JP2681762B2 - Implant material - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an implant material used for artificial dental roots, bone filling materials and the like.

[0002]

2. Description of the Related Art Conventionally, local fresh autologous bones, freeze-dried allogeneic bones, xenogeneic bones, etc. have been used as a bone substitute material for a jaw bone defect cavity, which occurs after various treatments in the oral region. There is a drawback that it cannot be applied to all cases because it depends on the site and size of the bone wound cavity, and as artificial biomaterials to compensate for this, cobalt chrome alloy, stainless steel Ru, titanium, and other metal materials, silicon, polyethylene, polymethacrylate, and other organic materials, alumina, bioglass, calcium phosphate, and other inorganic materials have been appropriately used. However, it is required that the material has excellent biocompatibility, directly binds to bone, and be stable in vivo for a long period of time. Currently, calcium phosphate, a sintered body of synthetic apatite containing phosphorus lime as the main component, A part of other ceramics is mainly used as a bone substitute material.

However, a sintered body of synthetic apatite is fragile in strength as a single body, and a composite of metal or the like has a drawback that it is difficult to adapt depending on the shape of the bone defect cavity because of poor moldability. . Further, since the moldability is poor, for example, a method of spraying synthetic apatite on the surface of a metal, ceramic, etc. that has been molded even for artificial tooth roots has been taken, but after molding, the shape can be changed or processed. It had the drawback of being difficult.

[0004]

SUMMARY OF THE INVENTION The present invention has been made to solve the drawbacks described in the prior art. It has excellent biocompatibility, can be molded, is suitable for a bone defect cavity, and has a prosthesis. An object of the present invention is to provide an implant material capable of holding an object maintenance device (attachment) and capable of being appropriately reinforced.

[0005]

[Means for Solving the Problems] An implant material comprises a base material composed of beef bone or the like (hereinafter simply referred to as calcined bone) which has been calcined at a high temperature for the purpose of removing synthetic apatite or organic matter, and which contains alumina and silicic acid. The main material is composed by adding a drug and baking. Also, if necessary,
A molten metal having a melting point equal to or higher than the melting point of the shell powder is directly injected into the hollow portion of the implant body having the hollow portion fired and formed into an appropriate shape for reinforcement.

[0006]

When alumina is added to the base material made of synthetic apatite or calcined bone, the base material becomes plastic and the molding process becomes easy. The filler containing silicic acid acts as a binder for alumina and a metal injected for reinforcement, and improves the strength of the implant material. The molten metal directly injected into the hollow portion formed in the implant body penetrates into the micropores of the porous implant material and is finished in a strong structure that does not separate from the implant material. Further, the elutrix and the molten metal are integrally combined with a part of the components to further improve the reinforcing property of the implant material.

[0007]

EXAMPLE 1 To explain one example of the present invention in detail, 1 part by volume of alumina and 1 part by volume of silicic acid containing silicic acid were added to 4 parts by volume of a base material made of synthetic apatite or calcined bone to form a bone defect part. The implant material is formed by molding the material into a suitable size and shape and then firing at a firing temperature of 900 to 1000 ° C. as a main material.

[0008]

Example 2 For the purpose of reinforcement, 1 part by volume of alumina and 1 part by volume of silicic acid containing silicic acid were added to 4 parts by volume of a base material made of synthetic apatite or calcined bone, and as shown in FIGS. 1 to 3, for example. In the hollow part 1 of the implant body 2 having the hollow part 1 fired and molded into a cylindrical shape for an artificial tooth root,
An implant material is formed by directly injecting a molten metal 3 such as platinum, gold, silver, palladium and alloys thereof having a melting point higher than the melting point of the wax. The implant body 2 before the molten metal 3 is injected is usually 950 to 1000 ° C.
It has been baked in. The hollow portion 1 is formed in the implant body before or after firing. 1 to 3 show various prosthesis maintenance devices (attachments) 4
And the composition of the implant body 2, 5 is a magnet,
6 is a keyer, 7 is a rubber ring, and 8 is a cap.

The implant material according to the present invention, which is formed into a cylindrical shape of about 2 mm, is extracted from a lower jaw anterior tooth of a mature male rabbit having a body weight of about 2 kg, and after healing of the tooth extraction hole, a lower jaw of about 2 mm in front of the chin hole. Fill and implant in a cylindrical bone wound cavity with a diameter of about 2 mm and a depth of about 5 mm created on the lower edge, and after implantation, 2
After weekly and weekly sterilization, the mandible was removed, ultra-soft image radiography was performed, and then fixed with 10% neutral formalin aqueous solution, decalcified with 10% formic acid / formalin aqueous solution, and embedded in paraffin. As a result of making thin sliced serial sections of about 8 mm, and performing heavy staining with hematoxylin and eosin, and microscopic examination, in the two weeks after transplantation, mild lymphocytes, mainly lymphocytes, were found at the boundary between the burned bone and the bed bone. The formation of juvenile granulation tissue with inflammatory cell infiltration and fibrous connective tissue were confirmed to be mixed, and at the lateral margins of the bone, hyperemia and dilation of capillaries were marked, and A young, narrow new bone was confirmed.
Furthermore, in the 4 weeks after transplantation, it was confirmed that fibrous connective tissue was present around the caustic bone, and new bone with a narrow lamellar bone was formed, and many osteoblasts were formed on the surface. The cell arrangement was confirmed, and it was demonstrated that the implant material according to the present application has excellent biocompatibility.

[0010]

As described above, the present invention has the following advantages.

Since it is excellent in biocompatibility, the implant material is organically joined to the bone after transplantation to the bone defect portion or the like to fill the bone defect portion.

Since it has excellent moldability, it can be easily molded into a size and shape that can be adapted to a bone defect.

The molten metal injected for the purpose of reinforcement is
It penetrates into the micropores of burnt bone that has become lath, firmly bonds to the implant material, and has a structure that does not separate, and at the same time combines with the filler and part of the molten metal component, it strengthens the implant material. Further improve. It can also be a medium or part of a prosthesis maintenance device (attachment) for coupling to the implant body.

[Brief description of the drawings]

FIG. 1 is a cross-sectional view showing one embodiment of the present invention.

FIG. 2 is a sectional view showing an example of an embodiment of the present invention.

FIG. 3 is a cross-sectional view showing an example of implementation of the present invention.

[Explanation of symbols]

1 Hollow part 5 Magnet 2 Implant body 6 Keyer 3 Molten metal 7 Rubber ring 4 Prosthesis maintenance device (attachment) 8 Cap

Claims (2)

(57) [Claims] 1. An implant material comprising a base material made of synthetic apatite or calcined bone and calcined by adding a glaze containing alumina and silicic acid as a main material. 2. A molten metal having a melting point equal to or higher than the melting point of the shell is directly injected into a hollow portion of an implant body having a hollow portion which is fired and formed into an appropriate shape for the purpose of holding a reinforcement and a prosthesis maintenance device. The implant material according to claim 1, characterized in that