JP2527132C - - Google Patents

Info

Publication number

JP2527132C

JP2527132C JP2527132C JP 2527132 C JP2527132 C JP 2527132C JP 2527132 C JP2527132 C JP 2527132C

Authority

JP

Japan

Prior art keywords

affected area

coating layer

bleeding

affected

hydrophilic polysaccharide

Prior art date

1998-04-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Lifetime

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• 239000000203 mixture Substances 0.000 claims description 15
• 150000004676 glycans Chemical class 0.000 claims description 14
• 229920001282 polysaccharide Polymers 0.000 claims description 14
• 239000005017 polysaccharide Substances 0.000 claims description 14
• 238000002360 preparation method Methods 0.000 claims description 12
• 239000000843 powder Substances 0.000 claims description 10
• LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical group O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 claims description 7
• 229920002581 Glucomannan Polymers 0.000 claims description 7
• 229920002907 Guar gum Polymers 0.000 claims description 7
• 229940046240 glucomannan Drugs 0.000 claims description 7
• 229960002154 guar gum Drugs 0.000 claims description 7
• 235000010417 guar gum Nutrition 0.000 claims description 7
• 239000000665 guar gum Substances 0.000 claims description 7
• 239000002245 particle Substances 0.000 claims description 7
• 206010052428 Wound Diseases 0.000 description 13
• 208000027418 Wounds and injury Diseases 0.000 description 13
• 239000011247 coating layer Substances 0.000 description 11
• 230000000740 bleeding effect Effects 0.000 description 10
• 238000012360 testing method Methods 0.000 description 10
• 241000894006 Bacteria Species 0.000 description 9
• 239000003814 drug Substances 0.000 description 9
• 210000000416 exudates and transudate Anatomy 0.000 description 9
• 230000035876 healing Effects 0.000 description 7
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
• 239000008280 blood Substances 0.000 description 5
• 210000004369 blood Anatomy 0.000 description 5
• 208000033809 Suppuration Diseases 0.000 description 4
• 239000002674 ointment Substances 0.000 description 4
• 238000010521 absorption reaction Methods 0.000 description 3
• 238000007796 conventional method Methods 0.000 description 3
• 229940079593 drug Drugs 0.000 description 3
• 230000023597 hemostasis Effects 0.000 description 3
• 230000009545 invasion Effects 0.000 description 3
• 239000010410 layer Substances 0.000 description 3
• 229920000642 polymer Polymers 0.000 description 3
• 208000003322 Coinfection Diseases 0.000 description 2
• 229920002307 Dextran Polymers 0.000 description 2
• 241000283973 Oryctolagus cuniculus Species 0.000 description 2
• 206010039509 Scab Diseases 0.000 description 2
• 229960001950 benzethonium chloride Drugs 0.000 description 2
• UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 2
• IVHBBMHQKZBJEU-UHFFFAOYSA-N cinchocaine hydrochloride Chemical compound [Cl-].C1=CC=CC2=NC(OCCCC)=CC(C(=O)NCC[NH+](CC)CC)=C21 IVHBBMHQKZBJEU-UHFFFAOYSA-N 0.000 description 2
• 229940045574 dibucaine hydrochloride Drugs 0.000 description 2
• 230000000694 effects Effects 0.000 description 2
• 208000015181 infectious disease Diseases 0.000 description 2
• 230000000699 topical effect Effects 0.000 description 2
• 208000035143 Bacterial infection Diseases 0.000 description 1
• 208000019300 CLIPPERS Diseases 0.000 description 1
• GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
• 206010053567 Coagulopathies Diseases 0.000 description 1
• 201000004624 Dermatitis Diseases 0.000 description 1
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 1
• 206010072170 Skin wound Diseases 0.000 description 1
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
• 239000004480 active ingredient Substances 0.000 description 1
• 230000000844 anti-bacterial effect Effects 0.000 description 1
• 208000022362 bacterial infectious disease Diseases 0.000 description 1
• 239000003899 bactericide agent Substances 0.000 description 1
• 229960000686 benzalkonium chloride Drugs 0.000 description 1
• CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
• 239000004202 carbamide Substances 0.000 description 1
• 229960003260 chlorhexidine Drugs 0.000 description 1
• 208000021930 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids Diseases 0.000 description 1
• 230000035602 clotting Effects 0.000 description 1
• 201000010099 disease Diseases 0.000 description 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
• 238000001035 drying Methods 0.000 description 1
• 230000003203 everyday effect Effects 0.000 description 1
• 239000010419 fine particle Substances 0.000 description 1
• 238000009472 formulation Methods 0.000 description 1
• 230000002439 hemostatic effect Effects 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 230000007794 irritation Effects 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• 239000003589 local anesthetic agent Substances 0.000 description 1
• 230000033001 locomotion Effects 0.000 description 1
• 231100000989 no adverse effect Toxicity 0.000 description 1
• 239000002504 physiological saline solution Substances 0.000 description 1
• 230000002035 prolonged effect Effects 0.000 description 1
• 230000001737 promoting effect Effects 0.000 description 1
• 230000008961 swelling Effects 0.000 description 1