JP2731353B2 - Skin cosmetics - Google Patents
Skin cosmeticsInfo
- Publication number
- JP2731353B2 JP2731353B2 JP18399594A JP18399594A JP2731353B2 JP 2731353 B2 JP2731353 B2 JP 2731353B2 JP 18399594 A JP18399594 A JP 18399594A JP 18399594 A JP18399594 A JP 18399594A JP 2731353 B2 JP2731353 B2 JP 2731353B2
- Authority
- JP
- Japan
- Prior art keywords
- present
- stability
- bisabolol
- safety
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Cosmetics (AREA)
Description
【０００１】[0001]
【産業上の利用分野】本発明は、皮膚化粧料に関し、さ
らに詳しくはエモリエント効果、使用時の官能特性、安
全性および安定性に優れた皮膚化粧料に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin cosmetic, and more particularly to a skin cosmetic excellent in emollient effect, organoleptic properties during use, safety and stability.
【０００２】[0002]
【従来技術および発明が解決しようとする課題】皮膚化
粧料にはエモリエント効果を目的に種々の油性基剤が配
合されている。従来より用いられていた油性基剤として
は、流動パラフィンおよびスクワランに代表される炭化
水素、オリブ油およびヒマシ油に代表されるトリグリセ
ライド、高級脂肪酸エステル、脂肪酸および高級アルコ
ール等が挙げられる。これらの中で、常温で液状の油性
基剤は、皮膚化粧料に相当量用いられ、効能・効果およ
び官能特性を決定する一因であることから重要視されて
いる。皮膚化粧料に応用される油性基剤の必要条件とし
て、上記のエモリエント効果および官能特性の他に、安
全性および安定性が挙げられる。2. Description of the Prior Art Various oily bases are incorporated into skin cosmetics for the purpose of emollient effect. Conventionally used oil bases include hydrocarbons such as liquid paraffin and squalane, triglycerides such as olive oil and castor oil, higher fatty acid esters, fatty acids and higher alcohols. Among these, oily bases that are liquid at room temperature are used in skin cosmetics in considerable amounts, and are regarded as important because they are factors that determine the efficacy, effect, and sensory characteristics. Prerequisites for an oily base applied to skin cosmetics include safety and stability, in addition to the emollient effect and sensory properties described above.
【０００３】しかしながら、代表的な油性基剤である流
動パラフィンは、安定性および安全性には優れているも
のの、使用時の油性感が強く官能特性上好ましくない。
これを改善するため、分岐構造の炭化水素であるスクア
ランが用いられている。スクアランは流動パラフィンに
比較して官能特性上は優れているものの、十分とは言え
ず、また親水基を有していないので乳液およびクリーム
等の乳化型製剤以外への配合は困難である。[0003] However, liquid paraffin, which is a typical oily base, is excellent in stability and safety, but has a strong oily feeling at the time of use and is not preferable in terms of sensory characteristics.
In order to improve this, squalane which is a hydrocarbon having a branched structure is used. Although squalane is superior to liquid paraffin in organoleptic properties, it cannot be said to be sufficient, and since it does not have a hydrophilic group, it is difficult to incorporate it into non-emulsified preparations such as emulsions and creams.
【０００４】オリブ油およびヒマシ油に代表されるトリ
グリセライドは、肌なじみ等の使用感には優れているも
のの、天然品は不飽和結合を有するものや不純物を含む
ために安定性が悪い。そこで、飽和高級脂肪酸を用いた
トリグリセライドやエステル類が合成されているが、安
定性には優れているものの、皮膚刺激性を示すものが少
なくなく問題視されている。[0004] Triglycerides represented by olive oil and castor oil are excellent in usability such as skin familiarity, but natural products are poor in stability due to containing unsaturated bonds and impurities. Therefore, triglycerides and esters using a saturated higher fatty acid have been synthesized. However, although they have excellent stability, some of them exhibit skin irritation and are regarded as a problem.
【０００５】高級脂肪酸および高級アルコールは常温で
固体のものが多く配合量に制限がある。不飽和の高級ア
ルコールおよび脂肪酸、または分岐の高級アルコールお
よび脂肪酸は常温で液状のものがあり、近年注目されて
いるが、前者は天然のトリグリセライドと同様に安定性
が悪く、後者は天然に存在しないものが多く、高価であ
る。[0005] Higher fatty acids and higher alcohols are often solid at room temperature, and their amounts are limited. Unsaturated higher alcohols and fatty acids, or branched higher alcohols and fatty acids are liquid at room temperature and have attracted attention in recent years, but the former has poor stability like natural triglycerides, and the latter does not exist in nature Lots of things and expensive.
【０００６】以上のように、従来の油性基剤にはそれぞ
れ問題点があり、これらの問題を解決するために、上記
の油性基剤を適宜混合し用いることや、新規の天然由来
トリグリセライドや合成エステル等の開発が行われてい
る。As described above, the conventional oil-based bases have respective problems. In order to solve these problems, the above-mentioned oil-based bases may be appropriately mixed and used, or a new naturally-derived triglyceride or synthetic base may be used. Development of esters and the like is underway.
【０００７】[0007]
【課題を解決するための手段】係る状況に鑑み鋭意検討
した結果、分岐構造を有するものが官能特性上優れてお
り、さらに水酸基に代表される親水基を有するものが各
種製剤への配合が容易であると考え、ビサボロールの水
素添加体である構造式化２で示される化合物を配合した
皮膚化粧料がエモリエント効果、使用時の官能特性、安
全性および安定性に優れていることを見いだし、本発明
を完成するに至った。As a result of intensive studies in view of the above circumstances, those having a branched structure are superior in terms of functional properties, and those having a hydrophilic group represented by a hydroxyl group are easily incorporated into various preparations. And found that skin cosmetics containing a compound represented by structural formula 2, which is a hydrogenated product of bisabolol, are excellent in emollient effect, sensory characteristics during use, safety and stability. The invention has been completed.
【０００８】[0008]
【化２】 Embedded image
【０００９】すなわち、本発明は前記構造式化２で示さ
れる化合物を配合することを特徴とする皮膚化粧料であ
る。[0009] That is, the present invention is a skin cosmetic comprising the compound represented by the structural formula (2).
【００１０】さらに、本発明の皮膚化粧料に従来より用
いられている油性基剤を合わせて用いると、従来の基剤
に起因するヌルつき感および油性感等の官能特性上の欠
点が解消される。また、本発明の皮膚化粧料に用いられ
る前記構造式化２で示される化合物は、水酸基を有する
ために、ローションへの配合も容易であり、エモリエン
ト効果の高いローションを提供することが可能となる。Further, when the conventionally used oily base is used in combination with the skin cosmetic of the present invention, defects in the sensory characteristics such as a feeling of nullness and oiliness caused by the conventional base are eliminated. You. Further, since the compound represented by the structural formula 2 used in the skin cosmetic of the present invention has a hydroxyl group, it can be easily incorporated into a lotion, and can provide a lotion having a high emollient effect. .
【００１１】以下、本発明の構成の詳細について説明す
る。本発明に用いられる化合物は、前記構造式化２で示
され、抽出法、製法等は特に問わない。また、該化合物
には立体異性体が存在するが、何れか単独または２種以
上の混合物でも差し支えない。Hereinafter, the configuration of the present invention will be described in detail. The compound used in the present invention is represented by Structural Formula 2, and the extraction method, production method, and the like are not particularly limited. The compound has stereoisomers, but any one of them or a mixture of two or more thereof may be used.
【００１２】本発明に用いられる化合物は、例えば、α
−ビサボロールをＺ．Ｎａｔｕｒｆｏｒｓｃｈ．、Ｃ：
Ｂｉｏｓｃｉ．、４６（５−６）、３４９−３５６
（１９９１）に記載されている、Ｈａｓｈｉｄｏｋｏら
の方法を用いて調製できる。本発明に用いられるビサボ
ロールの水素添加体を、以下水添ビサボロールという。
水素添加する前のビサボロールは、構造中に不飽和結合
を有するため、経時で変臭・変色する。The compound used in the present invention is, for example, α
-Bisabolol as Z.I. Natureforsch. , C:
Biosci. , 46 (5-6), 349-356
(1991) using the method of Hashidoko et al. The hydrogenated bisabolol used in the present invention is hereinafter referred to as hydrogenated bisabolol.
Before hydrogenation, bisabolol has an unsaturated bond in its structure, and therefore changes its odor and color over time.
【００１３】本発明に用いられる水添ビサボロールの配
合量は、特に限定されるものではないが、本発明の目的
である、エモリエント効果、使用時の官能特性、安全性
および安定性を示す範囲を検討した結果、最終組成物の
総量を基準に０．０１〜２０重量％が好ましい。The amount of hydrogenated bisabolol to be used in the present invention is not particularly limited, but the range of the purpose of the present invention is to exhibit the emollient effect, sensory characteristics during use, safety and stability. As a result of the examination, the content is preferably 0.01 to 20% by weight based on the total amount of the final composition.
【００１４】本発明が適用される製剤としては、ローシ
ョン、クリーム、乳液、パックおよび入浴剤等が挙げら
れる。The preparations to which the present invention is applied include lotions, creams, emulsions, packs, bath salts and the like.
【００１５】本発明の皮膚化粧料には、必須構成成分の
他に、上記製剤を形成するため、本発明の効果を損なわ
ない範囲で該製剤に応じた基剤、保存剤、香料および色
剤等を適宜配合することができる。In the skin cosmetic of the present invention, in addition to the essential constituents, the base, preservative, fragrance, and coloring agent corresponding to the preparation are formed in order to form the above-mentioned preparation without impairing the effects of the present invention. Etc. can be appropriately compounded.
【００１６】[0016]
【実施例】以下実施例により本発明を更に詳細に説明す
る。なお、以下における％表示は、特に指定しない限
り、重量％を示す。The present invention will be described in more detail with reference to the following examples. In addition,% display below shows% by weight, unless otherwise specified.
【００１７】実施例中の官能試験、安全性試験および保
存安定性試験は以下の通りである。The sensory test, safety test and storage stability test in the examples are as follows.
【００１８】（官能試験および安全性試験）２０名の女
性パネラーによる実用テストを実施し、「感触」、「エ
モリエント効果」、「皮膚刺激性」について、「感触が
良い」、「エモリエント効果が高い」、「皮膚刺激性が
無い」と答えた人数で評価した。(Sensory Test and Safety Test) Practical tests were conducted by 20 female panelists, and "feel good" and "high emollient effect" were obtained for "feel", "emollient effect" and "skin irritation". And "No skin irritation".
【００１９】（保存安定性試験）５℃および４０℃の恒
温槽に試料を１か月間保存し、両者の着色および匂いの
変化を比較し、変化の無いものを○、若干変化のあるも
のを△、著しい変化のあるものを×とした。(Storage stability test) Samples were stored in a thermostat at 5 ° C. and 40 ° C. for one month, and the changes in coloring and odor of both samples were compared. Δ, those with significant changes were marked as x.
【００２０】実施例１ ローション剤Example 1 Lotion agent
【００２１】[0021]
【表１】 [Table 1]
【００２２】表１の組成の通り、本発明のローションを
常法に従って調製し、上記の試験を実施した。According to the composition shown in Table 1, the lotion of the present invention was prepared according to a conventional method, and the above test was carried out.
【００２３】比較例１ ローション剤Comparative Example 1 Lotion agent
【００２４】[0024]
【表２】 [Table 2]
【００２５】表２の組成の通り、比較用のローションを
常法に従って調製し、上記の試験を実施した。According to the composition shown in Table 2, a lotion for comparison was prepared according to a conventional method, and the above test was carried out.
【００２６】実施例２ クリームExample 2 Cream
【００２７】[0027]
【表３】 [Table 3]
【００２８】表３の組成の通り本発明の水添ビサボロー
ルを配合したクリームを常法に従って調製し、上記試験
を実施した。A cream containing the hydrogenated bisabolol of the present invention according to the composition shown in Table 3 was prepared according to a conventional method, and the above test was carried out.
【００２９】比較例２ クリームComparative Example 2 Cream
【００３０】[0030]
【表４】 [Table 4]
【００３１】表４の組成の通り比較用のクリームを常法
に従って調製し、上記試験を実施した。A cream for comparison was prepared according to a conventional method according to the composition shown in Table 4, and the above test was carried out.
【００３２】実施例３ 乳液Example 3 Emulsion
【００３３】[0033]
【表５】 [Table 5]
【００３４】表５の組成の通り本発明の水添ビサボロー
ルを配合した乳液を常法に従って調製し、上記試験を実
施した。An emulsion containing the hydrogenated bisabolol of the present invention according to the composition shown in Table 5 was prepared according to a conventional method, and the above test was carried out.
【００３５】比較例３ 乳液Comparative Example 3 Emulsion
【００３６】[0036]
【表６】 [Table 6]
【００３７】表６の組成の通り比較用のクリームを常法
に従って調製し、上記試験を実施した。A cream for comparison was prepared according to a conventional method according to the composition shown in Table 6, and the above test was carried out.
【００３８】実施例１〜３および比較例１〜３の、上記
官能試験および安定性試験結果を表７に示す。Table 7 shows the results of the above sensory tests and stability tests of Examples 1 to 3 and Comparative Examples 1 to 3.
【００３９】[0039]
【表７】 [Table 7]
【００４０】表７に示した如く、本発明の実施例１〜３
は、官能特性、安全性および安定性に優れており、水添
ビサボロールを応用した本発明の皮膚化粧料が各種製剤
形態で優れていることは明かである。水添ビサボロール
の替わりにスクワランを用いた比較例１は感触がやや劣
り、安定性が著しく悪くスクワランが分離してしまっ
た。水添ビサボロールの替わりに流動パラフィンを用い
た比較例２は、安定性には優れているものの、感触が著
しく悪かった。水添ビサボロールの替わりにミリスチン
酸イソセチルを用いた比較例３は、感触およびエモリエ
ント効果に著しく劣り、刺激を感じるパネラーもあり安
全性上も問題視される。As shown in Table 7, Examples 1 to 3 of the present invention
Is excellent in sensory characteristics, safety and stability, and it is clear that the skin cosmetic of the present invention to which hydrogenated bisabolol is applied is excellent in various formulation forms. In Comparative Example 1 in which squalane was used in place of hydrogenated bisabolol, the feel was slightly inferior, the stability was extremely poor, and squalane was separated. Comparative Example 2, in which liquid paraffin was used instead of hydrogenated bisabolol, was excellent in stability, but had a very bad feel. Comparative Example 3, in which isocetyl myristate was used in place of hydrogenated bisabolol, was remarkably inferior in feel and emollient effect, and some panelists felt irritation, which was regarded as a problem in safety.
【００４１】実施例４ 化粧水Example 4 Lotion
【００４２】[0042]
【表８】 [Table 8]
【００４３】表８の組成の通り常法に従い本発明の水添
ビサボロールを配合したローションを調製した。According to the composition shown in Table 8, a lotion containing the hydrogenated bisabolol of the present invention was prepared according to a conventional method.
【００４４】実施例５ 乳液Example 5 Emulsion
【００４５】[0045]
【表９】 [Table 9]
【００４６】表９の組成の通り常法に従い本発明の水添
ビサボロールを配合した乳液を調製した。An emulsion containing the hydrogenated bisabolol of the present invention was prepared according to a conventional method according to the composition shown in Table 9.
【００４７】実施例６ パックExample 6 Pack
【００４８】[0048]
【表１０】 [Table 10]
【００４９】表１０の組成の通り常法に従い本発明の水
添ビサボロールを配合したパックを調製した。A pack containing the hydrogenated bisabolol of the present invention was prepared according to a conventional method according to the composition shown in Table 10.
【００５０】実施例７ ヘアートニックExample 7 Hair Tonic
【００５１】[0051]
【表１１】 [Table 11]
【００５２】表１１の組成の通り常法に従い本発明の水
添ビサボロールを配合したヘアートニックを調製した。According to a conventional method, a hair tonic containing the hydrogenated bisabolol of the present invention was prepared according to the composition shown in Table 11.
【００５３】実施例４〜７は上記の官能特性試験、安全
性および安定性の各項目において何れも優れていた。Examples 4 to 7 were all excellent in the above-mentioned sensory property test, safety and stability.
【００５４】[0054]
【発明の効果】以上記載の如く、本発明は、エモリエン
ト効果、官能特性、安全性および安定性に優れた皮膚化
粧料を提供することは明かである。As described above, it is apparent that the present invention provides a skin cosmetic excellent in emollient effect, sensory characteristics, safety and stability.
Claims (1)
料。1. The following structural formula: A skin cosmetic comprising a compound represented by the formula:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18399594A JP2731353B2 (en) | 1994-07-12 | 1994-07-12 | Skin cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18399594A JP2731353B2 (en) | 1994-07-12 | 1994-07-12 | Skin cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0826966A JPH0826966A (en) | 1996-01-30 |
| JP2731353B2 true JP2731353B2 (en) | 1998-03-25 |
Family
ID=16145484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP18399594A Expired - Fee Related JP2731353B2 (en) | 1994-07-12 | 1994-07-12 | Skin cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2731353B2 (en) |
-
1994
- 1994-07-12 JP JP18399594A patent/JP2731353B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0826966A (en) | 1996-01-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4767625A (en) | Lamella type single phase liquid crystal composition and oil-base cosmetic compositions using the same | |
| JPS63192703A (en) | External agent for skin | |
| AU9742501A (en) | Method for reducing the appearance of dark circles under the eyes | |
| JPH0818948B2 (en) | Aqueous cosmetic and its manufacturing method | |
| JPS63192704A (en) | Cosmetic | |
| US5474775A (en) | Cosmetic compositions containing 2,3-butanediol fatty acid diesters | |
| JPH0791173B2 (en) | Liposomes containing skin cosmetics | |
| JPH0520410B2 (en) | ||
| JP5000033B2 (en) | Advanced hydrogenated lecithin | |
| JPS61204109A (en) | Emulsion-type composition for external use | |
| JP2731353B2 (en) | Skin cosmetics | |
| JPS6025908A (en) | Skin cosmetic | |
| JPH0669532B2 (en) | Oil-in-water emulsion composition | |
| JPH0620531B2 (en) | Emulsified composition | |
| JPH0611693B2 (en) | Emulsified cosmetics | |
| JP2818887B2 (en) | Gelling agent for oils | |
| JPH09268120A (en) | Water-in-oil type emulsified composition | |
| JPH09249548A (en) | Water-in-oil emulsion composition | |
| JPH0611695B2 (en) | Emulsified cosmetics | |
| KR100262176B1 (en) | A stick type lip-care compositions containing retinoid | |
| JP2964261B2 (en) | Oil-in-water emulsion cosmetic | |
| JPS6026081B2 (en) | Composition of lipophilic cream | |
| JPS61129187A (en) | Esterification product and cosmetic containing same | |
| JP2002104927A (en) | Emulsion type solid cosmetic | |
| JPS58140007A (en) | Cosmetic |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
| R371 | Transfer withdrawn |
Free format text: JAPANESE INTERMEDIATE CODE: R371 |
|
| S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| FPAY | Renewal fee payment (prs date is renewal date of database) |
Year of fee payment: 12 Free format text: PAYMENT UNTIL: 20091219 |
|
| FPAY | Renewal fee payment (prs date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20101219 Year of fee payment: 13 |
|
| FPAY | Renewal fee payment (prs date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20101219 Year of fee payment: 13 |
|
| FPAY | Renewal fee payment (prs date is renewal date of database) |
Year of fee payment: 14 Free format text: PAYMENT UNTIL: 20111219 |
|
| FPAY | Renewal fee payment (prs date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20111219 Year of fee payment: 14 |
|
| FPAY | Renewal fee payment (prs date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20121219 Year of fee payment: 15 |
|
| FPAY | Renewal fee payment (prs date is renewal date of database) |
Year of fee payment: 15 Free format text: PAYMENT UNTIL: 20121219 |
|
| FPAY | Renewal fee payment (prs date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20131219 Year of fee payment: 16 |
|
| LAPS | Cancellation because of no payment of annual fees |