JP2537186C

JP2537186C -

Info

Publication number: JP2537186C
Authority: JP; Japan
Prior art keywords: filter; liposomes; population; liposome; pore size
Prior art date: 1999-06-28
Legal status : Expired - Lifetime

Application number

Other languages

English (en)

Japanese (ja)

Original Assignee

ザリポソームカンパニーインコーポレーテツド

Publication date

1999-06-28

Links

239000002502 liposome Substances 0.000 claims description 216
238000000034 method Methods 0.000 claims description 125
239000011148 porous material Substances 0.000 claims description 82
150000002632 lipids Chemical class 0.000 claims description 69
238000009826 distribution Methods 0.000 claims description 57
239000000203 mixture Substances 0.000 claims description 26
239000000126 substance Substances 0.000 claims description 26
239000002904 solvent Substances 0.000 claims description 24
239000004417 polycarbonate Substances 0.000 claims description 23
229920000515 polycarbonate Polymers 0.000 claims description 23
238000005311 autocorrelation function Methods 0.000 claims description 15
239000003599 detergent Substances 0.000 claims description 15
239000008188 pellet Substances 0.000 claims description 7
239000000843 powder Substances 0.000 claims description 7
239000012062 aqueous buffer Substances 0.000 claims description 6
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239000000523 sample Substances 0.000 description 32
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150000003904 phospholipids Chemical class 0.000 description 24
238000002360 preparation method Methods 0.000 description 24
238000005516 engineering process Methods 0.000 description 23
230000008569 process Effects 0.000 description 20
WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 16
229920001202 Inulin Polymers 0.000 description 15
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HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 14
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TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 11
ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 11
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IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
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