JP2527132C - - Google Patents

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external medicine composition containing a hydrophilic polysaccharide,
More specifically, the present invention relates to an external medicine composition comprising a powder of a hydrophilic polysaccharide for hemostasis, treatment of skin wounds and inflammation. 2. Description of the Related Art Conventionally, an ointment has been applied or used to stop bleeding of a wound on a skin, or to treat an ordinary wound, suppuration and other inflamed wounds. It is common practice to apply a bandage. However, rapid bleeding is important for bleeding for rapid healing of the affected area, and after bleeding is stopped, the plasma, pus, and other exudates from the affected area are effectively eliminated. It is important that the bacteria be removed by drying to prevent growth and prevent secondary infection by bacteria from the outside world. However, with an ointment or a bandage, it is impossible to sufficiently remove exudate from the affected area. Further, the ointment coating layer has a high fluidity and is extremely insufficient for the purpose of completely covering the affected part and sufficiently isolating it from the outside. Therefore, application of the ointment cannot prevent bacteria and the like from entering from the outside. Bandages likewise lack such isolation from the outside world. Under such circumstances, as an external preparation having the property of absorbing and exuding exudate from blood and other affected parts, Japanese Patent Publication No. 57-1266 (hereinafter referred to as P publication) discloses a crosslinked dextran. Formulations comprising dried spherical polymer particles such as cross-linked carboxymethyl-dextran are disclosed. [0004] However, in the preparation according to the P publication, even after the spherical polymer particles constituting the preparation absorb the exudate from the affected area and swell to form a coating layer, the respective spherical polymer particles are independent of each other. The entire coating layer is extremely brittle,
It can be easily scraped off with a spatula as described in the fifth column of the P gazette. For this reason, when the preparation is applied to an affected area on the body surface, the swollen preparation covering the affected area is accompanied by physical exercise or other accidental impact that can be unwillingly applied near the affected area. There is a danger that the coating layer will be partially torn or fall off, exposing the affected surface. When such exposure occurs, the surface of the affected area may be newly infected with bacteria from the outside world, and especially when infected with bacteria resistant to treatment, it may develop into a serious disease. Therefore, the integrity of the covering layer of the affected area needs to be maintained as much as possible. [0005] In contrast to the conventional preparations as disclosed in the P publication, the present invention absorbs exudates such as blood, plasma, pus, etc. in the affected area to form a very dense, essentially unstructured coating layer. It is intended to provide a preparation characterized by being formed. [0006] That is, the present invention is an external preparation comprising a powder composed of dry fine particles of a hydrophilic polysaccharide such as glucomannan or guar gum. [0007] Hydrophilic polysaccharides such as glucomannan, guar gum and the like have a very strong water absorbency, and quickly and heavily absorb exudates from the affected skin, such as blood, plasma and pus, to dry the affected area and promote healing. In addition, in the case of bleeding, it also has a rapid hemostasis effect, thereby enabling a rapid healing of the affected area. Further, these hydrophilic polysaccharides swell by absorbing exudate from the affected part to form a thick paste, and form a very dense and essentially non-structured coating layer on the surface of the affected part. . Due to this denseness of the coating layer, the invasion of bacteria from the outside through the coating layer is prevented, and the permeation of air is almost completely blocked. Further, since the coating layer formed by swelling is gelatinized in a homogeneous and non-structured manner, it differs from the aggregate of particles as disclosed in the P publication and has a strong stickiness, and can be coated even if there is physical movement or other accidental impact. Partial tearing or detachment of the layer is very unlikely and thus the integrity of the coating layer is maintained, eliminating the possibility of bacterial infection from the outside world. Further, these hydrophilic polysaccharides have no irritation to the affected area of the skin,
It has no adverse effect even if it is in prolonged contact with the affected area. In addition, since it has a high affinity for water, it is very easy to wash it off with a physiological saline or the like at the time of replacement when necessary. In the external medicine composition of the present invention, it is usually preferable to use a hydrophilic polysaccharide powder pulverized to 200 mesh or less. For use, if bleeding occurs due to a cut, apply the powder to the wound. The strong water absorption of the hydrophilic polysaccharide promotes rapid clotting of the blood, so that the amount of bleeding is very low and therefore almost no scab is formed. In addition, it absorbs blood and swells to form a dense layer, preventing the invasion of bacteria, so it does not purify and heals quickly, and after healing, the coating layer of the hydrophilic polysaccharide falls off naturally . In addition, even when used for purulent wounds, the composition of the present invention absorbs exudate and dries the affected part due to its strong water absorption, so that purulent wounds are healed rapidly and meanwhile, due to bacteria from the outside world. Secondary infections are also prevented. The composition of the present invention may be composed of a hydrophilic polysaccharide alone. If desired, the composition may contain various externally applied active ingredients, for example, a local anesthetic such as dibucaine hydrochloride, a bactericide such as benzethonium chloride, benzalkonium chloride, and chlorhexidine, and other powders, which are uniformly dispersed. As shown in the following test examples, the present preparation has an effect of promoting healing of wounds with bleeding, for example. [Test Example] Ten rabbits were randomly divided into two groups, which were group A and group B. At 10 am on the test day, each rabbit had its back shaved with a clipper. The right and left sides of the shaved back were used for testing. In Group A, the right part was used for the control test and the left part was used for the sample test. In Group B, the right part was used for the sample test and the left part was used for the control test. First, the skin 2.5cm x 2.5cm of the test part was sterilized with rubbing alcohol,
Bleeding was performed using a sterile scalpel with a wound about 5 mm in length. Control wounds were immediately covered with sterile gauze (one that does not adhere to the wound) 2.0 cm x 2.0 cm and fixed with a bandage. The test wound was immediately sprinkled with the present preparation [glucomannan (10 examples) and guar gum (10 examples) having a particle size of 200 mesh or less). After sprinkling a sufficient amount and confirming hemostasis, it was covered with sterilized gauze 2.0 cm × 2.0 cm and further fixed with a bandage. Thereafter, at 10 am every day, the bandage and gauze were removed, and it was observed whether or not the wound had healed, and replaced with a new sterile gauze. The day on which the scab was observed to fall off naturally was defined as the day of healing. The number of elapsed days and the number of wounds healed on each observation day are shown in Tables 1 and 2 below. [Table 1] [Table 2] From these results, the hydrophilic polysaccharide closely covers the affected area to prevent the invasion of bacteria and the like from the outside to prevent infection, and also suppresses bleeding and absorbs exudate by its hemostatic effect caused by its water absorption. Thus, it is recognized that healing is accelerated by keeping the affected area dry. [Example 1] Powdered external medicine composition Glucomannan or guar gum is pulverized by a conventional method to a particle size of 200 mesh or less to obtain an externally applied medicine composition of the present invention. Example 2 Powder External Medicine Composition The following components are uniformly mixed by a conventional method to prepare an external medicine composition. Glucomannan or guar gum (200 mesh or less) 99.8 g Dibucaine hydrochloride 0.1 g Benzethonium chloride 0.1 g [Example 3] Aqueous topical drug composition The following components are uniformly mixed by a conventional method to prepare a topical drug composition. Things. Glucomannan or guar gum (200 mesh or less) 5.0 g Urea 5.0 g Parabens 0.1 g Water 89.9 mL

Claims (1)

Claims: 1. An external preparation comprising a hydrophilic polysaccharide powder. 2. The external preparation composition according to claim 1, wherein the hydrophilic polysaccharide powder is glucomannan or guar gum powder. 3. The external composition according to claim 2, wherein the hydrophilic polysaccharide powder has a particle size of 200 mesh or less.