JP2635437B2 - Artificial bone composites for clavicle, long bone and flat bone reconstruction - Google Patents

Artificial bone composites for clavicle, long bone and flat bone reconstruction

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Publication number
JP2635437B2
JP2635437B2 JP28183490A JP28183490A JP2635437B2 JP 2635437 B2 JP2635437 B2 JP 2635437B2 JP 28183490 A JP28183490 A JP 28183490A JP 28183490 A JP28183490 A JP 28183490A JP 2635437 B2 JP2635437 B2 JP 2635437B2
Authority
JP
Japan
Prior art keywords
bone
artificial
artificial bone
clavicle
reconstruction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP28183490A
Other languages
Japanese (ja)
Other versions
JPH04156841A (en
Inventor
茂栄 高木
清 新城
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Osaka Cement Co Ltd
Original Assignee
Sumitomo Osaka Cement Co Ltd
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Publication date
Application filed by Sumitomo Osaka Cement Co Ltd filed Critical Sumitomo Osaka Cement Co Ltd
Priority to JP28183490A priority Critical patent/JP2635437B2/en
Publication of JPH04156841A publication Critical patent/JPH04156841A/en
Application granted granted Critical
Publication of JP2635437B2 publication Critical patent/JP2635437B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Description

【発明の詳細な説明】 〔産業上の利用分野〕 本発明は鎖骨、長管骨および偏平骨再建用人工骨複合
材料に関するものである。更に詳しく述べるならば本発
明は鎖骨、および肋骨の骨欠損部分を、その形状・寸法
に適合するように補填し、かつ、所定部位に錨着するこ
とのできる鎖骨、長管骨および偏平骨再建用人工骨複合
材料に関するものである。Description: TECHNICAL FIELD The present invention relates to an artificial bone composite material for reconstruction of a clavicle, a long bone, and a flat bone. More specifically, the present invention provides a reconstruction of a clavicle, a long bone and a flat bone capable of filling a clavicle and a bone defect portion of a rib so as to conform to its shape and size, and anchoring it to a predetermined site. The present invention relates to an artificial bone composite material for use.

〔従来の技術〕[Conventional technology]

従来鎖骨、および肋骨に骨欠損を生じた場合その再建
には １）皮下組織、および皮膚のみの縫合 ２）自家骨の移植（腸骨、腓骨、および脛骨より採取
し、キュルシュナー鋼線、Ｋnscher髄内釘、金属板、
又は骨ネジなどにより固定） ３）血管柄付骨移植 ４）合成繊維、又は金属材料からなる人工骨の補綴 ５）合成樹脂布帛による補綴 などが知られている。In the case of bone defects in the conventional clavicle and ribs, 1) suture of the subcutaneous tissue and skin only 2) transplantation of autologous bone (collected from iliac bone, fibula and tibia, Kurschner wire, Knscher marrow Inner nail, metal plate,
3) Prosthesis of artificial bone made of synthetic fiber or metal material 5) Prosthesis of synthetic resin cloth and the like.

しかし、上記１）,2）,3）および４）の方法では手術
を受けた患者の美容上および機能上の問題があった。ま
た、上記２）,4）および５）の方法では補綴材料の固定
が困難で、骨折、充填物の破損、脱填および内臓損傷の
危険性が高く、しかも骨採取部に合併症を生ずるなどの
問題があり、更に上記３）の方法は、微細手術を行う必
要があり、手術の技法が面倒であった。However, the above methods 1), 2), 3) and 4) have problems in cosmetics and functions of patients who have undergone surgery. Further, it is difficult to fix the prosthetic material by the methods 2), 4) and 5), and there is a high risk of fracture, damage to the filling material, unloading and damage to the internal organs, and furthermore, complications may occur in the bone extraction part. In addition, the method 3) requires a fine operation, and the operation technique is troublesome.

上記の問題点を解消するためにキールボーン（Kiel b
one）、又はボーンセメント（Bone cement）などの補強
材を併用することが提案されている。In order to solve the above problems, Kielbourne (Kiel b
It has been proposed to use a reinforcing material such as one) or bone cement together.

しかしキールボーンの使用には、同化の遅延、および
骨折防止および固定法の困難さなどの問題点があり、ボ
ーンセメントの使用には、骨欠損部に大きさを合わせる
ことが難しく、生理的な胸壁の運動を阻害し、かつ合併
症を誘発するなどの問題点があった。However, the use of keelbone has problems such as delay of assimilation and difficulty of fracture prevention and fixation.The use of bone cement makes it difficult to adjust the size to the bone defect, There were problems such as inhibiting the movement of the chest wall and inducing complications.

また鎖骨、長管骨および偏平骨の再建の場合、人工骨
の周囲に骨性架橋が形成され恒久的な再建が達成される
ことが望まれていた。In the case of reconstruction of the clavicle, the long bone and the flat bone, it has been desired that a bone bridge is formed around the artificial bone to achieve permanent reconstruction.

〔発明が解決しようとする課題〕[Problems to be solved by the invention]

本発明は従来の鎖骨、長管骨および偏平骨の再建法の
上記問題点を解消し、これらの骨欠損部の形状・寸法に
適合させることが容易で、内臓損傷の発生の危険性がな
く、又は低く、補綴部位への錨着が容易にかつ、短時間
内に再現するのに有効であり、しかも骨性架橋の可能な
鎖骨、長管骨および偏平骨再建用人工骨複合材料を提供
しようとするものである。The present invention solves the above-mentioned problems of the conventional methods of reconstructing the clavicle, the long bone and the flat bone, making it easy to adapt to the shape and dimensions of these bone defects, without the risk of causing visceral damage. Provided is an artificial bone composite material for clavicle, long tube bone and flat bone reconstruction, which is effective to easily and quickly reproduce anchoring to a prosthetic site in a short period of time, and is capable of osseous cross-linking. What you want to do.

〔課題を解決するための手段・作用〕[Means and actions to solve the problem]

本発明の鎖骨、長管骨および偏平骨再建用人工骨複合
材料は、シート状材料からなる包接部材と、前記包接部
材の内側に包接された人工骨部材とを含み、 前記包接部材用シート状がポリエチレン繊維からなる
メッシュ布帛であり、かつ、前記包接部材の端末部が、
前記人工骨部材の外側に伸び出ていて、前記人工骨部材
に接合すべき骨の端末部分を挿入するための筒状室を形
成していることを特徴とするものである。An artificial bone composite material for reconstruction of a clavicle, a long bone, and a flat bone according to the present invention includes an inclusion member made of a sheet-like material, and an artificial bone member enclosed inside the inclusion member. The member sheet shape is a mesh fabric made of polyethylene fiber, and the end portion of the inclusion member is
The present invention is characterized in that a cylindrical chamber extending outside the artificial bone member and for inserting a terminal portion of a bone to be joined to the artificial bone member is formed.

第１図には本発明の鎖骨、長管骨および偏平骨再建用
人工骨複合材料の一実施態様が示されている。FIG. 1 shows an embodiment of an artificial bone composite material for reconstruction of a clavicle, a long bone and a flat bone according to the present invention.

第１図において、人工骨複合材料１は筒状に形成され
た包接部材２および、その内部に包接されている人工骨
部材３により構成されている。人工骨部材３は、補綴す
べき骨の形状・寸法に適合するように整形加工された人
工骨材料であって、その一部に形成された凹部（溝）
に、自家骨５が移植されていて、複合体を形成してい
る。包接部材２はポリエチレン繊維からなるメッシュ
（粗目）布帛を、人工骨部材３に巻きつけるか、或は、
人工骨部材を収容するのに適合した形状・寸法の筒状体
に縫合形成されたものである。In FIG. 1, an artificial bone composite material 1 includes an inclusion member 2 formed in a cylindrical shape, and an artificial bone member 3 enclosed therein. The artificial bone member 3 is an artificial bone material shaped and shaped to conform to the shape and dimensions of the bone to be prosthetic, and a concave portion (groove) formed in a part thereof.
Then, the autogenous bone 5 is implanted to form a complex. The enclosure member 2 is formed by winding a mesh (coarse) cloth made of polyethylene fiber around the artificial bone member 3 or
It is formed by sewing on a cylindrical body having a shape and dimensions suitable for accommodating the artificial bone member.

包接部材２の端末部分には、人工骨部材３の外側に伸
び出ている筒状室４が形成されている。この筒状室４
は、本発明の人工骨複合材料により、鎖骨、又は肋骨の
骨欠損部を補綴するとき、残存している骨の端末部分を
挿入させるために設けられたものであって、残存骨の端
末と、人工骨部材−自家骨複合体の端末とは、筒状室４
内で接合され（必要があれば両端末はワイヤーで錨着さ
れ）、この接合部分は、それを囲繞する包接部材により
包接保持される。A tubular chamber 4 extending outside the artificial bone member 3 is formed at a terminal portion of the inclusion member 2. This cylindrical chamber 4
With the artificial bone composite material of the present invention, when prosthesis of a clavicle or a bone defect part of a rib, it is provided for inserting a terminal portion of a remaining bone, and is provided with a terminal of a remaining bone. The terminal of the artificial bone member-autogenous bone composite is the cylindrical chamber 4.
(The two ends are anchored with wires if necessary), and this joint is held by an enclosing member surrounding it.

上記自家骨移植は、ワイヤー、人工骨部材、包接部材
の疲労破損を防止するために有効である。The autologous bone graft is effective for preventing fatigue damage of the wire, the artificial bone member, and the inclusion member.

本発明の人工骨材料に用いられる包接部材は、ポリエ
チレン繊維からなるメッシュ（粗目）布帛により形成さ
れる。このようなポリエチレン繊維メッシュ布帛として
はマーレックスメッシュ（Marlex Mesh、商標、BARD
（バード）社製）が知られている。The inclusion member used for the artificial bone material of the present invention is formed of a mesh (coarse) cloth made of polyethylene fibers. As such a polyethylene fiber mesh cloth, Marlex Mesh (trademark, BARD
(Bird) is known.

本発明の人工骨複合材料に用いられる人工骨部材は、
一般に、セラミック、カーボン、金属、および硬質有機
合成樹脂から選ばれた少なくとも１種を主構成成分とし
て用いて形成され、これらは多孔質であってもよく、或
は非多孔質であってもよい。The artificial bone member used in the artificial bone composite material of the present invention,
Generally, it is formed using at least one selected from ceramic, carbon, metal, and hard organic synthetic resin as a main component, and these may be porous or non-porous. .

人工骨部材料セラミックとしては、アルミナ、ジルコ
ニア、およびリン酸カルシウム系化合物などが利用でき
る。一般に、セラミック材料としては水酸アパタイト
〔Ca10（PO4）６（OH）２〕を用いることが好ましい。
このような水酸アパタイトの組成に格別の限定はない
が、一般に、カルシウムとリンの含有量が1:1.60〜1:1.
70のモル比をなしているものが好ましい。このようなリ
ン酸カルシウム系セラミック材料は、ゾルーゲル法によ
り合成され、凍結乾燥され、かつ1000〜1350℃の温度で
焼結されていることが好ましい。As the artificial bone material ceramic, alumina, zirconia, a calcium phosphate compound, or the like can be used. Generally, it is preferable to use hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 ] as a ceramic material.
Although there is no particular limitation on the composition of such hydroxyapatite, generally, the content of calcium and phosphorus is 1: 1.60 to 1: 1.
Those having a molar ratio of 70 are preferred. Such a calcium phosphate-based ceramic material is preferably synthesized by a sol-gel method, freeze-dried, and sintered at a temperature of 1000 to 1350 ° C.

また人工骨部材形成用金属としては、例えばステンレ
ス鋼、チタン、タンタル、チタン合金、ニッケル−クロ
ム合金、ニッケル−クロム−コバルト合金、およびコバ
ルト−クロム−モリブデン合金などから選ばれた少なく
とも１種からなるものが用いられる。The metal for forming an artificial bone member is, for example, at least one selected from stainless steel, titanium, tantalum, a titanium alloy, a nickel-chromium alloy, a nickel-chromium-cobalt alloy, and a cobalt-chromium-molybdenum alloy. Things are used.

更に、人工骨部材形成用硬質有機材料としては、高密
度ポリエチレン樹脂、ポリテトラフルオロエチレン樹
脂、ポリメチルアクリレート樹脂、ポリエステル樹脂お
よびシリコーン樹脂などから選ばれた少なくとも１種か
らなるものが用いられる。Further, as the hard organic material for forming the artificial bone member, a material composed of at least one selected from high-density polyethylene resin, polytetrafluoroethylene resin, polymethyl acrylate resin, polyester resin, silicone resin and the like is used.

人工骨部材形成材料は、多孔質材料でも非多孔質材料
でもよいが、一般には多孔質材料であることが好まし
い。例えば、多孔質リン酸カルシウム焼結体が本発明の
人工骨部材として有用なものである。The artificial bone member forming material may be a porous material or a non-porous material, but is generally preferably a porous material. For example, a porous calcium phosphate sintered body is useful as the artificial bone member of the present invention.

多孔質リン酸カルシウム焼結体は、下記のようにして
製造することができる。The porous calcium phosphate sintered body can be manufactured as follows.

例えばリン酸カルシウム（100重量部）に、粒径１〜6
00ミクロンの眞球状の有機合成樹脂粒子（０〜70重量
部）と直径１〜30ミクロンの有機重合体繊維（１〜５重
量部）とを均一混合し、この混合物を所望の形状寸法の
成形物に成形し、この成形物を200〜800℃の温度に加熱
して有機合成樹脂粒子および有機重合体繊維を熱分解し
て除去して、多孔質成形物とする。次に、この多孔質成
形物を800〜1350℃の温度、好ましくは1000〜1350℃の
温度で焼成する。この多孔質焼結体を所望の形状、寸法
に切削加工する。For example, calcium phosphate (100 parts by weight)
A 00 micron spherical organic synthetic resin particle (0 to 70 parts by weight) and an organic polymer fiber (1 to 5 parts by weight) having a diameter of 1 to 30 microns are uniformly mixed, and the mixture is molded into a desired shape and size. The molded article is heated to a temperature of 200 to 800 ° C. to thermally decompose and remove the organic synthetic resin particles and the organic polymer fiber to obtain a porous molded article. Next, the porous molded product is fired at a temperature of 800 to 1350 ° C, preferably at a temperature of 1000 to 1350 ° C. This porous sintered body is cut into a desired shape and dimensions.

気孔形成用有機合成樹脂粒子としては、ポリプロピレ
ン樹脂、ポリメチルメタクリレート樹脂、ポリスチレン
樹脂などからなる粒子が用いられ、有機重合体繊維とし
ては、獣毛、絹繊維、セルロース繊維、ポリエステル繊
維、ポリオレフィン繊維などを用いることができる。As the pore-forming organic synthetic resin particles, particles made of polypropylene resin, polymethyl methacrylate resin, polystyrene resin and the like are used, and as the organic polymer fiber, animal hair, silk fiber, cellulose fiber, polyester fiber, polyolefin fiber, etc. Can be used.

上記のようにして製造される多孔質リン酸カルシウム
焼結体は、１〜600ミクロンの多数の眞球状独立空孔と
孔径１〜30ミクロンの多数の毛細管状空隙通路とを有し
ており眞球状独立空孔は毛細管状空隙通路により互に、
かつ外部空間に連通されている。空孔は眞球状、又はほ
ぼ眞球状の形状を有し、かつ焼結体内に均一に分布され
ていることが好ましい。このような空孔は、骨細胞が修
骨場として場の認識を行い、かつ活性化のための空間、
すなわち骨修復に対する細胞認識現場（細胞居住空間）
を提供するものである。骨細胞は、特定の曲率を有する
眞球状空間に滞留することを非常に好むもので、その孔
径は１〜600ミクロンであることが好ましく10〜300ミク
ロンの範囲内にあることがより好ましい。また空孔が眞
球形、又は、ほぼ眞球形であると、得られる多孔質体の
機械的強度が高くなる。孔径１〜30ミクロンの毛細管空
隙通路は破骨細胞、骨芽細胞、体液、白血球などの選択
的進入を許すが粒径の大きなコラーゲン繊維やマクロフ
ァージなどの進入を阻止し、それによってコラーゲン繊
維の異状増殖、それに伴う周囲の炎症偽関節、およびガ
ンの発生を防止することができる。空孔内に進入した上
記の細胞等はこの寸法の空孔に滞留することを非常に好
み骨の再生速度の制御、骨の再吸収の制御および新生骨
の誘起を促進することができる。The porous calcium phosphate sintered body produced as described above has a large number of spherical independent pores of 1 to 600 microns and a large number of capillary void passages of a pore diameter of 1 to 30 microns. The pores are mutually connected by a capillary void passage,
And it is communicated with the external space. It is preferable that the holes have a true spherical shape or a substantially true spherical shape, and are uniformly distributed in the sintered body. Such vacancies create a space for the bone cells to recognize the place as an osteopath, and for activation,
That is, the site of cell recognition for bone repair (cell living space)
Is provided. Bone cells are highly preferred to reside in a spherical space having a specific curvature, and the pore size is preferably 1-600 microns, more preferably 10-300 microns. When the pores are spherical or almost spherical, the mechanical strength of the obtained porous body is increased. Capillary void passages with a pore size of 1 to 30 microns allow the selective invasion of osteoclasts, osteoblasts, body fluids, leukocytes, etc., but block the invasion of collagen fibers and macrophages with a large particle size, thereby causing abnormal collagen fibers Proliferation, concomitant inflamed pseudoarthritis, and the occurrence of cancer can be prevented. The cells and the like that have entered the pores are very fond of staying in pores of this size, and can promote the control of the rate of bone regeneration, the control of bone resorption, and the induction of new bone.

本発明の人工骨複合材料を形成するには、所定の寸法
を有する包接部材用ポリエチレン繊維メッシュ布帛を人
工骨部材に巻きつけてもよいし、或は上記布帛を縫合し
て筒状体を形成し、その中に人工骨部材を挿入してもよ
い。いづれの場合も包接部材の端末に筒状室が形成され
ていることが必要である。In order to form the artificial bone composite material of the present invention, a polyethylene fiber mesh cloth for the inclusion member having a predetermined size may be wound around the artificial bone member, or the above-mentioned cloth is stitched to form a tubular body. It may be formed and an artificial bone member inserted therein. In any case, it is necessary that a cylindrical chamber is formed at the end of the inclusion member.

本発明の人工骨複合材料を用いて鎖骨、又は肋骨の再
建を行うには、鎖骨、又は肋骨の骨欠如部分の残存骨の
端末を、包接部材の端末筒状室内に挿入して、これを人
工骨の端末と接合させ、必要があれば人工骨端末と、残
存骨の端末とをワイヤーなどで連結し、包接部材を、骨
の周囲の筋肉に縫合錨着する。In order to carry out reconstruction of the clavicle or the rib using the artificial bone composite material of the present invention, the clavicle or the end of the remaining bone of the bone lacking portion of the rib is inserted into the end cylindrical chamber of the clathrate member. Is joined to the end of the artificial bone, and if necessary, the end of the artificial bone and the end of the remaining bone are connected by a wire or the like, and the inclusion member is attached to the muscle around the bone by suture anchoring.

本発明の人工骨複合材料を用いて鎖骨、長管骨又は偏
平骨の骨欠損部を補綴すると、手術後の経過と共に膠原
繊維組織が人工骨複合材料の微小空孔内へ入り込んで強
度を補強すると共に骨新生を促進する。この場合空孔の
サイズ、包接部材の伸縮、包接部材布帛の厚さ等の調
整、さらに線維芽細胞を積極的に誘導する物質の塗布あ
るいは透み込ませること等により、より一層安定して固
定が可能となる。When a bone defect of a clavicle, a long bone, or a flat bone is prosthetic using the artificial bone composite material of the present invention, the collagen fiber tissue enters the micropores of the artificial bone composite material with the progress of the operation and strengthens the strength. And promote bone regeneration. In this case, by adjusting the size of the pores, the expansion and contraction of the inclusion member, the thickness of the inclusion member cloth, and the like, and further applying or penetrating a substance that actively induces fibroblasts, the stability is further improved. Can be fixed.

本発明の人工骨複合材料を用いると、人工骨と、残存
骨との接合部分は、ポリエチレン繊維メッシュ布帛から
なる包接部材で包み込まれているため、安定した支持力
が得られ、このため、骨の再建が順調に行われ、軟部支
持組織の再建が容易で、これによりストレスの分散、及
び循環の改善が得られ、また疼痛もなく美容上も優れた
術後の成果が得られる。When the artificial bone composite material of the present invention is used, since the joint between the artificial bone and the remaining bone is wrapped by the inclusion member made of the polyethylene fiber mesh cloth, a stable supporting force is obtained, and therefore, Reconstruction of the bone is performed smoothly, the reconstruction of the soft tissue support is easy, and the dispersion of the stress and the improvement of the circulation are obtained, and the painless and cosmetically excellent postoperative result is obtained.

また、包接部材が粗目布帛から形成されているため、
骨新生のための骨性架橋が促進される。In addition, since the inclusion member is formed from coarse cloth,
Bone bridging for bone formation is promoted.

更に、ポリエチレン繊維メッシュ布帛からなる包接部
材にボーン モリホジェネテック プロテイン（Bone m
orphogenetic protein,BMP）を塗布あるいは透み込ませ
て積極的に骨誘導を計り、金属、セラミック等からなる
人工骨部の安定性、支持性を高めることもできる。また
金属、セラミック等からなる人工骨部材とポリエチレン
繊維メッシュ布帛からなる包接部材とを組み合せ、骨欠
損部及び空隙部を充填し、周辺の支持組織（骨膜、靭
帯、筋膜、筋腱）に包接部材を錨着し、人工骨部材の安
定性、支持性及び血液循環を高めるなどのように、多方
面における応用が期待出来る。In addition, the inclusion member made of polyethylene fiber mesh fabric is used as a bone molyphogenetec protein (Bone m
Orthogenetic protein (BMP) can be applied or penetrated to actively measure bone induction to enhance the stability and support of artificial bones made of metals, ceramics, and the like. In addition, an artificial bone member made of metal, ceramic, or the like is combined with an inclusion member made of polyethylene fiber mesh fabric to fill a bone defect portion and a void portion, and to provide a surrounding supporting tissue (periosteum, ligament, fascia, muscle tendon). It can be expected to be applied in various fields, such as anchoring the inclusion member to enhance the stability, supportability and blood circulation of the artificial bone member.

〔実施例〕〔Example〕

本発明を更に実施例により説明する。 The present invention is further described by way of examples.

実施例１ Ａ 人工骨部材用セラミック材料 住友セメント株式会社製、水酸アパタイトボーンセラ
ム−Ｐ（商標）を所要形状、寸法に整形加工して使用し
た。Example 1 A Ceramic Material for Artificial Bone Member Hydroxyapatite bone serum-P (trademark) manufactured by Sumitomo Cement Co., Ltd. was used after shaping into a required shape and dimensions.

Ｂ 包接部材 布帛：ポリエチレン長繊維メッシュ布帛（マーレック
スメッシュ） Ｃ 人工骨部材の作成 上記布帛（長さ4cm、幅8cm）を人工骨部材に巻きつ
け、その両端に長さに2cmの筒状室を形成した。B Inclusion member Cloth: Polyethylene long fiber mesh cloth (Marrex mesh) C Preparation of artificial bone member The above cloth (4 cm in length and 8 cm in width) is wrapped around an artificial bone member, and a cylindrical shape of 2 cm in length is wound on both ends thereof. A chamber was formed.

補綴手術 男性患者の右鎖骨悪性リンパ腫による病変部（長さ約
6cm）を切除した。残存鎖骨の端末を、人工骨複合材料
の包接部材の筒状室に挿入して、その端末と人工骨部材
の端末とを接合させ、両端末をワイヤーで締結し、包接
部材をナイロン糸により烏口鎖骨靭帯、広頚筋、三角
筋、大胸筋に縫着固定した。手術後約６カ月で、骨癒合
が完成し、肩関節の運動制限なく無痛で患者は無病状態
で現職に復帰している。Prosthetic Surgery Lesions due to malignant lymphoma of the right clavicle in male patients
6 cm). Insert the terminal of the remaining clavicle into the cylindrical chamber of the inclusion member of the artificial bone composite material, join the terminal and the terminal of the artificial bone member, fasten both ends with a wire, and use a nylon thread for the inclusion member. Sewn to the crow's clavicle ligament, platysma, deltoid, and pectoralis major. Approximately six months after the operation, the bone union was completed, and the patient returned to his current position without any pain without any limitation of shoulder movement.

〔発明の効果〕〔The invention's effect〕

本発明の鎖骨、長管骨および偏平骨再建用人工骨複合
材料は、下記の効果を奏し得るものである。The artificial bone composite material for reconstruction of the clavicle, the long bone and the flat bone of the present invention can exhibit the following effects.

1.任意の形状・寸法を有する人工骨部材を整形加工して
形成することができる。1. It can be formed by shaping an artificial bone member having an arbitrary shape and dimensions.

2.人工骨部材の離散を防止し、内臓損傷を防止すること
ができる。2. The artificial bone member can be prevented from being separated and the internal organs can be prevented from being damaged.

3.軟部支持組織の再建により血液の循環が良好であり、
骨新生を促進する。3. Blood circulation is good due to reconstruction of soft tissue support,
Promotes bone regeneration.

4.組織誘導が可能であって、強固な鎖骨、長管骨および
偏平骨を再建することができる。4. Tissue can be guided and solid clavicle, long bone and flat bone can be reconstructed.

5.靭帯、腱、筋および骨膜との錨着が容易で、ストレス
の分散に役立つ。5. Easy anchoring with ligaments, tendons, muscles and periosteum, helping to spread stress.

6.生理的な胸壁の運動を妨げない。6. Does not interfere with physiological chest wall movement.

7.骨再生を短時間内に達成できる。7. Bone regeneration can be achieved within a short time.

8.美容上満足し得る。8. You can be satisfied with beauty.

9.骨性架橋が可能である。9. Bone bridging is possible.

すなわち、本発明の人工骨複合材料は、従来至難とさ
れてきた鎖骨、長管骨および偏平骨の再建を、可能に
し、かつ、すぐれた効果を有するものである。That is, the artificial bone composite material of the present invention enables reconstruction of the clavicle, the long bone, and the flat bone, which has been difficult so far, and has an excellent effect.

【図面の簡単な説明】[Brief description of the drawings]

第１図は本発明の人工骨複合材料の構成を示す説明図で
ある。 １……人工骨複合材料、２……包接部材、 ３……人工骨部材、４……筒状室、 ５……自家骨。FIG. 1 is an explanatory view showing the structure of the artificial bone composite material of the present invention. 1 ... artificial bone composite material, 2 ... inclusion member, 3 ... artificial bone member, 4 ... cylindrical chamber, 5 ... autogenous bone.

Claims (1)

(57)【特許請求の範囲】(57) [Claims] 【請求項１】シート状材料からなる包接部材と、前記包
接部材の内側に包接されている人工骨部材とを含み、 前記包接部材用シート状材料がポリエチレン繊維からな
るメッシュ布帛であり、かつ、前記包接部材の端末部
が、前記人工骨部材の外側に伸び出ていて、前記人工骨
部材に接合すべき骨の端末部分を挿入するための筒状室
を形成していることを特徴とする、鎖骨、長管骨および
偏平骨再建人工骨複合材料。1. An enclosure member made of a sheet material, and an artificial bone member enclosed inside the enclosure member, wherein the sheet material for the enclosure member is a mesh cloth made of polyethylene fiber. The end portion of the inclusion member extends outside the artificial bone member to form a cylindrical chamber for inserting the terminal end portion of the bone to be joined to the artificial bone member. An artificial bone composite material for reconstructing a clavicle, a long bone, and a flat bone.
JP28183490A 1990-10-22 1990-10-22 Artificial bone composites for clavicle, long bone and flat bone reconstruction Expired - Lifetime JP2635437B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP28183490A JP2635437B2 (en) 1990-10-22 1990-10-22 Artificial bone composites for clavicle, long bone and flat bone reconstruction

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP28183490A JP2635437B2 (en) 1990-10-22 1990-10-22 Artificial bone composites for clavicle, long bone and flat bone reconstruction

Publications (2)

Publication Number Publication Date
JPH04156841A JPH04156841A (en) 1992-05-29
JP2635437B2 true JP2635437B2 (en) 1997-07-30

Family

ID=17644660

Family Applications (1)

Application Number Title Priority Date Filing Date
JP28183490A Expired - Lifetime JP2635437B2 (en) 1990-10-22 1990-10-22 Artificial bone composites for clavicle, long bone and flat bone reconstruction

Country Status (1)

Country Link
JP (1) JP2635437B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001231797A (en) * 2000-02-23 2001-08-28 National Institute For Materials Science Modularized artificial bone

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Publication number Priority date Publication date Assignee Title
TW201707653A (en) * 2015-08-18 2017-03-01 Pao Nan Biotech Co Ltd Apparatus for preventing resected fibula sections from bone mergence and connection capable of effectively preventing resected fibula from rigid re-mergence
JP6963966B2 (en) * 2017-10-23 2021-11-10 株式会社クラレ Porous ceramic material and its manufacturing method
CN111494710A (en) * 2020-05-18 2020-08-07 上海市第六人民医院 High-strength combined artificial bone-artificial ligament composite graft and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001231797A (en) * 2000-02-23 2001-08-28 National Institute For Materials Science Modularized artificial bone

Also Published As

Publication number Publication date
JPH04156841A (en) 1992-05-29

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