JP2692713B2 - Molded formulation - Google Patents
Molded formulationInfo
- Publication number
- JP2692713B2 JP2692713B2 JP2134472A JP13447290A JP2692713B2 JP 2692713 B2 JP2692713 B2 JP 2692713B2 JP 2134472 A JP2134472 A JP 2134472A JP 13447290 A JP13447290 A JP 13447290A JP 2692713 B2 JP2692713 B2 JP 2692713B2
- Authority
- JP
- Japan
- Prior art keywords
- particles
- particle size
- less
- baking soda
- total amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明は、粒度がコントロールされた重曹粒子を含有
し、その配合生地の打錠性を著しく向上させた成型製剤
に関する。DETAILED DESCRIPTION OF THE INVENTION [Industrial field of use] The present invention relates to a molded preparation which contains baking soda particles of which the particle size is controlled and which has a significantly improved tableting property of the compounded dough.
重曹は入浴剤、胃腸薬、含そう剤、膣剤等の沸騰錠剤
等の成分として、錠剤、顆粒剤などに成型されて使用さ
れることが多い。Baking soda is often used as a component of effervescent tablets such as bath salts, gastrointestinal agents, mouthwashes, vaginal agents, etc. after being molded into tablets, granules and the like.
しかし、重曹粒子は、それ同士及び他の成分との結合
性が弱いため、成型が困難であり、特に高速で成型する
際には大きな問題があった。そのため、重曹粒子を含有
する組成物を成型するには、従来、多量の結合剤を使用
しなければならなかった。しかし、多量の結合剤を使用
すると、相対的に成型物中の重曹含量が少なくなるた
め、１回当たりの使用量を多くしなければならないと共
に、使用者に異和感を与え好ましくなく、また製造コス
トが高くなるという欠点があった。However, since the baking soda particles have weak bonding properties with each other and other components, they are difficult to mold, and there is a big problem particularly when molding at high speed. Therefore, in order to mold a composition containing baking soda particles, a large amount of binder must be used conventionally. However, when a large amount of binder is used, the content of sodium bicarbonate in the molded product becomes relatively small, so that the amount used per one time has to be increased, and the user feels uncomfortable. There is a drawback that the manufacturing cost becomes high.
また、これまで、少量の添加で高い効果が得られる結
合剤の研究がなされているが、かかる結合剤は未だ見出
されていない。Further, until now, studies have been made on binders that can obtain high effects even when added in a small amount, but such binders have not yet been found.
かかる実状において、本発明者は鋭意研究を行った結
果、重曹の粒径をコントロールすることにより、その配
合生地の打錠性が著しく向上することを見出し、本発明
を完成した。In this situation, as a result of intensive studies, the present inventor found that controlling the particle size of baking soda significantly improves the tableting property of the compounded dough, and completed the present invention.
すなわち、本発明は、粒径45μｍ以下の粒子が全量の
10重量％以下で、かつ粒径500μｍ以上の粒子が全量の1
0重量％以下である粒度分布を有する重曹粒子を含有す
ることを特徴とする成型製剤、及び上記重曹粒子と酸と
を含有することを特徴とする成型製剤を提供するもので
ある。That is, in the present invention, the total amount of particles having a particle size of 45 μm or less is
10% by weight or less and particles with a particle size of 500 μm or more account for 1% of the total amount.
The present invention provides a molded preparation characterized by containing baking soda particles having a particle size distribution of 0% by weight or less, and a molded preparation characterized by containing the above baking soda particles and an acid.
本発明に係わる重曹粒子の粒度分布としては、粒径45
μｍ以下の粒子が全量の10％（重量基準、以下同じ）以
下で、かつ粒径500μｍ以上の粒子が全量の10％以下で
あることが必要であり、好ましくは粒径45μｍ以下の粒
子が全量の５％以下で、かつ粒径500μｍ以上の粒子が
全量の５％以下である。The particle size distribution of the baking soda particles according to the present invention is a particle size of 45
It is necessary that particles with a size of μm or less are 10% or less of the total amount (weight basis, the same applies below) and particles with a particle size of 500 μm or more are 10% or less of the total amount, and preferably particles with a particle size of 45 μm or less are the total amount. And 5% or less of the total amount of particles having a particle size of 500 μm or more.
粒径45μｍ以下の粒子を全量の10％を越えて含有して
いる重曹を使用した場合は、特に打錠性の向上を認めな
い。また、粒径500μｍ以上の粒子を全量の10％を越え
て含有している重曹を使用した場合は、その成型製剤を
使用した場合、重曹の溶解性が悪くなり、重曹のみが溶
け残り、その製剤の効果を低下させる場合もある。When using baking soda containing particles having a particle size of 45 μm or less in an amount exceeding 10% of the total amount, no improvement in tableting property is observed. In addition, when using baking soda containing particles with a particle size of 500 μm or more in an amount of more than 10% of the total amount, when the molded preparation is used, the solubility of baking soda becomes poor and only baking soda remains undissolved. In some cases, the effect of the formulation may be reduced.
このような本発明の成型製剤は、粒径45μｍ以下の粒
子が全量の10重量％以下で、かつ粒径500μｍ以上の粒
子が全量の10重量％以下である粒度分布を有する重曹粒
子を含有する生地を打錠することにより得られ、例え
ば、酸と組合わせて成型した入浴剤、飲料等の発泡製
剤、あるいはそれ単独で、又は他の薬効成分と組合わせ
て成型した胃腸薬、含そう剤、膣剤等の沸騰錠剤等とし
て用いられる。Such a molded preparation of the present invention contains baking soda particles having a particle size distribution in which particles having a particle size of 45 μm or less are 10% by weight or less of the total amount, and particles having a particle size of 500 μm or more are 10% by weight or less of the total amount. Obtained by tableting the dough, for example, a bath salt formed by combining with an acid, a foaming preparation such as a beverage, or a gastrointestinal drug formed by combining it alone or in combination with other medicinal ingredients, a mouthwash. It is used as a boiling tablet for vaginal preparations.
酸と組合わせて成型した入浴剤の具体例としては、本
発明の重曹粒子とコハク酸、フマル酸、リンゴ酸、酒石
酸、クエン酸、アジピン酸、安息香酸等の１種又は２種
以上の有機酸とを配合形成した弱酸性入浴剤が挙げられ
る。かかる弱酸性入浴剤における本発明重曹粒子と酸の
配合量は、入浴剤を浴湯に加えたとき浴湯が弱酸性を呈
するような比率、すなわち入浴剤の0.01重量％水溶液が
pH4〜７、特に好ましくはpH6.0〜6.7になるような配合
割合が好ましい。Specific examples of the bath agent molded in combination with an acid include the baking soda particles of the present invention and one or more organic compounds such as succinic acid, fumaric acid, malic acid, tartaric acid, citric acid, adipic acid and benzoic acid. A weakly acidic bathing agent prepared by mixing and forming an acid is mentioned. The blending amount of the baking soda particles of the present invention and the acid in such a weakly acidic bathing agent is such that when the bathing agent is added to the bathing water, the bathing water exhibits a weak acidity, that is, a 0.01 wt% aqueous solution of the bathing agent.
The mixing ratio is preferably pH 4 to 7, and particularly preferably pH 6.0 to 6.7.
上記のような特定の粒度分布を有する重曹粒子を含有
する本発明の成型製剤は、その配合生地の打錠性が著し
く高く、また本発明の成型製剤を入浴剤等に用いた場合
に重曹の溶解性が非常に良好となる。The molded preparation of the present invention containing baking soda particles having a specific particle size distribution as described above has a significantly high tableting property of the compounded dough, and when the molded preparation of the present invention is used as a bathing agent or the like, The solubility is very good.
次に実施例を挙げて本発明を更に詳細に説明するが、
本発明はこれら実施例に限定されるものではない。Next, the present invention will be described in more detail with reference to examples.
The present invention is not limited to these examples.
実施例 第１表に示す粒度分布を有する各種重曹粒子を用い、
第２表に示す組成の入浴剤を調製した後、16メッシュの
篩で粗粒を取り除いた。その後、菊水（株）製ロータリ
ー打錠機にてその配合生地の打錠テスト（50g/錠）を下
記の方法により行った。Example Using various baking soda particles having a particle size distribution shown in Table 1,
After preparing a bath agent having the composition shown in Table 2, coarse particles were removed with a 16-mesh sieve. Then, a tableting test (50 g / tablet) of the compounded dough was carried out by a rotary tableting machine manufactured by Kikusui Co., Ltd. by the following method.
また、得られた錠剤について、その浴湯中での溶解性
を下記の方法により調べた。The solubility of the obtained tablets in bath water was examined by the following method.
その結果を第３表に示す。 Table 3 shows the results.
＜評価方法＞ 打錠テスト： 打錠速度を変えて連続打錠し、キャッピングの発生し
ない限界速度を求める（重曹Ｄを使用した場合の限界速
度を1.0とする。）。<Evaluation method> Tableting test: Continuously tableting is performed while changing the tableting speed, and the limit speed at which capping does not occur is determined (the limit speed when baking soda D is used is 1.0).
錠剤溶解性： 錠剤１錠を40℃、150の湯で満たした浴槽（ステン
レス製）中に投入し、錠剤崩壊後の浴槽の底の溶け残り
状態を肉眼で評価した。Tablet solubility: One tablet was placed in a bath (made of stainless steel) filled with hot water at 40 ° C. and 150, and the undissolved state of the bottom of the bath after tablet disintegration was visually evaluated.
評価基準 ○…肉眼評価でほとんど溶け残りを認めない。Evaluation Criteria O: Almost no unmelted residue is recognized by visual evaluation.
△…肉眼評価で少し溶け残りを認める。B: Some unmelted residue is recognized by visual evaluation.
×…肉眼評価で明解な溶け残りを認める。X: Clear unmelted residue is recognized by visual evaluation.
Claims (3)
下で、かつ粒径500μｍ以上の粒子が全量の10重量％以
下である粒度分布を有する重曹粒子を含有することを特
徴とする成型製剤。1. A baking soda particle having a particle size distribution in which particles having a particle size of 45 μm or less are 10% by weight or less of the total amount, and particles having a particle size of 500 μm or more are 10% by weight or less of the total amount. Molded formulation.
ことを特徴とする成型製剤。2. A molded preparation comprising the baking soda particles according to claim 1 and an acid.
下で、かつ粒径500μｍ以上の粒子が全量の10重量％以
下である粒度分布を有する重曹粒子を含有する生地を打
錠することを特徴とする成型製剤の製造方法。3. A dough containing baking soda particles having a particle size distribution in which particles having a particle size of 45 μm or less are 10% by weight or less of the total amount and particles having a particle size of 500 μm or more are 10% by weight or less of the total amount are tableted. A method for producing a molded preparation, which comprises:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2134472A JP2692713B2 (en) | 1990-05-23 | 1990-05-23 | Molded formulation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2134472A JP2692713B2 (en) | 1990-05-23 | 1990-05-23 | Molded formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0429926A JPH0429926A (en) | 1992-01-31 |
| JP2692713B2 true JP2692713B2 (en) | 1997-12-17 |
Family
ID=15129120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2134472A Expired - Lifetime JP2692713B2 (en) | 1990-05-23 | 1990-05-23 | Molded formulation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2692713B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009138403A1 (en) | 2008-05-13 | 2009-11-19 | Solvay (Société Anonyme) | Process for the joint production of sodium carbonate and sodium bicarbonate |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62234015A (en) * | 1986-04-02 | 1987-10-14 | Lion Corp | Foamable bathing agent |
-
1990
- 1990-05-23 JP JP2134472A patent/JP2692713B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0429926A (en) | 1992-01-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0278224B1 (en) | Process for the production of disinfecting working contact lenses - cleaning agents tablets | |
| EP1994922B1 (en) | Skin cleansing composition | |
| JPH04217620A (en) | Transparent, stable and antiperspiring gel-like stick | |
| EP0370969A2 (en) | Skin cleaning composition | |
| US3976601A (en) | Water soluble lubricant for tabletting compositions | |
| GB2081092A (en) | Improving taste acceptability of pharmaceutical compositions | |
| JP7217167B2 (en) | Solid bath agent | |
| JP5619684B2 (en) | Cleaning composition | |
| JP4934254B2 (en) | Weakly acidic detergent composition | |
| US4536389A (en) | Bactericidal tabletting composition and tablets formed therefrom | |
| US5958454A (en) | Effervescent bath tablet compositions | |
| KR101230934B1 (en) | Non hydrous cosmetic compositions of bubbling pill type containing hydrophilic active ingredients | |
| JP2692713B2 (en) | Molded formulation | |
| EP0095871A2 (en) | Improvements in or relating to tooth treatment compositions | |
| JP2003096489A (en) | Solid soap | |
| JP3245570B2 (en) | Washing soap | |
| JP4135263B2 (en) | Creamy detergent composition | |
| DE60024132T2 (en) | A BREWING COMPOSITION CONTAINING HISTAMINE H 2 ANTAGONISTS | |
| JPH04360823A (en) | Bathing agent composition | |
| JP2504710B2 (en) | Bath agent composition | |
| JPH03246215A (en) | Foamy hair cosmetic | |
| EP0868166B2 (en) | Hair bleaching agents | |
| JPS62228022A (en) | Sugar-coated tablet of multiple vitamin | |
| JPS59101420A (en) | Rectal composition containing indomethacin | |
| JP4088772B2 (en) | Procaterol dry syrup formulation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20080905 Year of fee payment: 11 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20080905 Year of fee payment: 11 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090905 Year of fee payment: 12 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20090905 Year of fee payment: 12 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100905 Year of fee payment: 13 |
|
| EXPY | Cancellation because of completion of term | ||
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20100905 Year of fee payment: 13 |