JP2635436B2 - Artificial bone composite for chest wall reconstruction - Google Patents

Artificial bone composite for chest wall reconstruction

Info

Publication number
JP2635436B2
JP2635436B2 JP2281833A JP28183390A JP2635436B2 JP 2635436 B2 JP2635436 B2 JP 2635436B2 JP 2281833 A JP2281833 A JP 2281833A JP 28183390 A JP28183390 A JP 28183390A JP 2635436 B2 JP2635436 B2 JP 2635436B2
Authority
JP
Japan
Prior art keywords
artificial bone
bone
chest wall
artificial
composite material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2281833A
Other languages
Japanese (ja)
Other versions
JPH04156840A (en
Inventor
茂栄 高木
清 新城
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Osaka Cement Co Ltd
Original Assignee
Sumitomo Osaka Cement Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Osaka Cement Co Ltd filed Critical Sumitomo Osaka Cement Co Ltd
Priority to JP2281833A priority Critical patent/JP2635436B2/en
Publication of JPH04156840A publication Critical patent/JPH04156840A/en
Application granted granted Critical
Publication of JP2635436B2 publication Critical patent/JP2635436B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Description

【発明の詳細な説明】 〔産業上の利用分野〕 本発明は胸壁再建用人工骨複合材料に関するものであ
る。更に詳しく述べるならば本発明は胸壁部の骨欠損部
分を、その形状・寸法に適合するように補填し、かつ、
所定部位に錨着することのできる胸壁再建用人工骨複合
材料に関するものである。Description: TECHNICAL FIELD The present invention relates to an artificial bone composite material for chest wall reconstruction. More specifically, the present invention compensates for a bone defect in the chest wall to fit its shape and size, and
The present invention relates to an artificial bone composite material for chest wall reconstruction that can be anchored to a predetermined site.

〔従来の技術〕[Conventional technology]

従来胸壁に骨欠損を生じた場合その再建には １）皮下組織、および皮膚のみの縫合 ２）大腿筋膜の移植補填 ３）大胸筋、または潤背筋の筋肉弁の利用 ４）骨移植 ５）合成繊維、又は金属材料からなる人工骨の補綴 ６）合成樹脂布帛による補綴 などが知られている。 Conventionally, if a bone defect occurs in the chest wall, 1) suture of the subcutaneous tissue and skin only 2) transplantation of the femoral fascia 3) use of the muscle valve of the pectoralis major or muscle of the back muscle 4) bone grafting 5 6) Prosthesis of synthetic bone made of synthetic fiber or metal material 6) Prosthesis of synthetic resin cloth and the like are known.

しかし、上記１）,2）,3）および４）の方法では手術
を受けた患者の奇異呼吸運動の発生を防止することが困
難であり、かつ美容上および手術手技上の困難があっ
た。また、上記４）および５）の方法では、補綴材料の
固定が困難で、骨折、充填物の破損、脱填および内臓損
傷の危険性が高く、しかも骨採取部に合併症を生ずるな
どの問題があった。However, the above methods 1), 2), 3) and 4) have difficulty in preventing the occurrence of paradoxical respiratory movements in patients who have undergone surgery, and also have cosmetic and surgical techniques. Further, in the methods 4) and 5), it is difficult to fix the prosthetic material, and there is a high risk of fracture, damage to the filling material, unloading and damage to the internal organs, and further, there is a problem that a complication occurs in the bone sampling portion. was there.

更に、上記６）の方法は簡便ではあるがこの方法のみ
では胸壁の動揺を生ずるという問題があった。Further, although the above method 6) is simple, there is a problem that the chest wall is swayed by this method alone.

上記の問題点を解消するためにキールボーン（Kiel b
one）、又はボーンセメント（Bone cement）などの補強
材を併用することが提案されている。In order to solve the above problems, Kielbourne (Kiel b
It has been proposed to use a reinforcing material such as one) or bone cement together.

しかしキールボーンの使用には、同化の遅延、および
骨折防止および固定法の困難さなどの問題点があり、ボ
ーンセメントの使用には、骨欠損部に大きさを合わせる
ことが難しく、生理的な胸壁の運動を阻害しかつ合併症
を誘発するなどの問題点があった。However, the use of keelbone has problems such as delay of assimilation and difficulty of fracture prevention and fixation.The use of bone cement makes it difficult to adjust the size to the bone defect, There were problems such as inhibiting the movement of the chest wall and inducing complications.

〔発明が解決しようとする課題〕[Problems to be solved by the invention]

本発明は従来の胸壁再建法の上記問題点を解消し、胸
壁の骨欠損部の形状・寸法に適合させることが容易で、
内臓損傷や奇異呼吸の発生の危険性がなく、又は低く、
補綴部位への錨着が容易で生理的な胸壁の運動が妨げ
ず、胸壁を容易にかつ、短時間内に再建するのに有効
な、胸壁再建用人工骨複合材料を提供しようとするもの
である。The present invention solves the above problems of the conventional chest wall reconstruction method, it is easy to adapt to the shape and size of the bone defect of the chest wall,
No or low risk of visceral damage or paradoxical breathing,
The purpose of the present invention is to provide an artificial bone composite material for chest wall reconstruction that is easily anchored to a prosthetic site, does not hinder physiological movement of the chest wall, and is effective for easily and quickly reconstructing the chest wall. is there.

〔課題を解決するための手段・作用〕[Means and actions to solve the problem]

本発明の胸壁再建用人工骨複合材料はポリエステル繊
維布帛からなる包接部材と、前記包接部材の内側を包接
された人工骨部材とを含み、前記包接部材の端末部が、
前記人工骨部材の外側に伸び出ていて、前記人工骨部材
に接合すべき骨の端末部分を挿入するための筒状室を形
成していることを特徴とするものである。The chest wall reconstruction artificial bone composite material of the present invention includes an inclusion member made of a polyester fiber cloth, and an artificial bone member included inside the inclusion member, and a terminal portion of the inclusion member,
The present invention is characterized in that a cylindrical chamber extending outside the artificial bone member and for inserting a terminal portion of a bone to be joined to the artificial bone member is formed.

第１図および第２図にはそれぞれ本発明の胸壁再建用
人工骨複合材料の一実施態様が示されている。1 and 2 show one embodiment of the artificial bone composite material for chest wall reconstruction according to the present invention, respectively.

第１図において、人工骨複合材料は筒状に形成された
包接部材２および、その内部に包接されている人工骨部
材３により構成されている。この場合人工骨部材３は、
補綴すべき骨の形状・寸法に適合するように整形加工さ
れた人工骨材料であってもよく、或は、多数のセラミッ
ク材料粒状体であってもよい。後者の場合、包接材料
は、その内部に収容されたセラミック材料粒状体を、所
望の形状・寸法に規制し得るような形状・寸法に形成さ
れていなければならない。In FIG. 1, the artificial bone composite material includes an enclosure member 2 formed in a cylindrical shape and an artificial bone member 3 enclosed therein. In this case, the artificial bone member 3
It may be an artificial bone material shaped and shaped to match the shape and dimensions of the bone to be prosthetic, or may be a number of ceramic material granules. In the latter case, the cladding material must be formed in a shape and size that can regulate the ceramic material granules contained therein to a desired shape and size.

包接部材２の端末は、人工骨部材３の外側に伸び出て
いる筒状室４を形成している。この筒状室４は、本発明
の人工骨複合材料により、胸壁の骨欠損部を補綴すると
き、残存している骨の端末部分を挿入させるために設け
られたものであって、残存骨の端末と、人工骨部材の端
末とは、筒状室４内で接合され（必要があれば両端末は
ワイヤーで錨着され）この接合部分は、それを囲繞する
包接部材により包接保持される。The end of the inclusion member 2 forms a cylindrical chamber 4 extending outside the artificial bone member 3. The tubular chamber 4 is provided for inserting the terminal portion of the remaining bone when prosthesis is performed on the bone defect of the chest wall by using the artificial bone composite material of the present invention, The terminal and the terminal of the artificial bone member are joined in the cylindrical chamber 4 (if necessary, both ends are anchored with a wire), and this joined portion is enclosed and held by the enclosing member surrounding it. You.

人工骨部材３が多数のセラミック粒状体からなる場合
でも、人工骨部材３の端末部と、筒状室４中に挿入され
た残存骨の端末部分との接合部分は、それを囲繞する包
接部材により包接され、所定の形状、位置に保持され
る。また包接部材中に多数のセラミック粒状体からなる
人工骨部材を収容している人工骨複合材料は必要に応じ
てその形状を若干変えることが可能である。Even when the artificial bone member 3 is made of a large number of ceramic granules, the joint between the terminal portion of the artificial bone member 3 and the terminal portion of the remaining bone inserted into the cylindrical chamber 4 is included in the surrounding area. It is enclosed by a member and held in a predetermined shape and position. Also, the artificial bone composite material in which the inclusion member contains an artificial bone member composed of a large number of ceramic particles can be slightly changed in shape as required.

第２図において、２枚の布帛からなる包接部材２が重
ね合わされ、これを、再建すべき肋骨の形状、寸法、個
数に合致するように縫い目4aに沿って縫合して筒状室４
が形成され、この筒状室４内に所要量の人工骨部材３が
充填される。In FIG. 2, a cladding member 2 made of two pieces of cloth is superimposed, and this is sewn along a seam 4a so as to match the shape, size, and number of ribs to be reconstructed.
Is formed, and the required amount of the artificial bone member 3 is filled in the cylindrical chamber 4.

本発明人工骨複合材料に用いられる包接部材は、ポリ
エステル繊維布帛からなるものであり、それは織物、編
物および不織布のいづれであってもよいが機械的強度が
高く形状・寸法の安定した織物であることが好ましい。
この布帛は、包接部材中にセラミック材料粒状体が収容
される場合、その漏出がないような布帛密度を有してい
るものであることが必要である。The inclusion member used in the artificial bone composite material of the present invention is made of a polyester fiber cloth, which may be any of a woven fabric, a knitted fabric and a nonwoven fabric, but is a woven fabric having a high mechanical strength and a stable shape and dimensions. Preferably, there is.
When the ceramic member is contained in the inclusion member, the cloth needs to have such a density that there is no leakage.

本発明に用いられるポリエステル繊維は、ポリエチレ
ンテレフタレート繊維であることが好ましいが、ポリエ
チレンテレフタレートを主成分とする共重合体、又は混
合物からなる繊維であってもよい。The polyester fiber used in the present invention is preferably a polyethylene terephthalate fiber, but may be a fiber composed of a copolymer or a mixture containing polyethylene terephthalate as a main component.

本発明の人工骨複合材料に用いられる人工骨部材は、
一般に、セラミック、カーボン、金属、および硬質有機
合成樹脂から選ばれた少なくとも１種を主構成成分とし
て用いて形成され、これらは多孔質であってもよく、或
は非多孔質緻密体であってもよい。人工骨部材料セラミ
ックとしては、アルミナ、ジルコニア、およびリン酸カ
ルシウム系化合物などが利用できる。一般にセラミック
材料としては水酸アパタイト〔Ca10（PO4）６（O
H）２〕を用いることが好ましい。このような水酸アパ
タイトの組成に格別の限定はないが、一般に、カルシウ
ムとリンの含有量が1:1.60〜1:1.70のモル比をなしてい
るものが好ましい。このようなリン酸カルシウム系セラ
ミック材料は、ゾル−ゲル法により合成され、凍結乾燥
され、かつ1000〜1350℃の温度で焼結されていることが
好ましい。The artificial bone member used in the artificial bone composite material of the present invention,
Generally, it is formed using at least one selected from ceramic, carbon, metal, and hard organic synthetic resin as a main component, and these may be porous or non-porous dense body. Is also good. As the artificial bone material ceramic, alumina, zirconia, a calcium phosphate compound, or the like can be used. Generally, hydroxyapatite [Ca 10 (PO 4 ) 6 (O
H) 2 ] is preferably used. Although there is no particular limitation on the composition of such hydroxyapatite, it is generally preferable that the content of calcium and phosphorus is in a molar ratio of 1: 1.60 to 1: 1.70. Such a calcium phosphate-based ceramic material is preferably synthesized by a sol-gel method, freeze-dried, and sintered at a temperature of 1000 to 1350 ° C.

また人工骨部材形成用金属としては、例えばステンレ
ス鋼、チタン、タンタル、チタン合金、ニッケル−クロ
ム合金、ニッケル−クロム−コバルト合金、およびコバ
ルト−クロム−モリブデン合金などから選ばれた少なく
とも１種からなるものが用いられる。The metal for forming an artificial bone member is, for example, at least one selected from stainless steel, titanium, tantalum, a titanium alloy, a nickel-chromium alloy, a nickel-chromium-cobalt alloy, and a cobalt-chromium-molybdenum alloy. Things are used.

更に、人工骨部材形成用硬質有機材料としては、高密
度ポリエチレン樹脂、ポリテトラフルオロエチレン樹
脂、ポリメチルアクリレート樹脂、ポリエステル樹脂お
よびシリコーン樹脂などから選ばれた少なくとも１種か
らなるものが用いられる。Further, as the hard organic material for forming the artificial bone member, a material composed of at least one selected from high-density polyethylene resin, polytetrafluoroethylene resin, polymethyl acrylate resin, polyester resin, silicone resin and the like is used.

人工骨部材形成材料は、多孔質材料でも非多孔質材料
でもよいが、一般には多孔質材料であることが好まし
い。例えば多孔質リン酸カルシウム焼結体が本発明の人
工骨部材として有用なものである。The artificial bone member forming material may be a porous material or a non-porous material, but is generally preferably a porous material. For example, a porous calcium phosphate sintered body is useful as the artificial bone member of the present invention.

多孔質リン酸カルシウム焼結体は、下記のようにして
製造することができる。The porous calcium phosphate sintered body can be manufactured as follows.

例えばリン酸カルシウム（100重量部）に、粒径１〜6
00ミクロンの眞球状の有機合成樹脂粒子（０〜70重量
部）と直径１〜30ミクロンの有機重合体繊維（１〜５重
量部）とを均一混合し、この混合物を所望の形状寸法の
成形物に成形し、この成形物を200〜800℃の温度に加熱
して有機合成樹脂粒子およひ有機重合体繊維を熱分解し
て除去して、多孔質成形物とする。次に、この多孔質成
形物を800〜1350℃の温度、好ましくは1000〜1350℃の
温度で焼成する。この多孔質焼結体を所望の形状、寸法
に切削加工する。For example, calcium phosphate (100 parts by weight)
A 00 micron spherical organic synthetic resin particle (0 to 70 parts by weight) and an organic polymer fiber (1 to 5 parts by weight) having a diameter of 1 to 30 microns are uniformly mixed, and the mixture is molded into a desired shape and size. The resulting molded article is heated to a temperature of 200 to 800 ° C. to thermally decompose and remove the organic synthetic resin particles and the organic polymer fibers to obtain a porous molded article. Next, the porous molded product is fired at a temperature of 800 to 1350 ° C, preferably at a temperature of 1000 to 1350 ° C. This porous sintered body is cut into a desired shape and dimensions.

気孔形成用有機合成樹脂粒子としては、ポリプロピレ
ン樹脂、ポリメチルメタクリレート樹脂、ポリスチレン
樹脂などからなる粒子が用いられ、有機重合体繊維とし
ては、獣毛、絹繊維、セルロース繊維、ポリエステル繊
維、ポリオレフィン繊維などを用いることができる。As the pore-forming organic synthetic resin particles, particles made of polypropylene resin, polymethyl methacrylate resin, polystyrene resin and the like are used, and as the organic polymer fiber, animal hair, silk fiber, cellulose fiber, polyester fiber, polyolefin fiber, etc. Can be used.

上記のようにして製造された多孔質リン酸カルシウム
焼結体は、１〜600ミクロンの多数の眞球状独立空孔と
孔径１〜30ミクロンの多数の毛細管状空隙通路とを有し
ており眞球状独立空孔は毛細管状空隙通路により互に、
かつ外部空間に連通されている。空孔は眞球状、又はほ
ぼ眞球状の形状を有し、かつ焼結体内に均一に分布され
ていることが好ましい。このような空孔は、骨細胞が修
骨場として場の認識を行い、かつ活性化のための空間、
すなわち骨修復に対する細胞認識現場（細胞居住空間）
を提供するものである。骨細胞は、特定の曲率を有する
眞球状空間に滞留することを非常に好むもので、その孔
径は１〜600ミクロンであることが好ましく10〜300ミク
ロンの範囲内にあることがより好ましい。また空孔が眞
球形、又は、ほぼ眞球形であると、得られる多孔質体の
機械的強度が高くなる。孔径１〜30ミクロンの毛細管空
隙通路は破骨細胞、骨芽細胞、体液、白血球などの選択
的進入を許すが粒径の大きなコラーゲン繊維やマクロフ
ァージなどの進入を阻止し、それによってコラーゲン繊
維の異状増殖、それに伴う周囲の炎症偽関節、およびガ
ンの発生を防止することができる。空孔内に進入した上
記の細胞等はこの寸法の空孔に滞留することを非常に好
み骨の再生速度の制御、骨の再吸収の制御および新生骨
の誘起を促進することができる。The porous calcium phosphate sintered body produced as described above has a large number of spherical independent pores of 1 to 600 microns and a large number of capillary void passages of a pore diameter of 1 to 30 microns, and has a spherical independent shape. The pores are mutually connected by a capillary void passage,
And it is communicated with the external space. It is preferable that the holes have a true spherical shape or a substantially true spherical shape, and are uniformly distributed in the sintered body. Such vacancies create a space for the bone cells to recognize the place as an osteopath, and for activation,
That is, the site of cell recognition for bone repair (cell living space)
Is provided. Bone cells are highly preferred to reside in a spherical space having a specific curvature, and the pore size is preferably 1-600 microns, more preferably 10-300 microns. When the pores are spherical or almost spherical, the mechanical strength of the obtained porous body is increased. Capillary void passages with a pore size of 1 to 30 microns allow the selective invasion of osteoclasts, osteoblasts, body fluids, leukocytes, etc., but block the invasion of collagen fibers and macrophages with a large particle size, thereby causing abnormal collagen fibers Proliferation, concomitant inflamed pseudoarthritis, and the occurrence of cancer can be prevented. The cells and the like that have entered the pores are very fond of staying in pores of this size, and can promote the control of the rate of bone regeneration, the control of bone resorption, and the induction of new bone.

本発明の人工骨複合材料を形成するには、所定の寸法
を有する包接部材用ポリエステル繊維布帛を人工骨部材
に巻きつけてもよいし、或は上記布帛を縫合して筒状空
間を形成し、その中に人工骨部材を挿入してもよい。い
づれの場合も、包接部材の端末に筒状室が形成されてい
ることが重要である。In order to form the artificial bone composite material of the present invention, a polyester fiber cloth for the inclusion member having a predetermined size may be wound around the artificial bone member, or the above cloth may be stitched to form a cylindrical space. Then, an artificial bone member may be inserted therein. In any case, it is important that a tubular chamber is formed at the end of the inclusion member.

本発明の人工骨複合材料を用いて胸壁の再建を行うに
は、胸壁の骨欠如部分の残存骨の端末を、包接部材の端
末筒状室内に挿入して、人工骨の端末と接合させ、必要
があれば人工骨端末と、残存骨の端末とをワイヤーなど
で連絡し、包接部材を、骨の周囲の筋肉に縫合錨着す
る。In order to reconstruct the chest wall using the artificial bone composite material of the present invention, the end of the remaining bone in the bone-deficient portion of the chest wall is inserted into the end cylindrical chamber of the clathrate member and joined to the end of the artificial bone. If necessary, the terminal of the artificial bone and the terminal of the remaining bone are connected by a wire or the like, and the inclusion member is attached to the muscle around the bone with a suture anchor.

本発明の人工骨複合材料を用いて胸壁の骨欠損部を補
綴すると、手術後の経過と共に膠原線維組織が人工骨複
合材料の微小空孔内へ入り込んで強度を補強する。この
場合空孔のサイズ、包接部材の伸縮、包接部材布帛の厚
さ等の調整、さらに線維芽細胞を積極的に誘導する物質
の塗布あるいは透み込ませること等により、より一層安
定して固定が可能となる。When the artificial bone composite material of the present invention is used to repair a bone defect in the chest wall, the collagen fiber tissue enters the micropores of the artificial bone composite material to reinforce the strength with the progress of the operation. In this case, by adjusting the size of the pores, the expansion and contraction of the inclusion member, the thickness of the inclusion member cloth, and the like, and further applying or penetrating a substance that actively induces fibroblasts, the stability is further improved. Can be fixed.

本発明の人工骨複合材料を用いると、人工骨と、残存
骨との接合部分は、ポリエステル繊維布帛からなる包接
部材で包み込まれているため、胸壁の再建が順調に行わ
れ、胸壁動揺により、呼吸に困難を生ずることがなく、
また疼痛もなく美容上も優れた術後の成果が得られる。When the artificial bone composite material of the present invention is used, the joint between the artificial bone and the remaining bone is wrapped by the inclusion member made of polyester fiber cloth, so that the reconstruction of the chest wall is smoothly performed, and the chest wall is shaken. , Without causing difficulty in breathing,
In addition, there is no pain and excellent postoperative results in cosmetics.

更に、ポリエステル繊維布帛からなる包接部材にボー
ン モルフォジェネテック プロテイン（Bone morphog
enetic protein,BMP）を塗布あるいは透み込ませて積極
的に骨誘導を計り、金属、セラミック等からなる人工骨
部の安定性、支持性を高めることもできる。また金属、
セラミック等からなる充填材とポリエステル繊維布帛か
らなる包接部材とを組み合せ、骨欠損部及び空隙部を充
填し、周辺の支持組織（骨膜、靭帯、筋膜、筋腱）に包
接部材を錨着し、人工骨部材の安定性、支持性を高める
などのような、多方面における応用が期待出来る。Bone morphogenetic protein (Bone morphog protein)
Enetic protein (BMP) can be applied or penetrated to actively measure osteoinduction to enhance the stability and support of artificial bones made of metals, ceramics, and the like. Also metal,
A filler made of ceramic or the like is combined with an inclusion member made of polyester fiber cloth to fill the bone defect and voids, and the inclusion member is anchored to surrounding supporting tissues (periosteum, ligament, fascia, muscle tendon). It can be expected to be applied in various fields, such as to improve the stability and supportability of the artificial bone member when worn.

〔実施例〕〔Example〕

本発明を更に実施例により説明する。 The present invention is further described by way of examples.

実施例１ Ａ 人工骨部用セラミック材料 住友セメント株式会社製 水酸アパタイト ボーンセラムＰ（商標）を使用した。Example 1 A Ceramic material for artificial bone part Hydroxyapatite bone serum P (trademark) manufactured by Sumitomo Cement Co., Ltd. was used.

Ｂ 包接部材 布帛：ポリエチレンテレフタレート長繊維布帛 Ｃ 人工骨部材の作成 上記布帛を２つに折り重ね縫合して、切除した肋骨部
分に対応する筒状部を形成し、この筒状部に上記セラミ
ック材料粒状体を充填した。B Inclusion member Cloth: Polyethylene terephthalate long fiber cloth C Preparation of artificial bone member The above cloth is folded and sewn into two parts to form a cylindrical part corresponding to the cut rib part, and the ceramic part is formed on this cylindrical part. Material granules were filled.

補綴手術 左第10肋骨悪性線維性組織球腫を有する成人男性の病
巣部の肋骨を約10cm切除し、残存肋骨の端末を、人工骨
複合材料の包接部材の筒状室に挿入して、その端末と人
工骨部材の端末とを接合させ、包接部材を肋間筋にナイ
ロン系により縫着固定した。Prosthetic surgery Left 10th rib Rib of the lesion of an adult male with malignant fibrous histiocytoma of about 10 cm was excised, and the terminal of the remaining rib was inserted into the cylindrical chamber of the inclusion member of the artificial bone composite material, The terminal was joined to the terminal of the artificial bone member, and the inclusion member was sewn and fixed to the intercostal muscle using a nylon system.

手術中、奇異呼吸の発生がなく、その後強固な胸壁が
再建された。すなわち、手術後、呼吸機能の低下は認め
られなかった。During the operation, no paradoxical breathing occurred, after which the strong chest wall was reconstructed. That is, no decrease in respiratory function was observed after the operation.

〔発明の効果〕〔The invention's effect〕

本発明の胸壁再建用人工骨複合材料は、下記の効果を
奏し得るものである。The artificial bone composite material for chest wall reconstruction of the present invention has the following effects.

1. 人工骨部材の寸法形状弯曲状態などを、所要に応じ
て変化させることができる。1. The dimensions and shape of the artificial bone member can be changed as required.

2. 人工骨部材の離散を防止し、内臓損傷を防止するこ
とができる。2. It can prevent the artificial bone member from being separated and prevent internal organ damage.

3. 奇異呼吸を防止することができる。3. It can prevent paradoxical breathing.

4. 組織誘導が可能であって、強固な胸壁を再建するこ
とができ、経時的に補強される。4. Tissue guidance is possible, and a strong chest wall can be reconstructed and reinforced over time.

5. 肋間筋および骨膜との錨着が容易である。5. Easy anchoring to intercostal muscle and periosteum.

6. 生理的な胸壁の運動を妨げない。6. Does not interfere with physiological chest wall movement.

7. 胸壁再現を短時間内に達成できる。7. Achieve chest wall reproduction in a short time.

8. 美容上満足し得る。8. Beauty satisfaction.

すなわち、本発明の人工骨複合材料は、従来至難とさ
れてきた胸壁の再建を、可能にし、かつ、すぐれた効果
を有するものである。That is, the artificial bone composite material of the present invention enables reconstruction of the chest wall, which has been considered difficult, and has excellent effects.

【図面の簡単な説明】[Brief description of the drawings]

第１図および第２図はそれぞれ本発明の人工骨複合材料
の構成を示す説明図である。 １……人工骨複合材料、２……包接部材、 ３……人工骨部材、４……筒状室。 4a……縫い目。FIG. 1 and FIG. 2 are explanatory diagrams each showing the configuration of the artificial bone composite material of the present invention. 1 ... artificial bone composite material, 2 ... inclusion member, 3 ... artificial bone member, 4 ... cylindrical chamber. 4a …… Seams.

Claims (2)

(57)【特許請求の範囲】(57) [Claims] 【請求項１】ポリエステル繊維布帛からなる包接部材
と、前記包接部材の内側を包接された人工骨部材とを含
み、 前記包接部材の端末部が、前記人工骨部材の外側に伸び
出ていて、前記人工骨部材に接合すべき骨の端末部分を
挿入するための筒状室を形成していることを特徴とする
胸壁再建用人工骨複合材料。An enclosure member made of a polyester fiber cloth, and an artificial bone member enclosing the inside of the enclosure member, wherein a terminal portion of the enclosure member extends outside the artificial bone member. An artificial bone composite material for chest wall reconstruction, characterized in that it forms a tubular chamber for inserting a terminal part of a bone to be joined to the artificial bone member. 【請求項２】前記人工骨部材が、多数の多孔質セラミッ
ク粒状体よりなる、請求項１に記載の材料。2. The material according to claim 1, wherein said artificial bone member comprises a number of porous ceramic granules.
JP2281833A 1990-10-22 1990-10-22 Artificial bone composite for chest wall reconstruction Expired - Lifetime JP2635436B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2281833A JP2635436B2 (en) 1990-10-22 1990-10-22 Artificial bone composite for chest wall reconstruction

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2281833A JP2635436B2 (en) 1990-10-22 1990-10-22 Artificial bone composite for chest wall reconstruction

Publications (2)

Publication Number Publication Date
JPH04156840A JPH04156840A (en) 1992-05-29
JP2635436B2 true JP2635436B2 (en) 1997-07-30

Family

ID=17644645

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2281833A Expired - Lifetime JP2635436B2 (en) 1990-10-22 1990-10-22 Artificial bone composite for chest wall reconstruction

Country Status (1)

Country Link
JP (1) JP2635436B2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6869445B1 (en) 2000-05-04 2005-03-22 Phillips Plastics Corp. Packable ceramic beads for bone repair
FR2955480B1 (en) * 2010-01-26 2012-01-06 Christian Choux THERACIC WALL OSTEOSYNTHESIS DEVICE
EP3069689B1 (en) * 2015-03-16 2017-12-06 G21 S.r.l. Thoracic prosthesis and its method of preparation
CN108056844A (en) * 2017-12-26 2018-05-22 云南大学 A kind of multisection type 3D printing Artificial Rib with retractable structure

Also Published As

Publication number Publication date
JPH04156840A (en) 1992-05-29

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