and sedimentation prevention compared to using Ramsan gum alone or CMC alone. It was found to be effective.
実施例２
硫酸バリウム、ラムザンガムは実施例１と同グレードの
ものを用いた。Example 2 Barium sulfate and Ramsan gum of the same grade as in Example 1 were used.
本実施例において表−２に示す配合で、実施例１と同じ
方法で各ｍ酸バリウム懸濁液（原ゾル）を調製し且つ実
施例１と同じ方法で測定した。。In this example, each m-acid barium suspension (original sol) was prepared in the same manner as in Example 1 using the formulations shown in Table 2, and was measured in the same manner as in Example 1. .
表−２から明らかな如く、ラムザンガムと２％水溶液粘
度が２０ｃＰ以下であるＣＭＣを使用すると、硫欣バリ
ウム懸濁液はラムザンガムと２％水溶液粘度が２０ｃＰ
以上であるＣＭＣを使用した懸濁液に比べて耐酸性、沈
降防止の点で驚異的な効果を示すことが判明した。As is clear from Table 2, when Ramsan gum and CMC with a 2% aqueous solution viscosity of 20 cP or less are used, the barium sulfate suspension has Ramsan gum and a 2% aqueous solution viscosity of 20 cP or less.
It has been found that this suspension exhibits surprising effects in terms of acid resistance and sedimentation prevention compared to the above suspensions using CMC.
表−１
表−２
Ｃ涼ゾル１００ｎ父に人工胃液１３ｍＪＬ添加［発明の
効果］
本発明Ｘ線用硫酸バリウム造影剤の懸〜分散安定剤とし
てラムザンガムと２％水溶液粘度が２０ｃＰ以下である
ＣＭＣを使用することによって。Table-1 Table-2 Addition of 13 mJL of artificial gastric fluid to 100 n of C-Ryosol [Effects of the invention] Ramsan gum and CMC having a 2% aqueous solution viscosity of 20 cP or less were used as suspension-dispersion stabilizers for the barium sulfate contrast agent for X-rays of the present invention. By using.
高濃度硫酸バリウム造影剤であっても、服用し易い低粘
度であって、沈殿しにくい、耐酸性が優れているなどの
諸条件を同時に満たすＸ線用硫酸バリウム造影剤を提供
することができる。Even if it is a high concentration barium sulfate contrast agent, it is possible to provide a barium sulfate contrast agent for X-rays that has a low viscosity that is easy to take, does not easily precipitate, and has excellent acid resistance. .
特許出願人第一・工業製薬株式会社Patent applicant Daiichi Kogyo Seiyaku Co., Ltd.
Claims (1)
ム、および２％水溶液粘度が２０ｃＰ以下であるカルボ
キシメチルセルロースナトリウムを含有することを特徴
とするＸ線用硫酸バリウム造影剤。A barium sulfate contrast agent for X-rays, characterized in that it contains ramsan gum as a suspension dispersion stabilizer for the barium sulfate contrast agent, and sodium carboxymethyl cellulose having a 2% aqueous solution viscosity of 20 cP or less.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63088489A JPH01261335A (en) | 1988-04-11 | 1988-04-11 | Barium sulfate contrast medium for x ray |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63088489A JPH01261335A (en) | 1988-04-11 | 1988-04-11 | Barium sulfate contrast medium for x ray |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH01261335A true JPH01261335A (en) | 1989-10-18 |
Family
ID=13944217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63088489A Pending JPH01261335A (en) | 1988-04-11 | 1988-04-11 | Barium sulfate contrast medium for x ray |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH01261335A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4029592A1 (en) * | 1990-09-19 | 1992-03-26 | Stockhausen Chem Fab Gmbh | Degradable absorption agent based on polymers - comprises at least one water swellable synthetic polymer and at least one polysaccharide, used for prepn. of hygiene articles, etc. |
| JPH07196536A (en) * | 1993-12-28 | 1995-08-01 | Nippon Paper Ind Co Ltd | Barium sulfate x ray contrast media |
| JPH07309782A (en) * | 1994-01-24 | 1995-11-28 | Takahiro Ogawa | Contrast medium |
-
1988
- 1988-04-11 JP JP63088489A patent/JPH01261335A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4029592A1 (en) * | 1990-09-19 | 1992-03-26 | Stockhausen Chem Fab Gmbh | Degradable absorption agent based on polymers - comprises at least one water swellable synthetic polymer and at least one polysaccharide, used for prepn. of hygiene articles, etc. |
| JPH07196536A (en) * | 1993-12-28 | 1995-08-01 | Nippon Paper Ind Co Ltd | Barium sulfate x ray contrast media |
| JPH07309782A (en) * | 1994-01-24 | 1995-11-28 | Takahiro Ogawa | Contrast medium |
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