JP2558421Y2 - Medical patch - Google Patents

Description

[Detailed description of the invention] [Industrial application field] The invention relates to a medical patch.

[Conventional technology]

In a medical patch comprising a conventionally known adhesive base and a pressure-sensitive adhesive layer containing a drug and a support for supporting the same, the entire adhesive layer is a single adhesive layer. It was a phase.

[Problems to be solved by the invention]

If the entire adhesive plaster layer is a single phase, the following problems occur.

I. When an adhesive plaster layer containing a necessary and sufficient amount of a drug and optimizing storage and release of the drug is not provided with an appropriate adhesive force for peeling off from the applied skin, it has a strong adhesive force. Therefore, it is painful to peel off, and a residual phenomenon occurs due to cohesive failure of the plaster.

B. If long-term application is required, it is preferable that the elastic layer has a soft composition with a small elastic modulus and a large layer thickness so that the plaster layer can easily follow the bending and stretching of the skin. Since the surface tackiness is stronger than the flow resistance of the entire layer, the same phenomenon as the above-mentioned a occurs.

C. The same phenomenon occurs when the thickness of the adhesive plaster layer has to be increased (80 μm or more) due to the total amount of the required medicine.

D. In general, an adhesive plaster layer having a smooth surface has a problem that even if it has a necessary minimum adhesive strength, it tends to scrape hairs on the skin which can be easily peeled off, thus causing pain.

E. When the entire plaster layer is microscopically a fine particle aggregate phase,
Although there is no scalp and easy to peel off, the thickness of the layer cannot be increased so much that the required amount of drug cannot be contained.

An object of the present invention is to provide a medical patch which is easy to peel off, does not give scalp or pain, has no plaster residue, and can contain a required amount of a drug.

[Means for solving the problem]

In order to achieve the above object, a medical patch according to the present invention is a medical patch comprising an adhesive plaster layer containing an adhesive base and a drug, and a support supporting the adhesive plaster layer. In the above, the adhesive plaster layer is formed into two layers, an inner layer composed of a microscopically uniform continuous phase, and an outer layer composed of a microscopically fine particle aggregate phase composed of adhesive polymer particles. It is characterized by having.

In the above description, the drug is contained in at least one of the inner layer and the outer layer depending on the type, and the drug concentration is preferably higher in the inner layer than in the outer layer.

Further, the composition of the adhesive base in each of the inner layer and the outer layer may be the same or different depending on necessity, and may be appropriately determined.

The thickness ratio of the inner layer to the outer layer is suitably from 7: 3 to 3: 7.

Further, it is desirable that the difference in solubility coefficient of the adhesive base between the inner layer and the outer layer is less than 1.0.

The fine particles in the outer layer preferably have a particle size of 500 μm or less.

Further, the softness of the support should be at least equal to the softness of a soft (low density) polyethylene film having a thickness of 80 μm.

[Action]

Since the inner layer of the adhesive plaster layer of the present invention is composed of a microscopically homogeneous continuous phase, the medicine can be necessary and sufficiently contained, and the material of the inner layer is By using a sufficiently soft material and increasing its thickness, the whole plaster layer can follow the flexion and elongation of the skin well, and the drug can smoothly move in the inner layer. On the other hand, since the outer layer of the adhesive plaster layer is composed of a microscopic aggregate of microparticles composed of adhesive polymer particles, the portion that comes into contact with the skin is not smooth and the microparticles on the surface of the outer layer adhere to the skin. In the state of contact, it is easy to peel off and the degree of releasability can be adjusted by changing the particle size, and since the drug easily passes through the outer layer, the release of the drug to the skin is good, Moreover, microscopically, each microparticle is in point contact with the skin, so that not only there is no irritation to the skin, but also it is easy to peel off.

〔Example〕

 An embodiment of the present invention will be described below with reference to the drawings.

The medical patch (1) shown in FIG. 1 includes an adhesive plaster layer (2) containing an adhesive base and a drug, and a support (3) supporting the same. The adhesive plaster layer (2) is an inner layer (2a) consisting of a microscopically homogeneous continuous phase
And an outer layer (2b) of a microscopically fine particle aggregate phase composed of adhesive polymer particles. The adhesive plaster layer (2) is a thin profit protective sheet. It is covered with (4).

FIG. 2 shows a state in which the fine particles (5) of the outer layer (2b) are microscopically and independently aggregated.

[Effect of the invention]

According to the medical patch of the present invention, the drug can be contained in the inner layer in a necessary and sufficient manner, so that the durability of the drug effect can be enhanced. Also, by using a sufficiently soft material for the inner layer and increasing its thickness, the whole plaster layer can follow the bending and stretching of the skin well,
There is no danger that the skin will peel off when bent. In addition, since the drug can move smoothly in the inner layer and the drug can easily pass through the outer layer, the drug can be easily released into the skin, and the drug can be effectively absorbed into the affected area. In addition, since the part in contact with the skin is not smooth and the fine particles on the outer layer surface are easily peeled off while in contact with the skin, there is no hairiness or pain at the time of peeling and no plaster remains, and Since the degree of releasability can also be adjusted by changing the particle size, in the case of infants with weak skin, it is also possible to adjust the releasability without damaging the skin. Furthermore, since the adhesive plaster layer is different in phase between the inner layer and the outer layer as described above, by appropriately selecting the thickness of both layers, adhesiveness, durable adhesion, depending on the purpose of use,
There is an advantage that the releasability, the drug content, the drug release property, and the like can be adjusted in a wide range.

[Brief description of the drawings]

The drawings show an embodiment of the present invention, and FIG. 1 is a vertical sectional view showing a state in which a peelable protective sheet is partially peeled off.
FIG. 2 is an enlarged detailed view of a portion A in FIG. (1) ... medical patch, (2) ... adhesive plaster layer,
(2a) ... inner layer, (2b) ... outer layer, (3) ... support.

Claims (1)

(57) [Scope of request for utility model registration] 1. A medical patch comprising an adhesive plaster layer (2) containing an adhesive base and a drug, and a support (3) supporting the same, wherein the adhesive plaster is Layer (2)
It is characterized by being formed in two layers: an inner layer (2a) consisting of a microscopically homogeneous continuous phase and an outer layer (2b) consisting of a microscopically aggregated phase consisting of adhesive polymer particles. Medical patch.