JP2820268B2 - Skin treatment material for transdermal administration - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a skin treatment material for applying substantially no irritation, such as micropores or microcracks, to the skin or mainly to the stratum corneum thereof during transdermal administration.

The administration of drugs by transdermal administration is expected to be a means of sufficiently exerting the medicinal effect without causing side effects such as gastrointestinal disorders as compared with oral administration, and further enhances percutaneous respiration by adding electric means. Ionphorase has recently been receiving increasing attention. ((Glass James et al., International Journal of Dermatology
JM et al., Int. J. Dermatol.) 19 519 (1980); Russo J., American Journal of Hospital Pharmacy (Russo J., Am. J. Hosp. Pharm.) 37 843.
(1980); Gangarosa LP, et al., Journal of Pharmacological Experiment and Therapy (Gangarosa LP et al., J. Pharmacol. Exp. The
r.) 212 377 (1980); Kwanbyes et al., Journal of Infectious Dessies (Kwon BS et a
L., J. Infect. Dis.) 140 1014 (1979); Hill JM et al., Annual of New York Academy of Science (Hill JM et al., Ann. NY. Acad. Sci.) 2
84 604 (1977) and Tannebaum M., Physical Therapy (Tannebaum M., Phys. Ther.) 60 792 (198)
0) and so on)). However, in the transdermal administration method of the passive diffusion method, the percutaneous absorption ability of a medicinal component has not yet been sufficiently elucidated, and for iontophoresis, drugs capable of sufficiently exhibiting medicinal effects are limited. The range of application for transdermal administration of drugs was very limited.

The present inventors have conducted intensive studies and found that the impedance or barrier ability of skin tissue mainly depends on the stratum corneum composed of hard proteins having a thickness of about several tens of microns. Thereby, micro-lacs and micropores can be formed in the stratum corneum with substantially no pain and without irritation, and as a result, transdermal administration of a drug having a large molecular weight such as a peptide such as insulin and calcitonin is effective. Knowledge that it can be achieved
The present invention has been reached.

That is, the object of the present invention is to provide a skin pretreatment material particularly suitable for iontophoresis as well as a mere passive diffusion type transdermal administration.

Hereinafter, regarding the configuration of the skin treatment material for transdermal administration of the present invention,
This will be described in detail with reference to the accompanying drawings.

The accompanying drawings are schematic cross-sectional views showing a laminated structure of the skin pretreatment material of the present invention. In the drawings, the material of the present invention is a coating material layer 1 made of a sheet or film material such as plastic, paper material, metal foil, etc. Various cyanoacrylate-based adhesives (so-called instantaneous adhesives) such as alkyl 2-cyanoacrylates such as ethyl, butyl, etc .; layer 2; polyethylene, silicon, Teflon, etc. having voids in any pattern, such as dot-like, linear, etc. A spacer layer 4 composed of various plastic films having a relatively low affinity for the adhesive or an arbitrary film or sheet material surface-treated with these plastics, cellophane, metal foil, plastic film or sheet material, And a support layer 5 composed of various films or sheet materials having stronger adhesiveness to the skin than the skin. That.

As is well known, cyanoacrylate-based adhesives are polymerized by moisture and are difficult to store. However, the above-mentioned laminated structure makes it possible to make stable storage up to the time of use more convenient, and furthermore, a spacer having voids 3 The layer 4 allows the relatively low-viscosity adhesive to be arbitrarily and accurately printed on the surface of the support layer 5 in a desired area, pattern, and shape. And other advantages can be achieved.

That is, at the time of use, the support is peeled between the spacer layer 4 and the support layer 5 and the support is adhered to the biological skin to be treated and peeled off, whereby the stratum corneum is effectively peeled off by a predetermined area. Is easily achieved.

It is also possible to coat a normal adhesive on the non-vacant portion of the spacer layer 4 and transfer it to the corresponding portion of the support layer 5 to make the skin contact easier. Needless to say, a desired surface treatment may be applied to make the surface of the No. 5 more compatible with the adhesive.

Further, the ratio of the vacant portion of the spacer layer 4 to the total area may be appropriately determined as desired, but is usually preferably about 0.01 to 10%. Further, the shape is arbitrary such as a dot shape, a linear shape, etc., but it is more preferable that the shape is uniformly dispersed throughout.

FIG. 2 shows another embodiment of the present invention, in which the adhesive layer 2 is provided only in the space 3 of the spacer layer 4.

[Brief description of the drawings]

FIGS. 1 and 2 are schematic explanatory sectional views of the laminated material of the present invention. 1 ... coating layer, 2 ... cyanoacrylate-based adhesive layer, 4 ... spacer layer, 5 ... support layer.

Claims (1)

(57) [Claims] 1. A skin treatment material for transdermal administration comprising a coating material layer, a cyanoacrylate adhesive layer, a spacer layer having a space of a predetermined area, and a support layer.